Pyridine oximes: Synthesis, reactions, and biological activity. (Review)

Chemistry of Heterocyclic Compounds

Volumn 39, Issue 7, 2003, Pages 825-865

  Abele, E ^a   Abele, R ^a   Lukevics, E ^a  

^a LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

Author keywords

Biological activity; Oximes; Pyridine

Indexed keywords

ACETAMIDE DERIVATIVE; ALDOXIME; ANALGESIC AGENT; ANTIASTHMATIC AGENT; ANTIDEPRESSANT AGENT; ANTIDIABETIC AGENT; ANTIDOTE; ANTIHISTAMINIC AGENT; ANTIHYPERTENSIVE AGENT; ANTIINFLAMMATORY AGENT; ANTIVIRUS AGENT; AZEPINE DERIVATIVE; BACTERICIDE; CEPHALOSPORIN DERIVATIVE; CERULOMYCIN; COLLISMYCIN A; CYTOTOXIC AGENT; FUNGICIDE; HEMIFLOXACIN MESYLATE; MESYLIC ACID DERIVATIVE; NATURAL PRODUCT; OBIDOXIME; ORGANOPHOSPHORUS COMPOUND; OXIME DERIVATIVE; PYRIDINE DERIVATIVE; RIDOGREL; SEDATIVE AGENT; SPASMOLYTIC AGENT; THROMBOXANE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALLERGY; ANALGESIA; ANTIVIRAL ACTIVITY; BACTERICIDAL ACTIVITY; BECKMANN REARRANGEMENT; CATALYSIS; CATALYST; CELL AGGREGATION; CHEMICAL REACTION; CYCLIZATION; CYTOTOXICITY; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGENATION; INFLAMMATION; ISCHEMIC HEART DISEASE; ISOMERISM; NONHUMAN; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE; PSORIASIS; REACTION ANALYSIS; REVIEW; SEDATION; STRUCTURE ANALYSIS; THROMBOSIS;

EID: 0347003669     PISSN: 00093122     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026181918567     Document Type: Review

References (539)

1. A. Go and Y. Usui, Jpn. Patent 01246251; Chem. Abstr., 112, 178691 (1990).
2. T. D. Kazarinova, L. I. Markova, and V. G. Kharchenko, Khim. Geterotsikl. Soedin., 647 (1994).
3. Yu. M. Shchekotikhin, Yu. A. Getmanenko, T. G. Nikolaeva, and A. P. Kriven'ko, Khim. Geterotsikl. Soedin., 1344 (2001).
4. K. Kantminene, G. Mikulskene, O. Khormin, and Z. I. Krivenko, Khim. Geterotsikl. Soedin., 487 (2002).
5. F. H. Case and P. J. McMenamin, J. Heterocycl. Chem., 5, 161 (1968).
6. A. B. Ash, F. A. Daniher, and B. E. Hackley, Jr., US Patent 3501486; Chem. Abstr., 72, 121377 (1970).
7. Mitsui Petrochemical Industries, Ltd., Jpn. Patent 8272965; Chem. Abstr., 97, 92154 (1982).
8. K. Yamauchi, F. Nishimura, and K. Tamaoki, Jpn. Patent 62240661; Chem. Abstr., 108, 167316 (1988).
9. H. Yanagisawa, Jpn. Patent 09216868; Chem. Abstr., 127, 190653 (1997).
10. H. M. Reyes-Rivera, R. O. Hutchins, and D. R. Dalton, J. Heterocycl. Chem., 32, 665 (1995).
11. B. B. Snider and B. Shi, Tetrahedron Lett., 42, 1639 (2001).
12. D. Heyl, S. A. Harris, and K. Folkers, Brit. Patent 613824; Chem. Abstr., 43, 4702 (1949).
13. M. Pitman and P. W. Sadler, J. Chem. Soc., 759 (1961).
14. 14. T. Nakashima, Yakugaku Zasshi, 77, 1298 (1957); Chem. Abstr., 52, 6345 (1958).
15. T. Nakashima, Yakugaku Zasshi, 77, 1298 (1957); Chem. Abstr., 52, 6345 (1958).
16. R. Cibulka, F. Hampl, H. Kotoucova, J. Mazac, and F. Liska, Coll. Czech. Chem. Commun., 65, 227 (2000).
17. S. Ranganathan, B. B. Singh, and P. V. Divekar, Can. J. Chem., 47, 165 (1969).
18. P. V. Divekar, G. Read, and L. C. Vining, Can. J. Chem., 45, 1215 (1967).
19. H. Guenther, Ger. Patent 3223913; Chem. Abstr., 100, 34419 (1983).
20. E. J. Poziomek, B. E. Hackley, Jr., and G. M. Steinberg, J. Org. Chem., 23, 714 (1958).
21. B. J. Hackley, Jr., E. J. Poziomek, G. M. Steinberg, W. and A. Mosher, J. Org. Chem., 27, 4220 (1962).
22. T. Mukaiyama, K. Saigo, and H. Takei, Bull. Chem. Soc. Jpn., 44, 190 (1971).
23. 22. K. Okon, J. W. Grochowski, W. Waclawek, and J. Zieba, Biul. Wojskowej Akad. Tech., 12, 25 (1963); Chem. Abstr., 60, 495 (1964).
24. K. Okon, J. W. Grochowski, W. Waclawek, and J. Zieba, Biul. Wojskowej Akad. Tech., 12, 25 (1963); Chem. Abstr., 60, 495 (1964).
25. S. E. Forman, US Patent 3192223; Chem. Abstr., 63, 9921 (1965).
26. L. Clark and L. J. Roth, J. Pharm. Sci., 52, 96 (1963).
27. F. A. McGinn, M. A. Dolliver, and W. B. McDowell, French Patent 1377691; Chem. Abstr., 62, 14636 (1965).
28. M. Amin, C. E. Twine, and J. A. Kepler, J. Labelled Compd. Radiopharm., 39, 875 (1997).
29. J. J. Kaminski, K. W. Knutson, and N. Bodor, Tetrahedron, 34, 2857 (1978).
30. L. Ya. Leitis, M. V. Shimanskaya, R. A. Zhuk, and S. A. Giller, Izv. Akad. Nauk LatvSSR. Ser. Khim., 336 (1976).
31. R. I. Ellin, D. Easterday, and A. A. Kondritzer, J. Med. Pharm. Chem., 5, 404 (1962).
32. R. Cibulka, D. Dvorak, F. Hampl, and F. Liška, Coll. Czech. Chem. Commun., 62, 1342 (1997).
33. W. S. Chilton and A. K. Butler, J. Org. Chem., 32, 1270 (1967).
34. F. A. Daniher, B. E. Hackley, Jr., and A. B. Ash, J. Org. Chem., 31, 2709 (1966).
35. 33. S. Ahmad, T. Akhtar, and R. Igbal, Islamabad J. Sci., 4, 39 (1977); Chem. Abstr., 92, 198226 (1980).
36. S. Ahmad, T. Akhtar, and R. Igbal, Islamabad J. Sci., 4, 39 (1977); Chem. Abstr., 92, 198226 (1980).
37. M. Nakai, F. Kimura, and T. Komata, Jpn. Patent 77139069; Chem. Abstr., 88, 89530 (1978).
38. R. Oesterlin and P. A. Pareene, US Patent 4246420; Chem. Abstr., 94, 139633 (1981).
39. L. I. Markova, T. D. Kazarinova, L. M. Yudovich, and V. G. Kharchenko, Khim. Geterotsikl. Soedin., 209 (1990).
40. W. Lowe, Arch. Pharm., 311, 414 (1978).
41. S. E. Forman, J. Org. Chem., 29, 3323 (1964).
42. S. E. Forman, US Patent 3150135; Chem. Abstr., 62, 2765 (1965).
43. 40. T. Kato and H. Hayashi, Yakugaku Zasshi, 83, 352 (1963); Chem. Abstr., 59, 7473 (1963).
44. T. Kato and H. Hayashi, Yakugaku Zasshi, 83, 352 (1963); Chem. Abstr., 59, 7473 (1963).
45. 41. Z. Binenfeld and J. Vorkapic, Farm. Glas., 25, 257 (1969); Chem. Abstr., 71, 112763 (1969).
46. Z. Binenfeld and J. Vorkapic, Farm. Glas., 25, 257 (1969); Chem. Abstr., 71, 112763 (1969).
47. R. H. Poirier, B. W. Fromm, E. J. Poziomek, J. A. Stein, and D. N. Kramer, US Patent 3624095; Chem. Abstr., 76, 59461 (1972).
48. Y. Tagawa, H. Arakawa, and Y. Goto, Heterocycles, 29, 1741 (1989).
49. 44. T. Kato, Y. Goto, and T. Chiba, Yakugaku Zasshi, 87, 689 (1967); Chem. Abstr., 67, 99968 (1967).
50. T. Kato, Y. Goto, and T. Chiba, Yakugaku Zasshi, 87, 689 (1967); Chem. Abstr., 67, 99968 (1967).
51. 45. T. Kato and Y. Goto, Yakugaku Zasshi, 85, 451 (1965); Chem. Abstr., 63, 5596 (1965).
52. T. Kato and Y. Goto, Yakugaku Zasshi, 85, 451 (1965); Chem. Abstr., 63, 5596 (1965).
53. T. Kato, Jpn. Patent 22844('64); Chem. Abstr., 62, 10418 (1965).
54. M. Grifantini, S. Martelli, and M. L. Stein, J. Pharm. Sci., 58, 460 (1969).
55. H. Y. Kirn, D. A. Lantrip, and P. L. Fuchs, Org. Lett., 3, 2137 (2001).
56. E. Bullock, B. Gregory, and A. W. Johnson, J. Am. Chem. Soc., 84, 2260 (1962).
57. 50. A. Avots, G. Glemite, I. Lazdins, L. Leitis, M. V. Shimanskaya, and G. Enins, USSR Inventor's Certificate 253065; Chem. Abstr., 72, 78894 (1970).
58. A. Avots, G. Glemite, I. Lazdins, L. Leitis, M. V. Shimanskaya, and G. Enins, USSR Inventor's Certificate 253065; Chem. Abstr., 72, 78894 (1970).
59. 51. W. Glinska and K. Niewiadomski, Acta. Pol. Pharm., 28, 229 (1971); Chem. Abstr., 76, 25061 (1972).
60. W. Glinska and K. Niewiadomski, Acta. Pol. Pharm., 28, 229 (1971); Chem. Abstr., 76, 25061 (1972).
61. 52. I. A. Poplavskaya, R. G. Kurmangalieva, S. F. Khalilova, and A. A. Espenbetov, Izv. Akad. Nauk. KazSSR. Ser. Khim., 53 (1985); Chem. Abstr., 105, 78802 (1986).
