Voluntary exercise augments acute effects of CB1-receptor inverse agonist on body weight loss in obese and lean mice

Pharmacology Biochemistry and Behavior

Volumn 77, Issue 1, 2004, Pages 117-125

  Zhou, Dan ^a,b   Shearman, Lauren P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Agouti mice; Cannabinoid; Food intake; ob ob mice; Obesity; Running wheels

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; AGOUTI PROTEIN; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; DRUG VEHICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APPETITE; ARTICLE; CONTROLLED STUDY; DARKNESS; DRUG EFFECT; EXERCISE; FEEDING; FEEDING BEHAVIOR; FOOD INTAKE; GENETIC MODEL; HYPOTHESIS; LEAN BODY WEIGHT; MOUSE; MOUSE STRAIN; NONHUMAN; OBESITY; PRIORITY JOURNAL; TREADMILL; WEIGHT GAIN; WEIGHT REDUCTION;

AGOUTI; MURINAE;

EID: 0346023969     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2003.10.015     Document Type: Article

References (57)

1. Alonso R., Voutsinos B., Fournier M., Labie C., Steinberg R., Souilhac J.et al. Blockade of cannabinoid receptors by SR141716 selectively increases Fos expression in rat mesocorticolimbic areas via reduced dopamine D2 function. Neuroscience. 91(2):1999;607-620.
2. Arner P. Impact of exercise on adipose tissue metabolism in humans. Int. J. Obes. Relat. Metab. Disord. 19(Suppl. 4):1995;S18-S21.
3. Arnone M., Maruani J., Chaperon F., Thiebot M.H., Poncelet M., Soubrie P.et al. Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors. Psychopharmacology (Berl). 132:1997;104-106.
4. Bartness T.J., Bamshad M. Innervation of mammalian white adipose tissue: implications for the regulation of total body fat. Am. J. Physiol. 275(5 Pt 2):1998;R1399-R1411.
5. Bartness T.J., Demas G.E., Song C.K. Seasonal changes in adiposity: the roles of the photoperiod, melatonin and other hormones, and sympathetic nervous system. Exp. Biol. Med. (Maywood). 227:2002;363-376.
6. Bensaid M., Gary-Bobo A.M., Esclangon A., Maffrand J.P., Le Fur G., Oury-Donat F.et al. The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Mol. Pharmacol. 63:2003;908-914.
7. Berrendero F., Garcia-Gil L., Hernandez M.L., Romero J., Cebeira M., de Miguel R.et al. Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development. Development. 125:1998;3179-3188.
8. Bulow J., Madsen J. Adipose tissue blood flow during prolonged, heavy exercise. Pflugers Arch. 363:1976;231-234.
9. Collin M., Hakansson-Ovesjo M., Misane I., Ogren S.O., Meister B. Decreased 5-HT transporter mRNA in neurons of the dorsal raphe nucleus and behavioral depression in the obese leptin-deficient ob/ob mouse. Mol. Brain Res. 81:2000;51-61.
10. Colombo G., Agabio R., Diaz G. Appetite suppression and weight loss after the cannabinoid antagonist SR141716. Life Sci. 63:1998;113-117.
11. Correia M.L.G., Haynes W.G., Rahmouni K., Morgan D.A., Sivitz W.I., Mark A.L. The concept of selective leptin reistance. Evidence from agouti yellow obese mice. Diabetes. 51:2002;439-442.
12. Cota D., Marsicano G., Tschop M., Grubler Y., Flachskamm C., Schubert M.et al. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipolysis. J. Clin. Invest. 112:2003;423-431.
13. Deroche-Gamonet V., Le Moal M., Piazza P.V., Soubrie P. SR141716, a CB1 receptor antagonist, decreases the sensitivity to the reinforcing effects of electrical brain stimulation in rats. Psychopharmacology. 157:2001;254-259.
14. y mice by certain stressors: a cautionary note. Neuroendocrinology. 72:2002;126-132.
