Interplay of Cu,Zn Superoxide Dismutase and Nitric Oxide Synthase in Neurodegenerative Processes

IUBMB Life

Volumn 55, Issue 10-11, 2003, Pages 629-634

  Rotilio, Giuseppe ^a   Aquilano, Karia ^a   Ciriolo, Maria Rosa ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

ALS; Carbonyls; Nitric oxide; nNOS; Proteasome; ROS

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE;

AMYOTROPHIC LATERAL SCLEROSIS; ENZYME ACTIVITY; HUMAN; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; REVIEW;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL LINE, TUMOR; CYSTEINE ENDOPEPTIDASES; HUMANS; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; MUTATION; NEURODEGENERATIVE DISEASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN; PROTEASOME ENDOPEPTIDASE COMPLEX; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 0345731023     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540310001628717     Document Type: Review

References (38)

1. Curtin, J. F., Donovan, M., and Cotter, T. G. (2002) Regulation and measurement of oxidative stress in apoptosis. J. Immunol. Methods 265, 49-72.
2. Beckman, J. S., and Lancaster, J., eds. (1996) Nitric oxide: Principle and Actions. Academic Press, San Diego.
3. Nauser, T., and Koppenol, W. H. (2002) The rate constant of the reaction of superoxide with nitrogen monoxide: approaching the diffusion limit. J. Phys. Chem. 106, 4084-4086.
4. Halliwell, B. and Gutteridge, J. M. C. (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Meth. Enzymol. 186, 1-85.
5. Floyd, R. A. (1999) Antioxidant, oxidative stress, and degenerative neurological disorders. Proc. Soc. Exp. Biol. Med. 222, 236-245.
6. Rotilio, G., Carri, M. T., Rossi, L., and Ciriolo, M. R. (2000) Copper-dependent oxidative stress and neurodegeneration. IUBMB Life 50, 309-314.
7. Slivka, A., Spina, M. B., and Cohen G. (1987) Reduced and oxidized glutathione in human and monkey brain. Neurosci Lett. 74, 112-118.
8. Aksenov, M. Y., Tucker, H. M., Nair, P., Aksenova, M. V., Butterfield, D. A., Estus, S., and Markesbery, W. R. (1998) The expression of key oxidative stress-handling genes in different brain regions in Alzheimer's disease. J. Mol. Sci. 11, 151-164.
9. de Haan, J. B., Newman, J. D., and Kola, I. (1992) Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains. Brain Res. Mol. Brain Res. 13, 179-187.
10. Roe, J. A., Wiedau-Pazos, M., Moy, V. N., Goto, J. L., Gralla, E. B., and Valentine J. (2002) In vivo peroxidative activity of FALS-mutant human Cu, Zn SODs expressed yeast. Free Rad. Biol. Med. 32, 169-174.
11. Urushitani, M., and Shimohama, S. (2002) The role of nitric oxide in amyotrophic lateral sclerosis Amyotroph. Lateral Scler. Other Motor Neuron Disord. 2, 71-81.
12. Ischiropoulos, H., and Beckman, J.S. (2003) Oxidative stress and nitration in neurodegeneration: cause, effect, or association? J. Clin. Invest. 111, 163-169.
13. Morrison, B. M., and Morrison, J. H. (1999) Amyotrophic lateral sclerosis associated with mutations in superoxide dismutase: a putative mechanism of degeneration. Brain Res Brain Res Rev. 29, 121-135.
14. Spooren, W. P., and Henger, B. (2000) DNA laddering and caspase 3-like activity in the spinal cord of a mouse model of familial amyotrophic lateral sclerosis. Cell Mol. Biol. 46, 63-69.
15. Julien, J. (2001) Amyotrophic lateral sclerosis: unfolding the toxicity of the misfolded. Cell 104, 581-591.