62. I. A. Poplavskaya, R. G. Kurmangalieva, S. F. Khalilova, and A. A. Espenbetov, Izv. Akad. Nauk. KazSSR. Ser. Khim., 53 (1985); Chem. Abstr., 105, 78802 (1986).
63. 53. R. G. Kurmangalieva, S. F. Khalilova, and I. A. Poplavskaya, Deposited Doc., VINITl, 4221 (1983); Chem. Abstr., 102, 45879 (1985).
64. R. G. Kurmangalieva, S. F. Khalilova, and I. A. Poplavskaya, Deposited Doc., VINITl, 4221 (1983); Chem. Abstr., 102, 45879 (1985).
65. V. V. Zakharychev, M. D. Golubtsova, and L. V. Kovalenko, Izv. Akad. Nauk. Ser. Khim., 499 (1999).
66. G. Cusmano, G. Macaluso, and M. Gruttadauria, Heterocycles, 36, 1577 (1993).
67. L. A. Safronova, T. D. Kazarinova, A. D. Shebaldova, and V. G. Kharchenko, Khim. Geterotsikl. Soedin., 1138 (1995).
68. R. Cibulka, F. Hampl, J. Smidrkal, Jr., and F. Liska, Tetrahedron Lett., 40, 6849 (1999).
69. W. E. Hahn and Z. Cebulska, Pol. J. Chem., 60, 305 (1986).
70. J. Druey and K. Schenker, US Patent 3004979; Chem. Abstr., 56, 3463 (1962).
71. R. E. Lyle, W. E. Krueger, and V. E. Gunn, J. Org. Chem., 48, 3574 (1983).
72. G. Galliani, F. Barzaghi, C. Bonetti, and E. Toja, Eur. Patent 288394; Chem. Abstr., 111, 39191 (1989).
73. S. Bergmeier, D. A. Downs, W. H. Moos, D. W. Moreland, and H. Tecle, US Patent 4710508; Chem. Abstr., 108, 150321 (1988).
74. N. Bodor, E. Shek, and T. Higuchi, J. Med. Chem., 19, 102 (1976).
75. F. Eloy and R. Lenaers, Chem. Rev., 62, 155 (1962).
76. E. Bernasek, J. Org. Chem., 22, 1263 (1957).
77. R. Delaby, P. Reynaud, and T. Tupin, Bull. Soc. Chim. France, 714 (1957).
78. 67. A. Spasov and E. Golovinskii, Compt. Rend. Acad. Bulg. Sci., 11, 287 (1958); Chem. Abstr., 53, 18026(1959).
79. A. Spasov and E. Golovinskii, Compt. Rend. Acad. Bulg. Sci., 11, 287 (1958); Chem. Abstr., 53, 18026(1959).
80. Yoshitomi Pharmaceutical Industries, Ltd., Jpn. Patent 8213542; Chem. Abstr., 97, 182215 (1982).
81. E. J. Poziomek and A. R. Melvin, US Patent 3209008; Chem. Abstr., 63, 18041 (1965).
82. M. Majewski, B. Serafin, J. Faff, and G. Borkowska, Eur. J. Med. Chem. - Chim. Ther., 13, 403 (1978).
83. V. E. Krivenchuk, N. V. Kokshareva, L. M. Sasinovich, V. E. Petrun'kin, and Yu. S. Kagan, Khim.-Farm. Zh., 9, No. 11, 18 (1975).
84. M. Majewski, B. Serafin, and T. Oklesinska, Rocz. Chem., 51, 975 (1977).
85. 73. M. Kocevar, M. Perdih, A. Petric, S. Polanc, M. Sollner, and B. Vercek, Vestn. Slav. Kem. Drus., 37, 373 (1990); Chem. Abstr., 114, 228687 (1991).
86. M. Kocevar, M. Perdih, A. Petric, S. Polanc, M. Sollner, and B. Vercek, Vestn. Slav. Kem. Drus., 37, 373 (1990); Chem. Abstr., 114, 228687 (1991).
87. C. Huether, J. M. Cretsos, and J. M. Shackelford, J. Chem. Eng. Data, 8, 624 (1963).
88. M. Kocevar, S. Polanc, M. Sollner, M. Tisler, and B. Vercek, Synth. Commun., 18, 1427 (1988).
89. E. Lustig, J. Phys. Chem., 65, 491 (1961).
90. E. J. Poziomek, D. N. Kramer, W. A. Mosher, and H. O. Michel, J. Am. Chem. Soc., 83, 3916 (1961).
91. G. Heinisch and W. Holzer, Tetrahedron Lett., 31, 3109 (1990).
92. J. Schnekenburger, Arch. Pharm., 302, 494 (1969).
93. J. Schnekenburger, Arch. Pharm., 302, 815 (1969).
94. G. A. Pearse, Jr., and M. Ericsson, J. Chromatogr., 177, 174 (1979).
95. 82. G. A. Pearse, Jr, Chem. Scr., 13, 110 (1979); Chem. Abstr., 91, 192697 (1979).
96. G. A. Pearse, Jr, Chem. Scr., 13, 110 (1979); Chem. Abstr., 91, 192697 (1979).
97. E. G. Vassian and R. K. Murmann, J. Org. Chem., 21, 4309 (1962).
98. J. Budka, F. Hampl, F. Liska, P. Scrimin, P. Tecilla, and U. Tonellato, J. Mol. Catal. A: Chem., 104, L201 (1996).
99. R. Cibulka, F. Hampl, T. Martinu, J. Mozac, S. Toteova, and F. Liska, Coll. Czech. Chem. Commun., 64, 1159 (1999).
100. E. Uhlig and D. Schneider, Z. Anorg. Allgem. Chem., 333, 90 (1964).
101. A. A. El-Asmy, M. E. Khalifa, T. H. Rakha, M. M. Hassanian, and A. M. Abdallah, Chem. Pharm. Bull., 48, 41 (2000).
102. B. Sen, Chem. Ind. (London), 562 (1958).
103. 89. A. Alessandro, D. Biagi, and L. Conti, Vini Ital., 11, 49 (1969); Chem. Abstr., 71, 11718 (1969).
104. A. Alessandro, D. Biagi, and L. Conti, Vini Ital., 11, 49 (1969); Chem. Abstr., 71, 11718 (1969).
105. 90. P. W. Beaupre and W. J. Holland, Microchim. Acta, 2, 1 (1984); Chem. Abstr., 101, 199010 (1984).
106. P. W. Beaupre and W. J. Holland, Microchim. Acta, 2, 1 (1984); Chem. Abstr., 101, 199010 (1984).
107. K. Barry Sharpless and H. P. Jensen, Inorg. Chem., 13, 2617 (1974).
108. T. L. Meek and G. E. Cheney, Can. J. Chem., 43, 64 (1965).
109. H. A. Suter and P. W. West, Anal. Chim. Acta, 13, 501 (1955).
110. 94. A. Doadrio and C. B. Marone, An. Real. Soc. Espan. Fis. Quim., Ser. B, 63, 557 (1967); Chem. Abstr., 68, 9046 (1968).
111. A. Doadrio and C. B. Marone, An. Real. Soc. Espan. Fis. Quim., Ser. B, 63, 557 (1967); Chem. Abstr., 68, 9046 (1968).
112. N. Kumar, G. S. Manku, A. N. Bhat, and B. D. Jain, Talanta, 17, 873 (1970).
113. R. J. Thompson, R. H. Gore, and F. Trussell, Anal. Chim. Acta, 31, 590 (1964).
114. P. Radhakrishna Murty and Ramachandra Rao, Khim. Geterotsikl. Soedin., 729 (1966).
115. I. Pattison and K. Wade, J. Chem. Soc. (A), 2618 (1968).
116. M. Orama and H. Saarinen, Acta Chem. Scand., 50, 1087 (1996).
117. V. Stuzka, J. Kvapil, and M. Kuras, Z. Anal. Chem., 179, 401 (1961).
118. 101. J. L. del Barrio, E. L. Abad, and S. Vicente-Perez, An. Quim., Ser. B, 82, 66 (1986); Chem. Abstr., 105, 145243 (1986).
119. J. L. del Barrio, E. L. Abad, and S. Vicente-Perez, An. Quim., Ser. B, 82, 66 (1986); Chem. Abstr., 105, 145243 (1986).
120. G. A. Pearse, P. R. Raithby, and J. Lewis, Polyhedron, 8, 301 (1989).
121. E. Lorenzo, J. Losada, and S. Vicente-Perez, Afinidad, 44, 497 (1987).
122. K. K. Tripathi and D. Banerjea, Z. Anal. Chem., 168, 326 (1959).
123. R. B. Moodie, B. J. Gregory, and K. Schofield, J. Chem. Soc. (B), 1687 (1970).
124. J. Suh, M. P. Suh, and J. D. Lee, Inorg. Chem., 24, 3088 (1985).
125. 107. J. Suh and K. I. Kim, Bull. Korean Chem. Soc., 6, 230 (1985); Chem. Abstr., 104, 108735 (1986).
126. J. Suh and K. I. Kim, Bull. Korean Chem. Soc., 6, 230 (1985); Chem. Abstr., 104, 108735 (1986).
127. J. Suh, B. N. Kwon, W. Y. Lee, and S. H. Chang, Inorg. Chem., 26, 805 (1987).
128. F. Mancin, P. Tecilla, and U. Tonellato, Eur. J. Org. Chem., 1045 (2000).
129. C. B. Aakeroy, A. M. Beatty, and D. S. Leinen, CrystEngComm [on-line computer file], 2000, Article No. 27. Avail. URL: http://www.rsc.org/ej/ce/2000/ b006043/b006043g.pdf;
130. Chem. Abstr., 134, 252244 (2001).
131. 111. C. B. Aakeroey, A. M. Beatty, and D. S. Leinen, Cryst. Growth Des., 1, 47 (2001); Chem. Abstr., 134, 29284 (2001).
132. C. B. Aakeroey, A. M. Beatty, and D. S. Leinen, Cryst. Growth Des., 1, 47 (2001); Chem. Abstr., 134, 29284 (2001).
133. M. Mazik, D. Bliiser, and R. Boese, Chem. Eur. J., 6, 2865 (2000).
134. P. Grammaticakis, Bull. Soc. Chim. France, 109 (1956).
135. A. Green, J. Chem. Soc., 2566 (1956).
136. 115. G. Leandri and D. Spinelli, Boll. Sci. Fac. Chim. Ind. Bologna, 19, 23 (1961); Chem. Abstr., 55, 18295 (1961).