15. Di Marzo V., Goparaju S.K., Wang L., Liu J., Batkai S., Jarai Z.et al. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. 410:2001;822-825.
16. Elam M., Svensson T.H., Thoren P. Brain monoamine metabolism is altered in rats following spontaneous, long-distance running. Acta Physiol. Scand. 130:1987;313-316.
17. Fan W., Boston B.A., Kesterson R.A., Hruby V.J., Cone R.D. Role of the melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 385:1997;165-168.
18. Foltin R.W., Fischman M.W., Byrne M.F. Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory. Appetite. 11:1988;1-14.
19. Friedman J.M., Halaas J.L. Leptin and the regulation of body weight in mammals. Nature. 395:1998;763-767.
20. Halaas J.L., Boozer C., Blair-West J., Fidahusein N., Denton D.A., Friedman J.M. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. U. S. A. 94:1997;8878-8883.
21. Harri M., Lindblom J., Malinen H., Hyttinen M., Lapvetelainen T., Eskola S.et al. Effect of access to a running wheel on behavior of C57BL/6J mice. Lab. Anim. Sci. 49:1999;401-405.
22. Harris R.B., Mitchell T.D., Mynatt R.L. Leptin responsiveness in mice that ectopically express agouti protein. Physiol. Behav. 75:2002;159-167.
23. Harrold J.A., Elliott J.C., King P.J., Widdowson P.S., Williams G. Down-regulation of cannabinoid (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: a role for endogenous cannabinoids in driving appetite for palatable food? Brain Res. 952:2002;232-238.
24. Herkenham M., Lynn A.B., Johnson M.R., Melvin L.S., de Costa B.R., Rice K.C. Characterization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiography study. J. Neurosci. 11:1991;563-583.
25. Hildebrandt A.L., Kelly-Sullivan D.M., Black S.C. Antiobesity effects of chronic cannabinoid CB1R antagonist treatment in diet-induced obese mice. Eur. J. Pharmacol. 462:2003;125-132.
26. Hoffmann P., Terenius L., Thoren P. Cerebrospinal fluid immunoreactive beta-endorphin concentration is increased by voluntary exercise in the spontaneously hypertensive rat. Regul. Pept. 28:1990;233-239.
27. Horowitz J.F. Regulation of lipid mobilization and oxidation during exercise in obesity. Exerc. Sport Sci. Rev. 29:2001;42-46.
28. Jamshidi N., Taylor D.A. Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. Br. J. Pharmacol. 134:2001;1151-1154.
29. Kirkham T.C., Williams C.M. Endogenous cannabinoids and appetite. Nutr. Res. Rev. 14:2001;65-86.
30. Kirkham T.C., Williams C.M., Fezza F., Di Marzo V. Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. Br. J. Pharmacol. 136:2002;550-557.
31. Koch J.E. Delta(9)-THC stimulates food intake in Lewis rats: effects on chow, high-fat and sweet high-fat diets. Pharmacol. Biochem. Behav. 68:2001;539-543.
32. Matsuda L.A., Bonner T.I., Lolait S.J. Localization of cannabinoid receptor mRNA in rat brain. J. Comp. Neurol. 327:1993;535-550.
33. Mattes R.D., Engelman K., Shaw L.M., Elsohly M.A. Cannabinoids and appetite stimulation. Pharmacol. Biochem. Behav. 49:1994;187-195.
34. Niederhoffer N., Hansen H.H., Fernandez-Ruiz J.J., Szabo B. Effects of cannabinoids on adrenaline release from adrenal medullary cells. Br. J. Pharmacol. 134:2001;1319-1327.
35. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T.et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:1995;540-543.
36. Raben A., Andersen H.B., Christensen N.J., Madsen J., Holst J.J., Astrup A. Evidence for an abnormal postprandial response to a high-fat meal in women predisposed to obesity. Am. J. Physiol. 267(4 Pt 1):1994;E549-E559.
