Activation of distinct multidrug‐resistance (P‐glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis

Molecular Carcinogenesis

Volumn 8, Issue 2, 1993, Pages 67-73

  Teeter, Larry D ^a   Estes, Marc ^a   Chan, John Y ^a   Becker, Frederick F ^a   Kuo, M Tien ^a   Atassi, Hammad ^b   Sell, Stewart ^b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

carcinogens; hepatocellular carcinoma; liver cell proliferation; Multidrug resistance genes

Indexed keywords

GLYCOPROTEIN P; MESSENGER RNA; N (2 FLUORENYL)ACETAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; LIVER CARCINOGENESIS; LIVER REGENERATION; MALE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RAT;

2-ACETYLAMINOFLUORENE; ANIMAL; BASE SEQUENCE; CARRIER PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; CLONING, MOLECULAR; DIETHYLNITROSAMINE; DNA PRIMERS; DNA, NEOPLASM; DRUG RESISTANCE; GENE EXPRESSION REGULATION, NEOPLASTIC; INTESTINES; KIDNEY; LIVER NEOPLASMS, EXPERIMENTAL; LIVER REGENERATION; MALE; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; P-GLYCOPROTEIN; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED F344; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION, GENETIC;

EID: 0027377964     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.2940080202     Document Type: Article

References (32)

1. The biochemistry of P‐glycoprotein—mediated multidrug resistance
2. The multidrug transporter, a doubleedged sword
3. Multidrug resistance gene family and chemical carcinogenesis
4. Structural analysis of the mouse mdr1a (P‐glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug‐resistant J774.2 cells
5. Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities
6. Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins
7. Cloning and characterization of a second member of the mouse mdr gene family
8. Isolation and expression of a complementary DNA that confers multidrug resistance
9. Expression of a multidrug resistance gene in human cancers
10. The multidrug resistance phenotype in human cancers
11. Expression of the multidrug‐resistance gene in hepatocarcinogenesis and regenerating rat liver
12. Carcinogen‐induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas
13. Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas
14. Coordinate activation of multidrug‐resistance (P‐glycoprotein) genes mdr2 and mdr3 during mouse liver regeneration
15. Activation of multidrug resistance (P‐glycoprotein) mdr3/mdr1a gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice
16. P‐glycoprotein expression during tumor progression in the rat liver
17. Cellular pattern of multidrug‐resistance gene expression during chemical hepatocarcinogenesis in the rat
18. Cellular events during hepatocarcinogenesis in rats and the question of premalignancy
19. The biochemical‐molecular pathology of the stepwise development of liver cancer: New insights and problems
20. Complete cDNA sequences encoding the Chinese hamster P‐glycoprotein gene family
21. Identification of distinct P‐glycoprotein gene sequences in rat
22. Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family
23. Isolation of biologically active ribonucleic acid from sources enriched in ribonucleases
24. The nucleotide sequence of the rat cytoplasmic β‐actin gene
25. The three mouse multidrug resistance (mdr) genes are expressed in a tissue‐specific manner in normal mouse tissues
26. Regulation of the multidrug resistance gene in regenerating rat liver
27. Regulation of 2‐acetylaminofluorene— and 3‐methylcholanthrene—mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver
28. Separation of drug transport and chloride channel functions of the human multidrug resistance P‐glycoprotein
29. Volume‐regulated chloride channel associated with the human multidrug‐resistance P‐glycoprotein
30. The multidrug resistance (mdr1) gene product functions as an ATP channel
31. Efficient inactivation of the mouse mdr genes in embryonic stem cells using homologous recombination