Effects of ALDH2 gene polymorphisms and alcohol-drinking behavior on micronuclei frequency in non-smokers

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 541, Issue 1-2, 2003, Pages 71-80

  Ishikawa, Hitoshi ^a   Yamamoto, Hidetaka ^a   Tian, Ying ^a   Kawano, Mitsuo ^a   Yamauchi, Toru ^a   Yokoyama, Kazuhito ^a  

^a MIE UNIVERSITY   (Japan)

Author keywords

Aldehyde dehydrogenase 2; ALDH2; CAs; CB; Chromosomal aberrations; CI; Cytokinesis block; ERCC2; Excision repair cross complementing group 2; Micronuclei; MN; Odds ratio; OR; SCEs; Sister chromatids exchanges; X ray repair cross complementing group 1; XRCC1

Indexed keywords

ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ALDEHYDE DEHYDROGENASE; ALDH2 PROTEIN, HUMAN; DNA BINDING PROTEIN; ERCC2 PROTEIN, HUMAN; HELICASE; PROTEIN; TRANSCRIPTION FACTOR; X RAY REPAIR CROSS COMPLEMENTING PROTEIN 1; X-RAY REPAIR CROSS COMPLEMENTING PROTEIN 1; XERODERMA PIGMENTOSUM GROUP D PROTEIN;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CONTROLLED STUDY; CYTOGENETICS; DNA POLYMORPHISM; DRINKING BEHAVIOR; EXCISION REPAIR; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTOXICITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; INTERMETHOD COMPARISON; MALE; MICRONUCLEUS; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; AGED; GENETIC POLYMORPHISM; GENETICS; MIDDLE AGED;

ADULT; AGED; ALCOHOL DRINKING; ALDEHYDE DEHYDROGENASE; DNA HELICASES; DNA-BINDING PROTEINS; HUMANS; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROTEINS; TRANSCRIPTION FACTORS; XERODERMA PIGMENTOSUM GROUP D PROTEIN;

EID: 0642275709     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(03)00179-7     Document Type: Article

References (50)

