CLA+ T cells in cutaneous diseases

European Journal of Dermatology

Volumn 14, Issue 1, 2004, Pages 13-18

  Santamaria Babí, Luis F ^a  

^a Research Center ^*  (Spain)

Author keywords

CLA; Homing; Skin

Indexed keywords

ALEFACEPT; ALLERGEN; ANTICONVULSIVE AGENT; ANTIPSORIASIS AGENT; BETA LACTAM ANTIBIOTIC; BIMOSIAMOSE; CHEMOKINE RECEPTOR CCR10; CHEMOKINE RECEPTOR CCR10 LIGAND; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR3; CUTANEOUS LYMPHOCYTE ASSOCIATED ANTIGEN; EFALIZUMAB; EFOMYCINE M; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4; LACTACYSTIN BETA LACTONE; LIGAND; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MEMBRANE ANTIGEN; PROTEASOME INHIBITOR; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ALOPECIA AREATA; ATOPIC DERMATITIS; CELL MIGRATION; CLINICAL FEATURE; CLINICAL TRIAL; CONTACT DERMATITIS; CUTANEOUS T CELL LYMPHOMA; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; EFFECTOR CELL; HERPES SIMPLEX; HUMAN; LYMPHOCYTE FUNCTION; LYMPHOCYTE HOMING; LYMPHOCYTIC INFILTRATION; MEMORY CELL; MICROENVIRONMENT; NONHUMAN; PATHOGENESIS; PEMPHIGOID; PROTEIN LOCALIZATION; PSORIASIS; REVIEW; SKIN ALLERGY; SKIN INFLAMMATION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TOXIC EPIDERMAL NECROLYSIS; VITILIGO;

ANIMALS; ANTIGENS, CD45; DERMATITIS, ATOPIC; FEMALE; HUMANS; LYMPHOMA, T-CELL, CUTANEOUS; MALE; PROGNOSIS; PSORIASIS; RISK ASSESSMENT; SKIN DISEASES; SUPERANTIGENS; T-LYMPHOCYTES;

EID: 0442329151     PISSN: 11671122     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (77)

1. Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 1997; 389: 978-81.
2. Picker LJ, Michie SA, Rott LS, Butcher EC. A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites. Am J Pathol 1990; 136: 1053-68.
3. Campbell JJ, Brightling CE, Symon FA, Qin S, Murphy KE, Hodge M, Andrew DP, Wu L, Butcher EC, Wardlaw AJ. Expression of chemokine receptors by lung T cells from normal and asthmatic subjects. J Immunol 2001; 166: 2842-8.
4. Pitzalis C, Cauli A, Pipitone N, Smith C, Barker J, Marchesoni A, Yanni G, Panayi GS. Cutaneous lymphocyte antigen-positive T lymphocytes preferentially migrate to the skin but not to the joint in psoriatic arthritis. Arthritis Rheum 1996; 39: 137-45.
5. Picker LJ, Martin RJ, Trumble A, Newman LS, Collins PA, Bergstresser PR, Leung DY. Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites. Eur J Immunol 1994; 24: 1269-77.
6. Picker LJ, Treer JR, Ferguson-Darnell B, Collins PA, Bergstresser PR, Terstappen LW. Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells. J Immunol 1993; 150: 1122-36.
7. Picker LJ, Kishimoto TK, Smith CW, Warnock RA, Butcher EC. ELAM-1 is an adhesion molecule for skin-homing T cells. Nature 1991; 349: 796-9.
8. Berg EL, Yoshino T, Rott LS, Robinson MK, Warnock RA, Kishimoto TK, Picker LJ, Butcher EC. The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1. J Exp Med 1991; 174: 1461-6.
9. Zollner TM, Asadullah K. Selectin and selectin ligand binding: a bittersweet attraction. J Clin Invest 2003; 112: 980-3.
10. Dimitroff CJ, Bernacki RJ, Sackstein R. Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin. Blood 2003; 10: 602-10.
11. Wagers AJ, Lowe JB, Kansas GS. An important role for the alpha 1,3 fucosyltransferase, FucT-VII, in leukocyte adhesion to E-selectin. Blood 1996; 88: 2125-32.
12. + T cell migration into the skin, but normal extravasation into visceral organs . J Immunol 2002; 168: 2139-46.
13. Smithson G, Rogers CE, Smith PL, Scheidegger EP, Petryniak B, Myers JT, Kim DS, Homeister JW, Lowe JB. Fuc-TVII is required for T-helper 1 and T-cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes. J Exp Med 2001; 194: 601-14.
14. Wagers AJ, Waters CM, Stoolman LM, Kansas GS. Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on alpha 1,3-fucosyltransferase VII gene expression. J Exp Med 1998; 188: 2225-31.
15. + Th2 cells. Eur J Immunol 2000; 30: 3533-41.
16. Nakayama F, Teraki Y, Kudo T, Togayachi A, Iwasaki H, Tamatani T, Nisnihara S, Mizulawa Y, Shiohara T, Narimatsu H. Expression of cutaneous lymphocyte-associated antigen regulated by a set of glycosyltransferases in human T cells: involvement of alpha 1, 3-fucosyltransferase VII and beta 1,4-galactosyltransferase I. J Invest Dermatol 2000; 115: 299-306.
17. Leung DY, Gately M, Trumble A, Ferguson-Darnell B, Schlievert PM, Picker LJ. Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. J Exp Med 1995; 181: 747-53.
18. Santamaria LF, Torres R, Gimenez-Arnau AM, Gimenez-Camarasa JM, Ryder H, Palacios JM, Beleta J. Rolipram inhibits staphylococcal enterotoxin B-mediated induction of the human skin-homing receptor on T lymphocytes. J Invest Dermatol 1999; 113: 82-6.
19. Zollner TM, Podda M, Pien C, Elliott PJ, Kaufmann R, Boehncke WH. Proteasome inhibition reduces superantigen-mediated T cell activotion and the severity of psoriasis in a SCID-hu model. J Clin Invest 2002; 109: 671-9.
20. + T cells in melanoma patients receiving interleukin 12. Cancer Res 2000; 60: 3559-68.
21. Dimitroff CJ, Kupper TS, Sackstein R. Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen. J Clin Invest 2003; 112: 1008-18.
22. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994; 76: 301-14.
23. Santamaria Babi LF, Moser R, Perez Soler MT, Picker LJ, Blaser K, Hauser C. Migration of skin-homing T cells across cytokine-activated human endothelial cell layers involves interaction of the cutaneous lymphocyte-associated antigen (CLA), the very late antigen-4 (VLA-4), and the lymphocyte function-associated antigen-1 (LFA-1). J Immunol 1995; 154: 1543-50.
24. Santamaria Babi LF, Perez Soler MT, Hauser C, Blaser K. Skin-homing T cells in human cutaneous allergic inflammation. Immunol Res 1995; 14: 317-24.
25. Robert C, Kupper TS. Inflammatory skin diseases, T cells, and immune surveillance. N Engl J Med 1999; 341: 1817-28.
26. + T cells migrate through superficial vascular plexus but not through deep vascular plexus endothelium. J Invest Dermatol 1997; 108: 343-8.
27. Biedermann T, Schwarzler C, Lametschwandtner G, Thoma G, Carballido-Perrig N, Kund J, de Vries JE, Rot A, Carballido JM. Targeting CLA/E-selectin interactions prevents CCR4-mediated recruitment of human Th2 memory cells to human skin in vivo. Eur J Immunol 2002; 32: 3171-80.
28. Laudanna C, Kim JY, Constantin G, Butcher E. Rapid leukocyte integrin activation by chemokines. Immunol Rev 2002; 186: 37-46.
