Pharmacognosy: Phytomedicines and their mechanisms

Veterinary Clinics of North America - Small Animal Practice

Volumn 34, Issue 1, 2004, Pages 291-327

  Larkins, Nicholas ^a   Wynn, Susan ^b  

^a Nutritional Laboratories   (United Kingdom)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALKALOID DERIVATIVE; ANALGESIC AGENT; APOCYNIN; ARTEMISININ; ASCORBIC ACID; CATECHIN; CURCUMIN; CYCLOOXYGENASE 2; CYTOCHROME C; FLAVANONE; GENISTEIN; KAEMPFEROL; LINOLEIC ACID; MYRICETIN; NONSTEROID ANTIINFLAMMATORY AGENT; OMEGA 3 FATTY ACID; PENICILLIN G; PHENOL DERIVATIVE; POLYUNSATURATED FATTY ACID; PREDNISONE; PROCYANIDIN DERIVATIVE; QUERCETIN; REACTIVE OXYGEN METABOLITE; RESORCINOL; RESVERATROL; SALICYLIC ACID; SILIBININ; TANNIN DERIVATIVE; UNINDEXED DRUG;

ANIMAL FOOD; ANIMAL HEALTH; ANTIINFLAMMATORY ACTIVITY; ANTIMALARIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPYRETIC ACTIVITY; DIET SUPPLEMENTATION; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; HERBAL MEDICINE; HUMAN; LIVER DISEASE; MALARIA; NONHUMAN; PEPPER; PHARMACOGNOSY; PHYTOCHEMISTRY; PHYTOTOXICITY; REVIEW; STRUCTURE ANALYSIS;

ANIMAL DISEASES; ANIMALS; HEALTH FOOD; PHARMACOGNOSY; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; STRUCTURE-ACTIVITY RELATIONSHIP; TREATMENT OUTCOME; VETERINARY MEDICINE;

ANIMALIA; CAPSICUM;

EID: 0742288753     PISSN: 01955616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cvsm.2003.09.006     Document Type: Review

References (175)

1. Newman D.J. Cragg G.M. Snader K.M. The influence of natural products on drug discovery Nat Prod Rep 17 2000 219-220
2. Huang K.C. The pharmacology of Chinese herbs 1999 CRC Press Boca Raton p. 450-2
3. Schmid W. Pflanzliche Bitterstoffe Planta Med 1996 34-40 Suppl
4. Halliwell B. Establishing the significance and optimal intake of dietary antioxidants. The biomarker concept Nutr Rev 57 1999 104-113
5. Van Acker S.A. Tromo M.N. Haenen G.R. van der Vijgh W.J. Bast A. Flavonoids as scavengers of nitric oxide radical Biochem Biophys Res Commun 214 1995 755-779
6. Baker M.E. Endocrine activity of plant-derived compounds: an evolutionary perspective Proc Soc Exp Biol Med 208 1995 131-138
7. Evans C.W. Trease and Evans' pharmacognosy 13th edition 1989 Bailliere Tindall Philadelphia
8. Knight J. Larkins N.J. Ganderton M. Armstrong K The use of Pholasin-based assays to evalute anti- and pro-oxidant capacity of extracts of certain functional foods: the effect of these foods on leucocytes in blood [abstract] Free Radic Biol Med 35 Suppl 1 2003 s38
9. Das U.N. Abrupt and complete occlusion of tumor-feeding vessels by gamma-linoleic acid Nutrition 18 7/8 2002 662-663
10. Naidu M.R. Das U.N. Kishan A. Intratumoral gamma-linolenic acid therapy of human gliomas, prostaglandins Prostaglandins Leukot Essent Fatty Acids 45 1992 181-184
11. Begin M.E. Das U.N. Ells G. Cytotoxic effects of essential fatty acids (EFA) in mixed cultures of normal and malignant human cells Prog Lipid Res 25 1986 573-578
12. Kelly G.S. Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide Altern Med Rev 4 2 1999 96-103
13. Potter S.M. Overview of proposed mechanisms for the hypo-cholesterolemic effect of soy J Nutr 125 3 Suppl 1995 606S-611S
14. Shils M.E. Olson J.A. Shike M Modern nutrition in health and disease 8th edition 1994 Lea & Febiger Philadelphia p. 290
15. Jenkinson A.M. et al. The effect of increased intakes of polyunsaturated fatty acids and vitamin E on DNA damage in human lymphocytes FASEB J 13 15 1999 2138-2142
16. Mo H. Elson C.E. Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids J Nutr 129 4 1999 804-813
17. Zhang R. et al. Enhancement of immune function in mice fed with high doses of soy daidzein Nutr Cancer 29 1997 24-28
