Two Novel Conserved Motifs in the Hepatitis C Virus NS3 Protein Critical for Helicase Action

Journal of Biological Chemistry

Volumn 278, Issue 45, 2003, Pages 44514-44524

  Lam, Angela M I ^b   Keeney, David ^b   Frick, David N ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; DISEASES; DNA; ENZYMES; HYDROLYSIS; MUTAGENESIS; RNA; VIRUSES;

GENOTYPES;

BIOCHEMISTRY;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ALANINE; ARGININE; DNA; HELICASE; MUTANT PROTEIN; NONSTRUCTURAL PROTEIN 3; NUCLEIC ACID; PHENYLALANINE; RNA; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DNA DENATURATION; ENZYME ACTIVITY; GENE TRANSLOCATION; GENOTYPE; HEPATITIS C VIRUS; HYDROLYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; SPECIES; WILD TYPE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CONSERVED SEQUENCE; DNA; DNA, SINGLE-STRANDED; HEPACIVIRUS; HUMANS; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RNA; RNA HELICASES; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0242582359     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306444200     Document Type: Article

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