Computer modeling and nanosecond simulation of the enzyme-substrate complex of the common lymphoblastic leukemia antigen (neprilysin) indicates shared residues at the primary specificity pocket (S1') with matrix metalloproteases

Journal of Molecular Modeling

Volumn 9, Issue 5, 2003, Pages 348-354

  Manzetti, Sergio ^a  

^a Proinformatixcom   (Norway)

Author keywords

Cancer; Modeling; Neprilysin; Simulation; Specificity; Substrate

Indexed keywords

ALANINE; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; ENZYME INHIBITOR; HYDROGEN; MATRIX METALLOPROTEINASE; MEMBRANE METALLOENDOPEPTIDASE; PHENYLALANINE; STROMELYSIN; TYROSINE; VALINE;

ALZHEIMER DISEASE; ARTICLE; COMPUTER MODEL; COMPUTER SIMULATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SELECTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; HYPERTENSION; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR DYNAMICS; MOLECULAR MODEL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TIME;

BINDING SITES; COMPUTER SIMULATION; MATRIX METALLOPROTEINASES; MODELS, MOLECULAR; NEPRILYSIN; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; TIME FACTORS;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0347300714     PISSN: 16102940     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00894-003-0158-5     Document Type: Article

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