18. Gaziano J.M. et al. A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly Ann Epidemiol 5 4 1995 255-260
19. Head K.A. Ipriflavone: an important bone-building isoflavone Altern Med Rev 4 1 1999 10-22
20. Seddon J.M. et al. Dietary carotenoids, vitamin A, C, and E, and advanced age-related macular degeneration: eye disease case-control study group JAMA 272 18 1994 1413-1420
21. Saija A. Scalese M. Lanza M. et al. Flavonoids as antioxidant agents: importance of their interaction with biomembranes Free Radic Biol Med 19 1995 481-486
22. Skaper S.D. Fabris M. Ferrari V. et al. Quercetin protects cutaneous tissue-associated cell types including sensory neurons from oxidative stress induced by glutathione depletion: cooperative effects of ascorbic acid Free Radic Biol Med 22 1997 669-678
23. Kim H.P. Mani I. Ziboh V.A. Effects of naturally-occurring flavonoids and biflavonoids on epidermal cyclooxygenase from guinea pigs Prostaglandins Leukot Essent Fatty Acids 58 1998 17-24
24. Bronner C. Landry Y. Kinetics of the inhibitory effect of flavonoids on histamine secretion from mast cells Agents Actions 16 1985 147-151
25. Kaul T.N. Middleton E. Jr. Ogra P.L. Antiviral effect of flavonoids on human viruses J Med Virol 15 1985 71-79
26. Stavric B. Quercetin in our diet: from potent mutagen to probable anticarcinogen Clin Biochem 27 1994 245-248
27. Scambia G. Raneletti F.O. Panici P.B. et al. Quercetin induces type-II estrogen-binding sites in estrogen-receptor-negative (MDA-MB231) and estrogen-receptor-positive (MCF-7) human breast-cancer cell lines Int J Cancer 54 1993 462-466
28. Castillo M.H. Perkins E. Campbell J.H. The effects of the bioflavonoid quercetin on squamous cell carcinoma of head and neck origin Am J Surg 158 1989 351-355
29. Beil W. Birkholz C. Sewing K.F. Effects of flavonoids on parietal cell acid secretion, gastric mucosal prostaglandin production and Helicobacter pylori growth Arzneimittelforschung 45 1995 697-700
30. Rice-Evans C. Wake up to flavonoids. International Congress and Symposium series 226 2000 Oxford, UK: Royal Society of Medicine Press
31. Bors W. Michel C. Schikora S. Interaction of flavonoids with ascorbate and determination of their univalent redox potentials; a pulse radiolysis study Free Radic Biol Med 19 1995 45-52
32. Bosisio E. et al. Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes Biotechnol Ther 4 1993 263-270
33. Thamsborg S.M. et al. Putative effect of silymarin on sawfly (Arge pullata)-induced hepatotoxicosis in sheep Vet Hum Toxicol 35 1996 89-96
34. Dehmlov C. Erhard J. De Groot H. Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silybin Hepatology 23 4 1996 749-754
35. Alarcon de la Lastra A.C. Martin M.J. Motilva V. Gastroprotection induced by silymarin, the hepatoprotective principle of Silybum marianum in ischemia-reperfusion mucosal injury: role of neutrophils Planta Med 61 1995 116-125
36. Magliulo E. Gaglardi B. Fiori G.P. Results of a double blind study on the effects of silymarin in the treatment of acute viral hepatitis, carried out at two medical centers Med Klin 73 28-29 1978 1060-1065
37. Florgheim G.L. Eberhard M. Tschumi P. Duckert F. Effects of penicillin and silymarin on liver enzymes and blood clotting factors in dogs given a boiled preparation of Amanita phalloides Toxicol Appl Pharmacol 46 2 1978 455-462
38. Vogel G. Tuchweber B. Trost W. Mengs U. Protection by silibinin against Amanita phalloides intoxication in beagles Toxicol Appl Pharmacol 73 3 1984 355-362
39. Hollman P.C.H. Wake up to flavanoids International Congress and Symposium, series 226 2000 Royal Society of Medicine Press Oxford, UK
40. Hollman P.C.H. Absorption, metabolism and bioavailability of flavonoids In: Rice-Evans C. Packer L. editors. Flavonoids in health and disease 1997 p. 483-522 Marcel Dekker New York
