Metal-induced hepatotoxicity

Seminars in Liver Disease

Volumn 16, Issue 1, 1996, Pages 3-12

  Britton, Robert S ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACID PHOSPHATASE; ALBUMIN; ALKADIENE; ALPHA TOCOPHEROL; AMINOPYRINE N DEMETHYLASE; ANTIOXIDANT; ASCORBIC ACID; CERULOPLASMIN; COPPER; CYTOCHROME P450; DNA; FERRITIN; FREE RADICAL; GLUTATHIONE; HEMOSIDERIN; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; IRON CHELATE; IRON DEXTRAN; LIPID; LIPID HYDROPEROXIDE; MALONALDEHYDE; METALLOTHIONEIN; N ACETYL BETA GLUCOSAMINIDASE; PENICILLAMINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSFERRIN; UNINDEXED DRUG;

DNA DAMAGE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GENE; HEMOCHROMATOSIS; HUMAN; IRON OVERLOAD; LIPID PEROXIDATION; LIVER CELL CARCINOMA; LIVER CELL MEMBRANE; LIVER LYSOSOME; LIVER MITOCHONDRION; LIVER TOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; WILSON DISEASE;

EID: 0029933296     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-1007214     Document Type: Review

References (105)

1. Tavill AS, Bacon BR: Hemochromatosis: iron metabolism and the iron overload syndromes. In: Zakim D, Boyer TD (eds) Hepatology: A textbook of liver disease. Philadelphia, W.B. Saunders. 1990, pp 1273-99.
2. Young SP, Aisen P: The liver and iron. In: Arias IM, Boyer JL, Fausto N, et al (eds) The liver. Biology and pathobiology. 3rd ed. New York, Raven Press, 1994, pp 597-617.
3. Gollan JL: Copper metabolism, Wilson's disease, and hepatic copper toxicosis In. Zakim D, Boyer TD (eds) Hepatology: A textbook of liver disease. Philadelphia, W.B. Saunders, 1990, pp 1249-72.
4. Sternlieb I. Copper and zinc. In: Arias IM, Boyer JL, Fausto N, et al (eds) The liver. Biology and pathobiology. 3rd ed. New York, Raven Press, 1994, pp 585-96.
5. Gordeuk VR, McLaren GD, Samowitz W: Etiologies, conse-quences, and treatment of iron overload. Crit Rev Clin Lab Sci 31:89-133, 1994.
6. Petrukhin K, Gilliam TC: Genetic disorders of copper metabolism. Curr Opin Pediatr 6:698-701, 1994.
7. Britton RS, Tavill AS, Bacon BR: Mechanisms of iron toxicity. In: Brock JH, Halliday JW, Pippard MJ, Powell LW (eds) Iron metabolism in health and disease. Philadelphia, W.B. Saunders, 1994, pp 311-51.
8. Lesnefsky EJ: Tissue iron overload and mechanisms of iron-catalyzed oxidative injury. Adv Exp Med Biol 366:129-46, 1994.
9. Stohs SJ, Bagchi D: Oxidative mechanisms in the toxicity of metal ions. Free Rad Biol Med 18:321-36, 1995.
10. Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. 2nd ed. Oxford, Oxford University Press, 1989.
11. Burkitt MJ, Mason RP: Direct evidence for in vivo hydroxyl-radical generation in experimental iron overload: an ESR spin-trapping investigation. Proc Natl Acad Sci USA 88:8440-4, 1991.
12. Kadiiska MB, Burkitt MJ, Xiang Q-U. Mason RP: Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping study. J Clin Invest 96:1653-7, 1995.
13. Kadiiska MB, Hanna PM, Hernandez L, Mason RP: In vivo evidence of hydroxyl radical formation after acute copper and ascorbic acid intake: electron spin resonance spin-trapping investigation. Mol Pharmacol 42:723-9, 1992.
14. Bacon BR, Tavill AS, Brittenham GM, et al: Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J Clin Invest 71:429-39, 1983.
15. Bacon BR, Brittenham GM, Tavill AS, et al: Hepatic lipid peroxidation in vivo in rats with chronic dietary iron overload is dependent on hepatic iron concentration. Trans Assoc Am Phys 96:146-54, 1983.
16. Bacon BR, Britton RS: The pathology of hepatic iron overload: a free radical-mediated process? Hepatology 11:127-37, 1990.