1. Butler M.G., Sanger W.G., Veomett G.E. Increased frequencies of sister-chromatid exchanges in alcoholics. Mutat. Res. 85:1981;71-76.
2. Lazutka J.R., Dedonyte V., Lekevicius R.K. Sister chromatid exchanges in lymphocytes of normal and alcoholic subjects. Experientia. 48:1992;508-512.
3. Maffei F., Fimognari C., Castelli E., Stefanini G.F., Forti G.C., Hrelia P. Increased cytogenetic damage detected by FISH analysis on micronuclei in peripheral lymphocytes from alcoholics. Mutagenesis. 15:2000;517-523.
4. Maffei F., Forti G.C., Castelli E., Stefanini G.F., Mattioli S., Hrelia P. Biomarkers to assess the genetic damage induced by alcohol abuse in human lymphocytes. Mutat. Res. 514:2002;49-58.
5. Rajah T.T., Ahuja Y.R. In vivo genotoxicity of alcohol consumption and lead exposure in printing press workers. Alcohol. 13:1996;65-68.
6. Kafer E. Disruptive effects of ethyl alcohol on mitotic chromosomes segregation in diploid and haploid strains of Aspergillus nidulans. Mutat. Res. 135:1984;53-75.
7. Rey M., Palermo A.M., Munoz E.R. Nondisjunction induced by ethanol in Drosophila melanogaster females. Mutat. Res. 268:1992;95-104.
8. Kaufman M.H. The teratogenic effects of alcohol following exposure during pregnancy, and its influence on the chromosome constitution of the pre-ovulatory egg. Alcohol Alcohol. 32:1997;113-128.
9. Wong R.H., Wang J.D., Hsieh L.L., Cheng T.J. Effects on sister chromatid exchange frequency of aldehyde dehydrogenase 2 genotype and smoking in vinyl chloride workers. Mutat. Res. 420:1998;99-107.
10. Harada S. Polymorphism of aldehyde dehydrogenase and its application to alcoholism. Electrophoresis. 10:1989;652-655.
11. Harada S., Agarwal D.P., Goedde H.W. Aldehydedehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet. 2:1981;982.
12. Thomasson H.R., Crabb D.W., Edenberg H.J., Li T.K. Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. Behav. Genet. 23:1993;131-136.
13. Morimoto K., Takeshita T. Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes. Environ. Health Perspect. 104(Suppl. 3):1996;563-567.
14. Goode E.L., Ulrich C.M., Potter J.D. Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol. Biomarkers Prev. 11:2002;1513-1530.
15. Norppa H. Genetic polymorphisms and chromosome damage. Int. J. Hyg. Environ. Health. 204:2001;31-38.
16. Fenech M., Morley A.A. Measurement of micronuclei in human lymphocytes. Mutat. Res. 148:1985;29-36.
17. Fenech M. The cytokinesis-block micronucleus technique and its application to genotoxicity studies in human populations. Environ. Health Perspect. 101(Suppl. 3):1993;101-107.
18. Norppa H., Luomahaara S., Heikanen H., Roth S., Sorsa M., Renzi L., Lindholm C. Micronucleus assay in lymphocytes as a tool to biomonitor human exposure to aneuploidgens and clastogens. Environ. Mol. Mutagen. 101(Suppl. 3):1993;139-143.
19. Fenech M. The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat. Res. 285:1993;35-44.
20. Bonassi S., Fenech M., Lando C., Lin Y.-P., Ceppi M., Chang W.P., Holland N., Kirsch-Volder M., Zeiger E., Ban S., Barale R., Bigatti M.P., Bolognesi C., Jia C., Giorgio M.D., Ferguson L.R., Fucic A., Lima O.G., Hrelia P., Krishnaja A.P., Lee T.-K., Migliore L., Mikhalevich L., Mirkova E., Mosesso P., Muller W.-U., Odagiri Y., Scarfi M.R., Szabova E., Vorobtsova I., Vral A., Zijno A. Human micronucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes. I. Effects of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei. Environ. Mol. Mutagen. 37:2001;31-45.
21. Fenech M., Holland N., Chang W.P., Zeiger E., Bonassi S. The human micronucleus project - an international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans. Mutat. Res. 428:1999;271-283.
22. Ishikawa H., Tian Y., Yamauchi T. Influence of gender, age and lifestyle factors on micronuclei frequency in healthy Japanese population. J. Occup. Health. 45:2003;179-181.
23. Norppa H., Hirvonen A., Jarventaus H., Vlachodimitropoulos D., Autio K., Catalan J., Uuskula M., Tasa G., Sorsa M. Role of glutathione S-transferase T1 and M1 genotypes in determining individual sensitivity to genotoxicity of diepoxybutane in cultured human lymphocytes. Hum. Exp. Toxicol. 14:1995;833.
24. Vlachodimitropoulos D., Norppa H., Autio K., Catalan J., Hirvonen A., Tasa G., Uuskula M., Demopoulos N.A., Sorsa M. GSTT1-dependent induction of centromere-negative and -positive micronuclei by 1,2:3,4-diepoxybutane in cultured human lymphocytes. Mutagenesis. 12:1997;397-403.
25. Falck G.C.M., Hirvonen A., Scarpato R., Saarikoski S.T., Migliore L., Norppa H. Micronuclei in blood lymphocytes and genetic polymorphism for GSTM1, GSTT1 and NAT2 in pesticide-exposed greenhouse workers. Mutat. Res. 441:1999;225-237.