29. Santamaria Babi LF, Moser B, Perez Soler MT, Moser R, Loetscher P, Villiger B, Bloser K, Hauser C. The interleukin-8 receptor B and CXC chemokines can mediate transendothelial migration of human skin homing T cells. Eur J Immunol 1996; 26: 2056-61.
30. Campbell JJ, Haraldsen G, Pan J, Rottmon J, Qin S, Ponath P, Andrew DP, Warnke R, Ruffing N, Kassam N, et al. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 1999; 400: 776-80.
31. Homey B, Dieu-Nosjean MC, Wiesenborn A, Massacrier C, Pin JJ, Oldham E, Catron D, Buchanan ME, Muller A, deWaal Malefyt R, et al. Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol 2000; 164: 6621-32.
32. Rottman JB, Smith TL, Ganley KG, Kikuchi T, Krueger JG. Potential role of the chemokine receptors CXCR3, CCR4, and the integrin alphaEbeta7 in the pathogenesis of psoriasis vulgaris. Lab Invest 2001; 81: 335-47.
33. Homey B, Wang W, Soto H, Buchonan ME, Wiesenborn A, Catron D, Muller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, et al. Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J Immunol 2000; 164: 3465-70.
34. Moroles J, Homey B, Vicori AP, Hudak S, Oldham E, Hedrick J, Orozco R, Copeland NG, Jenkins NA, McEvoy LM, et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc Natl Acad Sci USA 1999; 96: 14470-5.
35. Homey B, Alenius H, Muller A, Sato H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bunemann E, et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med 2002; 8: 157-65.
36. + skin homing T cells. J Immunol 2002; 169: 1189-96.
37. Santamaria Babi LF, Picker LJ, Perez Soler MT, Drzimalla K, Flohr P, Blaser K, Hauser C. Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen. J Exp Med 1995; 181: 1935-40.
38. + T cells specific for a skin-tropic virus. J Clin Invest 2002; 110: 537-48.
39. Hunger RE, Yawalkar N, Braathen LR, Brand CU. The HECA-452 epitope is highly expressed on lymph cells derived from human skin. Br J Dermatol 1999; 141: 565-9.
40. Bohle B, Schwihla H, Hu HZ, Friedl-Hajek R, Sowka S, Ferreira F, Breiteneder H, Bruijnzeel-Koomen CA de Weger RA, Mudde GC, et al. Long-lived Th2 clones specific for seasonal and perennial allergens can be detected in blood and skin by their TCR-hypervariable regions. J Immunol 1998; 160: 2022-7.
41. Leung DY, Bieber T. Atopic dermatitis. Lancet 2003; 361: 151-60.
42. Jung K, Linse F, Pals ST, Heller R, Moths C, Neumann C. Adhesion molecules in atopic dermatitis: patch tests elicited by house dust mite. Contact Dermatitis 1997; 37: 163-72.
43. Abernathy-Carver KJ, Sampson HA, Picker LJ, Leung DY. Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen. J Clin Invest 1995; 95: 913-8.
44. Akdis CA, Akdis M, Trautmonn A, Blaser K. Immune regulation in atopic dermatitis. Curr Opin Immunol 2000; 12: 641-6.
45. Jung T, Schulz S, Zachmann K, Neumann C. Expansion and proliferation of skin-homing T cells in atopic dermatitis as assessed at the single cell level. Int Arch Allergy Immunol 2003; 130: 143-9.
46. + lymphocytes from children with atopic dermatitis contain an increased percentage of cells bearing staphylococcal-related T cell receptor variable segments. Clin Exp Allergy 1998; 28: 1264-72.
47. Strickland I, Hauk PJ, Trumble AE, Picker LJ, Leung DY. Evidence for superantigen involvement in skin homing of T cells in atopic dermatitis. J Invest Dermatol 1999; 112: 249-53.
48. Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Asano N, Mitsui H, Tada Y, Wakugawa M, Watanabe T, Torii H, et al. Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris. J Allergy Clin Immunol 2003; 111: 592-7.
49. Kakinumo T, Nakamura K, Wakugawa M, Mitsui H, Tada Y, Saeki H, Torii H, Asahina A, Onai N, Matsushima K, et al. Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity. J Allergy Clin Immunol 2001; 107: 535-41.
50. + T cell subsets against keratinocytes. J Immunol 2000; 165: 3058-64.
51. + T cells. J Invest Dermatol 1998; 111: 621-8.
52. Davison S, Allen M, Harmer A, Vaughan R, Barker JN. Increased T cell receptor vbeta2 chain expression in skin haming lymphocytes in psoriasis. Br J Dermatol 1999; 140: 845-8.
53. Prinz JC, Vollner S. The clonally selected T cells of psoriatic skin lesions can be detected in the fraction of CLA-positive tonsillar T cells of psoriasis patients with streptococcal sore throat. Br J Dermatol 2002; 147: Abstract 1061.
54. Baker BS, Garioch JJ, Hardman C, Powles A, Fry L. Induction of cutaneous lymphocyte-associated antigen expression by group A streptococcal antigens in psoriasis. Arch Dermatol Res 1997; 289: 671-6.
55. + T cells in the blood of psoriasis patients correlates closely with the severity of their disease. Clin Exp Immunol 2001; 126: 365-9.
