메뉴 건너뛰기




Volumn 134, Issue 1, 2004, Pages 24-30

Amino Acids Do Not Alter the Insulin-Induced Activation of the Insulin Signaling Pathway in Neonatal Pigs

Author keywords

Insulin receptor; Liver; Muscle; Protein kinase B; Protein synthesis; Skeletal muscle; Translation initiation

Indexed keywords

AMINO ACID; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MUSCLE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN S6;

EID: 0347356636     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.1.24     Document Type: Article
Times cited : (36)

References (38)
  • 1
    • 0000556087 scopus 로고
    • The role of skeletal and cardiac muscle in the regulation of protein metabolism
    • (Munro, H. N., ed.). Academic Press, New York, NY
    • Young, V. R. (1970) The role of skeletal and cardiac muscle in the regulation of protein metabolism. In: Mammalian Protein Metabolism, Vol. 4 (Munro, H. N., ed.), pp. 585-674. Academic Press, New York, NY.
    • (1970) Mammalian Protein Metabolism , vol.4 , pp. 585-674
    • Young, V.R.1
  • 2
    • 4244119039 scopus 로고
    • Leucine metabolism in newborns
    • Denne, S. C. & Kalhan, S. C. (1987) Leucine metabolism in newborns. Am. J. Physiol. 253: E608-E615.
    • (1987) Am. J. Physiol. , vol.253
    • Denne, S.C.1    Kalhan, S.C.2
  • 4
    • 0030003211 scopus 로고    scopus 로고
    • Protein synthesis in skeletal muscle and jejunum is more responsive to feeding in 7- than in 26-day-old pigs
    • Davis, T. A., Burrin, D. G., Fiorotto, M. L. & Nguyen, H. V. (1996) Protein synthesis in skeletal muscle and jejunum is more responsive to feeding in 7- than in 26-day-old pigs. Am. J. Physiol. 270: E802-E809.
    • (1996) Am. J. Physiol. , vol.270
    • Davis, T.A.1    Burrin, D.G.2    Fiorotto, M.L.3    Nguyen, H.V.4
  • 5
    • 0031913458 scopus 로고    scopus 로고
    • Roles of insulin and amino acids in the regulation of protein synthesis in the neonate
    • Davis, T. A., Burrin, D. G., Fiorotto, M. L., Reeds, P. J. & Jahoor, F. (1998) Roles of insulin and amino acids in the regulation of protein synthesis in the neonate. J. Nutr. 128: 347S-350S.
    • (1998) J. Nutr. , vol.128
    • Davis, T.A.1    Burrin, D.G.2    Fiorotto, M.L.3    Reeds, P.J.4    Jahoor, F.5
  • 9
    • 0037230069 scopus 로고    scopus 로고
    • Amino acids independently stimulate skeletal muscle protein synthesis in neonatal pigs
    • O'Connor, P. M., Bush, J. A., Suryawan, A., Nguyen H. V. & Davis, T. A. (2003) Amino acids independently stimulate skeletal muscle protein synthesis in neonatal pigs. Am. J. Physiol. 284: E110-E119.
    • (2003) Am. J. Physiol. , vol.284
    • O'Connor, P.M.1    Bush, J.A.2    Suryawan, A.3    Nguyen, H.V.4    Davis, T.A.5
  • 10
    • 0033635106 scopus 로고    scopus 로고
    • Developmental changes in the feeding-induced stimulation of translation initiation in muscle of neonatal pigs
    • Davis, T. A., Nguyen, H. V., Suryawan, A., Bush, J. A., Jefferson, L. S. & Kimball, S. R. (2000) Developmental changes in the feeding-induced stimulation of translation initiation in muscle of neonatal pigs. Am. J. Physiol. 279: E1226-E1234.
    • (2000) Am. J. Physiol. , vol.279
    • Davis, T.A.1    Nguyen, H.V.2    Suryawan, A.3    Bush, J.A.4    Jefferson, L.S.5    Kimball, S.R.6
  • 11
    • 0035199775 scopus 로고    scopus 로고
    • Developmental changes in the feeding-induced activation of the insulin-signaling pathway in neonatal pigs
    • Suryawan, A., Nguyen, H. V., Bush, J. A. & Davis, T. A. (2001) Developmental changes in the feeding-induced activation of the insulin-signaling pathway in neonatal pigs. Am. J. Physiol. 281: E908-E915.
    • (2001) Am. J. Physiol. , vol.281
    • Suryawan, A.1    Nguyen, H.V.2    Bush, J.A.3    Davis, T.A.4
  • 12
    • 0036081276 scopus 로고    scopus 로고
    • Developmental decline in components of signal transduction pathways regulating protein synthesis in pig muscle
    • Kimball, S. R., Farrell, P. A., Nguyen, H. V., Jefferson, L. S. & Davis, T. A. (2002) Developmental decline in components of signal transduction pathways regulating protein synthesis in pig muscle. Am. J. Physiol. 282: E585-E592.
    • (2002) Am. J. Physiol. , vol.282
    • Kimball, S.R.1    Farrell, P.A.2    Nguyen, H.V.3    Jefferson, L.S.4    Davis, T.A.5
  • 13
    • 0035044213 scopus 로고    scopus 로고
    • Clinical review 125: The insulin receptor and its cellular targets