137. G. Leandri and D. Spinelli, Boll. Sci. Fac. Chim. Ind. Bologna, 19, 23 (1961); Chem. Abstr., 55, 18295 (1961).
138. J. Bielavsky, J. Vachek, and F. Ornst, Coll. Czech. Chem. Commun., 37, 1044 (1972).
139. V. Hankonyi, Z. Binenfeld, and V. Karas-Gasparec, Croat. Chem. Acta, 44, 329 (1972).
140. J. Szuszkiewicz and S. Zoramer-Urbanska, Rocz. Chem., 51, 1307 (1977).
141. R. Mathis, H. Goncalves, L. Lopez, and F. Mathis, Compt. Rend. Acad. Sci., Ser. B, 276, 897 (1973).
142. 120. S. Vicente-Perez, E. L. Del Bario, and J. L. Abad, An. Quim., Ser. B, 81, 75 (1985); Chem. Abstr., 103, 188596 (1985).
143. S. Vicente-Perez, E. L. Del Bario, and J. L. Abad, An. Quim., Ser. B, 81, 75 (1985); Chem. Abstr., 103, 188596 (1985).
144. S. F. Mason, J. Chem. Soc., 22 (1960).
145. D. Prevorsek and M. G. Ribaud, Compt. Rend. Acad. Sci., 247, 1333 (1958).
146. G. A. Pearse, Jr., Acta Chem. Scand., B33, 742 (1979).
147. L. Larsson and G. Wallerberg, Acta Chem. Scand., B16, 788 (1962).
148. G. Hvistendahl, K. Undheim, and J. H. Blanch, Chem. Scr., 7, 21 (1975); Chem. Abstr., 82, 138728 (1975).
149. G. Hvistendahl, K. Undheim, and J. H. Blanch, Chem. Scr., 7, 21 (1975); Chem. Abstr., 82, 138728 (1975).
150. V. I. Zaretskii, A. Ben-Bassat, and D. Lavie, J. Heterocycl. Chem., 12, 837 (1975).
151. G. A. Pearse and S. Jacobsson, Org. Mass Spectrom., 15, 331 (1980).
152. J. Tirouflet and E. Laviron, Compt. Rend. Acad. Sci., 246, 274 (1958).
153. N. G. Lordi and E. M. Cohen, Anal. Chim. Acta, 25, 281 (1961).
154. 130. A. E. Lorenzo, J. L. del Barrio, and S. Vicente-Perez, An. Quim., Ser. B., 83, 233 (1987); Chem. Abstr., 108, 87053 (1988).
155. A. E. Lorenzo, J. L. del Barrio, and S. Vicente-Perez, An. Quim., Ser. B., 83, 233 (1987); Chem. Abstr., 108, 87053 (1988).
156. R. Cibulka, I. Cisarova, J. Ondracek, F. Liska, and J. Ludvig, Coll. Czech. Chem. Commun., 66, 170 (2001).
157. 132. P. Cecchi, Ricerca Sci., 28, 2526 (1958); Chem. Abstr., 53, 14650 (1959).
158. P. Cecchi, Ricerca Sci., 28, 2526 (1958); Chem. Abstr., 53, 14650 (1959).
159. J. S. Kwiatkowski, W. Herzog, and B. Szczodrowska, J. Mol. Struct., 26, 333 (1975).
160. E. J. Poziomek, J. Pharm. Sci., 54, 333 (1965).
161. 135. V. E. Caprio, M. W. Jones, and M. A. Brimble, Molecules, [on-line computer file], 6, m202 (2001). Avail. URL: http://www.mdpi.org./molbank/m0202. htm; Chem. Abstr., 136, 118360 (2002).
162. V. E. Caprio, M. W. Jones, and M. A. Brimble, Molecules, [on-line computer file], 6, m202 (2001). Avail. URL: http://www.mdpi.org./molbank/m0202. htm; Chem. Abstr., 136, 118360 (2002).
163. CIBA Ltd., Brit. Patent 842968; Chem. Abstr., 55, 8434 (1961).
164. R. T. Major and K. W. Ohly, J. Med. Pharm. Chem., 4, 51 (1961).
165. K. Kawashima, Jpn. Patent 09235240; Chem. Abstr., 127, 248019 (1997).
166. E. L. Schumann, US Patent 3167563; Chem. Abstr., 62, 10418 (1965).
167. F. Dorn, Eur. Patent 49854; Chem. Abstr., 97, 163017 (1982).
168. T. Hirose and N. Kimura, PCT Int. Appl. WO Pat. 9843949; Chem. Abstr., 129, 275705 (1998).
169. P. L. Ferrarini, C. Mod, and S. Belfiore, J. Heterocycl. Chem., 33, 1185 (1996).
170. A. Da Settimo, G. Biagi, G. Primofiore, P. L. Ferrarini, and O. Livi, Farmaco, Ed. Sci., 33, 770 (1978).
171. G. L. Karup, H. F. Preikschat, and S. B. Pedersen, PCT Int. Appl. WO Pat. 9925688; Chem. Abstr., 131, 5189 (1999).
172. Ishihara Sangyo Kaisha, Ltd., Jpn. Patent 8183495; Chem. Abstr., 95, 132689 (1981).
173. J. Druey, K. Eichenberger, P. Schmidt, and A. Rossi, Swiss Patent 373753; Chem. Abstr., 61, 5615 (1964).
174. S. Tanaka, Y. Funaki, S. Hashimoto, and H. Matsumoto, Jpn. Patent 78116378; Chem. Abstr., 90, 103840 (1979).
175. E. J. E. Freyne, A. H. M. Raeymaekers, V. Sipido, and M. G. Venet, Eur. Patent 221601; Chem. Abstr., 107, 115497 (1987).
176. E. J. Poziomek, R. H. Poirier, B. W. Fromm, D. N. Kramer, J. A. Stockinger, and M. D. Pankau, J. Org. Chem., 29, 217 (1964).
177. T. Goshima, Y. Kitagawa, S. Kaji, H. Hayakawa, and A. Watanabe, Jpn. Patent 0499767; Chem. Abstr., 117, 131079 (1992).
178. T. Naito, H. Kobayashi, H. Ogura, and K. Zama, Jpn. Patent 0491077; Chem. Abstr., 117, 150899 (1992).
179. P. L. Ferrarini, C. Mori, M. Badawneh, V. Calderone, R. Greco, C. Manera, A. Martinelli, P. Nieri, and G. Saccomanni, Eur. J. Med. Chem., 35, 815 (2000).
180. P. L. Ferrarini, C. Mori, M. Badawneh, C. Manera, G. Saccomanni, V. Calderone, R. Scatizzi, and P. L. Barili, Eur. J. Med. Chem., 32, 955 (1997).
181. K. Rubina, Yu. Goldberg, A. Gaukhman, and M. Shymanska, Synth. Commun., 19, 3129 (1989).
182. K. Rubina, J. Popelis, Yu Goldberg, and M. Shimanskaya, Khim. Geterotsikl. Soedin., 1641 (1992).
183. A. Goh, S. Imada, K. Jikihara, K. Endo, Y. Yamamoto, and Y. Usui, Eur. Patent 299382; Chem. Abstr., 110, 212627 (1989).
184. C. L. Cornell and D. E. Green, PCT Int. Appl. WO Pat. 9707099; Chem. Abstr., 126, 238216 (1997).
185. E. Abele, R. Abele, K. Rubina, J. Popelis, I. Sleiksa, and E. Lukevics, Synth. Commun., 28, 2621 (1998).
186. E. Abele, R. Abele, P. Arsenyan, I. Shestakova, I. Kanepe, I. Antonenko, J. Popelis, and E. Lukevics, Bioinorg. Chem. Appl., in press.
187. K. Rubina, A Gaukhman, and E. Lukevics, Zh. Org. Khim., 34, 1418 (1998).
188. E. Abele, R. Abele, J. Popelis, and E. Lukevics, Org. Prep. Proced. Int., 32, 153 (2000).
189. R. E. Banks, W. Jondi, and A. E. Tipping, J. Chem. Soc. Chem. Commun., 1268 (1989).
190. L. A. Paquette, US Patent 3218329; Chem. Abstr., 64, 3494 (1966).
191. M. Mascal, N. M. Hext, R. Warmuth, J. R. Arnall-Culliford, M. H. Moore, and J. P. Turkenburg, J. Org. Chem., 64, 8479 (1999).
192. K. Fujimoto, K. Shibue, and T. Takebayashi, Jpn. Patent 10291971; Chem. Abstr., 130, 3773 (1999).
193. S. M. Bromidge, F. Brown, F. Cassidy, M. S. G. Clark, E. J. Collings, S. Dabbs, R. E. Faulkner, J. M. Loudon, B. S. Orlek, and G. J. Riley, Bioorg. Med. Chem. Lett., 4, 557 (1994).
194. W. H. Guendel, Z. Naturforsch., 36B, 1031 (1981).
195. J. Schnekenburger and D. Heber, Tetrahedron, 30, 4055 (1974).
196. J. Schnekenburger and D. Heber, Arch. Pharm., 308, 225 (1975).
197. M. J. Wanner and G.-J. Koomen, J. Org. Chem., 61, 5581 (1996).
198. E. Abele, K. Rubina, and E. Lukevics, Latv. J. Chem., No. 1, 77 (2000).
199. Farbenfabriken Bayer A.-G., Brit. Patent 945068; Chem. Abstr., 60, 12051 (1964).
200. J. Kaufmann and F. Kober, J. Organomet. Chem., 71, 49 (1974).
201. 174. X. Zhou, Gaodeng Xuexiao Huaxue Xuebao, 5, 683 (1984); Chem. Abstr., 102, 6144 (1985).
202. X. Zhou, Gaodeng Xuexiao Huaxue Xuebao, 5, 683 (1984); Chem. Abstr., 102, 6144 (1985).
203. T. Miyasaka and S. Noguchi, Chem. Lett., 701 (1985).
204. S. Ginsburg and I. B. Wilson, J. Am. Chem. Soc., 79, 481 (1957).
205. T. Goto and S. Sakawa, Eur. Patent 136640; Chem. Abstr., 103, 22474 (1985).
206. C. Fest, W. Brandes, G. Haenssler, and P. Reinecke, Ger. Patent 3608383; Chem. Abstr., 107, 217494 (1987).
207. F. Iwasaki and M. Mitsuharu, Jpn. Patent 08157438; Chem. Abstr., 125, 167402 (1996).
208. A. Raoult and M. Vilkas, Bull. Soc. Chim. France, Fr., 3315 (1968).
209. P. Ya. Romanovskii, A. Krikis, and G. Cipens, USSR Inventor's Certificate 487884;
210. Chem. Abstr., 84, 17161 (1976).
211. P. Ya. Romanovskii, T. Plutsin'skii, and G. Kuprishevskii, Khim. Geterotsikl. Soedin., 1336 (1977).
212. T. Plucinski and G. Kupryszewski, Pol. J. Chem., 55, 573 (1981).
213. T. Katagi, H. Kataoka, K. Takahashi, T. Fujioka, M. Kunimoto, Y. Yamaguchi, M. Fujiwara, and T. Inoi, Chem. Pharm. Bull., 40, 2419 (1992).