56. Friedrich M, Wolff G, Philipp S, et al. Bimosiamose, a pan-selectin antagonist, improves disease manifestation both in human psoriatic skin SCID mice and psoriatic patients. Selectin antagonists as a new treatment strategy for inflammatory diseases. International Investigative Dermatology 2003; Abstract 367.
57. Schon MP, Krahn T, Schon M, Rodriguez ML, Antonicek H, Schultz JE, Ludwig RJ, Zollner TM, Bischoff E, Bremm KD, et al. Efomycine M, a new specific inhibitor af selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation. Nat Med 2002; 8: 366-72.
58. Ellis CN, Krueger GG. Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N Engl J Med 2001; 345: 248-55.
59. Gottlieb AB, Krueger JG, Wittkowski K, Dedrick R, Walicke PA, Gorovoy M. Psoriasis as a model for T cell-mediated disease: immunobiologic and clinical effects of treatment with multiple doses of efolizumab, an anti-CD11a antibody. Arch Dermatol 2002; 138: 591-600.
60. Gonzalez FJ, Leyva L, Posadas S, Luque I, Blanca M, Santomaria L, Juarez C. Participation of T lymphocytes in cutaneous allergic reactions to drugs. Clin Exp Allergy 1998; 28 (Suppl. 4): 3-6.
61. Gonzalez FJ, Carvajol MJ, del Pozo V, Lahoz C, Santamaria L, Blanca M, Juarez C. Erythema multiforme to phenobarbital: involvement of eosinophils and T cells expressing the skin homing receptor. J Allergy Clin Immunol 1997; 100: 135-7.
62. Gonzalez FJ, Carvajal MJ, Leiva L, Juarez C, Blanca M, Santamaria LF. Expression of the cutaneous lymphocyte-associated antigen in circulating T cells in drug-allergic reactions. Int Arch Allergy Immunol 1997; 113: 345-7.
63. Blanca M, Posadas S, Torres MJ, Leyva L, Mayorga C, Gonzalez L, Juarez C, Fernandez J, Santamaria LF. Expression of the skin-homing receptor in peripheral blood lymphocytes from subjects with nonimmediate cutaneous allergic drug reactions. Allergy 2000; 55: 998-1004.
64. Blanca M, Leyva L, Torres MJ, Mayorga C, Cornejo-Garcia J, Antunez-Rodriguez C, Santamaria LF, Juarez C. Memory to the hapten in non-immediate cutaneous allergic reactions to betalactams resides in a lymphocyte subpopulation expressing both CD45RO ond CLA markers. Blood cells, Molecules, and Diseases 2003; 31: 75-9.
65. Leyva L, Torres MJ, Posadas S, Blanca M, Besso G, O'Valle F, del Moral RG, Santamaria LF, Juarez C. Anticonvulsant-induced toxic epidermal necrolysis: monitoring the immunologic response. J Allergy Clin Immunol 2000; 105: 157-65.
66. Nossif A, Bensusson A, Dorothee G, Mami-Chouaib F, Bachot N, Bagot M, Boumsell L, Roujeau JC. Drug specific cytotoxic T cells in the skin lesions of a patient with toxic epidermal necrolysis. J Invest Dermotol 2002; 118: 728-33.
67. Borowitz MJ, Weidner A, Olsen EA, Picker LJ. Abnormalities of circulating T cell subpopulations in patients with cutaneous T cell lymphoma: cutaneous lymphocyte-associated antigen expression on T cells correlates with extent of disease. Leukemia 1993; 7: 859-63.
68. Heald PW, Yan SL, Edelson RL, Tigelaar R, Picker LJ. Skin-selective lymphocyte homing mechanisms in the pathogenesis of leukemic cutaneous T cell lymphoma. J Invest Dermatol 1993; 101: 222-6.
69. Ferenczi K, Fuhlbrigge RC, Pinkus J, Pinkus GS, Kupper TS. Increased CCR4 expression I in cutaneous T cell lymphoma. J Invest Dermatol 2002; 119: 1405-10.
70. Ogg GS, Rod Dunbar P, Romero P, Chen JL, Cerundolo V. High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo. J Exp Med 1998; 188: 1203-8.
71. + T cells of the perilesionol site. Lab Invest 2000; 80: 1299-309.
72. Teraki Y, Hotta T, Shiohara T. Skin-homing interleukin-4 and -13-producing cells contribute to bullous pemphigoid: remission of disease is associated with increased frequency of interleukin-10-producing cells. J Invest Dermatol 2001; 117: 1097-102.
73. Yano S, Nakomura K, Okochi H, Tamaki K. Analysis of the expression of cutaneous lymphocyte-associated antigen on the peripheral blood and cutaneous lymphocytes of alopecia areata patients. Acta Derm Venereol 2002; 82: 82-5.
74. Adams DH, Yannelli JR, Newmon W, Lawley T, Ades E, Rosenberg SA, Shaw S. Adhesion of tumour-infiltrating lymphocytes to endothelium: a phenotypic ond functional analysis. Br J Cancer 1997; 75: 1421-31.
75. Musette P, Bachelez H, Flageul B, Delarbre C, Kourilsky P, Dubertret L, Gachelin G. Immune-mediated destruction of melanocytes in halo nevi is associated with the local expansion of a limited number of T cell clones. J Immunol 1999; 162: 1789-94.
76. Piletto PA, Wirth S, Hommel L, Sourat JH, Hauser C. Circulating skin-homing T cells in atopic dermatitis. Selective up-regulation of HLA-DR, interleukin-2R, and CD30 and decrease after combined UV-A and UV-B phototherapy. Arch Dermatol 1996; 132: 1171-6.
77. Sigmundsdottir H, Gudjonsson JE, Valdimarsson H. The effects of ultraviolet B treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasis. Br J Dermatol 2003; 148: 996-1000.