Antibody Cross-Reactivity between Myelin Oligodendrocyte Glycoprotein and the Milk Protein Butyrophilin in Multiple Sclerosis

Journal of Immunology

Volumn 172, Issue 1, 2004, Pages 661-668

  Guggenmos, Johannes ^a   Schubart, Anna S ^a   Ogg, Sherry ^b   Andersson, Magnus ^c   Olsson, Tomas ^c   Mather, Ian H ^b   Linington, Christopher ^d,e  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b UNIVERSITY OF MARYLAND   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

^e UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; AUTOANTIBODY; BUTYROPHILIN; EPITOPE; MILK PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PEPTIDE; UNCLASSIFIED DRUG;

ADULT; AMINO TERMINAL SEQUENCE; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; CATTLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; CROSS REACTION; DIET; ENVIRONMENTAL FACTOR; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MOLECULAR MIMICRY; MULTIPLE SCLEROSIS; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL;

EID: 0347364679     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.1.661     Document Type: Article

References (51)

1. Willer, C. J., and G. C. Ebers. 2000. Susceptibility to multiple sclerosis: interplay between genes and environment. Curr. Opin. Neurol. 3:241.
2. Conlon, P., J. R. Oksenberg, J. Zhang, and L. Steinman. 1999. The immunobiology of multiple sclerosis: an autoimmune disease of the central nervous system. Neurobiol. Dis. 6:149.
3. Levin, M. C., S. M. Lee, F. Kalume, Y. Morcos, F. C. Dohan, Jr., K. A. Hasty, J. C. Callaway, J. Zunt, D. Desiderio, and J. M. Stuart. 2002. Autoimmunity due to molecular mimicry as a cause of neurological disease. Nat. Med. 8:509.
4. Oldstone, M. B. 1998. Molecular mimicry and immune-mediated diseases. FASEB J. 12:1255.
5. Fujinami, R. S., and M. B. Oldstone. 1985. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science 230:1043.
6. Gran, B., B. Hemmer, M. Vergelli, H. F. McFarland, and R. Martin, R. 1999. Molecular mimicry and multiple sclerosis: degenerate T-cell recognition and the induction of autoimmunity. Ann. Neurol. 45:559.
7. Gautam, A. M., R. S. Liblau, G. Chelvanayagam, L. Steinman, and T. Boston. 1998. A viral peptide with limited homology to a self peptide can induce clinical signs of experimental autoimmune encephalomyelitis. J. Immunol. 161:60.
8. Mokhtarian, F., Z. Zhang, Y., Shi, E. Gonzales, and R. A. Sobel. 1999. Molecular mimicry between a viral peptide and a myelin oligodendrocyte glycoprotein peptide induces autoimmune demyelinating disease in mice. J. Neuroimmunol. 95:43.
9. Grogan, J. L., A. Kramer, A. Nogai, L. Dong, M. Ohde, J. Schneider-Mergener, and T. Kamradt. 1999. Cross-reactivity of myelin basic protein-specific T cells with multiple microbial peptides: experimental autoimmune encephalomyelitis induction in TCR transgenic mice. J. Immunol. 163:3764.
10. Wucherpfennig, K. W., and J. L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.
11. Hemmer, B., Fleckenstein, B. T., M. Vergelli, G. Jung, H. McFarland, R. Martin, and K. H. Wiesmuller. 1997. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone. J. Exp. Med. 185:1651.
12. Benoist, C., and D. Mathis. 2001. Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?. Nat. Immunol. 2:797.
13. Strobel, S., and A. M. Mowat. 1998. Immune responses to dietary antigens: oral tolerance. Immunol. Today 19:173.
14. Barbeau, W. E. 1997. Interactions between dietary proteins and the human system: implications for oral tolerance and food-related diseases. Adv. Exp. Med. Biol. 415:183.