214. E. Abele and E. Lukevics, Org. Prep. Proced. Int., 32, 235 (2000).
215. E. Abele, R. Abele, K. Rubina, J. Popelis, A. Gaukhman, and E. Lukevics, Khim. Geterotsikl. Soedin., 1325 (1998).
216. E. Abele, K. Rubina, R. Abele, A. Gaukhman, and E. Lukevics, J. Chem. Res. (S), 618 (1998).
217. 188. W. Zhao, Huaxue Shiji, 19, 273 (1997); Chem. Abstr., 127, 330917 (1997).
218. W. Zhao, Huaxue Shiji, 19, 273 (1997); Chem. Abstr., 127, 330917 (1997).
219. Mitsui Petrochemical Industries, Jpn. Patent 8272966; Chem. Abstr., 97, 92153 (1982).
220. Mitsui Petrochemical Industries, Jpn. Patent 8272964; Chem. Abstr., 97, 92152 (1982).
221. 191. S. Biniecki and Z. Kabzinska, Acta Pol. Pharm., 26, 277 (1969); Chem. Abstr., 72, 66760 (1970).
222. S. Biniecki and Z. Kabzinska, Acta Pol. Pharm., 26, 277 (1969); Chem. Abstr., 72, 66760 (1970).
223. J. Schnekenburger and D. Heber, Arch. Pharm., 308, 594 (1975).
224. G. Rosini, G. Baccolini, and S. Cacchi, J. Org. Chem., 38, 1060 (1973).
225. E. Abele, R. Abele, and E. Lukevics, Latv. J. Chem., No. 3, 63 (1999).
226. G. M. Keseru, G. T. Balogh, and T. Karancsi, Bioorg. Med. Chem. Lett., 10, 1775 (2000).
227. J. Schnekenburger and D. Heber, Arch. Pharm., 308, 33 (1975).
228. W. Korytnyk and S. C. Srivastava, J. Med. Chem., 16, 638 (1973).
229. M. V. Rubtsov, E. S. Nikitskaya, and V. S. Usovskaya, Zh. Obshch. Khim., 25, 2453 (1955).
230. M. V. Balyakina, N. L. Yakovleva, and V. I. Gunar, Khim.-Farm. Zh., 14, No. 6, 79 (1980).
231. 200. P. Bourbon, J. Poey, and F. Rioufol, Ann. Pharm. Fr., 21, 117 (1963); Chem. Abstr., 59, 5830 (1963).
232. P. Bourbon, J. Poey, and F. Rioufol, Ann. Pharm. Fr., 21, 117 (1963); Chem. Abstr., 59, 5830 (1963).
233. E. K. Orlova, V. M. Bulaev, A. I. El'kin, L. M. Meshcheryakova, and V A. Zagorevskii, Khim.-Farm. Zh., 13, No. 1, 47 (1979).
234. J. Volke, R. Kubicek, and F. Santavy, Coll. Czech. Chem. Commun., 25, 871 (1960).
235. R. Cibulka, F. Liska, and J. Ludvik, Coll. Czech. Chem. Commun., 65, 1630 (2000).
236. E. Testa and F. Fava, Chimia, 11, 310 (1957).
237. S. Negi, M. Matsukura, M. Mizuno, K. Miyake, and N. Minami, Synthesis, 991 (1996).
238. E. Niemers and R. Hiltmann, Synthesis, 593 (1976).
239. M. Akazome, T. Kondo, and Y. Watanabe, J. Mol. Catal., 80, 383 (1993).
240. L. N. Koikov, N. V. Alexeeva, E. A. Lisitza, E. S. Krichevsky, N. B. Grigoryev, A. V. Danilov, I. S. Severina, N. V. Pyatakova, and V. G. Granik, Mendeleev Commun., 165 (1998).
241. R. Oesterlin, Ger. Patent 3038778; Chem. Abstr., 95, 132681 (1981).
242. R. I. Ellin, J. Am. Chem. Soc., 80, 6588 (1958).
243. H. Weber, Arch. Pharm., 309, 769 (1976).
244. J. Schnekenburger, Arch. Pharm., 303, 116 (1970).
245. J. L. La Mattina and R. T. Suleske, Org. Synth., 64, 19 (1986).
246. W. Lowe, Arch. Pharm., 311, 848 (1978).
247. E. Abele and E. Lukevics, Heterocycles, 53, 2285 (2000)
248. B. A. Trofimov, Adv. Heterocycl. Chem., 51, 177 (1990).
249. B. A. Trofimov and A. I. Mikhaleva, Heterocycles, 37, 1193 (1994).
250. B. A. Trofimov and A. I. Mikhaleva, Zh. Org. Khim., 32, 1127 (1996).
251. A. Trofimov, Vinylpyrroles. Chem. Heterocycl. Compd., Wiley, New York, 48, 131 (1992).
252. A. V. Afonin, I. A. Ushakov, O. V. Petrova, L. N. Sobenina, A. I. Mikhaleva, V. K. Voronov, and B. A. Trofimov, Zh. Org. Khim., 36, 1074 (2000).
253. O. V. Petrova, A. I. Mikhaleva, L. N. Sobenina, E. Yu. Schmidt, and E. I. Kositsyna, Mendeleev Comm., 162 (1997).
254. 222. R. Acheson, G. Paglietti, and G. A. Pinna, Studi Sassar., Ser. 2, 60, 333 (1982); Chem. Abstr., 101, 23793 (1984).
255. R. Acheson, G. Paglietti, and G. A. Pinna, Studi Sassar., Ser. 2, 60, 333 (1982); Chem. Abstr., 101, 23793 (1984).
256. T. Kakizawa, K. Sakai, Y. Naoi, and M. Onaya, Jpn. Patent 7629484; Chem. Abstr., 85, 94232 (1976).
257. W.-H. Gundel, Z. Naturforsch., 35B, 896 (1980).
258. R. N. Fitzgerald, D. K. Jung, and J. F. Eaddy, PCT Int. Appl. WO Pat. 0183479; Chem. Abstr., 135, 357918 (2001).
259. Y. Tamura, J.-H. Kirn, Y. Miki, H. Hayashi, and M. Ikeda, J. Heterocycl. Chem., 12, 481 (1975).
260. H. Takasugi, K. Ito, S. Nishino, A. Tanaka, and T. Takaya, Eur. Patent 257897; Chem. Abstr., 110, 8207 (1989).
261. J. E. Thompson, R. M. Cubbon, R. T. Cummings, L. S. Wicker, R. Frankshun, B. R. Cunningham, P. M. Cameron, P. T. Meinke, N. Liverton, Y. Weng, and J. A. DeMartino, Bioorg. Med. Chem. Lett., 12, 1219 (2002).
262. M. A. Voinov and L. V. Voladarsky, Russ. Chem. Bull., 46, 126 (1997).
263. H. Moehrle, D. Ottersbach, and A. Steigel, Pharmazie, 47, 403 (1992).
264. V. A. Artemov, A. M. Shestopalov, and V. P. Litvinov, Zh. Org. Khim., 31, 595 (1995).
265. V. P. Artyomov, A. M. Shestopalov, and V. P. Litvinov, Synthesis, 927 (1996).
266. I. N. Azerbaev, I. A. Poplavskaya, R. G. Kurmangalieva, and S. F. Khalilova, Khim. Geterotsikl. Soedin., 1525 (1978).
267. J. Mayrargue, S. Labidalle, J. Randriatsoa, H. Moskowitz, and M. Miocque, J. Heterocycl. Chem., 21, 1765 (1984).
268. J. D. Davenport, US Patent 4283403; Chem. Abstr., 95, 203926 (1981).
269. Y.-Y. Ku, T. Grieme, P. Sharma, Y.-M. Pu, P. Raje, H. Morton, and S. King, Org. Lett., 3, 4185 (2001).
270. E. Lukevics and P. Arsenyan, Khim. Geterotsikl. Soedin., 1155 (1998).
271. E. Lukevics, P. Arsenyan, and M. Veveris, Metal-Based Drugs, 5, 251 (1998).
272. K. Samula, Rocz. Chem., 45, 2063 (1971).
273. M. Suarez, Y. Verdecia, E. Ochoa, E. Salfran, L. Moran, N. Martin, R. Martinez, M. Quinteiro, C. Seoane, J. L. Soto, H. Novoa, N. Blaton, O. M. Peelers, and C. De Ranter, Eur. J. Org. Chem., 2079 (2000).
274. CIBA Ltd., French Patent 4041; Chem. Abstr., 69, 59223 (1968).
275. P. Schmidt, K. Eichenberger, and M. Wilhelm, US Patent 3277105; Chem. Abstr., 69, 59224 (1968).
276. N. Ito and S. Saijo, Jpn. Patent 7595273; Chem. Abstr., 84, 105568 (1976).
277. F. J. Villani, J. Hannon, E. A. Wefer, T. A. Mann, and J. B. Morton, J. Org. Chem., 40, 1734 (1975).
278. S. Tanaka, K. Wachi, and A. Terada, Chem. Pharm. Bull., 28, 2083 (1980).
279. J. E. Baldwin, S. P. Romeril, V. Lee, and T. D. W. Claridge, Org. Lett., 3, 1145 (2001).
280. R. Grigg, F. Heaney, J. Markandu, S. Surendrakumar, M. Thornton-Pett, and W. J. Warnock, Tetrahedron, 47, 4007 (1991).
281. M. Gotoh, B. Sun, K. Hirayama, and M. Noguchi, Tetrahedron, 52, 887 (1996).
282. H. M. Reyes-Rivera, R. O. Hutchins, and D. R. Dalton, J. Heterocycl. Chem., 32, 665 (1995).
283. Laboratoires Toraude, Neth. Patent 6611571 ; Chem. Abstr., 67, 64402 (1967).
284. M. Nakanishi, K. Arimura, and H. Ao, Jpn. Patent 7361478; Chem. Abstr., 80, 37121 (1973).
285. V. L. Narayanan, H. H. Gadebusch, and R. D. Haugwitz, US Patent 4022901; Chem. Abstr., 87, 39496 (1977).
286. L. F. de Costa Leite, R. M. Srivastava, and A. P. Cavalcanti, Bull. Soc. Chim. Belg., 98, 203 (1989).
287. S. Borg, K. Luthman, F. Nyberg, L. Terenius, and U. Hacksell, Eur. J. Med. Chem., 28, 801 (1993).
288. B. A. Moloney, P. D. Riordan, and R. G. Hunt, PCT Int. Appl. WO Pat. 9730047; Chem. Abstr., 127, 248115 (1997).
289. V. J. Bauer, W. J. Fanshawe, and S. R. Safir, US Patent 3551437; Chem. Abstr., 75, 5911 (1971).
290. S. Yurugi, A. Miyake, T. Fushimi, E. Imamiya, H. Matsumura, and Y. Imai, Chem. Pharm. Bull., 21, 1641 (1973).
291. 258. M. Kocevar, S. Polanc, M. Sollner, and B. Vercek, J. Serb. Chem. Soc., 53, 75 (1988); Chem. Abstr., 111, 232682 (1989).
