The impact of codon 54 variation in intestinal fatty acid binding protein gene on the pathogenesis of diabetes mellitus in Chinese

Chinese Medical Journal

Volumn 112, Issue 2, 1999, Pages 99-102

  Xiang, Kunsan ^a   Zheng, Taishan ^a   Jia, Weiping ^a   Sun, Duoqi ^a   Ding, Wei ^a   Lu, Junxi ^a   Tang, Junling ^a  

^a Shanghai Sixth People's Hospital   (China)

Author keywords

Codon variation; Diabetes mellitus; Intestinal fatty acid binding protein gene; Islet beta cell function

Indexed keywords

ALANINE; CARRIER PROTEIN; FABP2 PROTEIN, HUMAN; FABP2 PROTEIN, MOUSE; FABP7 PROTEIN, HUMAN; FATTY ACID BINDING PROTEIN; INSULIN; THREONINE; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; ASIAN; CHINA; CODON; GENETIC VARIABILITY; GENETICS; HUMAN; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; SECRETION;

ALANINE; ASIAN CONTINENTAL ANCESTRY GROUP; CARRIER PROTEINS; CHINA; CODON; DIABETES MELLITUS, TYPE 2; FATTY ACID-BINDING PROTEINS; HUMANS; INSULIN; INSULIN RESISTANCE; NEOPLASM PROTEINS; THREONINE; TUMOR SUPPRESSOR PROTEINS; VARIATION (GENETICS);

EID: 0033068921     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 1995; 44:863.
2. Sweetser DA, Birkenmeier EH, Klisak IJ, et al. The human and rodent intestinal fatty acid binding protein gene. J Biol Chem 1987; 262:16060.
3. Baier IJ, Sacchettini JC, Knowler WC, et al. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J Clin Invest 1995;95:1281.
4. Knowler WC, Pettitt DJ, Saad MF, et al. Diabetes mellitus in the Pima Indians: incidence, risk factors, and pathogenesis. Diabetes Metab Rev 1990;3:1.