The minimal model of glucose regulation: A biography

Advances in Experimental Medicine and Biology

Volumn 537, Issue , 2003, Pages 1-19

  Bergman, Richard N ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

CONFERENCE PAPER; CYBERNETICS; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HISTORY OF MEDICINE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SENSITIVITY; MATHEMATICAL ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SYSTEM ANALYSIS;

EID: 0348109298     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-9019-8_1     Document Type: Conference Paper

References (64)

1. Ader, M., Pacini, G., Yang, Y.J., and Bergman, R.N., 1985, Importance of glucose per se to intravenous glucose tolerance: comparison of the minimal model prediction with direct measurements, Diabetes 34:1092-1103.
2. Ader, M., and Bergman, R.N., 1987, Insulin sensitivity in the intact organism, in: Bailliere's Clinics in Endocrinology and Metabolism, K.G.M.M. Alberti, P. D. Home, and R. Taylor, eds., Bailliere Tindall, London.
3. Ader, M., Ni, T.-C., and Bergman, R.N., 1997, Glucose effectiveness assessed under dynamic and steady state conditions: comparability of uptake versus production components, J. Clin. Invest. 99:1187-1199.
4. Andres, R., Swerdloff, R., Pozefsky, T., and Coleman, D., 1966, Manual feedback technique for the control of blood glucose concentration, in: Automation in Analytical Chemistry, J. Skeggs, ed., Mediad, Inc., New York.
5. Basu, A., Caumo, A., Bettini, F., Gelisio, A., Alzaid, A., Cobelli, C., and Rizza, R.A., 1997, Impaired basal glucose effectiveness in NIDDM: contribution of defects in glucose disappearance and production, measured using an optimized minimal model independent protocol, Diabetes 46:421-432.
6. Beard, J.C., Ward, W.K., Halter, J.B., Wallum, B.J., and Porte, D., Jr., 1987, Relationship of islet function to insulin action in human obesity, J. Clin. Endocrinol. Metab. 65:59-64.
7. Bergman, R.N., 1989, Toward physiological understanding of glucose tolerance: minimal-model approach (Lilly Lecture), Diabetes 38:1512-1527.
8. Bergman, R.N., 1995, Insulin sensitivity from the minimal model, in: Research Methodologies in Human Diabetes - Part 2, Walter de Gruyter, Berlin.
9. Bergman, R.N., and Ader, M., 1993, Concepts emerging from the minimal model approach, in: Current Topics in Diabetes Research, F. Belfiore, R.N. Bergman, and G.M. Molinatti, eds., Karger, Basel.
10. Bergman, R.N., and Cobelli, C., 1980, Minimal modeling, partition analysis and the estimation of insulin sensitivity, Fed. Proc. 39:110-115.
11. Bergman, R.N., Finegood, D.T., and Ader, M., 1985, Assessment of insulin sensitivity in vivo, Endocr. Rev. 6:45-86.
12. Bergman, R.N., Phillips, L.S., and Cobelli, C., 1981, Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and B-cell glucose sensitivity from the response to intravenous glucose, J. Clin. Invest. 68:1456-1467.
13. Bergman, R.N., Prager, R., Volund, A., and Olefsky, J.M., 1987, Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp, J. Clin. Invest. 79:790-800.
14. Best, J.D., Kahn, S.E., Ader, M., Watanabe, R.M., Ni, T.-C., and Bergman, R.N., 1996, Role of glucose effectiveness in the determination of glucose tolerance, Diab. Care 19:1018-1030.
15. Bradley, D.C., Poulin, R.A., and Bergman, R.N., 1992, Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo, Diabetes 42:296-306.
16. Brownlee, M., 1994, Glycation and diabetic complications, Diabetes 43:836-841.
17. Buchanan, T.A., Metzger, B.E., Freinkel, N., and Bergman, R.N., 1990, Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes, Am. J. Obstet. Gynecol. 162:1008-1014.
18. Buchanan, T.A., Xiang, A.H., Peters, R.K., Kjos, S.L., Berkowitz, K., Marroquin, A., Goico, J., Ochoa, C., and Azen, S.P., 2000, Response of pancreatic b-cells to improved insulin sensitivity in women at high risk for type 2 diabetes, Diabetes 49:782-788.
19. Cahill, G.F., Jr., Herrera, M.G., Morgan, A.P., Soeldner, J.S., Steinke, J., Levy, P.L., Reichard, G.A., and Kipnis, D.M., 1966, Hormone-fuel interrelationships during fasting, J. Clin. Invest. 45:1751-1769.
20. Caumo, A., Vicini, P., and Cobelli, C., 1996, Is the minimal model too minimal? Diabetologia 39:997-1000.
21. I? Diabetologia 40:362-364.