292. M. Kocevar, S. Polanc, M. Sollner, and B. Vercek, J. Serb. Chem. Soc., 53, 75 (1988); Chem. Abstr., 111, 232682 (1989).
293. V. E. Marquez, M. T. DiParsia, and J. A. Kelley, J. Heterocycl. Chem., 14, 1427 (1977).
294. J. Lessel, Arch. Pharm., 326, 383 (1993).
295. E. J. Poziomek and A. R. Melvin, J. Org. Chem., 26, 3769 (1961).
296. Y. Tagawa, N. Honjo, Y. Goto, and T. Kato, Chem. Pharm. Bull., 34, 4984 (1986).
297. J. Plenkiewicz and E. Osuchowska, Pol. J. Chem., 52, 1597 (1978).
298. C. K. Bradsher, T. W. G. Solomons, and F. R. Vaughan, J. Org. Chem., 25, 757 (1960).
299. J. Wagner, J. Bendig, and D. Kreysig, Z. Chem., 23, 407 (1983).
300. R. W. L. Kimber and J. C. Parham, J. Org. Chem., 28, 3205 (1963).
301. T. M. Bargar, J. K. Dulworth, and M. C. Graham, J. Heterocycl. Chem., 21, 261 (1984).
302. K. Goerlitzer, P. M. Dobberkau, and P. G. Jones, Pharmazie, 51, 392 (1996).
303. C. K. Bradsher and S. A. Telang, J. Org. Chem., 31, 941 (1966).
304. B. Vercek, I. Leban, B. Stanovnik, and M. Tisler, Heterocycles, 9, 1327 (1978).
305. M. Kocevar, B. Mlakar, M. Perdih, A. Petric, S. Polanc, and B. Vercek, Tetrahedron Lett., 33, 2195 (1992).
306. B. Mlakar, B. Stefane, M. Kocevar, and S. Polanc, Heterocycles, 48, 961 (1998).
307. B. Mlakar, B. Stefane, M. Kocevar, and S. Polanc, Tetrahedron, 54, 4387 (1998).
308. T. Yamauchi, F. Nishimura, K. Nakao, K. Tamaki, and Y. Enomoto, Chem. Express, 5, 737 (1990).
309. L. Bauer and R. E. Hewitson, J. Org. Chem., 27, 3982 (1962).
310. E. H. Huntress and H. C. Walter, J. Am. Chem. Soc., 70, 3702 (1948).
311. Y. Yamamoto and Y. Ogawa, Heterocycles, 42, 35 (1996).
312. 278. T. Kato, Y. Goto, and T. Chiba, Yakugaku Zasshi, 86, 1022 (1966); Chem. Abstr., 66, 85680 (1967).
313. T. Kato, Y. Goto, and T. Chiba, Yakugaku Zasshi, 86, 1022 (1966); Chem. Abstr., 66, 85680 (1967).
314. A. Jossang-Yanagida and C. Gansser, J. Heterocycl. Chem., 15, 249 (1978).
315. G. Hangay, M. Barabas, I. Udvardy Nagy, E. Marvanyos, L. Uerogdi, L. Vereczkey, L. Jaszlits, K. Biro, A. Jednakovits, and E. Radvanyi Hegedues, Hung. Patent 71410; Chem. Abstr., 124, 307601 (1996).
316. M. Barabas, I. Udvardy Nagy, E. Marvanyos, L. Uerogdi, L. Vereczkey, L. Jaszlits, K. Biro, A. Jednakovits, and E. Radvanyi, Hung. Patent 71409; Chem. Abstr., 127, 34128 (1997).
317. I. L. Megson, Drugs Fut., 25, 701 (2000).
318. G. Heinisch, T. Langer, P. Lukavsky, D. Marschhofer, and D. Purin, Sci. Pharm., 66, 9 (1998).
319. U. Niewoehner, U. E. Mueller, E. Perzborn, E. Bischoff, and H. G. Dellweg, Eur. Patent 471259; Chem. Abstr., 116, 214360 (1992).
320. E. J. Freyne, A. H. M. Raeymaekers, M. G. Venet, V. K. Sipido, and F. De Clerck, Drugs Fut., 15, 463 (1990).
321. M. Sato, N. Miyata, T. Ishii, Y. Kobayashi, and H. Amada, PCT Int. Appl. WO Pat. 0196309; Chem. Abstr., 136, 37524 (2002).
322. T. W. Hart and B. W. Sharp, Eur. Patent 404671; Chem. Abstr., 115, 92075 (1991).
323. 288. Gy. Rutkai, E. Koltai, and L. Urogdy, Izotoptech. Diagn., 37, 211 (1994); Chem. Abstr., 123, 339638 (1995)
324. Gy. Rutkai, E. Koltai, and L. Urogdy, Izotoptech. Diagn., 37, 211 (1994) ; Chem. Abstr., 123, 339638 (1995)
325. . 289. M. D. Gruett and G. Y. Lesher, US Patent 4305948; Chem. Abstr., 96, 122642 (1982).
326. W. D. Jones, Jr., R. A. Schnettler, and R. C. Dage, Eur. Patent 140375; Chem. Abstr., 103, 196004 (1985).
327. P. Literati Nagy, B. Balazs, M. Boross, J. Szilbereky, G. Zsila, L. Abraham, G. Blasko, B. Gachalyi, A. Almasi, and G. Nemeth, PCT Int. Appl. WO Pat. 9004584; Chem. Abstr., 113, 211848 (1990).
328. L. Urogdi, M. Barabas, E. Marvanyos, M. Torok, and Z. Csakai, PCT Int. Appl. WO Pat. 9843948; Chem. Abstr., 129, 316145 (1998).
329. M. Nakanishi and Y. Tsuda, Jpn. Patent 7310075; Chem. Abstr., 78, 111133 (1973).
330. K. Takacs, P. L. Nagy, I. Kiss, A. Simay, M. Szentivanyi, S. Virag, and K. Farago, Ger. Patent 2738589; Chem. Abstr., 89, 6123 (1978).
331. H. Yanagisawa, M. Takamura, T. Fujita, and T. Fujiwara, Jpn. Patent 11193272; Chem. Abstr., 131, 87823 (1999).
332. H. Yanagisawa, T. Fujita, K. Fujimoto, T. Yoshioka, K. Wada, M. Oguchi, T. Fujiwara, and H. Horikoshi, Eur. Patent 708098; Chem. Abstr., 125, 58495 (1996).
333. M. Fujita, T. Seki, H. Inada, and T. Sano, PCT Int. Appl. WO Pat. 9858930; Chem. Abstr., 130, 66518 (1999).
334. M. Fujita, T. Seki, H. Inada, K. Shimizu, A. Takahama, and T. Sano, Bioorg. Med. Chem. Lett., 12, 341 and 771 (2002).
335. M. Fujita and T. Seki, Bioorg. Med. Chem. Lett., 12, 1383 (2002).
336. C. Malen, B. Danree, and X. Pascaud, Ger. Patent 2217180; Chem. Abstr., 78, 16052 (1973).
337. D. C. Cook, T. W. Hart, I. M. McLay, M. N. Palfreyman, and R. J. A. Walsh, Eur. Patent 321274; Chem. Abstr., 112, 7390 (1990).
338. P. Bellevergue, G. Lassalle, P. H. Williams, and J. C. Muller, French Patent 2735470; Chem. Abstr., 126, 212044 (1997).
339. C. Almansa, J. Bartroli, C. Gonzalez, C. Torres, and E. Carceller, Spanish Patent 2041211; Chem. Abstr., 120, 323271 (1994).
340. M. Shiraishi and T. Watanabe, Eur. Patent Appl. 623597; Chem. Abstr., 123, 143639 (1995).
341. H. Yanagisawa, M. Takamura, T. Fujita, and T. Fujiwara, PCT Int. Appl. WO Pat. 9737970; Chem. Abstr., 127, 307307 (1997).
342. E. L. Schumann, US Patent 3329677; Chem. Abstr., 68, 87193 (1968).
343. C. Van der Stelt, P. S. Hofman, and A. B. H. Funcke, Arzneim.-Forsch., 21, 1415 (1971).
344. W. Mathes and J. P. Da Vanzo, French Patent M2092; Chem. Abstr., 60, 9252 (1964).
345. E. L. Schumann, US Patent 3205234; Chem. Abstr., 63, 14826 (1965).
346. Y. Pei and H. Teckle, US Patent 5208343; Chem. Abstr., 119, 160124 (1993).
347. P. D. Suzdak, K. Frederiksen, K. E. Andersen, P. O. Soerensen, L. J. S. Knutsen, and E. B. Nielsen, Eur. J. Pharmacol., 224, 189 (1992).
348. E. Toja, C. Bonetti, A. Butti, P. Hunt, M. Fortin, F. Barzaghi, M. L. Formento, A. Maggioni, A. Nencioni, and G. Galliani, Eur. J. Med. Chem., 26, 853 (1991).
349. E. Toja, C. Bonetti, A. Butti, P. Hunt, M. Fortin, F. Barzaghi, M. L. Formento, A. Maggioni, A. Nencioni, and G. Galliani, Eur. J. Med. Chem., 27, 519 (1992).
350. S. M. Bromidge, B. S. Orlek, and S. Dabbs, PCT Int. Appl. WO Pat. 9204323; Chem. Abstr., 117, 69735 (1992).
351. 315. M. H. Jung, J.-G. Park, J.-S. Oh, and H.-G. Cheon, Korean J. Med. Chem., 8, 38 (1998); Chem. Abstr., 129, 216488 (1998).
352. M. H. Jung, J.-G. Park, J.-S. Oh, and H.-G. Cheon, Korean J. Med. Chem., 8, 38 (1998); Chem. Abstr., 129, 216488 (1998).
