Inhibition of the Transforming Growth Factor-β/Smad Signaling Pathway in the Epithelium of Oral Lichen

Journal of Investigative Dermatology

Volumn 121, Issue 6, 2003, Pages 1-8

  Karatsaidis, Andreas ^a   Schreurs, Olav ^a   Axéll, Tony ^a   Helgeland, Kristen ^a   Schenck, Karl ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

Epithelial proliferation; Keratinocytes; Oral mucosa

Indexed keywords

MESSENGER RNA; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; BASAL CELL; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KERATINOCYTE; LICHEN PLANUS; MOUTH MUCOSA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0346364792     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2003.12633.x     Document Type: Article

References (54)

1. Andreasen JO: Oral lichen planus. 1. A clinical evaluation of 115 cases. Oral Surg Oral Med Oral Pathol 25:31-42, 1968
2. Ashcroft GS, Yang X, Glick AB, et al: Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol 1:260-266, 1999
3. Axell T, Rundquist L: Oral lichen planus - A demographic study. Community Dent Oral Epidemiol 15:52-56, 1987
4. Beer HD, Gassmann MG, Munz B, Steiling H, Engelhardt F, Bleuel K, Werner S: Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair. J Investig Dermatol Symp Proc 5:34-39, 2000
5. Bitzer M, von Gersdorff G, Liang D, Dominguez-Rosales A, Beg AA, Rojkind M, Bottinger EP: A mechanism of suppression of TGF-β/SMAD signaling by NF-κB/Rela. Genes Dev 14:187-197, 2000
6. Bolewska J, Reibel J: T lymphocytes, Langerhans cells and HLA-DR expression on keratinocytes in oral lesions associated with amalgam restorations. J Oral Pathol Med 18:525-528, 1989
7. Bolewska J, Holmstrup P, Moller-Madsen B, Kenrad B, Danscher G: Amalgam associated mercury accumulations in normal oral mucosa, oral mucosal lesions of lichen planus and contact lesions associated with amalgam. J Oral Pathol Med 19:39-42, 1990
8. de Caestecker MP, Parks WT, Frank CJ, Castagnino P, Bottaro DP, Roberts AB, Lechleider RJ: Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. Genes Dev 12:1587-1592, 1998
9. Cui W, Fowlis DJ, Cousins FM, Duffie E, Bryson S, Balmain A, Akhurst RJ: Concerted action of TGF-β1 and its type II receptor in control of epidermal homeostasis in transgenic mice. Genes Dev 9:945-955, 1995
10. Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y, Wang XF: Transforming growth factor-β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci USA 92:5545-5549, 1995
11. Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, Gauthier JM: Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 17:3091-3100, 1998
12. Dotto GP: Signal transduction pathways controlling the switch between keratinocyte growth and differentiation. Crit Rev Oral Biol Med 10:442-457, 1999
13. Ebner R, Chen RH, Shum L, et al: Cloning of a type I TGF-β receptor and its effect on TGF-β binding to the type II receptor. Science 260:1344-1348, 1993
14. Freedberg IM, Tomic-Canic M, Komine M, Blumenberg M: Keratins and the keratmocyte activation cycle. J Invest Dermatol 116:633-640, 2001
15. Gandarillas A: Epidermal differentiation, apoptosis, and senescenc: Common pathways? Exp Gerontol 35:53-62, 2000
16. Glick AB, Kulkarni AB, Tennenbaum T, et al: Loss of expression of transforming growth factor-β in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. Proc Natl Acad Sci USA 90:6076-6080, 1993
17. Hannon GJ, Beach D: P15ink4b is a potential effector of TGF-β-induced cell cycle arrest. Nature 371:257-261, 1994
18. He W, Cao T, Smith DA, Myers TE, Wang XJ: Smads mediate signaling of the TGFβ superfamity in normal keratinocytes but are lost during skin chemical carcinogenesis. Oncogene 20:471-483, 2001
19. He W, Li AG, Wang D, et al: Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues. EMBO J 21:2580-2590, 2002
20. Hedberg N, Ng A, Hunter N: A semi-quantitative assessment of the histopathology of oral lichen planus. J Oral Pathol 15:268-272, 1986
21. Holmstrup P, Thorn JJ, Rindum J, Pindborg JJ: Malignant development of lichen planus-affected oral mucosa. J Oral Pathol 17:219-225, 1988
22. Jetten AM, Harvat BL: Epidermal differentiation and squamous metaplasia: From stem cell to cell death. J Dermatol 24:711-725, 1997
23. Jiang CK, Tomic-Canic M, Lucas DJ, Simon M, Blumenberg M: TGF β promotes the basal phenotype of epidermal keratinocytes: Transcriptional induction of k#5 and k#14 keratin genes. Growth Factors 12:87-97, 1995
24. Kane CJ, Hebda PA, Mansbridge JN, Hanawalt PC: Direct evidence for spatial and temporal regulation of transforming growth factor-β 1 expression during cutaneous wound healing. J Cell Physiol 148:157-173, 1991
25. Karatsaidis A, Schreurs O, Helgeland K, Axell T, Schenck K: Erythematous and reticular forms ot oral lichen planus and oral lichenoid reactions differ in pathological features related to disease activity. J Oral Pathol Med 32:275-281, 2003
26. Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL: Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF β receptor for degradation. Mol Cell 6:1365-1375, 2000
27. Keski-Oja J, Koli K: Enhanced production of plasminogen activator activity in human and marine keratinocytes by transforming growth factor-β1. J Invest Dermatol 99:193-200, 1992
28. Kramer IR, Lucas RB, Pindborg JJ, Sobin LH: Definition of leukoplakia and related lesions: An aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol 46:518-539, 1978
29. Lebrun JJ, Takabe K, Chen Y, Vale W: Roles of pathway-specific and inhibitory Smads in activin receptor signaling. Mol Endocrinol 13:15-23, 1999
30. Mansbridge JN, Hanawalt PC: Role of transforming growth factor-β in the maturation of human epidermal keratinocytes. J Invest Dermatol 90:336-341, 1988
31. Massague J: How cells read TGF-β signals. Nat Rev Mol Cell Biol 1:169-178, 2000
32. Min BM, Woo KM, Lee G, Park NH: Terminal differentiation of normal human oral keratinocytes is associated with enhanced cellular TGF-β and phospholipase c-γ1 levels and apoptotic cell death. Exp Cell Res 249:377-385, 1999
33. Miyazono K, Olofsson A, Colosetti P, Heldin CH: A role of the latent TGF-β1-binding protein in the assembly and secretion of TGF-β1. EMBO J 10:1091-1101, 1991
34. Nakao A, Afrakhte M, Moren A, et al: Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature 389:631-635, 1997a
35. Nakao A, Imamura T, Souchelnytskyi S, et al: TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J 16:5353-5362, 1997b
36. Nunes I, Gleizes PE, Metz CN, Rifkin DB: Latent transforming growth factor-β binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-β. J Cell Biol 136:1151-1163, 1997
37. Pasche B: Role of transforming growth factor-β in cancer. J Cell Physiol 186:153-168, 2001
38. Paterson IC, Matthews JB, Huntley S, Robinson CM, Fahey M, Parkinson EK, Prime SS: Decreased expression of TGF-β cell surface receptors during progression of human oral squamous cell carcinoma. J Pathol 193:458-467, 2001
39. Pietenpol JA, Holt JT, Stein RW, Moses HL: Transforming growth factor β1 suppression of c-myc gene transcription: Role in inhibition of keratinocyte proliferation. Proc Natl Acad Sci USA 87:3758-3762, 1990
40. Prime SS, Matthews JB, Patel V, et al: TGF-β receptor regulation mediates the response to exogenous ligand but is independent of the degree of cellular differentiation in human oral keratinocytes. Int J Cancer 56:406-412, 1994
41. Roberts AB: Molecular and cell biology of TGF-β. Miner Electrolyte Metab 24:111-119, 1998
42. Salonen L, Axell T, Hellden L: Occurrence of oral mucosal lesions, the influence of tobacco habits and an estimate of treatment time in an adult Swedish population. J Oral Pathol Med 19:170-176, 1990
43. Sellheyer K, Bickenbach JR, Rothnagel JA, et al: Inhibition of skin development by overexpression of transforming growth factor β1 in the epidermis of transgenic mice. Proc Natl Acad Sci USA 90:5237-5241, 1993
44. Ta BM, Gallagher GT, Chakravarty R, Rice RH: Keratinocyte transglutaminase in human skin and oral mucosa: Cytoplasmic localization and uncoupling of differentiation markers. J Cell Sci 95:631-638, 1990
45. Ten Dijke P, Goumans MJ, Itoh F, Itoh S: Regulation of cell proliferation by Smad proteins. J Cell Physiol 191:1-16, 2002
46. Ulloa L, Doody J, Massague J: Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway. Nature 397:710-713, 1999
47. Verderio E, Gaudry C, Gross S, Smith C, Downes S, Griffin M: Regulation of cell surface tissue transglutaminase: Effects on matrix storage of latent transforming growth factor-β binding protein-1. J Histochem Cytochem 47:1417-1432, 1999
48. Wakefield LM, Smith DM, Flanders KC, Sporn MB: Latent transforming growth factor-β from human platelets. J Biol Chem 263:7646-7654, 1988
49. Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 81:323-330, 1995
50. Wrana JL, Attisano L, Wieser R, Ventura F, Massague J: Mechanism of activation of the TGF-β receptor. Nature 370:341-347, 1994
51. Yamamoto T, Osaki T: Characteristic cytokines generated by keratinocytes and mononuclear infiltrates in oral lichen planus. J Invest Dermatol 104:784-788, 1995
52. Yang L, Chan T, Demare J, Iwashina T, Ghahary A, Scott PG, Tredget EE: Healing of burn wounds in transgenic mice overexpressing transforming growth factor-β1 in the epidermis. Am J Pathol 159:2147-2157, 2001
53. Zambruno G, Marchisio PC, Marconi A, Vaschieri C, Melchiori A, De Giannetti A, Luca M: Transforming growth factor-β1 modulates β1 and β5 integrin receptors and induces the de novo expression of the αvβ6 heterodimer in normal human keratinocytes: Implications for wound healing. J Cell Biol 129:853-865, 1995
54. Zwaagstra JC, Kassam Z, O'Connor-McCourt MD: Down-regulation of transforming growth factor-β receptors: Cooperativity between the types I, II, and III receptors and modulation at the cell surface. Exp Cell Res 252:352-362, 1999