22. Cobelli, C., Bettini, F., Caumo, A., and Quon, M.J., 1998, Overestimation of minimal model glucose effectiveness in presence of insulin response is due to undermodeling, Am. J. Physiol. 275:E1031-E1036.
23. Dea, M., Hamilton-Wessler, M., Ader, M., Poulin, R.A., Moore, D., and Markussen, J., 1997, Long-acting insulin analogue NN304 has similar transendothelial transport to porcine insulin, Diabetes 46:164A.
24. DeFronzo, R.A., Tobin, J.D., and Andres, R., 1979, Glucose clamp technique: a method for quantifying insulin secretion and resistance, Am. J. Physiol. 237:E214-E223.
25. Donner, C.C., Fraze, E., Chen, Y.D.I., Hollenbeck, C.B., Foley, J.E., and Reaven, G.M., 1985, Presentation of a new method for specific measurement of in vivo insulin-stimulated glucose disposal in humans: comparison of this approach with the insulin clamp and minimal model techniques, J. Clin. Endocrinol. Metab. 60:723-726.
26. Dunaif, A., and Finegood, D.T., 1996, b-Cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome, J. Clin. Endocrinol. Metab. 81:942-947.
27. Finegood, D.T., Pacini, G., and Bergman, R.N., 1984, The insulin sensitivity index: correlation in dogs between values determined from the intravenous glucose tolerance test and the euglycemic glucose clamp, Diabetes 33:362-368.
28. Foster, D.M., Boston, R.C., Jacquez, J.A., and Zech, L., 1989, A resource facility for kinetic analysis: modeling using the SAAM computer programs, Health Phys. 57 (Suppl 1):457-466.
29. Garcia, G.V., Freeman, R.V., Supiano, M.A., Smith, M.J., Galecki, A.T., and Halter, J.B., 1997, Glucose metabolism in older adults: a study including subjects more than 80 years of age, J. Am. Geriatr. Soc. 45:813-817.
30. Getty, L., Hamilton-Wessler, M., Ader, M., Dea, M.K., and Bergman, R.N., 1998, Biphasic insulin secretion during intravenous glucose tolerance test promotes optimal interstitial insulin profile, Diabetes 47:1941-1947.
31. Greif, P., Wastney, M., Linares, O., and Boston, R., 1998, Balancing needs, efficiency, and functionality in the provision of modeling software: a perspective of the NIH WinSAAM project, in: Mathematical Modeling in Experimental Nutrition. A.J. Clifford and H.-G. Müller, eds., Plenum Press, New York.
32. Grodsky, G.M., 1972, A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling, J. Clin. Invest. 51:2047-2059.
33. Hamilton-Wessler, M., Ader, M., Dea, M., Moore, D., Jorgensen, P.N., Markussen, J., and Bergman, R.N., 1999, Mechanism of protracted metabolic effects of fatty acid acylated insulin, NN304, in dogs: retention of NN304 by albumin, Diabetologia 42:1254-1263.
34. Hamilton-Wessler, M., Ellmerer, M., Dea, M.K., Mittelman, S.D., van Citters, G.W., and Kim, S.P., 2000, Insulin resistance in dogs with transendothelial transport defect, Diabetes 49 (Suppl 1), A59.
35. Hodgkin, A.L., 1951, The ionic basis of electrical activity in nerve and muscle, Biol. Rev. 26:339-401.
36. Howard, G., O'Leary, D.H., Zaccaro, D., Haffner, S., Rewers, M., Hamman, R., Selby, J.V., Saad, M.F., Savage, P., and Bergman, R. for the IRAS Investigators, 1996, Insulin sensitivity and atherosclerosis: the Insulin Resistance Atherosclerosis Study (IRAS), Circulation 93:1809-1817.
37. Jansson, P.A., Fowelin, J.P., von Schenck, H.P., Smith, U.P., and Lonnroth, P.N., 1993, Measurement by microdialysis of the insulin concentration in subcutaneous interstitial fluid: Importance of the endothelial barrier for insulin, Diabetes 42:1469-1473.
38. Kahn, S.E., Beard, J.C., Schwartz, M.W., Ward, W.K., Ding, H.L., Bergman, R.N., Taborsky, G.J., Jr., and Porte, D., Jr., 1989, Increased B-cell secretory capacity as mechanism for islet adaptation to nicotinic-acid-induced insulin resistance, Diabetes 38:562-568.
39. Kahn, S.E., Prigeon, R.L., McCulloch, D.K., Boyko, E.J., Bergman, R.N., Schwartz, M.W., Neifing, J.L., Ward, W.K., Beard, J.C., Palmer, J.P., and Porte, D., Jr., 1993, Quantification of the relationship between insulin sensitivity and B-cell function in human subjects: evidence for a hyperbolic function, Diabetes 42:1663-1672.
40. King, G.L., and Johnson, S.M., 1985, Receptor-mediated transport of insulin across endothelial cells, Science 227:1583-1586.
41. Knott, G.D., 1979, MLAB - a mathematical modeling tool, Comput. Progr. Biomed. 10:271-280.
42. Korytkowski, M.T., Berga, S.L., and Horwitz, M.J., 1995, Comparison of the minimal model and the hyperglycemic clamp for measuring insulin sensitivity and acute insulin response to glucose, Metabolism 44:1121-1125.