15. Gaboriau-Routhiau, V., and M. C. Moreau. 1996. Gut flora allows recovery of oral tolerance to ovalbumin in mice after transient breakdown mediated by cholera toxin or Escherichia coli heat-labile enterotoxin. Pediatr. Res. 39:625.
16. Miller, A., O. Lider, O. Abramsky, and H. L. Weiner. 1994. Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals. Eur. J. Immunol. 24:1026.
17. Strobel, S. 1996. Neonatal oral tolerance. Ann. NY Acad. Sci. 778:88.
18. Wifier, S., I. Astsaturov, R. Cheung, K. K. Schrade, L. Gunaratnam, D. D. Wood, M. A. Moscarello, P. O'Connor, C. McKerlie, D. J. Becker, and H. M. Dosch. 2001. T cells of multiple sclerosis patients target a common environmental peptide that causes encephalitis in mice. J. Immunol. 166:4751.
19. Stefferl, A., A. Schubart, M. Storch, A. Amini, I. Mather, H. Lassmann, and C. Linington. 2000. Butyrophilin, a milk protein, modulates the encephalitogenic T cell response to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis. J. Immunol. 165:2859.
20. Bernard, C. C., T. G. Johns, A. Slavin, M. Ichikawa, C. Ewing, J. Liu, and J. Bettadapura. 1997. Myelin oligodendrocyte glycoprotein: a novel candidate autoantigen in multiple sclerosis. J. Mol. Med. 75:77.
21. Storch, M. K., A. Stefferl, U. Brehm, R. Weissert, E. Wallstrom, M. Kerschensteiner, T. Olsson, C. Linington, and H. Lassmann. 1998. Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Brain Pathol. 8:681.
22. Genain, C. P., B. Cannella, S. L. Hauser, and C. S. Raine. 1999. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat. Med. 5:170.
23. Iglesias, A., J. Bauer, T. Litzenberger, A. Schubart, and C. Linington. 2001. T cell and B cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Glia 36:220.
24. Linington, C., M. Bradl, H. Lassmann, C. Brunner, and K. Vass. 1988. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. Am. J. Pathol. 130:443.
25. Kerlero de Rosbo, N. R. Milo, M. B. Lees, D. Burger, C. C. A. Bernard, and A. Ben-Nun. 1993. Reactivity to myelin antigens in multiple sclerosis: peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J. Clin. Invest. 92:2602.
26. Kerlero de Rosbo, N., M. Hoffman, I. Mendel, I. Yust, J. Kaye, R. Bakimer, S. Flechter, O. Abramsky, R. Milo, A. Kami, and A. Ben-Nun: 1997. Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracelluiar domain of MOG is directed against three main regions. Eur. J. Immunol. 27:3059.
27. + multiple sclerosis. Eur. J. Immunol. 28:3329.
28. Lindert, R. B., C. G. Haase, U. Brehm, H. Wekerle, C. Linington, and R. Hohlfeld. 1999. Multiple sclerosis: B and T cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein (MOG). Brain 122:2089.
29. Karni, A., R. Bakimer-Kleiner, O. Abramsky, and A. Ben-Nun. 1999. Elevated levels of antibody to myelin oligodendrocyte glycoprotein is not specific for patients with multiple sclerosis. Arch. Neurol. 56:311.
30. Reindl, M., C. Linington, U. Brehm, R. Egg, E. Dilitz, F. Deisenhammer, W. Poewe, and T. Berger. 1999. Myelin oligodendrocyte glycoprotein specific autoantibodies in multiple sclerosis. Brain 122:2047.
31. Haase, C. G., J. Guggenmos, U. Brehm, A. Andersson, T. Olsson, M. Reindl, J. M. Schneidewind, U. K. Zettl, F. Heidenreich, T. Berger, et al. 2001. The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls. J. Neuroimmunol. 114:220.
32. Raine, C. S., B. Cannella, S. L. Hauser, and C. P. Genain. 1999. Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: a case for antigen-specific antibody mediation. Ann. Neurol. 46:144.
