메뉴 건너뛰기




Volumn 5, Issue 5, 2003, Pages 372-378

Isoprenoid metabolism and the pleiotropic effects of statins

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; ATORVASTATIN; CERIVASTATIN; CHOLESTEROL; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVALONIC ACID; MEVINOLIN; PLACEBO; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN;

EID: 0346278773     PISSN: 15233804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11883-003-0008-z     Document Type: Review
Times cited : (80)

References (59)
  • 1
    • 0034471646 scopus 로고    scopus 로고
    • Direct vascular effects of HMG-CoA reductase inhibitors
    • Laufs U, Liao JK: Direct vascular effects of HMG-CoA reductase inhibitors. Trends Cardiovasc Med 2001, 10:143-148.
    • (2001) Trends Cardiovasc. Med. , vol.10 , pp. 143-148
    • Laufs, U.1    Liao, J.K.2
  • 2
    • 0036118915 scopus 로고    scopus 로고
    • Pleiotropic effects of HMG-CoA reductase inhibitors
    • Werner N, Nickenig G, Laufs U: Pleiotropic effects of HMG-CoA reductase inhibitors. Basic Res Cardiol 2002, 97:105-116.
    • (2002) Basic Res. Cardiol. , vol.97 , pp. 105-116
    • Werner, N.1    Nickenig, G.2    Laufs, U.3
  • 3
    • 0037319739 scopus 로고    scopus 로고
    • Statin effects beyond lipid lowering - Are they clinically relevant?
    • Bonetti PO, Lerman LO, Napoli C, Lerman A: Statin effects beyond lipid lowering - are they clinically relevant? Eur Heart J 2003, 24:225-248.
    • (2003) Eur. Heart J. , vol.24 , pp. 225-248
    • Bonetti, P.O.1    Lerman, L.O.2    Napoli, C.3    Lerman, A.4
  • 4
    • 0037456528 scopus 로고    scopus 로고
    • Mechanisms of plaque stabilization with statins
    • Libby P, Aikawa M: Mechanisms of plaque stabilization with statins. Am J Cardiol 2003, 20:4B-8B.
    • (2003) Am. J. Cardiol. , vol.20
    • Libby, P.1    Aikawa, M.2
  • 6
    • 0035122832 scopus 로고    scopus 로고
    • Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: Involvement of angiotensin AT1 receptor expression and Rac1 GTPase
    • Wassmann S, Laufs U, Baumer AT, et al.: Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase. Mol Pharmacol 2001, 59:646-654.
    • (2001) Mol. Pharmacol. , vol.59 , pp. 646-654
    • Wassmann, S.1    Laufs, U.2    Baumer, A.T.3
  • 7
    • 0036162113 scopus 로고    scopus 로고
    • Cellular antioxidant effects of atorvastatin in vitro and in vivo
    • Wassmann S, Laufs U, Muller K, et al.: Cellular antioxidant effects of atorvastatin in vitro and in vivo. Arterioscler Thromb Vasc Biol 2002, 22:300-305.
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 300-305
    • Wassmann, S.1    Laufs, U.2    Muller, K.3
  • 8
    • 0035186999 scopus 로고    scopus 로고
    • Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy
    • Takemoto M, Node K, Nakagami H, et al.: Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy. J Clin Invest 2001, 108:1429-1437.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1429-1437
    • Takemoto, M.1    Node, K.2    Nakagami, H.3
  • 9
    • 0036199909 scopus 로고    scopus 로고
    • Impact of HMG CoA reductase inhibition on small GTPases in the heart
    • Laufs U, Kilter II, Konkol C, et al.: Impact of HMG CoA reductase inhibition on small GTPases in the heart. Cardiovasc Res 2002, 53:911-920.
    • (2002) Cardiovasc. Res. , vol.53 , pp. 911-920
    • Laufs, U.1    Kilter, I.I.2    Konkol, C.3
  • 10
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein JL, Brown MS: Regulation of the mevalonate pathway. Nature 1990, 343:425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 11
    • 0034730812 scopus 로고    scopus 로고
    • Targeting Rho in cardiovascular disease
    • Laufs U, Liao JK: Targeting Rho in cardiovascular disease. Circ Res 2000, 87:526-528.
    • (2000) Circ. Res. , vol.87 , pp. 526-528
    • Laufs, U.1    Liao, J.K.2
  • 12
    • 0032508533 scopus 로고    scopus 로고
    • Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
    • Laufs U, Liao JK: Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem 1998, 273:24266-24271.