41. Hollman P.C.H. Katan M.B. Absorption, metabolism, and bioavailability of flavonoids In: Rice-Evans C. Packer L. editors Flavonoids in health and disease 1999 p. 483-516 Marcel Dekker New York
42. Rice-Evans C.A. Miller N.J. Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids Free Radic Biol Med 20 1996 933-956
43. Weber C. Erl W. Pietsch A. Strobel M. Ziegler-Heitbrock H.W. Weber P.C. Antioxidants inhibit monocyte adhesion by suppressing NF-κB mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals Arterioscler Thromb 14 10 1994 1665-1673
44. Saller R. Meier R. Brignoli R. The use of silymarin in the treatment of liver diseases Drugs 61 14 2001 2035-2063
45. Van Acker S.A. Tromo M.N. Haenen G.R. van der Vijgh W.J. Bast A. Flavonoids as scavengers of nitric oxide radical Biochem Biophys Res Commun 214 1995 755-759
46. Virgili F. Kobuchi H. Packer L. Nitogen monoxide (NO) metabolism In: Rice-Evans C. Packer L. editors. Flavonoids in health and disease 1997 p. 421-436 Marcel Dekker New York
47. Budavari S. O'Neil M. Smith A. Heckelman P. Obenchain J. editors. Merck Index 12th edition 2000 Merck and CO NJ
48. Haslam E. Natural polyphenols (vegetable tannins) as drugs: possible modes of actions J Nat Prod 59 1996 205-215
49. Colantuoni A. Bertuglia S. Magistretti M.J. Effects of Vaccinium myrtillus anthocyanosides on arterial vasomotion Arzneimittelforschung 41 1991 905-909
50. Bertuglia S. Malandrino S. Colantuoni A. Effect of Vaccinium myrtillus anthrocyanosides on ischemic-reperfusion injury in hamster cheek pouch microcirculation Pharmacol Res 31 1995 183-187
51. Detre Z. Jellinek H. Miskulin M. et al. Studies on vascular permeability in hypertention: action of anthrocynanosides Clin Physiol Biochem 4 1986 143-149
52. Magistretti M.J. et al. Antiulcer activity of an anthocyanidin from Vaccinium myrtillus Arzneimittelforschung 38 1988 686-690
53. Larkins N.J. Free radical biology and pathology J Equine Vet Sci 9 2 1999 84 89 134-135
54. Halliwell B. Gutteridge J.M. Antioxidant defences Free radicals in biology and medicine 3rd edition 1999 Oxford Science Publications Oxford, UK p. 105-245
55. Madhave D.L. et al. Food antioxidants. Technological, toxicological and health perspectives 1996 Marcel Dekker New York
56. Babior B.M. Superoxide: a two-edged sword Braz J Med Biol Res 30 1997 141-150
57. Halliwell B. Free radicals and antioxidants: a personal view Nutr Rev 52 8 Part 1 1994 253-265
58. Gutteridge J.M. Antioxidants, nutritional supplements and life-threatening diseases Br J Biomed Sci 51 3 1994 288-295
59. Halliwell B. Oxidative stress, nutrition and health: experimental strategies for optimisation of nutritional antioxidant intake in humans Free Radic Res 25 1 1996 57-74
60. Halliwell B. Gutteridge J.M. Antioxidant defences Free radicals in biology and medicine 3rd edition 1999 Oxford Science Publications Oxford, UK p. 229-30
61. Halliwell B. Gutteridge J.M. Reactive species as useful biomolecules Free radicals in biology and medicine 3rd edition 1999 Oxford Science Publications Oxford, UK p. 430-536
62. Morel I. Cillard P. Cillard J. Role of flavonoids and iron chelation in antioxidant action Methods Enzymol 234 1994 437-443
63. Torel J. et al. Antioxidant activity of flavonoids and reactivity with peroxyl radical Phytochemistry 25 1986 383-387
64. Mutoh M. et al. Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure Carcinogenesis 21 5 2000 959-963
65. Maekawa K. et al. The molecular mechanism of inhibition of interleukin-1beta-induced cyclooxygenase-2 expression in human synovial cells by Tripterygium wilfordii Hook F extract Inflamm Res 48 11 1999 575-581
66. Foreman H.J. Thomas M.J. Oxidant production and bactericidal activity of phagocytes Annu Rev Physiol 48 1986 669-680
