PGG-Glucan activates NF-κB-like and NF-IL-6-like transcription factor complexes in a murine monocytic cell line

Journal of Leukocyte Biology

Volumn 62, Issue 6, 1997, Pages 865-873

  Adams, David S ^a   Pero, Stephanie C ^a   Petro, J Benjamin ^a   Nathans, Robin ^b   Mackin, William M ^b   Wakshull, Eric ^b  

^a WORCESTER POLYTECHNIC INSTITUTE   (United States)

^b Alpha Beta Technology Inc   (United States)

Author keywords

BMC2.3 cell; Immunomodulator; Signal transduction

Indexed keywords

BETAFECTIN; GLUCAN; GLUCOSE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; NUCLEAR FACTOR; POLY BETA DEXTRO GLUCOPYRANOSYL BETA DEXTRO GLUCOPYRANOSE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ELECTROPHORETIC MOBILITY; IMMUNOMODULATION; MESSENGER RNA SYNTHESIS; MONOCYTE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTOSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0031471317     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.62.6.865     Document Type: Article

References (53)

1. Stone, B. A., Clarke, A. E. (1992) (1→3)-β-Glucans and animal defense mechanisms. In Chemistry and Biology of (1→3)-β-Glucans. Australia: La Trobe University Press, 525-564.
2. Bohn, J. A., BeMiller, J. N. (1995) (1→3)-D-Glucans as biological response modifiers: A review of structure-function activity relationships. Carbohydrate Polymers 28, 3-14.
3. Czop, J. K., Fearon, D. T., Austen, K. F. (1978) Opsonin-independent phagocytosis of activators of the alternative complement pathway by human monocytes. J. Immunol. 120, 1132-1138.
4. Roecklein, J. A., Swartz, R. P., Yeager, H., Jr. (1992) Non-opsonic uptake of Mycobacterium avium complex by human monocytes and alveolar macrophages. J. Lab. Clin. Med. 119, 772-781.
5. Cain, J. A., Newman, S. L., Ross, G. D. (1987) Role of complement receptor type three and serum opsonins in the neutrophil response to yeast. Complement 4, 75-86.
6. Czop, J. K., Austen, K. F. (1985a) A β-glucan inhibitable receptor on human monocytes: Its identity with the phagocytic receptor for particulate activators of the alternative complement pathway. J. Immunol. 134, 2588-2593.
7. Sherwood, E. R., Williams, D. L., DiLuzio, N. R. (1986) Glucan stimulates production of antitumor cytolytic-cytostatic factors by macrophages. J. Biol. Respir. Med. 6, 504-526.
8. Sherwood, E. R., Williams, D. L., McNamee, R. B., Jones, K. L., Browder, I. W., DiLuzio, N. R. (1987) Enhancement of interleukin-1 and interleukin-2 production of soluble glucan. Int. J. Immunopharmacol. 9, 261-267.
9. Seljelid, R., Figenschau, I., Bogwald, J., Rasmussen, L. T., Austgulen, R. (1989) Evidence that tumor necrosis induced by animated β1-3D polyglucose is mediated by a concerted action of local and systemic cytokines. Scand. J. Immunol. 30, 687-694.
10. Czop, J. K., Austen, K. F. (1985b) Generation of leukotrienes by human monocytes upon stimulation of their β-glucan receptor during phagocytosis. Proc. Natl. Acad. Sci. USA 82, 2751-2755.
11. Doita, M., Rasmussen, L. T., Seljelid, R., Lipsky, P. E. (1991) Effect of soluble animated β-1,3-D-polyglucose on human monocytes: Stimulation of cytokine and prostaglandin E-2 production but not antigen-presenting function. J. Leukoc. Biol. 49, 342-351.
12. Abel, G., Czop, J. K. (1992) Stimulation of human monocyte β-glucan receptors by glucan particles induces production of TNF-α and IL-1β. Int. J. Immunopharmacol. 14, 1363-1373.
13. Steadman, R., Petersen, M. M., Topley, N., Williams, D., Matthews, N., Spur, B., Williams, J. D. (1990) Differential augmentation by recombinant human TNF-α of neutrophil responses to particulate zymosan and glucan. J. Immunol. 144, 2712-2718.
