Serial MR in gene therapy for recurrent glioblastoma: Initial experience and work in progress

American Journal of Neuroradiology

Volumn 18, Issue 8, 1997, Pages 1401-1406

  Deliganis, Anastasia V ^a   Baxter, Alexander B ^a   Berger, Mitchel S ^a   Marcus, Stephen G ^b   Maravilla, Kenneth R ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Brain neoplasms; Drugs, effects; Glioblastoma multiforme; Magnetic resonance

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE; VIRUS VECTOR;

ADULT; AGED; BRAIN TUMOR; CANCER REGRESSION; CANCER SURGERY; CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; FEMALE; GENE THERAPY; GLIOBLASTOMA; HUMAN; IMAGE ANALYSIS; MALE; MULTICENTER STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; RECURRENT CANCER; TREATMENT OUTCOME;

ADULT; AGED; ANTIVIRAL AGENTS; BRAIN; BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; CRANIOTOMY; FEMALE; FOLLOW-UP STUDIES; GANCICLOVIR; GENE THERAPY; GLIOBLASTOMA; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM, RESIDUAL; TREATMENT OUTCOME;

EID: 0031545926     PISSN: 01956108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (13)

1. Walker MD, Green, SB, Byar DP, et al. Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 1980;303:1323-1329
2. Berger MS, Prados M, Van Gilder J. Gene Therapy for the Treatment of Recurrent Glioblastoma Multiforme with In Vivo Tumor Transduction with the Herpes Simplex Thymidine Kinase Gene/ Ganciclovir System: A Phase I/II Study. Gaithersburg, Md: Genetic Therapy Inc; December 22, 1994, Version 3.0
3. Kun LE, Gajar A, Muhlbauer M, et al. Clinical protocol: stereotactic injection of herpes simplex thymidine kinase vector producer cells (PA317-G1Tk1SvNa.7) and intravenous ganciclovir for the treatment of progressive or recurrent primary supratentorial pediatric malignant brain tumors. Hum Gene Ther 1995; 6:1231-1255
4. Izquierdo M, Cortes M, deFelipe P, et al. Long-term rat survival after malignant brain tumor regression by retroviral gene therapy. Gene Ther 1995;2:66-69
5. Ram Z, Culver KW, Walbridge S, et al. In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res 1993;53:83-88
6. Culver KW, Ram Z, Walbridge S, et al. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 1992;256:1550-1552
7. Fine HA. Novel biologic therapies for malignant gliomas. Neurol Clin 1995;13:827-844
8. Wu KJ, Cano WG, Meylaerts SAG, et al. Bystander tumoricidal effect in the treatment of experimental brain tumors. Neurosurgery 1994;35:1094-1103
9. Smith MM, Thompson JE, Castillo M, et al. MR of recurrent high-grade astrocytomas after intralesional immunotherapy. AJNR Am J Neuroradiol 1996;17:1065-1071
10. Albert FK, Forsting M, Sartor K, et al. Early postoperative magnetic resonance imaging after resection of malignant glioma: objective evaluation of residual tumor and its influence on regrowth and prognosis. Neurosurgery 1994;34:45-61
11. Berger MS, Deliganis AV, Dobbins J, et al. The effect of extent of resection on recurrence in patients with low grade cerebral hemisphere gliomas. Cancer 1994;74:1784-1791
12. Nitta T, Sato K. Prognostic implications of the extent of surgical resection in patients with intracranial malignant gliomas. Cancer 1995;75:2727-2731
13. Forsting M, Albert FK, Kunze S, et al. Extirpation of glioblastomas: MR and CT follow-up of residual tumor and regrowth patterns. AJNR Am J Neuroradiol 1993;14:77-87