17. Sokol RJ, Devereaux MW, O'Brien K, et al: Abnormal hepatic mitochondrial respiration and cytochrome C oxidase activity in rats with long-term copper overload. Gastroenterology 105:178-187, 1993.
18. Dabbagh AJ, Mannion T, Lynch SM, Frei B: The effect of iron overload on rat plasma and liver oxidant status in vivo. Biochem J 300:799-803, 1994.
19. Dresow B, Albert C, Zimmermann I, Nielsen P: Ethane exhalation and vitamin E/ubiquinol status as markers of lipid peroxidation in ferrocene iron-loaded rats. Hepatology 21:1099-1105, 1995.
20. Young IS, Trouton TG, Torney JJ, et al: Antioxidant status and lipid peroxidation in hereditary haemochromatosis. Free Rad Biol Med 16:393-7, 1994.
21. von Herbay A, de Groot H, Hegi U, et al: Low vitamin E content in plasma of patients with alcoholic liver disease, hemochromatosis and Wilson's disease. J Hepatol 20:41-6, 1994.
22. Niemela O, Parkkila S, Britton RS, et al: Hepatic lipid peroxidation in patients with hereditary hemochromatosis (Abstract). Hepatology 22:372A, 1995.
23. Sokol RJ, Twedt D, McKim JM Jr, et al: Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis. Gastroenterology 107:1788-98, 1994.
24. Summer KH, Eisenburg J: Low content of hepatic reduced glutathione in patients with Wilson's disease. Biochem Med 34:107-11, 1985.
25. Iancu TC, Shiloh H: Morphological observations in iron overload: an update. Adv Exp Med Biol 356:255-65, 1994.
26. Goldfischer S, Sternlieb I: Changes in the distribution of hepatic copper in relation to the progression of Wilson's disease (hepatolenticular degeneration). Am J Physiol 53:883-901, 1968.
27. LaRusso NF: Hepatic lysosomes in intracellular digestion and biliary secretion. In: Forte JG (ed) Handbook of physiology. The gastrointestinal system III. Bethesda, American Physiological Society, 1989, pp 677-91.
28. Peters TJ, Seymour CA: Acid hydrolase activities and lysosomal integrity in liver biopsies from patients with iron overload. Clin Sci Mol Med 50:75-8, 1976.
29. Seymour CA, Peters TJ: Organelle pathology in primary and secondary haemochromatosis with special reference to lysosomal changes. Br J Haematol 40:239-53, 1978.
30. Selden C, Owen M, Hopkins IMP, Peters TJ: Studies on the concentration and intracellular localization of iron proteins in liver biopsy specimens from patients with iron overload with special reference to their role in lysosomal disruption. Br J Haematol 44:593-603, 1980.
31. Peters TJ, O'Connell MJ, Ward RJ: Role of free-radical mediated lipid peroxidation in the pathogenesis of hepatic damage by lysosomal disruption. In: Poli G, Cheeseman KH, Dianzani MU, Slater TF (eds) Free radicals in liver injury. Oxford, IRL Press, 1985. pp 107-15.
32. Stäl P, Glaumann H, Hultcrantz R: Liver cell damage and lysosomal iron storage in patients with idiopathic hemochromatosis. A light and electron microscopic study. J Hepatol 11:172-80, 1990.
33. Frigerio R, Mela Q, Passiu G, et al: Iron overload and lysosomal stability in β-thalassemia intermedia and trait: correlation between serum ferritin and serum N-acetyl-β-D-glucosaminidase levels. Scand J Haematol 33:252-5, 1984.
34. O'Connell MJ, Ward RJ, Baum H, Peters TJ: The role of iron in ferritin and haemosiderin-mediated lipid peroxidation in lysosomes. Biochem J 229:135-9, 1985.
35. O'Connell M, Halliwell B, Moorhouse CP, et al: Formation of hydroxyl radicals in the presence of ferritin and haemosiderin. Is haemosiderin formation a biological protective mechanism? Biochem J 234:727-31, 1986.
36. Hultcrantz R, Ahlberg J, Glaumann H: Isolation of two lysosomal populations from iron-overloaded rat liver with different iron concentration and proteolytic activity. Virchows Arch (Cell Pathol) 47:55-65, 1984.
37. LeSage GD, Kost LJ, Barham SS, LaRusso NF: Biliary excretion of iron from hepatocyte lysosomes in the rat. A major excretory pathway in experimental iron overload. J Clin Invest 77:90-7, 1986.