43. Lewis, G.F., Vranic, M., Harley, P., and Giacca, A., 1997, Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans, Diabetes 46:1111-1119.
44. Manning, R.D., Jr., and Guyton, A.C., 1982, Control of blood volume, Rev. Physiol. Biochem. Pharmacol. 93:70-114.
45. Martin, B.C., Warram, J.H., Krolewski, A.S., Bergman, R.N., Soeldner, J.S., and Kahn, C.R., 1992, Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study, Lancet 340:925-929.
46. McDonald, C., Dunaif, A., and Finegood, D.T., 2000, Minimal-model estimates of insulin sensitivity are insensitive to errors in glucose effectiveness, J. Clin. Endocrinol. Metab. 85:2504-2508.
47. Miles, P.D.G., Levisetti, M., Reichart, D., Khoursheed, M., Moossa, A.R., and Olefsky, J.M., 1995, Kinetics of insulin action in vivo: identification of rate-limiting steps, Diabetes 44:947-953.
48. Mittelman, S.D., and Bergman, R.N., 2000, Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin, Am. J. Physiol. 279:E630-E637.
49. Ni, T.-C., Ader, M., and Bergman, R.N., 1997, Reassessment of glucose effectiveness and insulin sensitivity from minimal model analysis: a theoretical evaluation of the single-compartment glucose distribution assumption, Diabetes 43:1813-1821.
50. Poulin, R.A., Steil, G.M., Moore, D.M., Ader, M., and Bergman, R.N., 1994, Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph, Diabetes 43:180-190.
51. Quon, M.J., Cochran, C., Taylor, S.I., and Eastman, R.C., 1994, Non-insulin-mediated glucose disappearance in subjects with IDDM: discordance between experimental results and minimal model analysis, Diabetes 43:890-896.
52. Rashevsky, N., 1940, Advances and Applications of Mathematical Biology, University of Chicago Press, Chicago.
53. Rebrin, K., Steil, G.M., Getty, L., and Bergman, R.N., 1995, Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin, Diabetes 44:1038-1045.
54. Rebrin, K., Steil, G.M., Mittelman, S., and Bergman, R.N., 1996, Causal linkage between insulin regulation of lipolysis and liver glucose output, J. Clin. Invest. 98:741-749.
55. Turing, A.M., 1936, On computable numbers, with an application to the Entscheidungsproblem, Proc. London Math. Soc. 2:230-265.
56. Steil, G. M., Ader, M., Moore, D.M., Rebrin, K., and Bergman, R.N., 1996, Transendothelial insulin transport is not saturable in vivo: no evidence for a receptor-mediated process, J. Clin. Invest. 97:1497-1503.
57. Taniguchi, A., Nakai, Y., Fukushima, M., Imura, H., Kawamura, H., Nagata, I., Florant, G.L., and Tokuyama, K., 1994, Insulin sensitivity, insulin secretion, and glucose effectiveness in subjects with impaired glucose tolerance: a minimal model analysis, Metabolism 43:714-718.
58. Valle, T., Tuomilehto, J., Bergman, R.N., Ghosh, S., Hauser, E.R., Eriksson, J., Nylund, S.J., Kohtamaki, K., Toivanen, L., Vidgren, G., Tuomilehto-Wolf, E., Ehnholm, C., Blaschak, J., Langefeld, C.D., Watanabe, R.M., Magnuson, V., Ally, D.S., Hagopian, W.A., Ross, E., Buchanan, T.A., Collins, F., and Boenke, M., 1998, Mapping genes for NIDDM: design of the Finland-United States investigation of NIDDM genetics (FUSION) study, Diab. Care 21:949-958.
59. Vicini, P., Caumo, A., and Cobelli, C., 1997. The hot IVGTT two-compartment minimal model: indexes of glucose effectiveness and insulin sensitivity, Am. J. Physiol. 273:E1024-E1032.
60. Weiner, N., 1965, Cybernetics or Control and Communication in the Animal, MIT Press, Boston.
61. Weyer, C., Bogardus, C., Mott, D.M., and Pratley, R.E., 1999, The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus, J. Clin. Invest. 104:787-794.
62. Wing, R.R., Blair, E.H., Bononi, P., Marcus, M.D., Watanabe, R., and Bergman, R.N., 1994, Caloric restriction per se is a significant factor in improvements in glycemic control and insulin sensitivity during weight loss in obese NIDDM patients, Diab. Care 17:30-36.
63. Yang, Y.J., Hope, I.D., Ader, M., and Bergman, R.N., 1989, Insulin transport across capillaries is rate limiting for insulin action in dogs, J. Clin. Invest. 84:1620-1628.
64. Yates, F.E., Marsh, D.J., and Iberall, A.S., 1972, Integration of the whole organism: a foundation for a theoretical biology, in: Challenging Biological Problems: Directions Towards Their Solution, J.A. Behnke, ed., Oxford University Press, New York.