    • (1998) J. Biol. Chem. , vol.273 , pp. 24266-24271
    • Laufs, U.1    Liao, J.K.2
  • 13
    • 0031014389 scopus 로고    scopus 로고
    • Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans
    • Tamai O, Matsuoka H, Itabe H, et al.: Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans. Circulation 1997, 95:76-82.
    • (1997) Circulation , vol.95 , pp. 76-82
    • Tamai, O.1    Matsuoka, H.2    Itabe, H.3
  • 14
    • 0037143688 scopus 로고    scopus 로고
    • ACC/AHA/NHLBI clinical advisory on the use and safety of statins
    • Pasternak RC, Smith SC Jr, Bairey-Merz CN, et al.: ACC/AHA/NHLBI clinical advisory on the use and safety of statins. Circulation 2002, 106:1024-1028.
    • (2002) Circulation , vol.106 , pp. 1024-1028
    • Pasternak, R.C.1    Smith Jr., S.C.2    Bairey-Merz, C.N.3
  • 15
    • 0035500039 scopus 로고    scopus 로고
    • AHA/ACC guidelines for preventing heart attack and death in patients with atherosclerotic cardiovascular disease: 2001 update. A statement for healthcare professionals from the American Heart Association and the American College of Cardiology
    • Smith SC Jr, Blair SN, Bonow RO, et al.: AHA/ACC guidelines for preventing heart attack and death in patients with atherosclerotic cardiovascular disease: 2001 update. A statement for healthcare professionals from the American Heart Association and the American College of Cardiology. J Am Coll Cardiol 2001, 38:1581-1583.
    • (2001) J. Am. Coll. Cardiol. , vol.38 , pp. 1581-1583
    • Smith Jr., S.C.1    Blair, S.N.2    Bonow, R.O.3
  • 16
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • West of Scotland Coronary Prevention Study Group
    • Shepherd J, Cobbe SM, Ford I, et al.: Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 1995, 333:1301-1307.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3
  • 17
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
    • Cholesterol and Recurrent Events Trial investigators
    • Sacks FM, Pfeffer MA, Moye LA, et al.: The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med 1996, 335:1001-1009.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 1001-1009
    • Sacks, F.M.1    Pfeffer, M.A.2    Moye, L.A.3
  • 18
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Study Group:
    • Scandinavian Simvastatin Study Group: Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994, 344:1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 19
    • 17544397518 scopus 로고    scopus 로고
    • Long-term effects on clinical outcomes of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation in the post coronary artery bypass graft trial
    • Post CABG Investigators
    • Knatterud GL, Rosenberg Y, Campeau L, et al.: Long-term effects on clinical outcomes of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation in the post coronary artery bypass graft trial. Post CABG Investigators. Circulation 2000, 102:157-165.
    • (2000) Circulation , vol.102 , pp. 157-165
    • Knatterud, G.L.1    Rosenberg, Y.2    Campeau, L.3
  • 20
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomised placebo-controlled trial
    • Heart Protection Study Group:
    • Heart Protection Study Group: MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002, 360:7-22.
    • (2002) Lancet , vol.360 , pp. 7-22
  • 21
    • 0037420492 scopus 로고    scopus 로고
    • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): A multicentre randomised controlled trial
    • Sever PS, Dahlof B, Poulter NR, et al.: Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 2003, 361:1149-1158.
    • (2003) Lancet , vol.361 , pp. 1149-1158
    • Sever, P.S.1    Dahlof, B.2    Poulter, N.R.3
  • 22
    • 0032554676 scopus 로고    scopus 로고
    • Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS)
    • Packard CJ: Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS). Circulation 1998, 97:1440-1445.
    • (1998) Circulation , vol.97 , pp. 1440-1445
    • Packard, C.J.1
  • 23
    • 0025376017 scopus 로고
    • Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular disease
    • [see comments]
    • Pekkanen J, Linn S, Heiss G, et al.: Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular disease [see comments]. N Engl J Med 1990, 322:1700-1707.
    • (1990) N. Engl. J. Med. , vol.322 , pp. 1700-1707
    • Pekkanen, J.1    Linn, S.2    Heiss, G.3
  • 24
    • 7144250513 scopus 로고    scopus 로고
    • Effective lipid modification by partial ileal bypass reduced long-term coronary heart disease mortality and morbidity: Five-year posttrial follow-up report from the POSCH. Program on the Surgical Control of the Hyperlipidemias
    • Buchwald H, Varco RL, Boen JR, et al.: Effective lipid modification by partial ileal bypass reduced long-term coronary heart disease mortality and morbidity: five-year posttrial follow-up report from the POSCH. Program on the Surgical Control of the Hyperlipidemias. Arch Intern Med 1998, 158:1253-1261.