14. Okazaki, M., Adachi, Y., Ohno, N., Yadomae, T. (1995) Structure-activity relationship of (1→3)-β-D-glucans in the induction of cytokine production from macrophages in vitro. Biol. Pharmacol. Bull. 18, 1320-1327.
15. 2-dependent and -independent mechanisms. Biochem. Pharmacol. 41, 1449-1454.
16. 2. J. Biol. Chem. 269, 19480-19487.
17. Tapper, H., Sundler, R. (1995) Protein kinase C and intracellular pH regulate zymosan-induced lysosomal enzyme secretion in macrophages. J. Leukoc. Biol. 58, 485-494.
18. Turner, N. C., Wood, L. J. (1994) Superoxide generation by guinea-pig peritoneal macrophages is inhibited by rolipram, staurosporine, and mepacrine in an agonist-dependent manner. Cell. Signal. 6, 923-931.
19. Glaser, K. B., Sung, A., Bauer, J., Weichman, B. M. (1993) Regulation of eicosanoid biosynthesis in the macrophage: Involvement of protein tyrosine phosphorylation and modulation by selective protein tyrosine kinase inhibitors. Biochem. Pharmacol. 45, 711-721.
20. + exchange activity during phagocytosis in human neutrophils: Role of Fcγ receptors and tyrosine kinases. J. Cell Biol. 132, 1037-1052.
21. Lyman, C. A., Simons, E. R., Melnick, D. A., Diamond, R. D. (1988) Induction of signal transduction in human neutrophils by Candida albicans hyphae: The role of pertussis toxin-sensitive guanosine triphosphate-binding proteins. J. Infect. Dis. 158, 1056-1064.
22. Hiemstra, P. S., Annema, A., Schippers, E. F., Van Furth, R. (1992) Pertussis toxin partially inhibits phagocytosis of immunoglobulin G-opsonized Staphylococcus aureus by human granulocytes but does not affect intracellular killing. Infect. Immun. 60, 202-205.
23. Bleicher, P., Mackin, W. (1995) Betafectin® PGG-Glucan: A novel carbohydrate immunomodulator with anti-infective properties. J. Biotech. Healthcare 2, 207-222.
24. Onderdonk, A. B., Cisneros, R. L., Hinkson, P., Ostroff, G. (1992) Anti-infective effect of poly-β1-6-glucotriosyl-β1-3-glucopyranose glucan in vivo. Infect. Immun. 60, 1642-1647.
25. Mackin, W., Brunke-Reese, D., Gu, Y., Crotty, C., Fisette, L. (1994) Enhanced microbicidal activities of human peripheral blood monocytes and neutrophils (PMN) after pre-treatment with PGG-Glucan (Betafectin). FASEB J. 8, 216a.
26. Stashenko, P., Wang, C. Y., Riley, E., Wu, Y., Ostroff, G., Niederman, R. (1995) Reduction of infection-stimulated periapical bone resorption by the biological response modifier PGG-Glucan. J. Dent. Res. 74, 323-330.
27. Wakshull, K., Correira, H., Sidloski, T. (1994) Synergistic stimulation of myeloid progenitor cell proliferation by a novel β-glucan and rmGM-CSF. J. Cell. Biochem. 18A (Suppl.), 22.
28. Poutsiaka, D. D., Mengozzi, M., Vannier, E., Sinha, B., Dinarello, C. A. (1993) Cross-linking of the β-glucan receptor on human monocytes results in interleukin-1 receptor antagonist but not interleukin-1 production. Blood 82, 3695-3700.
29. Kovacsovics-Bankowski, M., Rock, K. L. (1994) Presentation of exogenous antigens by macrophages: Analysis of major histocompatibility complex class I and II presentation and regulation by cytokines. Eur. J. Immunol. 24, 2421-2428.
30. Dignam, J. D., Lebovitz, R. M., Roeder, R. G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489.
31. Prywes, R., Roeder, R. G. (1986) Inducible binding of a factor to the c-fos enhancer. Cell 47, 777-784.
32. Kerr, L. D. (1995) Electrophoretic mobility shift assay. Meth. Enzymol. 254, 619-632.
33. Lenardo, M. J., Baltimore, D. (1989) NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control. Cell 58, 227-229.