67. Babior B.M. Phagocytes and oxidative stress Am J Med 109 2000 33-34
68. Lentsh A.B. Ward P.A. Regulation of inflammatory vascular damage J Pathol 190 2000 434-448
69. Poli G. Serial review: reactive oxygen and nitrogen in inflammation Free Radic Biol Med 33 2002 301-302
70. Müller A.A. et al. Plant-derived acetophenones with antiasthmatic and anti-inflammatory properties: inhibitory effects on chemotaxis, right angle light scatter and actin polymerization of polymorphonuclear granulocytes Planta Med 65 7 1999 590-594
71. Lapperre T.S. Jimenez L.A. Antonicelli F. Drost E.M. Hiemstra P.S. Stolk J. et al. Apocynin increases glutathione synthesis and activates AP-1 in alveolar epithelial cells FEBS Lett 443 2 1999 235-239
72. Pearse D.B. Dodd J.M. Ischemia-reperfusion lung injury is prevented by apocynin, a novel inhibitor of leukocyte NADPH oxidase Chest 116 1 Suppl 1999 55S-56S
73. Engels F. Renirie B.F. Hart B.A. Labadie R.P. Nijkamp F.P. Effects of apocynin, a drug isolated from the roots of Picrorrhiza kurroa, on arachidonic acid metabolism FEBS Lett 305 3 1992 254-256
74. Lafeber F.P. Beukelman C.J. van den Worm E. van Roy J.L. Vianen M.E. van Roon J.A. et al. Apocynin, a plant-derived, cartilage-saving drug, might be useful in the treatment of rheumatoid arthritis Rheumatology (Oxf) 38 11 1999 1088-1093
75. Hart B.A. Simons J.M. Metabolic activation of phenols by stimulated neutrophils: a concept for a selective type of anti-inflammatory drug Biotechnol Ther 3 3-4 1992 119-135
76. Loew D. Mollerfeld J. Schrodter A. Puttkammer S. Kaszkin M. Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo Clin Pharmacol Ther 69 5 2001 356-364
77. Leblan D. Chantre P. Fournie B. Harpagophytum procumbens in the treatment of knee and hip osteoarthritis. Four-month results of a prospective, multicenter, double-blind trial versus diacerhein Joint Bone Spine 67 5 2000 462-467
78. Gobel H. Heinze A. Ingwersen M. Niederberger U. Gerber D. Effects of Harpagophytum procumbens LI 174 (devil's claw) on sensory, motor and vascular muscle agility in the treatment of unspecific back pain Schmerz 15 1 2001 10-18
79. Langcake P. et al. The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection or injury Physiol Plant Pathol 9 1976 77-78
80. Subbaramaiah K. et al. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells J Biol Chem 273 34 1998 21875-21882
81. Flynn D.L. Rafferty M.F. Boctor A.M. Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally occurring diaryheptanoids: inhibiting activities of curcuminoids and yakuchinones Prostaglandins Leukot Med 22 3 1986 357-360
82. Piper J.T. Singhal S.S. Salameh M.S. Torman R.T. Awasthi Y.C. Awasthi S. Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver Int J Biochem Cell Biol 30 4 1998 445-456
83. Kawamori T. Lubet R. Steele V.E. Kelloff G.J. Kaskey R.B. Rao C.V. et al. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent Cancer Res 59 3 1999 597-601
84. Das U.N. Abrupt and complete occlusion of tumor-feeding vessels by gamma-linoleic acid Nutrition 18 7/8 2002 662-663
85. Duke J.A. Handbook of phytochemical constituents of GRAS herbs and other economic plants 1992 CRC Press Ann Arbor
86. Duke J.A. Handbook of biologically active phytochemicals and their activities 1992 CRC Press Ann Arbor
87. Huang K.C. The pharmacology of Chinese herbs 2nd edition 1999 CRC Press Ann Arbor 381-3
88. Takasuna K. et al. Protective effects of kampo medicines and baicalin against intestinal toxicity of a new anticancer comptothecin derivative, irinotecam hydrochloride (CPT-II), in rats Jpn J Cancer Res 86 1995 978-984
89. Sheng W.D. et al. Clinical evaluation in Malaria East Afr Med J 74 1997 283-284