353. S. M. Bromidge, B. S. Orlek, and S. Dabbs, PCT Int. Appl. WO Pat. 9206959; Chem. Abstr., 117, 90154 (1992).
354. M. H. Botero Cid, U. Holzgrabe, E. Kostenis, K. Mohr, and C. Trankle, J. Med. Chem., 37, 1439 (1994).
355. R. Rips and H. Gozlan, Ger. Patent 2411194; Chem. Abstr., 82, 57573 (1975).
356. S. Bergmeier, D. A. Downs, W. H. Moos, D. W. Moreland, and H. Tecle, Eur. Patent 271798; Chem. Abstr., 110, 57518 (1989).
357. I. Matsumoto and F. Sasaki, Jpn. Patent 7237950; Chem. Abstr., 77, 164501 (1972).
358. F. M. Pallos and J. R. DeBaun, US Patent 3978219; Chem. Abstr., 85, 137586 (1976).
359. J. C. Head, G. J. Warrelow, and R. P. Alexander, PCT Int. Appl. WO Pat. 9600215; Chem. Abstr., 124, 260856 (1996), Chem. Abstr., 132, 194296 (2000).
360. J. C. Head, G. J. Warrelow, and R. P. Alexander, PCT Int. Appl. WO Pat. 9600215; Chem. Abstr., 124, 260856 (1996), Chem. Abstr., 132, 194296 (2000).
361. J. N. Astoin, F. Lepage, and J. P. M. J. Fromantin, Eur. Patent 82058; Chem. Abstr., 99, 139782 (1983).
362. S. L. Lee, B. B. Williams, and M. M. Kochhar, J. Pharm. Sci., 56, 1354 (1967).
363. G. Galliani, F. Barzaghi, A. Butti, C. Bonetti, and E. Toja, Eur. Patent 239445; Chem. Abstr., 108, 204502 (1988).
364. E. Toja, C. Bonetti, F. Barzaghi, and G. Galliani, Eur. Patent 308284; Chem. Abstr., 111, 57549 (1989).
365. Warner-Lambert Co., Jpn. Patent 63258457; Chem. Abstr., 112, 98387 (1990).
366. E. Toja, C. Bonetti, F. Barzaghi, and G. Galliani, Eur. Patent 452170; Chem. Abstr., 116, 41311 (1992).
367. 329. G. Bejeuhr, U. Holzgrabe, K. Mohr, U. Suerig, and A. Von Petersenn, Pharm. PharmacoL Lett., 2, 100 (1992); Chem. Abstr., 118, 32529 (1993).
368. G. Bejeuhr, U. Holzgrabe, K. Mohr, U. Suerig, and A. Von Petersenn, Pharm. PharmacoL Lett., 2, 100 (1992); Chem. Abstr., 118, 32529 (1993).
369. T. Nassif-Makki, C. Trankle, D. Zlotos, G. Bejeuhr, A. Cambareri, C. Pfletschinger, E. Kostenis, K. Mohr, and U. Holzgrabe, J. Med. Chem., 42, 849 (1999).
370. P. H. L. Wei and S. C. Bell, US Patent 4443606; Chem. Abstr., 101, 23468 (1984).
371. A. Palani, S. Shapiro, J. W. Clader, W. J. Greenlee, K. Cox, J. Strizki, M. Endres, and B. M. Baroudy, J. Med. Chem., 44, 3339 (2001).
372. R. Kirsch, M. Roesner, R. Bender, and C. Meichsner, Ger. Patent 4344452; Chem. Abstr., 123, 313931 (1995).
373. 334. G. Steensholt and O. G. Clausen, Acta Pathol. Microbiol. Scand., 56, 327 (1962); Chem. Abstr., 63, 15387 (1965).
374. G. Steensholt and O. G. Clausen, Acta Pathol. Microbiol. Scand., 56, 327 (1962); Chem. Abstr., 63, 15387 (1965).
375. S. Ueno, E. Shimogo, T. Kawasaki, D. Immaru, and Y. Osaka, Jpn. Patent 7135065; Chem. Abstr., 76, 3698 (1972).
376. A. Murabayashi, A. Takase, H. Takenaka, and M. Masuko, PCT Int. Appl. WO Pat. 9532182; Chem. Abstr., 124, 202032 (1996).
377. 337. G. Leandri, L. Maioli, and L. Ruzzier, Boll. Sci. Fac. Chim. Ind. Bologna, 15, No. 3, 57 (1957); Chem. Abstr., 52, 7291 (1958).
378. G. Leandri, L. Maioli, and L. Ruzzier, Boll. Sci. Fac. Chim. Ind. Bologna, 15, No. 3, 57 (1957); Chem. Abstr., 52, 7291 (1958).
379. E. Golowinsky and K. I. Markov, Z. Naturforsch., 13B, 725 (1958).
380. J. H. Kwak, Y. N. Jeong, and J. I. Oh, Eur. Patent 688772; Chem. Abstr., 124, 289515 (1996).
381. C. Y. Hong, Y. K. Kirn, J. H. Chang, S. H. Kirn, H. Choi, D. H. Nam, Y. Z. Kim, and J. H. Kwak, J. Med. Chem., 40, 3584 (1997).
382. C. Y. Hong, Y. K. Kim, S. H. Kirn, J. H. Chang, H. Choi, D. H. Nam, A. R. Kim, J. H. Lee, and K. S. Park, US Patent 5776944; Chem. Abstr., 129, 122580 (1998).
383. S. J. Yoon, Y. H. Chung, C. W. Lee, J. S. Lee, N. D. Kim, Y. H. Jin, W. J. Song, I. H. Kim, W. Y. Yang, D. R. Choi, and J. H. Shin, PCT Int. Appl. WO Pat. 0071541; Chem. Abstr., 134, 17486 (2001).
384. L. M. Ednie, M. R. Jacobs, and P. C. Appelbaum, J. Antimicrob. Chemother., 45, 525 (2000).
385. F. Trecourt, B. Gervais, O. Mongin, C. Le Gal, F. Mongin, and G. Queguiner, J. Org. Chem., 63, 2892 (1998).
386. J. Mlochowski and W. Sliwa, Rocz. Chem., 45, 803 (1971).
387. M. G. Kim, J. C. Jung, M. J. Sung, Y. K. Choi, S. G. An, S.-J. Lee, G.-J. Yoon, and M. H. Park, Bioorg. Med. Chem. Lett., 6, 2077 (1996).
388. H. Yamamoto, T. Terasawa, A. Nakamura, K. Kawabata, K. Sakane, S. Matsumoto, Y. Matsumoto, and S. Tawara, Bioorg. Med. Chem., 8, 1159 (2000).
389. K. Y. Chang, S. H. Kim, G. Nam, J. H. Seo, J. H. Kim, and D.-C. Ha,
390. Y. Nishitani, H. Itani, and T. Irie, PCT Int. Appl. WO Pat. 0032606; Chem. Abstr., 133, 30627 (2000).
391. H. Yamamoto, T. Terasawa, A. Okhi, F. Shirai, K. Kawabata, K. Sakane, S. Matsumoto, Y. Matsumoto, and S. Tawara, Bioorg. Med. Chem., 8, 43 (2000).
392. 351. K. Bethe, W. D. Erdmann, L. Lendle, and G. Schmidt, Arch. Exptl. Pathol. Pharmakol., 231, 3 (1957); Chem. Abstr., 51, 16929 (1957).
393. K. Bethe, W. D. Erdmann, L. Lendle, and G. Schmidt, Arch. Exptl. Pathol. Pharmakol., 231, 3 (1957); Chem. Abstr., 51, 16929 (1957).
394. R. I. Volkova, Dokl. Akad. Nauk, 188, 354 (1969).
395. F. R. Sidell and W. A. Groff, J. Pharm. Sci., 60, 860 (1971).
396. 354. H. Oldiges and K. Schoene, Arch. Toxikol., 26, 293 (1970); Chem. Abstr., 74, 40705 (1971).
397. H. Oldiges and K. Schoene, Arch. Toxikol., 26, 293 (1970); Chem. Abstr., 74, 40705 (1971).
398. F. R. Sidell, W. A. Groff, and A. Kaminskis, J. Pharm. Sci., 61, 1136 (1972).
399. 356. I. K. Nazer and T. E. Archer, Toxicol. Appl. Pharmacol., 31, 459 (1975); Chem. Abstr., 83, 73027 (1975).
400. I. K. Nazer and T. E. Archer, Toxicol. Appl. Pharmacol., 31, 459 (1975); Chem. Abstr., 83, 73027 (1975).
401. I. Carvalho and J. Miller, Heterocycl. Commun., 1, 403 (1995).
402. J. Kassa and J. Bielavsky, Pharmacol. Toxicol., 81, 144 (1997).
403. 359. D. M. Monaco, G. Med. Mil., 118, 1 (1968); Chem. Abstr., 69, 26222 (1968).
404. D. M. Monaco, G. Med. Mil., 118, 1 (1968); Chem. Abstr., 69, 26222 (1968).
405. 360. I. B. Wilson and S. Ginsburg, Biochim. Biophys. Acta, 18, 168 (1955); Chem. Abstr., 50, 1105 (1956).
406. I. B. Wilson and S. Ginsburg, Biochim. Biophys. Acta, 18, 168 (1955); Chem. Abstr., 50, 1105 (1956).
407. I. B. Wilson, S. Ginsburg, and D. Nachmansohn, US Patent 2816113; Chem. Abstr., 52, 10212 (1958).
408. B. E. Hackley, Jr., and O. O. Owens, J. Org. Chem., 24, 1120 (1959).
409. 363. M. Nenner, Biochem. Pharmacol., 23, 1255 (1974); Chem. Abstr., 83, 54193 (1975).
410. M. Nenner, Biochem. Pharmacol., 23, 1255 (1974); Chem. Abstr., 83, 54193 (1975).
411. A. L. Green, US Patent 2996510; Chem. Abstr., 56, 4736 (1962).
412. K.-B. Augustinsson, H. Hasselquist, and L. Larsson, Acta. Chem. Scand., 14, 1253 (1960).
413. B. E. Hackley, Jr., E. J. Poziomek, and G. M. Steinberg, US Patent 3093539; Chem. Abstr., 59, 12767 (1963).
414. R. I. Ellin, D. E. Easterday, and A. A. Kondritzer, US Patent 3140289; Chem. Abstr., 61, 13289 (1964).
415. 368. C. Runti, A. Stener, G. Sottocasa, and M. C. Pugliarello, Boll. Chim. Farm., 103, 103 (1964); Chem. Abstr., 61, 3065 (1964).
416. C. Runti, A. Stener, G. Sottocasa, and M. C. Pugliarello, Boll. Chim. Farm., 103, 103 (1964); Chem. Abstr., 61, 3065 (1964).