    • (1998) Arch. Intern. Med. , vol.158 , pp. 1253-1261
    • Buchwald, H.1    Varco, R.L.2    Boen, J.R.3
  • 25
    • 0035804846 scopus 로고    scopus 로고
    • Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: The MIRACL study: A randomized controlled trial
    • Schwartz GG, Olsson AG, Ezekowitz MD, et al.: Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial. JAMA 2001, 285:1711-1718.
    • (2001) JAMA , vol.285 , pp. 1711-1718
    • Schwartz, G.G.1    Olsson, A.G.2    Ezekowitz, M.D.3
  • 26
    • 0035312651 scopus 로고    scopus 로고
    • Rapid improvement of nitric oxide bioavailability after lipid-lowering therapy with cerivastatin within two weeks
    • John S, Delles C, Jacobi J, et al.: Rapid improvement of nitric oxide bioavailability after lipid-lowering therapy with cerivastatin within two weeks. J Am Coll Cardiol 2001, 37:1351-1358.
    • (2001) J. Am. Coll. Cardiol. , vol.37 , pp. 1351-1358
    • John, S.1    Delles, C.2    Jacobi, J.3
  • 27
    • 0035943091 scopus 로고    scopus 로고
    • Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days
    • Tsunekawa T, Hayashi T, Kano H, et al.: Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days. Circulation 2001, 104:376-379.
    • (2001) Circulation , vol.104 , pp. 376-379
    • Tsunekawa, T.1    Hayashi, T.2    Kano, H.3
  • 28
    • 0035581239 scopus 로고    scopus 로고
    • Rapid effects on vascular function after initiation and withdrawal of atorvastatin in healthy, normocholesterolemic men
    • Laufs U, Wassmann S, Hilgers S, et al.: Rapid effects on vascular function after initiation and withdrawal of atorvastatin in healthy, normocholesterolemic men. Am J Cardiol 2001, 88:1306-1307.
    • (2001) Am. J. Cardiol. , vol.88 , pp. 1306-1307
    • Laufs, U.1    Wassmann, S.2    Hilgers, S.3
  • 29
    • 0032896636 scopus 로고    scopus 로고
    • Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions
    • Kaesemeyer WH, Caldwell RB, Huang J, Caldwell RW: Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions. J Am Coll Cardiol 1999, 33:234-241.
    • (1999) J. Am. Coll. Cardiol. , vol.33 , pp. 234-241
    • Kaesemeyer, W.H.1    Caldwell, R.B.2    Huang, J.3    Caldwell, R.W.4
  • 30
    • 0031032831 scopus 로고    scopus 로고
    • Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month
    • O'Driscoll G, Green D, Taylor RR: Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month. Circulation 1997, 95:1126-1131.
    • (1997) Circulation , vol.95 , pp. 1126-1131
    • O'Driscoll, G.1    Green, D.2    Taylor, R.R.3
  • 31
    • 0035584083 scopus 로고    scopus 로고
    • Effect of pravastatin on endothelial function in patients with coronary artery disease (cholesterol-independent effect of pravastatin)
    • Masumoto A, Hirooka Y, Hironaga K, et al.: Effect of pravastatin on endothelial function in patients with coronary artery disease (cholesterol-independent effect of pravastatin). Am J Cardiol 2001, 88:1291-1294.
    • (2001) Am. J. Cardiol. , vol.88 , pp. 1291-1294
    • Masumoto, A.1    Hirooka, Y.2    Hironaga, K.3
  • 32
    • 0037177167 scopus 로고    scopus 로고
    • Withdrawal of statins increases event rates in patients with acute coronary syndromes
    • Heeschen C, Hamm CW, Laufs U, et al.: Withdrawal of statins increases event rates in patients with acute coronary syndromes. Circulation 2002, 105:1446-1452.
    • (2002) Circulation , vol.105 , pp. 1446-1452
    • Heeschen, C.1    Hamm, C.W.2    Laufs, U.3
  • 33
    • 0032488379 scopus 로고    scopus 로고
    • Increased thrombotic vascular events after change of statin
    • Thomas M, Mann J: Increased thrombotic vascular events after change of statin. Lancet 1998, 352:1830-1831.
    • (1998) Lancet , vol.352 , pp. 1830-1831
    • Thomas, M.1    Mann, J.2
  • 34
    • 0035895319 scopus 로고    scopus 로고
    • An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro
    • Aikawa M, Rabkin E, Sugiyama S, et al.: An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro. Circulation 2001, 103:276-283.