34. Mahoney, C. W., Shuman, J., McKnight, S. L., Chen, H., Huang, K. (1992) Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site selective DNA binding. J. Biol. Chem. 267, 19396-19403.
35. Min, W., Pober, J. S., Johnson, D. R. (1996) Kinetically coordinated induction of TAP1 and HLA class I by IFNγ. J. Immunol. 156, 3174-3183.
36. Adams, D. S., Griffin, L. A., Nachajko, W. R., Reddy, V. B., Wei, C. (1991) A synthetic DNA encoding a modified human urokinase resistant to inhibition by serum plasminogen activator inhibitor. J. Biol. Chem. 266, 8476-8482.
37. Baldwin, A. S. (1996) The NF-κB and IκB proteins: New discoveries and insights. Annu. Rev. Immunol. 14, 649-683.
38. Sweet, M. J., Hume, D. A. (1996) Endotoxin signal transduction in macrophages. J. Leukoc. Biol. 60, 8-26.
39. Barnes, P. J., Karin, M. (1997) Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336, 1066-1071.
40. Lewis, H., Kaszubska, W., DeLamarter, J. F., Whelan, J. (1994) Cooperativity between two NF-κB complexes, mediated by high-mobility-group protein I(Y), is essential for cytokine-induced expression of the E-selectin promoter. Mol. Cell. Biol. 14, 5701-5709.
41. Ray, A., Ray, B. (1995) Lipopolysaccharide-mediated induction of the bovine interleukin-6 gene in monocytes requires both NF-κB and C/ EBP binding sites. DNA Cell Biol. 14, 795-802.
42. Petersen, U. M., Bjorklund, G., Ip, Y. T., Engstrom, Y. (1995) The dorsal-related immunity factor, Dif, is a sequence-specific trans-activator of Drosophila Cecropin gene expression. Eur. Mol. Biol. Org. J. 14, 3146-3158.
43. Leclair, K. P., Blanar, M. A., Sharp, P. A. (1992) The p50 subunit of NF-κB associates with the NF-IL6 transcription factor. Proc. Natl Acad. Sci. USA 89, 8145-8149.
44. Ruocco, M. R., Chen, X., Ambrosino, C., Dragonetti, E., Liu, W., Mallardo, M., DeFalco, G., Palmieri, C., Franzoso, G., Quinto, I., Venuta, S., Scala, G. (1996) Regulation of HIV-1 long terminal repeats by interaction of C/EBP (NF-IL6) and NF-κB/Rel transcription factors. J. Biol. Chem. 271, 22479-22486.
45. Kalkhoven, E., Wissink, S., Van Der Saag, P. T., Van Der Burg, B. (1996) Negative interaction between the RelA(p65) subunit of NF-κB and the progesterone receptor. J. Biol. Chem. 271, 6217-6224.
46. Thanos, D., Maniatis, T. (1992) The high mobility group protein HMG-1(Y) is required for NF-κB-dependent virus induction of the human IFN-γ gene. Cell 71, 777-789.
47. Hirai, H., Fujisawa, J., Suzuki, K., Ueda, K., Muramutsu, M., Tsuboi, A., Aral, N., Yoshida, M. (1992) Transcriptional activator Tax of HTLV-1 binds to the NF-κB precursor p 105. Oncogene 7, 1737-1742.
48. Tran-Thi, T. A., Decker, K., Baeuerle, P. A. (1995) Differential activation of transcription factors NF-κB and AP-1 in rat liver macrophages. Hepatol. 22, 613-619.
49. Akira, S. (1992) NF-IL-6 and gene regulation. Res. Immunol. 143, 734-736.
50. Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T., Akira, S. (1993) Transcription factors NF-IL-6 and NF-κB synergistically activate transcription of the inflammatory cytokines IL-6 and IL-8. Proc. Natl. Acad. Sci. USA 90, 10193-10197.
51. Kunsch, C., Ruben, S. M., Rosen, C. A. (1992) Selection of optimal κB/ Rel DNA-binding motifs: Interaction of both subunits of NF-κB with DNA is required for transcriptional activation. Mol. Cell. Biol. 12, 4412-4421.
52. Amoah-Apraku, B., Chandler, L. J., Harrison, J. K., Tang, S. S., Ingelfinger, J. R., Guzman, N. J. (1995) NF-κB and transcriptional control of renal epithelial-inducible nitric oxide synthase. Kidney Int. 48, 674-682.
53. d) mice respond to bacterial lipopolysaccharide by activating NF-κB. J. Leukoc. Biol. 57, 174-179.