90. Preininger V. The pharmacology and toxicology of the papaveraceae alkaloids In: Mankse R.H. Holmes H.L. editors. The alkaloids, vol. 15 1975 p. 239-250 Academic Press New York
91. Evans W.C. Trease and Evans' pharmacognosy 13th edition 1989 Bailliere Tindall Philadelphia p. 480-517
92. Lees R.S. et al. Lipoprotein metabolism 1976 Springer-Verlag New York
93. Ikeda I. et al. Some aspects of mechanism of inhibition of cholesterol absorption by beta-sitosterol Biochim Biophys Acta 732 1983 651
94. Nigro N.D. Combined inhibitors of carcinogenesis: effect of azoxymethane-induced intestinal cancer in rats J Natl Cancer Inst 69 1982 103
95. Bouic P.J. Lamprecht J.H. Plant sterols and sterolins: a review of their immune-modulating properties Altern Med Rev 4 3 1999 170-177
96. Bouic P.J. Immunomodulation in HIV/AIDS: the Tygerberg/Stellenbosch University experience AIDS Bull 6 1997 18-20
97. Wilson M.D. et al. Review of cholesterol absorption with emphasis on dietary and bilary cholesterol J Lipid Res 35 1994 943-955
98. Ishiwata K. et al. Influence of apolipoprotein E phenotype on metabolism of lipids and lipoproteins after plant stanol ingestion in Japanese subjects Nutrition 18 2002 561-565
99. Poli G. Serial review: reactive oxygen and nitrogen in Inflammation Free Radic Biol Med 33 2002 301-302
100. Gupta M.B. et al. Anti-inflammatory and antipyretic activities of beta-sitosterol Planta Med 39 1980 157-163
101. Bouic P.J. Etsebeth S. Liebenberg R.W. et al. Beta-sitosterol and beta-sitosterol glycoside stimulate human peripheral blood lymphocyte proliferation: implications for their use as an immunomodulatory vitamin combination Int J Immunopharmacol 18 1996 693-700
102. Ivorra M.D. D'Ocon M.P. Paya M. Villar A. Antihyperglycemic and insulin-releasing effects of β-sitosterol 3-β-D-glucoside and its aglycone, β-sitosterol Arch Int Pharmacodyn Ther 296 1988 224-231
103. Szutrely H.P. Clinical trials in treatment of prostate adenoma Med Klin 77 1982 520-528
104. Klippel K.F. et al. A multi-centric, placebo controlled, double-blind clinical trial of beta-sitosterol for the treatment of benign prostatic hyperplasia Br J Urol 80 1997 427-432
105. Berges R.R. et al. Randomised, placebo controlled, double blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia Lancet 345 1995 1529-1532
106. Bouic P.J. Clark A. Lamprecht J. Freestone M. Pool E.J. Liebenberg R.W. et al. The effects of B-sitosterol (BSS) and B-sitosterol glucoside (BSSG) mixture on selected immune parameters of marathon runners: inhibition of post marathon immune suppression and inflammation Int J Sports Med 20 4 1999 258-262
107. Shutt D.A. et al. Steroid and phytoestrogen binding to sheet uterine receptors in vitro J Endocrinol 52 1972 299-310
108. Piantelli M. Maggiano N. Ricci R. Iarocca L.M. Capelli A. Scambia G. et al. Tamoxifen and quercetin interact with type II estrogen binding sites and inhibit the growth of human melanoma cells J Invest Dermatol 105 1995 248-253
109. Shen F. Xue X Weber G. Tamoxifen and genistein synergistically down-regulate signal transduction and proliferation in estrogen receptor-negative human breast carcinoma MDA-MD-435 cells Anticancer Res 19 3A 1999 1657-1662
110. Kuiper G.G. Lemmen J.G. Carlsson B. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta Endocrinology 139 10 1998 4252-4263
111. Molteni A. Brizio-Molteni L. Persky V. In vitro hormonal effects of soybean isoflavones J Nutr 125 Suppl 1995 751s-756s
112. Herman C. Adlercreutz T. Goldin B.R. Soybean phytoestrogens intake and cancer risk J Nutr 125 Suppl 1995 757s-770s
113. Barnes S. Effect of genistein on in vitro and in vivo models of cancer J Nutr 125 Suppl 1995 177s-783s
114. Fotsis T. Pepper M. Adlercreutz H. Hase T. Montesano R. Schweigerer L. Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis J Nutr 125 Suppl 1995 790s-797s
