Rapid improvement of nitric oxide bioavailability after lipid-lowering therapy with cerivastatin within two weeks

Journal of the American College of Cardiology

Volumn 37, Issue 5, 2001, Pages 1351-1358

  John, Stefan ^a   Delles, Christian ^a   Jacobi, Johannes ^a   Schlaich, Markus P ^a   Schneider, Markus ^b   Schmitz, Gerd ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CERIVASTATIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; N(G) METHYLARGININE; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DOUBLE BLIND PROCEDURE; ENDOTHELIUM CELL; FEMALE; FOREARM BLOOD FLOW; HEART MUSCLE ISCHEMIA; HUMAN; HYPERCHOLESTEROLEMIA; MALE; PATHOGENESIS; PLETHYSMOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VALIDATION PROCESS; VASODILATATION;

ADULT; ANTICHOLESTEREMIC AGENTS; BIOLOGICAL AVAILABILITY; BLOOD FLOW VELOCITY; CHOLESTEROL, LDL; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; FOREARM; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; NITRIC OXIDE; PLETHYSMOGRAPHY; PYRIDINES; VASODILATION;

EID: 0035312651     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(01)01128-7     Document Type: Article

References (29)

1. The effect of cholesterol lowering and antioxidant therapy on endothelium dependent coronary vasomotion
2. Beneficiai effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease
3. Vascular function in the forearm of hypercholesterolemic patients off and on lipid lowering medication
4. Increased bioavailability of nitric oxide after lipid lowering therapy in hypercholesterolemic patients. A randomized, placebo-controlled, double-blind study
5. The pathogenesis of atherosclerosis: A perspective for the 1990s
6. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines
7. Nitric oxide protects against leukocyte-endothelium interactions in the early stages of hypercholesterolemia
8. Regulation of vascular homeostasis by nitric oxide
9. Atherosclerosis - An inflammatory disease
10. Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP
11. Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits
12. Regression of coronary artery disease as a result of intensive lipid lowering therapy in men with high levels of apolipoprotein B
13. Simvastatin, an HMG-Coenzyme A reductase inhibitor, improves endothelial function within one month
14. Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes. The RECIFE (Reduction of Cholesterol in Ischemia and Function of the Endothelium) trial
15. Single LDL-apharesis improves endothelium-dependent vasodilation in hypercholesterolemic humans
16. Improvement of coronary vasodilation capacity through single LDL apharesis
17. Physician noncompliance with the 1993 National Cholesterol Educafion Program (NCEP-ATPII) guidelines
18. Nonanticoagulant heparin increases endothelial nitric oxide synthase activity: Role of inhibitory guanine nucleotide proteins
19. Nonanticoagulant heparin prevents coronary endothelial dysfunction after brief ischemia-reperfusion injury in the dog
20. Hyperlipidemia and coronary disease. Correction of the increased thrombogenic potential with cholesterol reduction
21. Atherosclerosis and the two faces of endothelial nitric oxide synthase
22. Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: Evidence for involvement of the renin-angiotensin system
23. Low-densiw lipoprotein-cholesterol determines vascular responsiveness to angiotensin II in normocholesterolemic humans
24. Vitamin C improves endothelium dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia
25. Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol lowering actions
26. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation
27. Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effects
28. Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men
29. Effect of cholesterol-lowering therapy on coronary endothelial vasomotor function in patients with coronary artery disease