38. Myers BM, Prendergast FG, Holman R, et al: Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload. J Clin Invest 88:1207-15, 1991.
39. Bacon BR, Park CH, Brittenham GM, et al: Hepatic mitochondrial oxidative metabolism in rats with chronic dietary iron overload. Hepatology 5:789-97, 1985.
40. Hultcrantz R, Glaumann H: Studies on the rat liver following iron overload: biochemical analysis after iron mobilization. Lab Invest 46:383-92, 1982.
41. Sternlieb I: Perspectives on Wilson's disease. Hepatology 12:1234-9, 1990.
42. Myers BM, Prendergast FG, Holman R, et al: Alterations in hepatocyte lysosomes in experimental copper overload in rats. Gastroenterology 105:1814-23, 1993.
43. Bacon BR, Britton RS, O'Neill R. Effects of vitamin E deficiency on hepatic mitochondrial lipid peroxidation and oxidative metabolism in rats with chronic dietary iron overload. Hepatology 9:398-404, 1989.
44. Bacon BR, O'Neill R, Britton RS: Hepatic mitochondrial energy production in rats with chronic iron overload. Gastroenterology 105:1134-40, 1993.
45. Bacon BR, O'Neill R, Park CH: Iron-induced peroxidative injury to isolated rat hepatic mitochondria. J Free Rad Biol Med 2:339-47, 1986.
46. 2+ on oxidative phosphorylation and the structural stability of isolated mitochondria. J Cell Biol 35:48A-49A, 1967.
47. 31P-NMR study on the energy state of rat liver in an experimental model of chronic dietary iron overload. Biochem Biophys Res Commun 176:1262-8, 1991.
48. Pietrangelo A, Borella F, Casalgrandi G, et al: Antioxidant activity of silybin in vivo during long-term iron overload in rats. Gastroenterology 109:1941-9, 1995.
49. Britton RS, O'Neill R, Bacon BR: Chronic dietary iron overload in rats results in impaired calcium sequestration by hepatic mitochondria and microsomes. Gastroenterology 101:806-11, 1991.
50. 2+ homeostasis in experimental iron overload: a possible factor in cell injury. Biochim Biophys Acta 1014:133-40, 1989.
51. Carafoli E: Intracellular calcium homeostasis. Annu Rev Biochem 56:395-433, 1987.
52. Bacon BR, Healey JF, Brittenham GM, et al: Hepatic microsomal function in rats with chronic dietary iron overload. Gastroenterology 90:1844-53, 1986.
53. Schacter BA, Marver HS, Meyer UA: Hemoprotein catabolism during stimulation of microsomal lipid peroxidation. Biochim Biophys Acta 279:221-7, 1972.
54. Levin W, Lu AYH, Jacobson M, et al: Lipid peroxidation and the degradation of cytochrome P-450 heme. Arch Biochem Biophys 158:842-53, 1973.
55. Waller RL, Glende EA Jr, Recknagel RO: Carbon tetrachloride and bromotrichloromethane toxicity. Dual role of covalent binding of metabolic cleavage products and lipid peroxidation in depression of microsomal calcium sequestration. Biochem Pharmacol 32:1613-7, 1983.
56. Bonkovsky HL, Mitchell WJ, Healey JF: Effect of hemochromatosis on hepatic cytochrome P450 and antipyrine metabolism in humans. Clin Chem 30:1430-1, 1984.
57. Pietrangelo A, Grandi R, Tripod A, et al: Lipid composition and fluidity of liver mitochondria, microsomes and plasma membrane of rats with chronic dietary iron overload. Biochem Pharmacol 39:123-8, 1990.
58. Link G, Pinson A, Hershko C: Ability of the orally effective iron chelators dimethyl- and diethyl-hydroxypyrid-4-one and of deferoxamine to restore sarcolemmal thiolic enzyme activity in iron-loaded heart cells. Blood 83:2692-7, 1994.
59. Wu J, Forbes JR, Chen HS, Cox DW: The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Nature Genetics 7:541-5, 1994.
60. Jong-Hon K, Togashi Y, Kasai H, et al: Prevention of spontaneous hepatocellular carcinoma in Long-Evans cinnamon rats with hereditary hepatitis by administration of D-penicillamine. Hepatology 18:614-20, 1993.
61. Li Y, Togashi Y, Sato S, et al: Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. A model of Wilson's disease. J Clin Invest 87:1858-61, 1991.
