Regulation of LPS induced IL-12 production by IFN-γ and IL-4 through intracellular glutathione status in human alveolar macrophages

Clinical and Experimental Immunology

Volumn 124, Issue 2, 2001, Pages 290-296

  Dobashi, K ^a   Aihara, M ^a   Araki, T ^a   Shimizu, Y ^a   Utsugi, M ^a   Iizuka, K ^a   Murata, Y ^a,b   Hamuro, J ^a   Nakazawa, T ^a   Mori, M ^a  

^a GUNMA UNIVERSITY   (Japan)

^b AJINOMOTO CO INC   (Japan)

Author keywords

Human alveolar macrophages; IFN ; IL 12 production; IL 4; Redox status

Indexed keywords

ACETYLCYSTEINE; BUTHIONINE SULFOXIMINE; GAMMA INTERFERON; GLUTATHIONE; INTERLEUKIN 12; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MESSENGER RNA;

ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; HELPER CELL; HUMAN; HUMAN CELL; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MONOCYTE; NATURAL KILLER CELL; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PLEIOTROPY; PRIORITY JOURNAL; T LYMPHOCYTE;

ACETYLCYSTEINE; CELL LINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MONOCYTES; PHENANTHRENES;

EID: 0034963058     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01535.x     Document Type: Article

References (41)

1. Interleukin-12: A bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency
2. CD4+ suppressor cells differentially affect the production of IFN-γ by effector cells of experimental autoimmune encephalomyelitis
3. Redox regulation of cellular activation
4. Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis
5. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns
6. The triggering and healing of tumor stromal inflammatory reactions regulated by oxidative and reductive macrophages
7. Macrophages and allergic lung disease
8. Dysregulation of interleukin 8, interleukin 10, and interleukin 12 release by alveolar macrophages from HIV type 1-infected subjects
9. Comparison of the regulations by Th2-type cytokines of the arachidonic-acid metabolic pathway in human alveolar macrophages and monocytes
10. Immune modulation of metalloproteinase production in human macrophages. Selective pretranslational suppression of interstitial collagenase and stromelysin biosynthesis by interferon-gamma
11. Differential regulation of interleukin-12 (IL-12), tumor necrosis factor-α, and IL-1β, production in human myeloid leukemia cell lines and peripheral blood mononuclear cells
12. Role of glutathione in macrophage activation. Effect of cellular gluthatione depletion on nitrite production and leishmanicidal activity
13. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
14. Lipoteichoic acid preparations of Gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway
15. The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: Evidence for multiple mRNA specie
16. The interleukin-12 p40 gene promoter is primed by interferon gamma in monocytic cells
17. Single-step method of RNA isolation by acid guanium thiocyanate-phenol-chloroform extraction
18. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Application to mammalian blood and other tissue
19. Alkaline hydrolysis of N-ethylmaleimide allows a rapid assay of glutathione disulfide in biological samples
20. Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2
21. Interferon-gamma (IFN-γ) regulates production of IL-10 and IL-12 in human herpesvirus-6 (HHV-6)-infected monocytes/macrophage lineage
22. Regulation of cellular glutathione
23. Effect of Ni (II) on tissue hydrogen peroxide content in mice as inferred from glutathione and glutathione disulfide measurements
24. Exercise-induced oxidative stress: Glutathione supplementation and deficiency
25. Mechanisms of cigarette smoke induced increased airspace permeability
26. Glutathione metabolism in resting and phagocytizing peritoneal macrophages
27. Effect of dental metal ions on glutathione level in THP-1 human monocytes
28. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
29. Regulation of interleukin-12 expression in human monocytes: Selective priming by interferon-γ of lipopolysaccharide-inducible p35 and p40 genes
30. Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity
31. Deficiency of the transcription factor c-fos increases lipopolysaccharide-induced macrophage interleukin 12 production
32. Ligation of CD40 on human dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity. T-T help via APC activation
33. High level of IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
34. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3; involvement of NF-kB downregulation in transcriptional repression of the p40 gene
35. Identification and characterization of novel est-2-related nuclear complex implicated in the activation of the human IL-12 p40 gene promoter
36. Structure and chromosomal location of mouse interleukin-12 p35 and p40 subunit genes
37. Molecular cloning and characterization of murine IL-12 genes
38. Defective antigen processing correlates with a low level of intracellular glutathione
39. Lentinan regulates the local inflammatory cellular reaction at tumor tissue - Its relation with antitumor effect
40. Expression of proinflammatory cytokines by flow-sorted alveolar macrophages in severe pneumonia