    • (2001) Circulation , vol.103 , pp. 276-283
    • Aikawa, M.1    Rabkin, E.2    Sugiyama, S.3
  • 35
    • 0036736742 scopus 로고    scopus 로고
    • Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol
    • Sukhova GK, Williams JK, Libby P: Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol. Arterioscler Thromb Vasc Biol 2002, 22:1452-1458.
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 1452-1458
    • Sukhova, G.K.1    Williams, J.K.2    Libby, P.3
  • 36
    • 0034704893 scopus 로고    scopus 로고
    • C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    • Ridker PM, Hennekens CH, Buring JE, Rifai N: C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000, 342:836-843.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 836-843
    • Ridker, P.M.1    Hennekens, C.H.2    Buring, J.E.3    Rifai, N.4
  • 37
    • 0035963529 scopus 로고    scopus 로고
    • Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
    • Ridker PM, Rifai N, Clearfield M, et al.: Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N Engl J Med 2001, 344:1959-1965.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1959-1965
    • Ridker, P.M.1    Rifai, N.2    Clearfield, M.3
  • 38
    • 0035814945 scopus 로고    scopus 로고
    • Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia
    • Ridker PM, Rifai N, Lowenthal SP: Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia. Circulation 2001, 103:1191-1193.
    • (2001) Circulation , vol.103 , pp. 1191-1193
    • Ridker, P.M.1    Rifai, N.2    Lowenthal, S.P.3
  • 39
    • 0033587667 scopus 로고    scopus 로고
    • Long-term effects of pravastatin on plasma concentration of C-reactive protein
    • The Cholesterol and Recurrent Events (CARE) Investigators
    • Ridker PM, Rifai N, Pfeffer MA, et al.: Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators. Circulation 1999, 100:230-235.
    • (1999) Circulation , vol.100 , pp. 230-235
    • Ridker, P.M.1    Rifai, N.2    Pfeffer, M.A.3
  • 40
    • 0030910648 scopus 로고    scopus 로고
    • The use of HMG-CoA reductase inhibitors to prevent accelerated graft atherosclerosis in heart transplant patients
    • Southworth MR, Mauro VF: The use of HMG-CoA reductase inhibitors to prevent accelerated graft atherosclerosis in heart transplant patients. Ann Pharmacother 1997, 31:489-491.
    • (1997) Ann. Pharmacother. , vol.31 , pp. 489-491
    • Southworth, M.R.1    Mauro, V.F.2
  • 41
    • 0030463459 scopus 로고    scopus 로고
    • Evaluation of fluvastatin in the treatment of hypercholesterolemia in renal transplant recipients taking cyclosporine
    • Goldberg R, Roth D: Evaluation of fluvastatin in the treatment of hypercholesterolemia in renal transplant recipients taking cyclosporine. Transplantation 1996, 62:1559-1564.
    • (1996) Transplantation , vol.62 , pp. 1559-1564
    • Goldberg, R.1    Roth, D.2
  • 42
    • 0029119711 scopus 로고
    • Effect of pravastatin on outcomes after cardiac transplantation
    • Kobashigawa JA, Katznelson S, Laks H, et al.: Effect of pravastatin on outcomes after cardiac transplantation. N Engl J Med 1995, 333:621-627.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 621-627
    • Kobashigawa, J.A.1    Katznelson, S.2    Laks, H.3
  • 43
    • 0033586472 scopus 로고    scopus 로고
    • Inhibition of proinflammatory cytokine production by pravastatin
    • Rosenson RS, Tangney CC, Casey LC: Inhibition of proinflammatory cytokine production by pravastatin. Lancet 1999, 353:983-984.
    • (1999) Lancet , vol.353 , pp. 983-984
    • Rosenson, R.S.1    Tangney, C.C.2    Casey, L.C.3
  • 44
    • 0037456569 scopus 로고    scopus 로고
    • Prevention of stroke and dementia with statins: Effects beyond lipid lowering
    • Vaughan CJ: Prevention of stroke and dementia with statins: Effects beyond lipid lowering. Am J Cardiol 2003, 91:23B-29B.
    • (2003) Am. J. Cardiol. , vol.91
    • Vaughan, C.J.1
  • 45
    • 0035936503 scopus 로고    scopus 로고
    • Reduction of stroke events with pravastatin: The Prospective Pravastatin Pooling (PPP) project
    • Byington RP, Davis BR, Plehn JF, et al.: Reduction of stroke events with pravastatin: the Prospective Pravastatin Pooling (PPP) project. Circulation 2001, 103:387-392.