115. Onozawa M. Fukuda K. Ohtani M. Effects of soybean isoflavones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP Jpn J Clin Oncol 58 17 1998 3833-3838
116. Peterson G. Evaluation of the biochemical targets of genistein in tumor cells J Nutr 125 Suppl 1995 784s-789s
117. Herman C. Adlercreutz T. Goldin B.R. Soybean phytoestrogen intake and cancer risk J Nutr 126 Suppl 1995 757s-770s
118. Carroll K. Guthrie N. So F.V. Chambers A.F. Anticancer properties of flavonoids In: Rice-Evans C. Packer L. editors. Flavonoids in health and disease 1990 p. 437-446 Marcel Dekker Philadelphia
119. Fotsis T. Montesano R. Pepper M. Adlercreutz H. Phytoestrogens and inhibition of angiogenesis Baillieres Clin Endocrinol Metab 12 4 1998 649-666
120. Bassleer C.T. Franchimont P.P. Henrotin Y.E. Franchimont N.M. Geenen V.G. Reginster J.Y. Effects of ipriflavone and its metabolites on human articular chondrocytes cultivated in clusters Osteoarthritis Cartilage 4 1 1996 1-8
121. Reginster J.Y. Ipriflavone: pharmacological properties and usefulness in postmenopausal osteoporosis Bone Miner 23 3 1993 223-232
122. Scheiber M.D. et al. Isoflavones and postmenopausal bone health: a viable alternative to estrogen therapy? Menopause Fall 6 3 1999 233-241
123. Head K.A. Ipriflavone: an important bone-building isoflavone Altern Med Rev 4 1 1999 10-22
124. Brekhman I. Dardymov I.V. New substances of plant origin which increase nonspecific resistance Annu Rev Pharmacol 9 1969 419-430
125. Panossian A.G. Oganessian A.S. Ambartsumian M. et al. Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva Phytomedicine 6 1 1999 17-26
126. Chang H.M. But P.P. Pharmacology and applications of Chinese materia medica, vol. 1 1987 World Scientific Publishing Singapore p. 199-209
127. Ip S.P. Ko K.M. The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: a comparative study with butylated hydroxytoluene Biochem Pharmacol 52 11 1996 1687-1693
128. Mak D.H. Ip S.P. Li P.C. et al. Effects of Schisandrin B and alpha-tocopherol on lipid peroxidation, in vitro and in vivo Mol Cell Biochem 165 2 1996 161-165
129. 4 intoxication model J Ethnopharmacol 67 1999 61-68
130. Ko K.M. Ip S.P. Poon M.K. Effect of a lignan-enriched fructus schisandrae extract on hepatic glutathione status in rats: protection against carbon tetrachloride toxicity Planta Med 61 2 1995 134-137
131. Kawamori T. Lubet R. Steele V.E. Kelloff G.J. Kaskey R.B. Rao C.V. et al. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent Cancer Res 59 3 1999 597-601
132. Piper J.T. Singhal S.S. Salameh M.S. Torman R.T. Awasthi Y.C. Awasthi S. Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver Int J Biochem Cell Biol 30 4 1998 445-456
133. Ip S.P. Mak D.H. Li P.C. Effect of a lignan-enriched extract of Schisandra chinensis on aflatoxin B1 and cadmium chloride-induced hepatotoxicity in rats Pharmacol Toxicol 78 6 1996 413-416
134. Hancke J. Burgos R. Wikman G. et al. Schizandra chinensis, a potential phytodrug for recovery of sport horses Fitoterapia 65 2 1994 113-118
135. Ahumada F. Hermosilla J. Hola R. et al. Studies on the effect of Schizandra chinensis extract on horses submitted to exercise and maximum effort Phytother Res 3 5 1989 175-179
136. Hancke J. Burgos R. Caceres D. et al. Reduction of serum hepatic transaminases and CPK in sport horses with poor performance treated with a standardized Schizandra chinensis fruit extract Phytomedicine 3 3 1996 237-240
137. Zykov MP. Prospects of immunostimulating vaccination against influenza including the use of Eleutherococcus senticosus and other preparations of plant origin. In: Proceedings of the Far East Science Center Symposium. Vladivostok: Far East Science Center, USSR Ac. Sci. 1986. p. 164-9.
