Diethylmaleate and buthionine sulfoximine, glutathione-depleting agents, differentially inhibit expression of inducible nitric oxide synthase in endotoxemic mice

Nitric Oxide - Biology and Chemistry

Volumn 3, Issue 3, 1999, Pages 265-271

  Kang, Keon Wook ^a   Pak, Young Mi Kim ^b   Kim, Nak Doo ^a  

^a Seoul National University   (South Korea)

^b Korea National Institute of Health   (South Korea)

Author keywords

Buthionine sulfoximine; Diethylmaleate; Glutathione; Inducible nitric oxide synthase; Nitric oxide

Indexed keywords

BUTHIONINE SULFOXIMINE; INTERLEUKIN 1BETA; MALEIC ACID DIETHYL ESTER; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INDUCTION; ENZYME INHIBITION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALIA;

EID: 0242673431     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1006/niox.1999.0233     Document Type: Article

References (34)

1. Rees D. D. Role of nitric oxide in the vascular dysfunction of septic shock. Biochem. Soc. Trans. 23:1995;1025-1029.
2. Szabo C. Alterations in nitric oxide production in various forms of circulatory shock. New Horizons. 3:1995;3-32.
3. Keller G. A., Barke R., Harty J. T., Humphrey E., Simmons R. L. Decreased hepatic glutathione levels in septic shock: Predisposition of hepatocytes to oxidative stress: An experimental approach. Arch. Surg. 120:1985;941-945.
4. Lee K. J., Andrejuk T., Dziuban S. W. Jr., Goldfarb R. D. Deleterious effects of buthionine sulfoximine on cardiac function during continuous endotoxemia. Proc. Soc. Exp. Biol. Med. 209:1995;178-184.
5. Nemeth I., Boda D. The ratio of oxidized/reduced glutathione as an index of oxidative stress in various experimental models of shock syndrome. Biomed. Biochim. Acta. 48:1989;S53-S57.
6. Zhang H., Spapen H., Nguyen D. N., Benlabed M., Buurman W. A., Vincent J. L. Protective effects of N-acetyl-l-cysteine in endotoxemia. Am. J. Physiol. 266:1994;H1746-H1754.
7. Cuzzocrea S., Zingarelli B., O'Connor M., Salzman A. L., Szabo C. Effect of l-buthionine-(S,R)-sulphoximine, an inhibitor of gamma-glutamylcysteine synthetase on peroxynitrite- and endotoxic shock-induced vascular failure. Br. J. Pharmacol. 123:1998;525-537.
8. Büchmuller-Rouiller Y., Corradin S. B., Smith J., Schneider P., Ransijin A., Jongeneel C. V., Mauel J. Role of glutathione in macrophage activation: Effect of cellular glutathione depletion on nitrite production and Leishmanicidal activity. Cell. Immunol. 164:1995;73-80.
9. Duval D. L., Sieg D. J., Billings R. E. Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione. Arch. Biochem. Biophys. 316:1995;699-706.
10. Hothersall J. S., Cunha F. Q., Neild G. H., Norohna-Dutra A. A. Induction of nitric oxide synthesis in J774 cells lowers intracellular glutathione: Effect of modulated glutathione redox status on nitric oxide synthase induction. Biochem. J. 322:1997;477-481.
11. Nathens A. B., Marshall J. C., Watson R. W. G., Dackiw A. P. B., Rostein O. D. Diethylmaleate attenuates endotoxin-induced lung injury. Surgery. 120:1996;360-366.
12. Jones J. J., McGilvary I. D., Nathens A. B. Glutathione depletion prevents lipopolysaccharide-induced local skin inflammation. Arch. Surg. 132:1997;1165-1169.
13. Vanella A., Di Giacomo C., Sorreniti V. Free radical scavenger depletion in post-ischemic reperfusion brain damage. Neurochem. Res. 18:1993;1337-1340.
14. Tiegs G., Wendel A. Leukotriene-mediated liver injury. Biochem. Pharmacol. 37:1988;2569-2573.
15. Deneke S. M., Fanburg B. L. Regulation of cellular glutathione. Am. J. Physiol. 257:1989;L163-L173.
16. Akerboom T. P. M., Sies H. Assay of glutathione, glutathione disulfide and glutathione mixed disulfides in biological samples. Methods Enzymol. 77:1982;373-382.
17. Beckman J. S., Conger K. A. Method Companion Method Enzymol. 7:1995;35-39.
18. Braman R. S., Hendrix S. A. Nanogram nitrite and nitrate determination in environmental and biological materials by vanadium (III) reduction with chemiluminescence detection. Anal. Chem. 61:1989;2715-2718.
19. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London). 227:1970;680-685.
20. Pak Y. K., Kanuck M. P., Berrios D., Briggs M. R., Cooper A. D., Ellsworth J. L. Activation of LDL receptor gene expression in HepG2 cells by hepatocyte growth factor. J. Lip. Res. 37:1996;985-998.
21. Wirth P. J., Thorgeirsson S. S. Glutathione synthesis and degradation in fetal and adult rat liver and Novikoff hepatoma. Cancer Res. 38:1978;2861-2865.
22. Lauterburg B. H., Vaishnav Y., Stillwell W. G., Mitchel J. R. The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis. J. Pharmacol. Exp. Ther. 213:1980;54-58.
23. Borroz K. I., Buetler T. M., Eaton D. L. Modulation of gamma-glutamylcysteine synthetase large subunit mRNA expression by butylated hydroxyanisole. Toxicol. Appl. Pharmacol. 126:1994;150-155.
24. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:1992;3051-3064.
25. Moncada S., Higgs A. The l-arginine-nitric oxide pathway. New Engl. J. Med. 329:1993;2002-2012.
26. Thiemermann C. The role of the l-arginine: Nitric oxide pathway in circulatory shock. Adv. Pharmacol. 28:1994;45-79.
27. Wu C. C., Chen S-J., Szabo C., Thiemermann C., Vane J. R. Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock. Br. J. Pharmacol. 114:1995;1666-1672.
28. Christman J. W., Holden E. P., Blackwell T. S. Strategies for blocking the systemic effects of cytokines in the sepsis syndrome. Crit. Care Med. 23:1995;955-963.
29. Billiau A., Vandekerckhove F. Cytokines and their interactions with other inflammatory mediators in the pathogenesis of sepsis and septic shock. Eur. J. Clin. Invest. 21:1991;559-573.
30. Dinarello C. A. Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock. Chest. 112:1997;321S-329S.
31. Chensue S. W., Terebuh P. D., Remick D. G., Scales W. E., Kunkel S. L. In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects. Am. J. Pathol. 138:1991;395-402.
32. Cunha F. Q., Assreuy J., Moss D. W., Rees D., Leak M. C., Moncada S., Carrier M., O'Donnell C. A., Liew F. Y. Differential induction of nitric oxide synthase in various organs of the mouse during endotoxaemia: Role of TNF-alpha and IL-1-beta. Immunology. 81:1994;211-215.
33. Geller D. A., Nussler A. K., Silvio M. D., Lowenstein C. J., Shapiro R. A., Wang S. C., Simmons R. L., Billiar T. R. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc. Natl. Acad. Sci. USA. 90:1993;522-526.
34. Peristeris P., Clark B. D., Gatti S., Faggioni R., Mantovani A., Mengozzi M., Orencole S. F., Sironi M., Ghezzi P. N-acetylcysteine and glutathione as inhibitors of tumor necrosis factor production. Cell. Immunol. 140:1992;390-399.