37. Rahmouni K., Haynes W.G., Morgan D.A., Mark A.L. Selective resistance to central neural administration of leptin in agouti obese mice. Hypertension. 39(2 Pt 2):2002;486-490.
38. Ranneries C., Bulow J., Buemann B., Christensen N.J., Madsen J., Astrup A. Fat metabolism in formerly obese women. Am. J. Physiol. 274(1 Pt 1):1998;E155-E161.
39. Ravinet-Trillou C., Arnone M., Delgorge C., Gonalons N., Keane P., Maffrand J.-P.et al. Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. Am. J. Physiol., Regul. Integr. Comp. Physiol. 284:2003;R345-R353.
40. Ravussin E., Smith S.R. Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus. Ann. N. Y. Acad. Sci. 967:2002;363-378.
41. Rinaldi-Carmona M., Barth F., Heaulme M., Shier D., Calandra B., Congy C.et al. SR141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset. FEBS Lett. 350:1994;240-244.
42. Santucci V., Storme J.-J., Soubrie P., Le Fur G. Arousal-enhancing properties of the CB1 cannabinoid receptor antagonist SR141716A in rats as assessed by electroencephalographic spectral and sleep-waking cycle analysis. Life Sci. 58:1996;PL103-PL110.
43. Seeley R.J., Yagaloff K.A., Fisher S.L., Burn P., Thiele T.E., van Dijk G.et al. Melanocortin receptors in leptin effects. Nature. 390:1997;349.
44. Sherwin C.M. Voluntary wheel running: a review and novel interpretation. Anim. Behav. 56:1998;11-27.
45. Simiand J., Keane M., Keane P.E., Soubrie P. SR 141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset. Behav. Pharmacol. 9:1998;179-181.
46. Stewart K.T., Rosenwasser A.M., Adler N.T. Interactions between nocturnal feeding and wheel running patterns in the rat. Physiol. Behav. 34:1985;601-608.
47. Stich V., de Glisezinski I., Berlan M., Bulow J., Galitzky J., Harant I.et al. Adipose tissue lipolysis is increased during a repeated bout of aerobic exercise. J. Appl. Physiol. 88:2000;1277-1283.
48. Tzavara E.T., Perry K.W., Rodriguez D.E., Bymaster F.P., Nomikos G.G. The cannabinoid CB(1) receptor antagonist SR141716A increases norepinephrine outflow in the rat anterior hypothalamus. Eur. J. Pharmacol. 426:2001;R3-R4.
49. Tzavara E.T., Davis R.J., Perry K.W., Li X., Salhof C., Bymaster F.P.et al. The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions. Brit. J. Pharmacol. 138:2003;544-553.
50. Vickers S.P., Webster L.J., Wyatt A., Dourish C.T., Kennett G.A. Preferential effects of the cannabinoid CB1 receptor antagonist, SR141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats. Psychopharmacology (Berl). 167:2003;103-111.
51. Werme M., Thoren P., Olson L., Brene S. Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen. Eur. J. Neurosci. 12:2000;2967-2974.
52. Williams C.M., Kirkham T.C. Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors. Psychopharmacology (Berl). 143:1999;315-317.
53. Williams C.M., Kirkham T.C. Reversal of delta 9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine. Pharmacol. Biochem. Behav. 71:2002;333-340.
54. Williams C.M., Kirkham T.C. Observational analysis of feeding induced by Delta(9)-THC and anandamide. Physiol. Behav. 76:2002;241-250.
55. Williams C.M., Rogers P.J., Kirkham T.C. Hyperphagia in pre-fed rats following oral delta-9-THC. Physiol. Behav. 65(2):1998;343-346.
56. Zhang Y., Proenca R., Maffel M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.
57. Zimmer A., Zimmer A.M., Hohmann A.G., Herkenham M., Bonner T.I. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc. Natl. Acad. Sci. U. S. A. 96:1999;5780-5785.