417. H. Engelhard, Belg. Patent 638533; Chem. Abstr., 62, 9114 (1965).
418. T. Nishimura and T. Yamazaki, Jpn. Patent 10218('65); Chem. Abstr., 63, 13277 (1965).
419. R. I. Ellin, US Patent 3285927; Chem. Abstr., 66, 28660 (1967).
420. G. Kuehn, G. W. Fischer, and Kh. Lohs, Arch. Pharm., 300, 363 (1967).
421. J. N. Wells, J. N. Davisson, I. Boime, D. R. Haubrich, and G. K. W. Yim, J. Pharm. Sci., 56, 1190(1967).
422. R. B. Margerison, French Patent 1448775; Chem. Abstr., 67, 43683 (1967).
423. 375. Y. Ashani and S. Cohen, Israel J. Chem., 5, 59 (1967); Chem. Abstr., 67, 73495 (1967).
424. Y. Ashani and S. Cohen, Israel J. Chem., 5, 59 (1967); Chem. Abstr., 67, 73495 (1967).
425. T. Nishimura, C. Yamazaki, and T. Ishiura, Bull Chem. Soc. Japan, 40, 2434 (1967).
426. C. S. Cross, Brit. Patent 1144433; Chem. Abstr., 70, 96638 (1969).
427. 378. R. Zech, Hoppe-Seyler's Z. Physiol. Chem., 350, 1415 (1969); Chem. Abstr., 72, 9459 (1970).
428. R. Zech, Hoppe-Seyler's Z. Physiol. Chem., 350, 1415 (1969); Chem. Abstr., 72, 9459 (1970).
429. 379. J. Schnekenburger, Fresenius' Z. Anal. Chem., 245, 388 (1969); Chem. Abstr., 71, 101082 (1969).
430. J. Schnekenburger, Fresenius' Z. Anal. Chem., 245, 388 (1969); Chem. Abstr., 71, 101082 (1969).
431. A. A. Hussain, Ger. Patent 1957447; Chem. Abstr., 73, 35228 (1970).
432. I. Bulete, Rom. Pat. 51935; Chem. Abstr., 73, 120678 (1970).
433. H. Kuhnen, Arzneim.-Forsch., 20, 774 (1970).
434. E. Dirks, A. Scherer, M. Schmidt, and G. Zimmer, Arzneim.-Forsch., 20, 197 (1970).
435. C. F. Barfknecht, J. P. Long, and F. W. Benz, J. Pharm. Sci., 60, 138 (1971).
436. 385. M. A. Macatin and P. P. Kar, Japan. J. Pharmacol., 21, 563 (1971); Chem. Abstr., 76, 107914 (1972).
437. M. A. Macatin and P. P. Kar, Japan. J. Pharmacol., 21, 563 (1971); Chem. Abstr., 76, 107914 (1972).
438. R. L. Salvador, M. Saucier, D. Simon, and R. Goyer, J. Med. Chem., 15, 646 (1972).
439. I. Hagedorn, US Patent 3773775; Chem. Abstr., 80, 47859 (1974).
440. T. Higuchi, N. S. Bodor, and E. Shek, US Patent 3929813; Chem. Abstr., 84, 135480 (1976).
441. I. Hagedorn, Ger. Patent 2616481; Chem. Abstr., 88, 50664 (1978).
442. D. Kiffer, M. Coq, and H. Coq, French Patent 2372826; Chem. Abstr., 90, 121598 (1979).
443. L. P. A. De Jong, H. P. Benschop, G. R. Van den Berg, G. Z. Wolring, and D. C. De Korte, Eur. J. Med. Chem., Chim. Ther., 16, 257 (1981).
444. H. P. Benschop, L. P. A. De Jong, and L. A. Kepner, Eur. Patent 23378; Chem. Abstr., 95, 61998 (1981).
445. G. Amitai, D. Balderman, R. Bruckstein-Davidovitch, and M. Spiegelstein, French Patent 2571053; Chem. Abstr., 105, 190965 (1986).
446. A. G. Panteleimonov, Yu. I. Loboda, V. B. Litvinov, L. V. Mukhina, F. P. Trinus, V. A. Portnyagina, A. G. Fadeicheva, N. I. Miryan, and L. S. Kulik, PCT Int. Appl. WO Pat. 8911474; Chem. Abstr., 112, 178688 (1990).
447. 395. D. Milatovic, J. Vorkapic-Furac, M. Skrinjaric-Spoljar, and E. Reiner, Acta Pharm. Jugosl., 39, 281 (1989); Chem. Abstr., 113, 6122 (1990).
448. D. Milatovic, J. Vorkapic-Furac, M. Skrinjaric-Spoljar, and E. Reiner, Acta Pharm. Jugosl., 39, 281 (1989); Chem. Abstr., 113, 6122 (1990).
449. 396. A. K. Sikder, K. S. Pandey, D. K. Jaiswal, S. N. Dube, D. Kumar, K. Husain, R. Bhattacharya, and S. Das Gupta, J. Pharm. Pharmacol., 44, 1038 (1992); Chem. Abstr., 118, 74927 (1993).
450. A. K. Sikder, K. S. Pandey, D. K. Jaiswal, S. N. Dube, D. Kumar, K. Husain, R. Bhattacharya, and S. Das Gupta, J. Pharm. Pharmacol., 44, 1038 (1992); Chem. Abstr., 118, 74927 (1993).
451. L. Y. Y. Hsiao and H. A. Musallam, US Patent 5130438; Chem. Abstr., 117, 212332 (1992).
452. J. Bielavsky, J. Kassa, I. Elsnerova, and L. Dejmek, Coll. Czech. Chem. Commun., 63, 199 (1998).
453. 399. V. Vittucci, G. Med. Mil., 128, 72 (1978); Chem. Abstr., 90, 6208 (1979).
454. V. Vittucci, G. Med. Mil., 128, 72 (1978); Chem. Abstr., 90, 6208 (1979).
455. 400. I. Bregovec, A. Deljac, M. Maksimovic, and Z. Binenfeld, Glas. Hem. Drus. Beograd, 49, 533 (1984); Chem. Abstr., 103, 87747 (1985).
456. I. Bregovec, A. Deljac, M. Maksimovic, and Z. Binenfeld, Glas. Hem. Drus. Beograd, 49, 533 (1984); Chem. Abstr., 103, 87747 (1985).
457. 401. B. Chen, K. Jiao, and H. Song, Huaxue Xuebao, 44, 417 (1986); Chem. Abstr., 106, 67059 (1987).
458. B. Chen, K. Jiao, and H. Song, Huaxue Xuebao, 44, 417 (1986); Chem. Abstr., 106, 67059 (1987).
459. S. K. Gomer, E. I. Isaacson, R. G. Brown, and J. N. Delgado, J. Pharm. Sci., 57, 1586 (1968).
460. 403. S. K. Raza, A. Khullar, and D. K. Jaiswal, Orient. J. Chem., 10, 253 (1994); Chem. Abstr., 123, 83166 (1995).
461. S. K. Raza, A. Khullar, and D. K. Jaiswal, Orient. J. Chem., 10, 253 (1994); Chem. Abstr., 123, 83166 (1995).
462. B. E. Hackley, Jr., E. J. Poziomek, and G. M. Steinberg, US Patent 3045025; Chem. Abstr., 58, 4525 (1963).
463. E. Merck A.-G., Belg. Pat. 631452; Chem. Abstr., 61, 5616 (1964).
464. B. E. Hackley, Jr., E. J. Poziomek, and G. M. Steinberg, US Patent 3135761; Chem. Abstr., 61, 9470 (1964).
465. F. Hauschild, R. Schmiedel, and W. D. Wiezorek, East Ger. Patent 38036; Chem. Abstr., 63, 13225 (1965).
466. I. Hagedorn and A. Luettringhaus, Ger. Patent 1200302; Chem. Abstr., 64, 5052 (1966).
467. C. N. Corder and J. L. Way, J. Med. Chem., 9, 638 (1966).
468. L. Ya. Leitis, M. V. Shimanskaya, and A. Ya. Varslavan, Izv. Akad. Nauk. LatvSSR. Ser. Khim., 249 (1969).
469. 411. I. Christenson, Acta Pharm. Suetica, 5, 249 (1968); Chem. Abstr., 69, 105495 (1968).
470. I. Christenson, Acta Pharm. Suetica, 5, 249 (1968); Chem. Abstr., 69, 105495 (1968).
471. J. Schnekenburger, Arch. Pharm., 302, 822 (1969).
472. J. Patocka and J. Bielavsky, Coll. Czech. Chem. Commun., 37, 2110 (1972).
473. 414. O. Mayer and H. Michalek, Biochem. Pharmacol., 20, 3029 (1971); Chem. Abstr., 16, 54965 (1972).
474. O. Mayer and H. Michalek, Biochem. Pharmacol., 20, 3029 (1971); Chem. Abstr., 16, 54965 (1972).
475. M. G. Filbert, J. H. Fleisher, and M. A. Lochner, Biochim. Biophys. Acta, 284, 164 (1972); Chem. Abstr., 78, 53553 (1973).
476. M. G. Filbert, J. H. Fleisher, and M. A. Lochner, Biochim. Biophys. Acta, 284, 164 (1972); Chem. Abstr., 78, 53553 (1973).
477. J. Bajgar, A. Jakl, and V. Hrdina, Biochem. Pharmacol., 20, 3230 (1971); Chem. Abstr., 76, 54988 (1972).
478. J. Bajgar, A. Jakl, and V. Hrdina, Biochem. Pharmacol., 20, 3230 (1971); Chem. Abstr., 76, 54988 (1972).
479. A. Babska, L. Bielski, L. Kuczynski, S. Respond, and H. Witek, Pol. J. Pharmacol. Pharm., 25, 175 (1973); Chem. Abstr., 79, 78556 (1973).
480. A. Babska, L. Bielski, L. Kuczynski, S. Respond, and H. Witek, Pol. J. Pharmacol. Pharm., 25, 175 (1973); Chem. Abstr., 79, 78556 (1973).
481. J. Bielavsky and F. Omst, Coll. Czech. Chem. Commun., 38, 2788 (1973).
482. I. Hagedorn, W. H. Guendel, J. Hoose, and C. Jenter, Arzneim.-Forsch., 26, 1273 (1976).
483. I. Hagedorn and W. Hohler, Arzneim.-Forsch., 26, 1515 (1976).
484. I. Hagedorn, I. Stark, K. Schoene, and H. Schenkel, Arzneim.-Forsch., 28, 2055 (1978).
485. H. C. Joshi, P. K. Ramachandran, and C. N. Haksar, Indian J. Chem., 17B, 162 (1979).
486. H. C. Joshi and P. K. Ramachandran, Indian J. Chem., 19B, 227 (1980).
487. 424. R. Wen, C. Zhu, and W. Song, Shanghai Diyi Yixueyuan Xuebao, 8, 273 (1981); Chem. Abstr., 96, 68766 (1982).
