Neurotoxicity of intracerebral injection of a replication-defective adenoviral vector in a semipermissive species (cotton rat)

Gene Therapy

Volumn 4, Issue 4, 1997, Pages 275-279

  Shine, H D ^a   Wyde, P R ^a   Aguilar Cordova, E ^a   Chen, S H ^a,b   Woo, S L C ^a,b   Grossman, R G ^a   Goodman, J C ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Adenoviral vector; Brain; Cotton rat; Neurotoxicity

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOROID PLEXUS; CONTROLLED STUDY; EPENDYMA; EXPRESSION VECTOR; HERPES SIMPLEX VIRUS; HISTOPATHOLOGY; INFLAMMATION; INJECTION SITE; INTRAPERITONEAL DRUG ADMINISTRATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION;

EID: 0030890406     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300397     Document Type: Article

References (18)

1. Ginsberg HS et al. A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia. Proc Natl AcaD Sci USA 1991; 88: 1651-1655.
2. Pacini DL, Dubovi EJ, Clyde WA. A new animal model for human respiratory tract disease due to adenovirus. J Infect Dis 1984; 150: 92-97.
3. Martin JC et al. 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine: a new potent and selective antiherpes agent. J Med Chem 1983; 26: 759-761.
4. Moolten FL. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986; 46: 5276-5281.
5. Moolten FL, Wells JM. Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J Natl Cancer Inst 1990; 82: 297-300.
6. Barba D, Hardin J, Jasodhara J, Gage FH. Thymidine kinasemediated killing of rat brain tumors. J Neurosurg 1993; 79: 729-735.
7. Chen S et al. Gene therapy for brain humors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci USA 1994; 91: 3054-3057.
8. Colak A et al. Adenovirus-mediated gene therapy for experimental spinal cord tumors: tumoricidal efficacy and functional outcome. Brain Res 1995; 691: 76-82
9. Colak A et al. Adenovirus-mediated gene therapy in an experimental model of breast cancer metastatic to the brain. Hum Gene Ther 1995; 6: 1317-1322.
10. Culver KW et al. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 1992; 256: 1550-1552.
11. Perez-Cruet MJ et al. Adenovirus-mediated gene therapy of experimental gliomas. J Neurosci Res 1994; 39: 506-511.
12. Viola JJ et al. Adenovirally mediated gene transfer into experimental solid brain tumors and leptomeningeal cancer cells. J Neurosurg 1995; 82: 70-76.
13. Goodman JC et al. Adenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: pathologic, radiologic and molecular studies. Hum Gene Ther 1996; 7: 1241-1250.
14. Byrnes AP, MacLaren RE, Charlton HM. Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination. J Neurosci 1996; 16: 3045-3055.
15. Byrnes AP, Rusby JE, Wood MJA, Charlton HM. Adenovirus gene transfer causes inflammation in the brain. Neuroscience 1995; 66: 1015-1024.
16. Ouahkene W, Gonin P, Eloit M. Short and long-term dissemination of deletion mutants of adenovirus in permissive (cotton rat) and non-permissive (mouse) species. J Gen Viral 1994; 75: 2765-2768.
17. Oualikene W, Gonin P, Eloit M. Lack of evidence of phenotypic complementation of El A E1B-deleted adenovirus type 5 upon superinfection by wild-type virus in the cotton rat. J Viral 1995; 69: 6518-6524.
18. Shine HD, Woo SLC. Adenovirus-mediated gene therapy of tumors in the central nervous system. In: Latchman DS (ed). Genetic Manipulation of the Nervous System. Academic Press: London, 1996, pp 53-71.