Developmental decline in components of signal transduction pathways regulating protein synthesis in pig muscle

American Journal of Physiology - Endocrinology and Metabolism

Volumn 282, Issue 3 45-3, 2002, Pages

  Kimball, Scot R ^a   Farrell, Peter A ^b   Nguyen, Hahn V ^c   Jefferson, Leonard S ^a   Davis, Teresa A ^c  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Mammalian target of rapamycin; Phosphatidylinositol 3 kinase; Protein 70 S6 kinase; Protein kinase B

Indexed keywords

AMINO ACID; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; FEEDING; GENE OVEREXPRESSION; MUSCLE DEVELOPMENT; NONHUMAN; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS REGULATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SWINE;

EID: 0036081276     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00269.2001     Document Type: Article

References (37)

1. Mechanism of activation of protein kinase B by insulin and IGF- 1
2. The role of PI 3-kinase in insulin action
3. Orally administered leucine stimulates protein synthesis in skeletal muscle of post-absorptive rats in association with increased eIF 4F formation
4. Leucine stimulates translation initiation in skeletal muscle of post-absorptive rats via a rapamycin-sensitive pathway
5. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP 1
6. Nutrient requirements and metabolism
7. Protein synthesis in skeletal muscle and jejunum is more responsive to feeding in 7- than in 26-day-old pigs
8. Roles of insulin and amino acids in the regulation of protein synthesis in the neonate
9. Differential effects of insulin on peripheral and visceral tissue protein synthesis in neonatal pigs
10. Response of muscle protein synthesis to fasting in suckling and weaned rats
11. Protein turnover in skeletal muscle of suckling rats
12. Enhanced response of muscle protein synthesis and plasma insulin to food intake in suckled rats
13. Developmental changes in the feeding-induced stimulation of translation initiation in muscle of neonatal pigs
14. Leucine metabolism in human newborns
15. Leucine kinetics during feeding in normal newborns
16. Target of rapamycin (TOR): Balancing the opposing forces of protein synthesis and degradation
17. Nutrients, via the TOR proteins, stimulate the association of Tap 42 with type 2A phosphatases
18. Ribosomal S 6 kinase signaling and the control of translation
19. S6 phosphorylation and signal transduction
20. eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
21. Protein turnover and growth in the whole body, liver, and kidney of the rat from the foetus to senility
22. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
23. Time course evaluation of protein synthesis and glucose uptake after acute resistance exercise in rats
24. Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast
25. Regulation of translation initiation in mammalian cells by amino acids
26. Feeding stimulates protein synthesis in muscle and liver of neonatal pigs through an mTOR-dependent process
27. Purification and characterization of eukaryotic initiation factor eIF- 2B from liver
28. Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF 4E and phosphorylation of ribosomal protein S6
29. Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase
30. Translational control of TOP mRNAs
31. Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino acid deficiency on protein translation
32. Bidirectional modulation of insulin action by amino acids
33. Assessment of cell signaling pathways in the regulation of mTOR by amino acids in rat adipocytes
34. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
35. A direct linkage between the phosphoinositide 3-kinase-Akt signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
36. Developmental changes in the feeding-induced activation of the insulin-signaling pathway in neonatal pigs
37. Response of skeletal muscle protein synthesis to insulin in suckling pigs decreases with development