488. R. Wen, C. Zhu, and W. Song, Shanghai Diyi Yixueyuan Xuebao, 8, 273 (1981); Chem. Abstr., 96, 68766 (1982).
489. P. Demerseman, D. Kiffer, L. Debussche, C. Lion, R. Royer, and H. Sentenac-Roumanou, Eur. J. Med. Chem., 23, 63 (1988).
490. D. Kiffer, C. Lion, H. Sentenac-Roumanou, P. Demerseman, R. Royer, and D. Leroux, French Patent 2605631; Chem. Abstr., 110, 135092 (1989).
491. F. J. Freenor, III, US Patent 4244959; Chem. Abstr., 94, 156770 (1981).
492. C. Lambert, R. Repin, and M. P. Latorse, Eur. Patent 316246; Chem. Abstr., 111, 194601 (1989).
493. B. Wenderoth, S. Brand, F. Schuetz, T. Kuekenhoehner, F. Roehl, E. Ammermann, and G. Lorenz, Ger. Patent 3835028; Chem. Abstr., 113, 211846 (1990).
494. Y. Hayase, H. Takenaka, and M. Masuko, Jpn. Patent 04182461; Chem. Abstr., 118, 59429 (1993).
495. M. Oda, C. Oota, and T. Tomita, Jpn. Patent 05201980; Chem. Abstr., 120, 134461 (1994).
496. S. Akiyama, T. Takeyama, H. Suzuki, Y. Yasumi, J. Watanabe, Y. Nakajima, H. Ohya, S. Sasabe, M. Nishioka, and T. Furusato, PCT Int. Appl. WO Pat. 9501340; Chem. Abstr., 122, 265368 (1995).
497. H. Gayer, B.-W. Krueger, D. Kuhnt, U. Heinemann, P. Gerdes, R. Tiemann, G. Haenssler, K. Stenzel, and S. Dutzmann, Ger. Patent 19532345; Chem. Abstr., 125, 247816 (1996).
498. P. J. De Fraine, PCT Int. Appl. WO Pat. 9729088; Chem. Abstr., 127, 220577 (1997).
499. K. Oberdorf, W. Grammenos, H. Sauter, T. Grote, B. Muller, R. Kirstgen, R. Muller, H. Bayer, A. Ptock, M. Rack, A. Harreus, F. Rohl, G. Lorenz, E. Ammermann, S. Strathmann, and V. Harries, PCT Int. Appl. WO Pat. 9730032; Chem. Abstr., 127, 234254 (1997).
500. C. Rentzea, A. Harreus, R. Kirstgen, E. Ammermann, and G. Lorenz, Ger. Patent 4334706; Chem. Abstr., 122, 314577 (1995).
501. B. Mueller, H. Sauter, H. Bayer, W. Grammenos, T. Grote, R. Kirstgen, K. Oberdorf, F. Roehl, N. Goetz, M. Rack, R. Mueller, G. Lorenz, E. Ammermann, S. Strathmann, and V. Harries, PCT Int. Appl. WO Pat. 9716427; Chem. Abstr., 127, 5016 (1997).
502. F. Rohl, V. Harries, E. Ammermann, G. Lorenz, S. Strathmann, A. Ptock, H. Sauter, W. Grammenos, T. Grote, H. Bayer, R. Kirstgen, K. Oberdorf, B. Muller, and R. Muller, PCT Int. Appl. WO Pat. 9812179; Chem. Abstr., 128, 257334 (1998).
503. T. Nishimura and T. Murakami, Jpn. Patent 11180954; Chem. Abstr., 131, 73561 (1999).
504. E. J. Canada, C. S. Galka, D. D. Johnson, N. Kirby, I. M. Morrison, B. S. Nader, and J. M. Renga, PCT Int. Appl. WO Pat. 9925713; Chem. Abstr., 130, 338098 (1999).
505. B.-W. Krueger, K. Stenzel, S. Dutzmann, A. Mauler-Machnik, and G. Haenssler, Ger. Patent 19745376; Chem. Abstr., 130, 267457 (1999).
506. W. Grammenos, K. Oberdorf, H. Sauter, A. Gypser, H. Bayer, M. Gewehr, T. Grote, B. Muller, A. Ptock, F. Rohl, G. Hamprecht, N. Gotz, E. Ammermann, G. Lorenz, and S. Strathmann, PCT Int. Appl. WO Pat. 9921833; Chem. Abstr., 130, 311704 (1999).
507. E. J. Canada, R. P. Gajewski, C. S. Galka, N. V. Kirby, I. M. Morrison, J. R. Phillips, M. E. Pieczko, B. J. Rieder, C. M. Carson, and Z. Huang, PCT Int. Appl. WO Pat. 0015646; Chem. Abstr., 132, 236989 (2000).
508. N. V. Kirby, E. J. Canada, I. M. Morrison, M. E. Pieczko, G. D. Gustafson, J. T. Mathieson, D. H. Cooper, C. S. Galka, and J. L. Adamski, PCT Int. Appl. WO Pat. 0015637; Chem. Abstr., 132, 222538 (2000).
509. J. Rheinheimer, K. Eicken, I. Rose, E. Ammermann, T. Grote, G. Lorenz, and S. Strathmann, Ger. Patent 19837794; Chem. Abstr., 132, 151689 (2000).
510. G. M. Nicholas and T. F. Molinski, Tetrahedron, 56, 2921 (2000).
511. H. Sano, T. Sugiura, Y. Nakagawa, H. Hamamura, A. Mitani, and T. Ando, PCT Int. Appl. WO Pat. 0134568; Chem. Abstr., 134, 366804 (2001).
512. R. P. Gajewski, N. V. Kirby, B. J. Rieder, C. M. Carson, Z. Huang, and S. L. Wilson, PCT Int. Appl. WO Pat. 0144196; Chem. Abstr., 135, 46109 (2001).
513. J. R. P. Cetusick and B. J. Rieder, PCT Int. Appl. WO Pat. 0224691; Chem. Abstr., 136, 279447 (2002).
514. N. V. Kirby, J. L. A. Butz, B. J. Rieder, J. M. Renga, J. R. P. Cetusic, I. M. Morrison, J. T. Mathieson, and G. D. Gustafson, PCT Int. Appl. WO Pat. 0224688; Chem. Abstr., 136, 279459 (2002).
515. A. Steinhards and W. Mathes, US Patent 2924604; Chem. Abstr., 56, 736 (1962).
516. G. Pissiotas and H. Rempfler, Eur. Patent 23891; Chem. Abstr., 95, 80739 (1981).
517. W. Fuehrer, J. Stetter, H. Foerster, L. Eue, and R. R. Schmidt, Ger. Patent 3221215; Chem. Abstr., 100, 138961 (1984).
518. J. Rheinheimer, K. Eicken, P. Plath, K. O. Westphalen, and B. Wuerzer, Eur. Patent 372329; Chem. Abstr., 113, 212007 (1990).
519. B. Hostettler and L. R. Waelder, Eur. Patent 445069; Chem. Abstr., 115, 256003 (1991).
520. E. Tanyama, S. Imada, T. Yamamoto, M. Nabeshima, A. Okui, and K. Okano, Jpn. Patent 02255656; Chem. Abstr., 114, 122072 (1991).
521. E. Taniyama, S. Imada, T. Yamamoto, M. Nabeshima, A. Okui, and K. Okano, Jpn. Patent 02273658; Chem. Abstr., 114, 185284 (1991).
522. J. Rheinheimer, K. Eicken, P. Plath, K. O. Westphalen, and B. Wuerzer, Ger. Patent 3910635; Chem. Abstr., 114, 102036 (1991).
523. T. Goshima, Y. Kitagawa, S. Kaji, H. Hayakawa, and A. Watanabe, Jpn. Patent 0499767; Chem. Abstr., 117, 131079 (1992).
524. J. M. Finn, Eur. Patent 539676; Chem. Abstr., 119, 160278 (1993).
525. S. Azuma, T. Hiramatsu, and Y. Ichikawa, Jpn. Patent 05320117; Chem. Abstr., 120, 270126 (1994).
526. J. Rheinheimer, U. J. Vogelbacher, E. Baumann, M. Gerber, K..-O. Westphalen, and H. Walter, Ger. Patent 4337322; Chem. Abstr., 123, 256751 (1995).
527. M. P. Sammes, F. C. Peacock, and N. Punja, S. African Pat. 6807759; Chem. Abstr., 74, 141550 (1971)
528. B. Kuhn, G. Salbeck, U. Doeller, S. Schnatterer, H. H. Schubert, W. Knauf, A. Waltersdorfer, and M. Kern, Ger. Patent 4213149; Chem. Abstr., 120, 191538 (1994).
529. D. Kuhnt, H. Gayer, P. Gerdes, S. Dutzmann, H. W. Dehne, and G. Haenssler, Ger. Patent 4328385; Chem. Abstr., 122, 239551 (1995).
530. B. Mueller, H. Sauter, H. Bayer, W. Grammenos, T. Grote, R. Kirstgen, K. Oberdorf, F. Roehl, N. Goetz, M. Rack, R. Mueller, G. Lorenz, E. Ammermann, S. Strathmann, and H. V. Siegfried, Ger. Patent 19540989; Chem. Abstr., 127, 34129 (1997).
531. K. Sugihara, A. Shudo, and S. Tsuchiya, Jpn. Patent 11180957; Chem. Abstr., 131, 73560 (1999).
532. H. Kai and M. Tomida, PCT Int. Appl. WO Pat. 0018737; Chem. Abstr., 132, 265185 (2000).
533. Laboratoire Choay, Brit. Patent 1221393; Chem. Abstr., 75, 20210 (1971).
534. S. H. Moon, H. J. Choi, S. J. Lee, J. U. Chung, J. R. Ha, K. W. Jeong, and S. W. Oh, PCT Int. Appl. WO Pat. 9955318; Chem. Abstr., 131, 322612 (1999).
535. J. A. Van Zorge, Eur. Patent 7678; Chem. Abstr., 93, 150279 (1980).
536. D. L. Boger, H. Miyauchi, and M. P. Hedrick, Bioorg. Med. Chem. Lett., 11, 1517 (2001).
537. T. G. C. Bird, and P. Pie, Eur. Patent 555068; Chem. Abstr., 122, 187392 (1995).
538. D. J. Morgans, Jr., S. Thode, and D. Sun, PCT Int. Appl. WO Pat. 0162731; Chem. Abstr., 135, 190450 (2001).
539. F. J. Villani, US Patent 3290320; Chem. Abstr., 66, 46340 (1967).