138. Wagner H. In: Chang H.M. et al. editors Advances in Chinese medicinal materials 1985 p. 159-170 World Scientific Publishing Singapore
139. Kupin V.I. et al. Eleutherococcus senticosus demonstrates nonspecific immunity in patients undergoing anti-tumor treatment Vopr Onkol 32 1986 21-26
140. Molokovskii D.S. et al. The action of adaptogenic plant preparations in experimental alloxan diabets Probl Endokrinol (Mosk) 35 1989 82-87
141. Dardymov I.V. et al. New substances of plant origin which increase non-specific resistance Annu Rev Pharmacol 9 1969 419-430
142. Hikino H. et al. Isolation and hypoglycaemic activity of eleutherans A, B, C, D, E, F and G: from Eleutherococcus senticosus roots J Nat Prod 49 1986 293-297
143. Debarcy B. Sironval C. Fortifying immunological defences by adaptogens and their practical use in horses HPH Scientific News 1991 17-25
144. Wong O.W. et al. Effect of strenuous exercise stress on chemiluminescence response of equine alveolar macrophages Equine Vet J 22 1 1990 33-35
145. Bohn B. Nebe C.T. Birr C. Flow-cytometric studies with Eleutherococcus senticosus extract as an immunomodulatory agent Arzneimittelforschung 10 1987 1193-1196
146. Ooi V.E.C. Liu F. A review of pharmacological activities of mushroom polysaccharides International Journal of Medicinal Mushrooms 1 3 1999 195-206
147. Borchers A.T. Stern J.S. Hackman R.M. Keen C.L. Gershwin M.E. Mushrooms, tumors, and immunity Proc Soc Exp Biol Med 221 4 1999 281-293
148. Okazaki M. Adachi Y. Ohno N. Yadomae T. Structure-activity relationship of (1→3)-beta-D-glucans in the induction of cytokine production from macrophages, in vitro Biol Pharm Bull 18 10 1995 1320-1327
149. Adachi Y. et al. The effect enhancement of cytokine production by macrophages stimulated with 1, 3 beta D glucan, grifolan, isolated from Grifola frondosa Biol Pharm Bull 17 1994 1554-1560
150. Ohno N. et al. Effect of beta-glucan on the nitric oxide synthesis of peritoneal macrophage (sic) in mice Biol Pharm Bull 19 1996 608-612
151. Nakano H. et al. A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent disease: effects on prolongation of survival and improvement of quality of life. Kanagawa Research Group Hepatogastroenterology 46 1999 2662-2668
152. Matsuoka H. et.al. Lentinan potentiates immunity and prolongs the survival time of some patients Anticancer Res 17 1997 2251-2255
153. Williams D.L. et al. Therapeutic efficacy of glucan in a murine model of hepatic metastatic disease Hepatology 5 1985 198-206
154. Ukawa Y. Ito H. Hisamatsu M. Antitumor effects of (1→3)-beta-D-glucan and (1→6)-beta-D-glucan purified from newly cultivated mushroom, Hatakeshimeji (Lyophyllum decastes Sing.) J Biosci Bioeng 90 1 2000 98-104
155. Shigesue K. Kodama N. Nanba H. Effects of maitake (Grifola frondosa) polysaccharide on collagen-induced arthritis in mice Jpn J Pharmacol 84 3 2000 293-300
156. Estrada A. van Kessel A. Laarveld B. Effect of administration of oat beta-glucan on immune parameters of healthy and immunosuppressed beef steers Can J Vet Res 63 4 1999 261-268