62. Sternlieb I, Quintana N, Volenberg I, Schilsky ML. An array of mitochondrial alterations in the hepatocytes of Long-Evans Cinnamon rats. Hepatology 22:1782-7, 1995.
63. Myers BM, Hamilton BA, Schilsky ML: Proliferation of hepatic lysosomes and autophagic vacuoles in the Long-Evans Cinnamon (LEC) rat (Abstract). Hepatology 22:373A, 1995.
64. Abe S, Yamazaki K, Takikawa S, Suzuki K: Impaired biliary excretion of copper and lysosomal enzymes in Long-Evans cinnamon. Tohoku J Exp Med 172:355-67, 1994.
65. McKim JM Jr, Devereaux MW, Petersen DR, et al: Mitochondrial oxidant injury in Long-Evans Cinnamon (LEC) rat liver containing high copper. Gastroenterology 106.A941, 1994.
66. Yamamoto F, Kasai H, Togashi Y, et al: Elevated level of 8-hydroxydeoxyguanosine in DNA of liver, kidneys, and brain of Long-Evans Cinnamon rats. Jpn J Cancer Res 84:508-11, 1993.
67. Mori M, Hattori A, Sawaki M, et al: The LEC rat: a model for human hepatitis, liver cancer, and much more. Am J Pathol 144:200-4, 1994
68. Stephenson GF, Chan HM, Cherian MG: Copper-metallothionein from the toxic milk mutant mouse enhances lipid peroxidation initiated by an organic hydroperoxide. Toxicol Appl Pharmacol 125:90-6, 1994.
69. Sakurai H, Satoh H, Hatanaka A, et al: Unusual generation of hydroxyl radicals in hepatic copper-metallothionein of LEC (Long-Evans Cinnamon) rats in the presence of hydrogen peroxide. Biochem Biophys Res Commun 199:313-8, 1994.
70. Bradbear RA, Bain C, Siskind V, et al: Cohort study of internal malignancy in genetic hemochromatosis and other chronic non-alcoholic liver diseases. J Natl Cancer Inst 75:81-4, 1985.
71. Niederau C, Fischer R, Sonnenberg A, et al: Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. N Engl J Med 313:1256-62, 1985.
72. Imlay JA, Chin SM, Linn S: Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. Science 240:640-2, 1988.
73. Toyokuni S, Sagripanti JL: Induction of oxidative single- and double-strand breaks in DNA by ferric citrate. Free Rad Biol Med 15:117-23, 1993.
74. Hruszkewycz AM: Evidence for mitochondrial DNA damage by lipid peroxidation. Biochem Biophys Res Commun 153:191-7, 1988.
75. Shires TK: Iron-induced DNA damage and synthesis in isolated rat liver nuclei. Biochem J 205:321-9, 1982.
76. Mello Filho AC, Meneghini R: In vivo formation of single strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction. Biochim Biophys Acta 781:56-63, 1984.
77. Starke PE, Farber JL: Ferric iron and Superoxide ions are required for the killing of cultured hepatocytes by hydrogen peroxide. Evidence for the participation of hydroxyl radicals formed by an iron-catalyzed Haber-Weiss reaction. J Biol Chem 260:10099-104, 1985.
78. Halliwell B, Gutteridge JMC: Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186:1-85, 1990.
79. Park J-W, Floyd RA: Lipid peroxidation products mediate the formation of 8-hydroxydeoxyguanosine in DNA. Free Rad Biol Med 12:245-50, 1992.
80. Edling JE, Britton RS, Grisham MB, Bacon BR: Increased unwinding of hepatic double-stranded DNA (dsDNA) in rats with chronic dietary iron overload (Abstract). Gastroenterology 98:A585, 1990.
81. Walles SAS, Erixson K: Single-strand breaks in DNA of various organs of mice induced by methyl methanesulfonate and dimethylsulfoxide determined by the alkaline unwinding technique. Carcinogenesis 5:319-22, 1984.
82. Hartley JA, Gibson NW, Zwelling LA, Yuspa SH: Association of DNA strand breaks with accelerated terminal differentiation in mouse epidermal cells exposed to tumor promoters. Cancer Res 45:4864-70, 1985.
83. Faux SP, Francis JE, Smith AG, Chipman JK: Induction of 8-hydroxydeoxyguanosine in Ah-responsive mouse liver by iron and Aroclor 1254. Carcinogenesis 13:247-50, 1992.