26. Ichiba M., Hagmar L., Rannug A., Hogstedt B., Alexandrie A.L., Carstensen U., Hemminki K. Aromatic DNA adducts. Carcinogenesis. 15:1994;1347-1352.
27. Pitarque M., Vaglenov A., Nosko M., Pavlova S., Petkova V., Hirvonen A., Creus A., Norppa H., Marcos R. Sister chromatid exchanges and micronuclei in peripheral lymphocytes of shoe factory workers exposed to solvents. Environ. Health Perspect. 110:2002;399-404.
28. Pavanello S., Clonfero E. Biological indicators of genotoxic risk and metabolic polymorphisms. Mutat. Res. 463:2000;285-308.
29. Watanabe M., Barzi F., Neal B., Ueshima H., Miyoshi Y., Okayama A., Choudhury S.R. Alcohol consumption and the risk of diabetes by body mass index levels in a cohort of 5636 Japanese. Diabetes Res. Clin. Pract. 57:2002;191-197.
30. Fenech M. The in vitro micronucleus technique. Mutat. Res. 455:2000;81-95.
31. Duell E.J., Wiencke J.K., Cheng T.J., Varkonyi A., Zuo Z.F., Ashok T.D.S., Mark E.J., Wain J.C., Christiani D.C., Kelsey K.T. Polymorphisms in the DNA repair gene XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cell. Carcinogenesis. 21:2000;965-971.
32. Harada S., Zhag S. New strategy for detection of ALDH2 mutant. Alcohol Alcohol. 28(Suppl. 1A):1993;11-13.
33. 1) with the disease. Am. J. Hum. Genet. 43:1988;744-748.
34. Suzuki K., Uchida A., Mizoi Y., Fukunaga T. A study on ADH2 and ALDH2 genotyping by PCR-RFLP and SSCP analyses with description of allele and genotype frequencies in Japanese, Fin, and Lapp populations. Alcohol Alcohol. 29:1994;21-27.
35. Hamajima N., Saito T., Matsuo K., Suzuki T., Nakamura T., Matsuura A., Okuma K., Tajima K. Genotype frequencies of 50 polymorphisms for 241 Japanese non-cancer patients. J. Epidemiol. 12:2002;229-236.
36. 2 allele is dominant. J. Clin. Invest. 83:1989;314-316.
37. Bohlke J.U., Singh S., Goedde H.W. Cytogenetic effects of acetaldehyde in lymphocytes of Germans and Japanese: SCE, clastogenic activity, and cell cycle delay. Hum. Genet. 63:1983;285-289.
38. Migliore L., Cocchi L., Scarpato R. Detection of the centromere in micronuclei by fluorescence in situ hybridization: its application to the human lymphocytes micronucleus assay after treatment with four suspected aneugens. Mutagenesis. 11:1996;285-290.
39. Singh N.P., Khan A. Acetaldehyde: genotoxicity and cytotoxicity in human lymphocytes. Mutat. Res. 337:1995;9-17.
40. Scott D., Barber J.B., Levine E.L., Burrill W., Roberts S.A. Radiation-induced micronucleus induction in lymphocytes identifies a high frequency of radiosensitive cases among breast cancer patients: a test for predisposition? Br. J. Cancer. 77:1998;614-620.
41. Trenz K., Rothfuss A., Schutz P., Speit G. Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation. Mutat. Res. 500:2002;89-96.
42. Fenech M. Important variables that influence base-line micronucleus frequency in cytokinesis-block lymphocytes - a biomarker for DNA damage in human populations. Mutat. Res. 404:1998;155-165.
43. Fenech M. The role of folic acid and Vitamin B12 in genomic stability of human cells. Mutat. Res. 475:2001;57-67.
44. Fenech M., Rinaldi J. The relationship between micronuclei in human lymphocytes and plasma levels of Vitamin C, Vitamin E, Vitamin B12 and folic acid. Carcinogenesis. 15:1994;1405-1411.
45. Zingg J.M., Jones P.A. Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis. 18:1997;869-882.
46. Blount B.C., Mack M.M., Wehr C.M., MacGregor J.T., Hiatt R.A., Wang G., Wickramasinghe S.N., Everson R.B., Ames B.N. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage, implications for cancer and neuronal damage. Proc. Natl. Acad. Sci. U.S.A. 94:1997;3290-3295.
47. Konishi T., Calvillo M., Leng A.-S., Feng J., Lee T., Lee H., Smith J.L., Sial S.H., Berman N., French S., Eysselein V., Lin K.-M., Wan Y.-J.Y. The ADH3*2 and CYP2E1 c2 allele increase the risk of alcoholism in Mexican American men. Exp. Mol. Pathol. 74:2003;183-189.
48. Iwahashi K., Ameno S., Ameno K., Okada N., Kinoshita H., Sakae Y., Nakamura K., Watanabe M., Ijiri I., Harada S. Relationship between alcoholism and CYP2E1 C/D polymorphism. Neuropsychobiology. 38:1998;218-221.
49. Abdel-Rahman S.Z., El-Zein R.A. The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by tobacco-specific nitrosamine NNK. Cancer Lett. 159:2000;63-71.
50. Lei Y.C., Hwang S.J., Chang C.C., Kuo H.W., Luo J.C., Chang M.J.W., Cheng T.J. Effects on sister chromatid exchange frequency of polymorphisms in DNA repair gene XRCC1 in smokers. Mutat. Res. 519:2002;93-101.