157. Waller K.P. Cloditz I.G. The effect of intramammary infusion of beta-1,3-glucan or interleukin-2 on leukocyte subpopulations in mammary glands of sheep Am J Vet Res 60 6 1999 703-707
158. Inchaisri C. Waller K.P. Johannisson A. Studies on the modulation of leucocyte subpopulations and immunoglobulins following intramammary infusion of beta 1, 3-glucan into the bovine udder during the dry period J Vet Med B Infect Dis Vet Public Health 47 5 2000 373-386
159. Chang H.M. But P.P. Pharmacology and applications of Chinese materia medica, vol. 1 1987 World Scientific Publishing Singapore
160. Chu D. et al. Fractionated extract of Astragalus membranaceus, a Chinese medicinal herb, potentiates LAK cell cytotoxicity generated by a low dose of recombinant interleukin-2 J Clin Lab Immunol 26 4 1988 183-187
161. Zang L.L. et al. Pharmacology and applications of Chinese materia medica Chin J Exp Clin Virol 10 1996 77
162. Zhang W.H. et al. Cellular proteins that bind to the hepatitis B virus post-transcriptional regulatory element Shanghai J Immunol 16 1996 224-228
163. Zee-Cheng R.K. Shi-quan-da-bu-tang, SQT. A potent Chinese biological response modified in cancer immunotherapy, potentiating and detoxification of anti-cancer drugs Methods Find Exp Clin Pharmacol 14 1992 725-736
164. Tu L.H. et al. CD83 expression influences CD4+ T-cell development in the thymus Chin Med J 107 1994 300-312
165. Chang H. et al. Pharmacology and applications of Chinese materia medica, vol. 2 1987 World Scientific Publishing Singapore
166. Zhang L.L. et al. Study on the anti-herpes simplex virus activity of a suppository or ointment form of Astragalus membranaceus combined with interferon alpha 2b in human diploid cell culture Chinese J Exp Clin Virol 12 3 1998 269-271
167. Kim E.J. et al. Inhibitory effect of Astragali Radix on COX-2 activity Korean Journal of Pharmacognosy 32 4 2001 82-85
168. Ge C.R. et al. Research of feed additive formulations for swine with Chinese traditional medicinal herbs as their ingredients Journal of Yunnan Agricultural University 17 1 2002 45-50
169. Zhang L.C. et al. Effect of adding Chinese herb polysaccharide preparations to a Newcastle disease inactivated vaccine on the development of the immune organs in chickens Chin J Vet Sci 18 4 1998 378-381
170. Benthsath A. Rusznak S. Szent-Györgyi A. Vitamin nature of flavone Nature 138 1936 27-35
171. Huguet A.I. Manez S. Alcaraz M.J. Superoxide scavenging properties of flavonoids in non-enzymatic systems Z Naturforsch 45 1990 19-24
172. Gyorgy I. Antus S. Foldiak G. Pulse radiolysis of silybin: one electron oxidation of the flavonoid at neutral pH Radiat Phys Chem 5 1992 39-81
173. Rice-Evans C. Miller N.J. Bolwell P.G. Bramley P.M. Pridham J.B. The relative antioxidant activities of plant-derived polyphenolic flavonoids Free Radic Res 22 1995 375-383
174. Salah N. Miller N.J. Paganga G. Tijburg L. Bolwell P.G. Rice-Evans C. Polyphenolic flavonoids as scavengers of aqueous phase radicals and chain-breaking antioxidants Arch Biochem Biophys 322 1995 339-346
175. Simic M.G. Jovanovic S.V. Interaction of oxygen radicals by dietary phenolic compounds in anticarcinogenesis Cancer Res 54 Suppl 1994 2044s-2051s