    • Kido, Y., Nakae, J. & Accili, D. (2001) Clinical review 125: The insulin receptor and its cellular targets. J. Clin. Endocrinol. Metab. 86: 972-979.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 972-979
    • Kido, Y.1    Nakae, J.2    Accili, D.3
  • 14
    • 0030013326 scopus 로고    scopus 로고
    • Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-1 phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase
    • Mendez, R., Myers, M. G., White, M. F. & Rhoads, R. E. (1996) Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-1 phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase. Mol. Cell. Biol. 16: 2857-2864.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2857-2864
    • Mendez, R.1    Myers, M.G.2    White, M.F.3    Rhoads, R.E.4
  • 16
    • 0030883848 scopus 로고    scopus 로고
    • PHAS/4E-BPs as regulators of mRNA translation and cell proliferation
    • Lawrence, J. C., Jr. & Abraham, R. T. (1997) PHAS/4E-BPs as regulators of mRNA translation and cell proliferation. Trends Biochem. Sci. 22: 345-349.
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 345-349
    • Lawrence Jr., J.C.1    Abraham, R.T.2
  • 17
    • 0032999830 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): Balancing the opposing forces of protein synthesis and degradation
    • Dennis, P. B., Fumagalli, S. & Thomas, G. (1999) Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation. Curr. Opin. Genet. Dev. 9: 49-54.
    • (1999) Curr. Opin. Genet. Dev. , vol.9 , pp. 49-54
    • Dennis, P.B.1    Fumagalli, S.2    Thomas, G.3
  • 18
    • 0028178928 scopus 로고
    • PDGF- and insulin-dependent p70S6k activation mediated by phosphatidylinositol-3-OH kinase
    • Chung, J., Grammer, T. C., Lemon, K. P., Kazlauskas, A. & Blenis, J. (1994) PDGF- and insulin-dependent p70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature (Lond.) 370: 71-75.
    • (1994) Nature (Lond.) , vol.370 , pp. 71-75
    • Chung, J.1    Grammer, T.C.2    Lemon, K.P.3    Kazlauskas, A.4    Blenis, J.5
  • 19
    • 0032079873 scopus 로고    scopus 로고
    • Regulation of translation initiation factors by signal transduction
    • Kleijn, M., Scheper, G. C., Voorma, H. O. & Thomas, A. A. (1998) Regulation of translation initiation factors by signal transduction. Eur. J. Biochem. 253: 531-544.
    • (1998) Eur. J. Biochem. , vol.253 , pp. 531-544
    • Kleijn, M.1    Scheper, G.C.2    Voorma, H.O.3    Thomas, A.A.4
  • 20
    • 0029873066 scopus 로고    scopus 로고
    • Translational and pretranslational regulation of protein synthesis by amino acid availability in primary cultures of rat hepatocytes
    • Kimball, S. R., Yancisin, M., Horetsky, R. L. & Jefferson, L. S. (1996) Translational and pretranslational regulation of protein synthesis by amino acid availability in primary cultures of rat hepatocytes. Int. J. Biochem. Cell Biol. 28: 285-294.
    • (1996) Int. J. Biochem. Cell Biol. , vol.28 , pp. 285-294
    • Kimball, S.R.1    Yancisin, M.2    Horetsky, R.L.3    Jefferson, L.S.4
  • 22
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • Hara, K., Yonezawa, K., Weng, Q. P., Kozlowski, M. T., Belham, C. & Avruch, J. (1998) Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem. 273: 14484-14494.
    • (1998) J. Biol. Chem. , vol.273 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng, Q.P.3    Kozlowski, M.T.4    Belham, C.5    Avruch, J.6
  • 24
    • 0032528917 scopus 로고    scopus 로고
    • Amino acid availability regulates p70 S6 kinase and multiple translation factors
    • Wang, X., Campbell, L. E., Miller, C. M. & Proucl, C. G. (1998) Amino acid availability regulates p70 S6 kinase and multiple translation factors. Biochem. J. 334: 261-267.
    • (1998) Biochem. J. , vol.334 , pp. 261-267
    • Wang, X.1    Campbell, L.E.2    Miller, C.M.3    Proucl, C.G.4
  • 25
    • 0033864552 scopus 로고    scopus 로고
    • Amino acids regulate skeletal muscle PHAS-I and p70 S6-kinase phosphorylation independently of insulin
    • Long, W., Saffer, L., Wei, L. & Barrett, E. J. (2000) Amino acids regulate skeletal muscle PHAS-I and p70 S6-kinase phosphorylation independently of insulin. Am. J. Physiol. 279: E301-E306.
    • (2000) Am. J. Physiol. , vol.279
    • Long, W.1    Saffer, L.2    Wei, L.3    Barrett, E.J.4
  • 26
    • 0035851205 scopus 로고    scopus 로고
    • Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