33. Berger, T., P. Rubner, F. Schautzer, R. Egg, H. Ulmer, I. Mayringer, E. Dilitz, F. Deisenhammer, and M. Reindl. 2003. Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event. N. Engl. J. Med. 349:139.
34. Jack, L. J. W., and I. H. Mather. 1990. Cloning and analysis of cDNA encoding bovine butyrophilin, an apical glycoprotein expressed in mammary tissue and secreted in association with the milk-fat globule membrane during lactation. J. Biol. Chem. 265:14481.
35. Henry, J., M. M. Miller, and P. Pontarotti. 1999. Structure and evolution of the extended B7 family. Immunol. Today 20:285.
36. Gardinier, M. V., P. Amiguet, C. Linington, and J.-M. Matthieu. 1992. Myelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily. J. Neurosci. Res. 33:177.
37. Pagany, M., M. Jagodic, C. Bourquin, T. Olsson, and C. Linington. 2003. Genetic variation in myelin oligodendrocyte glycoprotein expression and susceptibility to experimental autoimmune encephalomyelitis. J. Neuroimmunol. 139:1.
38. Derbinski, J., A. Schulte, B. Kyewski, and L. Klein. 2001. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2:1032.
39. Delarasse, C., P. Daubas, L. T. Mars, C. Vizler, T. Litzenburger, A. Iglesias, J. Bauer, B. Della Gaspera, A. Schubart, L. Decker, et al. 2003. Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice. J. Clin. Invest. 112:544.
40. Besson Duvanel, C., P. Honegger, and J.-M. Matthieu. 2001. Antibodies directed against rubella virus induce demyelination in aggregating rat brain cell cultures. J. Neurosci. Res. 65:446.
41. Butcher, P. J. 1986. Milk consumption and multiple sclerosis: an etiological hypothesis. Med. Hypotheses 19:169.
42. Malosse, D., H. Perron, A. Sasco, and J. M. Seigneurin. 1992. Correlation between milk and dairy product consumption and multiple sclerosis prevalence: a worldwide study. Neuroepidemiology 11:304.
43. Lauer, K. 1997. Diet and multiple sclerosis. Ann. Neurol. 49:55.
44. Kennel De March, A., M. De Bouwerle, M. N. Kolopp-Sarda, G. C. Faure, M. C. Bene, and C. C. Bernard. 2003. Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis. J. Neuroimmunol. 135:117.
45. Karjalainen, J., J. M. Martin, M. Knip, J. Ilonen, B. H. Robinson, E. Savilahti, H. K. Akerblom, and H. M. Dosch. 1992. A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N. Engl. J. Med. 327:302.
46. Kimura, K., S. F. Hunter, M. S. Thollander, E. V. Loftus, Jr., L. J. Melton III, P. C. O'Brien, M. Rodriguez, and S. F. Phillips. 2000. Concurrence of inflammatory bowel disease and multiple sclerosis. Mayo Clinic Proc. 75:802.
47. Kawahito, Y., G. W. Cannon, P. S. Gulko, E. F. Remmers, R. E. Longman, V. R. Reese, J. Wang, M. M. Griffiths, and R. L. Wilder. 1998. Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. J. Immunol. 161:4411.
48. Brehm, U., S. J. Piddlesden, M. V. Gardinier, and C. Linington. 1999. Epitope specificity of demyelinating monoclonal autoantibodies directed against the human myelin oligodendrocyte glycoprotein (MOG). J. Neuroimmunol. 97:9.
49. Von Büdingen, H.-C., S. L. Hauser, A. Fuhrmann, C. B. Nabavi, J. I. Lee, and C. P. Genain. 2002. Molecular characteristation of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination. Proc. Natl. Acad. Sci. USA 99:8207.
50. Breithaupt, C., A. Schubart, H. Zander, A. Skerra, R. Huber, C. Linington, and U. Jacob. 2003. Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein. Proc. Natl. Acad. Sci. USA 100:9446.
51. Gutgemann, I., A. M. Fahrer, J. D. Altman, M. M. Davis, and Y. H. Chien. 1998. Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen. Immunity 8:667.