    • (2001) Circulation , vol.103 , pp. 387-392
    • Byington, R.P.1    Davis, B.R.2    Plehn, J.F.3
  • 46
    • 0036098338 scopus 로고    scopus 로고
    • Lipid-lowering drug use and cardiovascular events after myocardial infarction
    • Klungel OH, Heckbert SR, de Boer A, et al.: Lipid-lowering drug use and cardiovascular events after myocardial infarction. Ann Pharmacother 2002, 36:751-757.
    • (2002) Ann. Pharmacother. , vol.36 , pp. 751-757
    • Klungel, O.H.1    Heckbert, S.R.2    de Boer, A.3
  • 47
    • 0032555154 scopus 로고    scopus 로고
    • Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
    • Endres M, Laufs U, Huang Z, et al.: Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 1998, 95:8880-8885.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 8880-8885
    • Endres, M.1    Laufs, U.2    Huang, Z.3
  • 48
    • 0037326998 scopus 로고    scopus 로고
    • Rapid effects of statins: From prophylaxis to therapy for ischemic stroke
    • Laufs U, Liao JK: Rapid effects of statins: from prophylaxis to therapy for ischemic stroke. Arterioscler Thromb Vasc Biol 2003, 23:156-157.
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 156-157
    • Laufs, U.1    Liao, J.K.2
  • 49
    • 18144435700 scopus 로고    scopus 로고
    • Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys
    • Williams JK, Sukhova GK, Herrington DM, Libby P: Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys. J Am Coll Cardiol 1998, 31:684-691.
    • (1998) J. Am. Coll. Cardiol. , vol.31 , pp. 684-691
    • Williams, J.K.1    Sukhova, G.K.2    Herrington, D.M.3    Libby, P.4
  • 50
    • 0025345124 scopus 로고
    • Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol
    • Reihner E, Rudling M, Stahlberg D, et al.: Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol. N Engl J Med 1990, 323:224-228.
    • (1990) N. Engl. J. Med. , vol.323 , pp. 224-228
    • Reihner, E.1    Rudling, M.2    Stahlberg, D.3
  • 51
    • 0028200059 scopus 로고
    • Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    • Blum CB: Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Am J Cardiol 1994, 73:3D-11D.
    • (1994) Am. J. Cardiol. , vol.73
    • Blum, C.B.1
  • 52
    • 0035825928 scopus 로고    scopus 로고
    • Warwick M. Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor
    • McTaggart F, Buckett L, Davidson R, et al.: Warwick M. Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am J Cardiol 2001, 87:28B-32B.
    • (2001) Am. J. Cardiol. , vol.87
    • McTaggart, F.1    Buckett, L.2    Davidson, R.3
  • 54
    • 0037189048 scopus 로고    scopus 로고
    • Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice
    • Laufs U, Gertz K, Dirnagl U, et al.: Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice. Brain Res 2002, 942:23-30.
    • (2002) Brain Res. , vol.942 , pp. 23-30
    • Laufs, U.1    Gertz, K.2    Dirnagl, U.3
  • 55
    • 0032805692 scopus 로고    scopus 로고
    • New insights into the pharmacodynamic and pharmacokinetic properties of statins
    • Corsini A, Bellosta S, Baetta R, et al.: New insights into the pharmacodynamic and pharmacokinetic properties of statins. Pharmacol Ther 1999, 84:413-428.
    • (1999) Pharmacol. Ther. , vol.84 , pp. 413-428
    • Corsini, A.1    Bellosta, S.2    Baetta, R.3
  • 56
    • 0037379362 scopus 로고    scopus 로고
    • Bile salt transporters: Molecular characterization, function, and regulation
    • Trauner M, Boyer JL: Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev 2003, 83:633-671.
    • (2003) Physiol. Rev. , vol.83 , pp. 633-671
    • Trauner, M.1    Boyer, J.L.2
  • 58
    • 0037154285 scopus 로고    scopus 로고
    • Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Munster (PROCAM) study
    • Assmann G, Cullen P, Schulte H: Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Munster (PROCAM) study. Circulation 2002, 105:310-315.
    • (2002) Circulation , vol.105 , pp. 310-315
    • Assmann, G.1    Cullen, P.2    Schulte, H.3
  • 59
    • 0035572718 scopus 로고    scopus 로고
    • Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors
    • Takemoto M, Liao JK: Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol 2001, 21:1712-1719.
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 1712-1719
    • Takemoto, M.1    Liao, J.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.