Effects on sister chromatid exchange frequency of polymorphisms in DNA repair gene XRCC1 in smokers

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 519, Issue 1-2, 2002, Pages 93-101

  Lei, Yu Chen ^a   Hwang, Shing Jen ^a   Chang, Chuen Chau ^a   Kuo, Hsen Wen ^b   Luo, Jiin Chyuan ^c   Chang, Ming J W ^c   Cheng, Tsun Jen ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Cigarette smoking; DNA repair; Glutathione S transferase M1; Metabolism; Microsomal epoxide hydrolase; Polymorphism; Sister chromatid exchange; X ray cross complementing group 1

Indexed keywords

ARGININE; DNA; EPOXIDE HYDROLASE; GLUTAMINE; GLUTATHIONE TRANSFERASE; MUTAGENIC AGENT; PROTEIN; PROTEIN X RAY CROSS COMPLEMENTING GROUP 1; UNCLASSIFIED DRUG;

ADULT; ANAMNESIS; ARTICLE; CELL ASSAY; CHROMOSOME ANALYSIS; CIGARETTE SMOKING; CODON; CONTROLLED STUDY; DNA DAMAGE; DNA POLYMORPHISM; DNA REPAIR; EPIDEMIOLOGICAL DATA; EXON; GENETIC DAMAGE; GENOTYPE; HUMAN; HUMAN CELL; LUNG CARCINOMA; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; METABOLISM; OCCUPATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUESTIONNAIRE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SISTER CHROMATID EXCHANGE;

ADULT; ALCOHOL DRINKING; DNA DAMAGE; DNA PRIMERS; DNA REPAIR; DNA-BINDING PROTEINS; EPOXIDE HYDROLASES; EXONS; GENETIC MARKERS; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; LYMPHOCYTES; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SISTER CHROMATID EXCHANGE; SMOKING;

EID: 0037179177     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(02)00127-4     Document Type: Article

References (43)

1. Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers
2. Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens
3. DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk
4. The XRCC1 glutamine 399 allele is a risk factor for adenocarcinoma of the lung
5. GST mu, diet and smoking as determinants of sister chromatid exchanges in lymphocytes
6. Polymorphisms in the DNA repair gene XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cell
7. Polymorphism of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population
8. The effect of tobacco on lung cancer depends on CYP2D6 activity
9. Association of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens
10. Human glutathione S-transferase mu deficiency as a marker for the susceptibility to bladder and larynx cancer among smokers
11. Modulation of benzo(a)pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism
12. Epoxide hydrolase: Biochemistry and molecular biology
13. Human mircosomal epoxide hydrolase: Genetic polymorphism and functional expression in vitro of amino acid variants
14. The human microsomal epoxide hydrolase gene (EPHX1): Complete nucleotide sequence and structural characterization
15. Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema
16. Association between lung cancer and microsomal epoxide hydrolase genotypes
17. Variation in DNA repair is a factor in cancer susceptibility: A paradigm for the promised and perils of individual and population risk estimation?
18. A Chinese hamster ovary cell mutant (EM-C11) with sensitivity to simple alkylating agents and a very high level of sister chromatid exchanges
19. Non-conservative amino acid substitution variants exist at polymorphic frequency in DNA repair gene in healthy humans
20. Domain specific interaction in the XRCC1-DNA polymerase β complex
21. The mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair
22. Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and the neck
23. Exposure to epichlorohydrin and dimethylformamide, glutathione S-tranferase and sister chromatid exchange frequencies in peripheral lymphocytes
24. New Giemsa method for the difference staining of sister chromatids
25. XRCC1 polymorphisms: Effects on alfatoxin B1-DNA adducts and glycophorin A variant frequency
26. The GSTT1 and CYP2E1 genotypes are possible factors causing vinyl chloride induced abnormal liver function
27. A case-control study of microsomal epoxide hydrolase, smoking, meat consumption, glutathione S-transferase M3, and risk of colorectal adenomas
28. Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population
29. DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study
30. Genetic polymorphisms in DNA repair genes and risk of lung
31. Nucleotide excision repair and the link with transcription
32. Oxygen radicals potentiate the genetic toxicity of tobacco-specific nitrosamines
33. Repair of oxidative DNA damage in vitro: A tool for screening antioxidative compounds
34. The Gln399 polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK
35. Lung cancer risk of GSTM1 null genotype is dependent on the extent of tobacco smoke exposure
36. Glutathione S-transferase M1 polymorphisms and lung cancer risk in African-Americans
37. Role of polymorphic GSTM1 and GSTT1 genotypes on NNK-induced genotoxicity
38. Modulations of DNA and protein adducts in smokers by genetic polymorphisms in GSTM1, GSTT1, NAT1 and NAT2
39. Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles Country
40. The association of microsomal epoxide hydrolase polymorphisms and lung cancer risk in African-Americans and Mexican-Americans
41. The interaction between microsomal epoxide hydrolase polymorphisms and cumulative cigarette smoking in different histological subtypes of lung cancer
42. Gene polymorphism for microsomal epoxide hydrolase and susceptibility to emphysema in a Japanese population