84. Kuchino Y, Mori F, Kasai H, et al. Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Nature 327:77-9, 1987.
85. Wood ML, Dizdaroglu M, Gajewski E, Essigmann JM: Mechanistic studies of ionizing irradiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry 29:7024-32, 1990.
86. Okada S, Hamazaki S, Ebina Y, et al: Nephrotoxicity and induction of the renal adenocarcinoma by ferric-nitrilotriacetate (Fe-NTA) in rats. In Urushizaki I, Aisen P, Listowsky I, Drysdale JW (eds) Structure and function of iron storage and transport proteins. New York, Elsevier, 1983, pp 473-8.
87. Umemura T, Sai K, Takagi A, Hasegawa R, Kurokawa Y: Formation of 8-hydroxydeoxyguanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetace (Fe-NTA). Carcinogenesis 11:345-7, 1990.
88. Yamada M, Awai M, Okigaki T: Rapid in vitro transformation system for liver epithelial cells by iron chelate, Fe-NTA. Cytotechnology 3:149-56, 1990.
89. Carmichael PL, Hewer A, Osborne MR, et al: Detection of bulky DNA lesions in the liver of patients with Wilson's disease and primary haemochromatosis. Mutation Res 326:235-43, 1995.
90. Aruoma OI, Halliwell B, Gajewski E, Dizdaroglu M: Copperion-dependent damage to the bases in DNA in the presence of hydrogen peroxide. Biochem J 273:601-4, 1991.
91. Toyokuni S, Sagripanti JL: Increased 8-hydroxydeoxyguanosine in kidney and liver of rats continuously exposed to copper. Toxicol Appl Pharmacol 126:91-7, 1994.
92. Masuda R, Yoshida MC, Sasaki M, et al: High susceptibility to hepatocellular carcinoma development in LEC rats with hereditary hepatitis. Jpn J Cancer Res 79:828-35, 1988.
93. Wu W-H, Meydani M, Meydani SN, et al: Effect of dietary iron overload on lipid peroxidation, prostaglandin synthesis and lymphocyte proliferation in young and old rats. J Nutr 120:280-9, 1990.
94. Golberg L, Martin LE, Batchelor A: Biochemical changes in the tissues of animals injected with iron. 3. Lipid peroxidation. Biochem J 83:291-8, 1962.
95. Hultcrantz R, Ericsson JLE, Hirth T. Levels of malondialdehyde production in rat liver following loading and unloading of iron. Virchows Arch 45:139-46, 1984.
96. Fletcher LM, Roberts FD, Irving MG et al: Effects of iron loading on free radical scavenging enzymes and lipid peroxidation in rat liver. Gastroenterology 97:1011-18, 1989.
97. Britton RS, O'Neill R, Bacon BR: Hepatic mitochondrial malondialdehyde metabolism in rats with chronic iron overload. Hepatology 11:93-7, 1990.
98. Houglum K, Filip M, Witztum JL, Chojkier M: Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload. J Clin Invest 86:1991-8, 1990.
99. Younes M, Trepkau H-D, Siegers C-P: Enhancement by dietary iron of lipid peroxidation in mouse colon. Res Commun Chem Pathol Pharmacol 70:349-54, 1990.
100. Brown KE, Kinter MT, Spitz DR: et al: Experimental iron overload is associated with increased levels of 4-hydroxynonenal, a toxic by-product of lipid peroxidation (Abstract). Hepatology 14:159A, 1991.
101. Parkkila S, Niemela O, Britton RS, et al: Vitamin E decreases the hepatic levels of aldehyde-derived peroxidation products in rats with iron overload. Am J Physiol 270:G376-84, 1996.
102. Ramm GA, Li SCY, Li L, et al: Chronic iron overload causes activation of rat lipocytes in vivo. Am J Physiol 268:G451-8, 1995.
103. Lindquist RR: Studies on the pathogenesis of hepatolenticular degeneration. III. The effect of copper on rat liver lysosomes. Am J Pathol 53:903-27, 1968.
104. Sokol RJ, Devereaux M, Mierau GW, et al: Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload. Modification by vitamin E deficiency. Gastroenterology 99:1061-71, 1990.
105. Yamada T, Sogawa K, Suzuki Y, et al: Elevation of the level of lipid peroxidation associated with hepatic injury in LEC mutant rat. Res Commun Chem Pathol Pharmacol 77:121-4, 1992.