Inhibition of LPS-induced NFκB activation by a glucan ligand involves down-regulation of IKKβ kinase activity and altered phosphorylation and degradation of IκBα

Shock

Volumn 13, Issue 6, 2000, Pages 446-452

  Williams, David L ^a   Ha, Tuanzhu ^a   Li, Chuanfu ^a   Laffan, John ^a   Kalbfleisch, John ^a   Browder, William ^a  

^a East Tennessee State University   (United States)

Author keywords

Glucan; IKK ; I B ; Liver; Lung; Macrophage; NF B; Phosphorylation; Sepsis

Indexed keywords

BETA 1,3 GLUCAN; BETA GLUCAN; BETA-1,3-GLUCAN; CHUK PROTEIN, MOUSE; DNA BINDING PROTEIN; GLUCAN; I KAPPA B; I KAPPA B KINASE; IKBKB PROTEIN, MOUSE; IKBKE PROTEIN, MOUSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGAND; LIPOPOLYSACCHARIDE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PROTEIN SERINE THREONINE KINASE;

ANIMAL; ARTICLE; CELL CULTURE; CELL LINE; CELL NUCLEUS; CYTOSOL; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; INSTITUTE FOR CANCER RESEARCH MOUSE; INTESTINE PERFORATION; LIVER; LUNG; MACROPHAGE; MALE; METABOLISM; MOUSE; PHOSPHORYLATION; PROTEIN PROCESSING; SEPSIS; SEPTIC SHOCK;

ANIMALS; BETA-GLUCANS; CELL LINE; CELL NUCLEUS; CELLS, CULTURED; CYTOSOL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GLUCANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; INTESTINAL PERFORATION; LIGANDS; LIPOPOLYSACCHARIDES; LIVER; LUNG; MACROPHAGES; MALE; MICE; MICE, INBRED ICR; NF-KAPPA B; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; SEPSIS; SHOCK, SEPTIC;

EID: 0034203996     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200006000-00005     Document Type: Article

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