Progressive neuronal and motor dysfunction in mice overexpressing the serine protease inhibitor protease nexin-1 in postmitotic Neurons

Journal of Neuroscience

Volumn 21, Issue 22, 2001, Pages 8830-8841

  Meins, Marita ^a   Piosik, Petra ^a,e   Schaeren Wiemers, Nicole ^a,f   Franzoni, Stefania ^a   Troncoso, Edgardo ^b   Kiss, Jozsef Z ^b   Brösamle, Christian ^c,g   Schwab, Martin E ^c   Molnár, Zoltán ^d,h   Monard, Denis ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^c University of Zurich Brain Research Institute   (Switzerland)

^d Inst of Cell Biol and Morphology   (Switzerland)

^e F HOFFMANN LA ROCHE LTD   (Switzerland)

^f UNIVERSITY HOSPITAL BASEL   (Switzerland)

^g GEOPHYSICAL LABORATORY   (United States)

^h UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Axonopathy; Layer V pyramidal cells; Motor behavior; Motor neuron disease; Muscle atrophy; PN 1; Proteolytic inhibition; Transgenic mice

Indexed keywords

PROTEASE NEXIN I; SERINE PROTEINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; EVOKED SOMATOSENSORY RESPONSE; FEMALE; HISTOPATHOLOGY; HOMEOSTASIS; MALE; MITOSIS; MOTOR DYSFUNCTION; MOUSE; MUSCLE ATROPHY; NERVE CELL; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE;

EID: 0035890083     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-22-08830.2001     Document Type: Article

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