    • Tremblay, F. & Marette, A. (2001) Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J. Biol. Chem. 276: 38052-38060.
    • (2001) J. Biol. Chem. , vol.276 , pp. 38052-38060
    • Tremblay, F.1    Marette, A.2
  • 27
    • 0030766238 scopus 로고    scopus 로고
    • Insulin-stimulated amino acid utilization during glucose and amino acid clamps decreases with development
    • Wray-Cahen, D., Beckett, P. R., Nguyen, H. V. & Davis, T. A. (1997) Insulin-stimulated amino acid utilization during glucose and amino acid clamps decreases with development. Am. J. Physiol. 273: E305-E314.
    • (1997) Am. J. Physiol. , vol.273
    • Wray-Cahen, D.1    Beckett, P.R.2    Nguyen, H.V.3    Davis, T.A.4
  • 28
    • 0030586811 scopus 로고    scopus 로고
    • Spectrophometric assay for measuring branched-chain amino acid concentrations: Application for measuring the sensitivity of protein metabolism to insulin
    • Beckett, P. R., Hardin, D. S., Davis, T. A., Nguyen, H. V., Wray-Cahen, D. & Copeland, K. C. (1996) Spectrophometric assay for measuring branched-chain amino acid concentrations: application for measuring the sensitivity of protein metabolism to insulin. Anal. Biochem. 240: 48-53.
    • (1996) Anal. Biochem. , vol.240 , pp. 48-53
    • Beckett, P.R.1    Hardin, D.S.2    Davis, T.A.3    Nguyen, H.V.4    Wray-Cahen, D.5    Copeland, K.C.6
  • 29
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • DeFronzo, R. A., Tobin, J. D. & Andres, R. (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237: E214-223.
    • (1979) Am. J. Physiol. , vol.237
    • DeFronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 30
    • 0027263674 scopus 로고
    • Amino acid compositions of body and milk protein change during the suckling period in rats
    • Davis, T. A., Fiorotto, M. L. & Reeds, P. J. (1993) Amino acid compositions of body and milk protein change during the suckling period in rats. J. Nutr. 123: 947-956.
    • (1993) J. Nutr. , vol.123 , pp. 947-956
    • Davis, T.A.1    Fiorotto, M.L.2    Reeds, P.J.3
  • 32
    • 0033597129 scopus 로고    scopus 로고
    • Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6
    • Kimball, S. R., Shantz, L. M., Horetsky, R. L. & Jefferson, L. S. (1999) Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6. J. Biol. Chem. 274: 11647-11652.
    • (1999) J. Biol. Chem. , vol.274 , pp. 11647-11652
    • Kimball, S.R.1    Shantz, L.M.2    Horetsky, R.L.3    Jefferson, L.S.4
  • 34
    • 0025802026 scopus 로고
    • Amino acids enhance insulin resistance to exogenous glucose infusion in overnight-fasted humans
    • Flakoll, P. J., Kulaylat, M., Frexes-Steed, M., Hill, J. O. & Abumrad, N. N. (1991) Amino acids enhance insulin resistance to exogenous glucose infusion in overnight-fasted humans. J. Parenter. Enteral Nutr. 15: 123-127.
    • (1991) J. Parenter. Enteral Nutr. , vol.15 , pp. 123-127
    • Flakoll, P.J.1    Kulaylat, M.2    Frexes-Steed, M.3    Hill, J.O.4    Abumrad, N.N.5
  • 36
    • 0036230645 scopus 로고    scopus 로고
    • Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation
    • Anthony, J. C., Reiter, A. K., Anthony, T. G., Crozier, S. J., Lang, C. H., MacLean, D. A., Kimball, S. R. & Jefferson, L. S. (2002) Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes 51: 928-936.
    • (2002) Diabetes , vol.51 , pp. 928-936
    • Anthony, J.C.1    Reiter, A.K.2    Anthony, T.G.3    Crozier, S.J.4    Lang, C.H.5    MacLean, D.A.6    Kimball, S.R.7    Jefferson, L.S.8
  • 37
    • 0037134910 scopus 로고    scopus 로고
    • Hepatic amino acid-dependent signaling is under the control of AMP-dependent protein kinase
    • Dubbelhuis, P. F. & Meijer, A. J. (2002) Hepatic amino acid-dependent signaling is under the control of AMP-dependent protein kinase. FEBS Lett. 521: 39-42.
    • (2002) FEBS Lett. , vol.521 , pp. 39-42
    • Dubbelhuis, P.F.1    Meijer, A.J.2
  • 38
    • 0033668261 scopus 로고    scopus 로고
    • Feeding stimulates protein synthesis in muscle and liver of neonatal pigs through an mTOR-dependent process
    • Kimball, S. R., Jefferson, L. S., Nguyen, H. V., Suryawan, A., Bush, J. A. & Davis, T. A. (2000) Feeding stimulates protein synthesis in muscle and liver of neonatal pigs through an mTOR-dependent process. Am. J. Physiol. 279: E1080-E1087.
    • (2000) Am. J. Physiol. , vol.279
    • Kimball, S.R.1    Jefferson, L.S.2    Nguyen, H.V.3    Suryawan, A.4    Bush, J.A.5    Davis, T.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.