16. Carri, M. T., Ferri, A., Battistoni, A., Famhy, L., Gabbianelli, R., Poccia, F., and Rotilio G. (1997) Expression of a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis induces mitochondrial alteration and increase of cytosolic Ca2 + concentration in transfected neuroblastoma SH-SY5Y cells. FEBS Lett. 414, 365-368.
17. Ciriolo, M. R., Aquilano, K., De Martino, A., Carri, M. T., and Rotilio G. (2001) Differential role of superoxide and glutathione in S-nitrosoglutathione-mediated apoptosis: a rationale for mild forms of familial amyotrophic lateral sclerosis associated with less active Cu,Zn superoxide dismutase mutants. J Neurochem. 77, 1433-1443.
18. Ciriolo, M. R., De Martino, A., Lafavia, E., Rossi, L., Carri, M. T., and Rotilio G. (2000) Cu,Zn-superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells. J. Biol. Chem. 275, 5065-5072.
19. Aquilano, K., Rotilio, G., and Ciriolo, M. R. (2003) Proteasome activation and nNOS down-regulation in neuroblastoma cells expressing a Cu,Zn superoxide dismutase mutant involved in familial ALS. J. Neurochem. 85, 1324-1335.
20. Wu, A. S., Kiaei, M., Aguirre, N., Crow, J. P., Calingasan. N. Y., Browne, S. E., and Beal, M. F. (2003) Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis. J. Neurochem. 85, 142-150.
21. Boll, M. C., Alcaraz-Zubeldia, M., Montes, S., Murillo-Bonilla, L., and Rios, C. (2003) Raised nitrate concentration and low SOD activity in the CSF of sporadic ALS patients. Neurochem. Res. 28. 699-703.
22. Sasaki, S., Shibata, N., Komori, T., and Iwata, M. (2000) iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis. Neurosci. Lett. 291, 44-48.
23. Anneser, J. M., Cookson, M. R., Ince, P. G., Shaw, P. J., and Borasio, G. D. (2001) Glial cells of the spinal cord and subcortical white matter up-regulate neuronal nitric oxide synthase in sporadic amyotrophic lateral sclerosis. Exp. Neurol. 171, 418-421.
24. Beal, M. F., Ferrante, R. J., Browne, S. E., Matthews, R. T., Kowall, N. W., and Brown, R. H. (1997) Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann. Neurol. 42, 644-654.
25. Beckman, J. S., Carson, M., Smith, C. D., and Koppenohl, W. H. (1993) ALS, SOD and peroxynitrite. Nature 364, 584.
26. Lee, M., Hyun, D., Jenner, P., and Hallywell, B. (2001) Effect of proteasome inhibition on cellular oxidative damage, antioxidant defence and nitric oxide production. J. Neurochem. 78, 32-41.
27. Keller, J. N., Hanni, K. B., and Markesbery, W. R. (2000) Impaired proteasome function in Alzheimer's disease. J. Neurochem. 75, 436-439.
28. Lopez Salon, M., Morelli, L., Castano, E. M., Soto, E. F., and Pasquini, J. M. (2000) Defective ubiquitination of cerebral proteins in Alzheimer's disease. J. Neurosci. Res. 62, 302-310.
29. McNaught, K. S., and Jenner, P. (2001) Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neurosci. Lett. 297, 191-194.
30. Ding, Q. and Keller, J. N. (2001) Proteasome and proteasome inhibition in the central nervous system. Free Rad. Biol. Med. 31, 574-584.
31. Keller, J. N., Hanni, K. B., and Markesbery, W. R. (2000) Possible involvement of proteasome inhibition in aging: implications for oxidative stress. Mech. Ageing Dev. 113, 61-70.
32. Allen, S., Heath, P. R., Kirby, J., Wharton, S. B., Cookson, M. R., Menzies, F. M., Banks, R. E., and Shaw, P. J. (2003) Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways. J. Biol. Chem. 278, 6371-6383.
33. Urushitani, M., Kurisu, J., Tsukita, K., and Takahashi, R. (2002) Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis. J. Neurochem. 83, 1030-1042.
34. Halliwell, B. (2002) Hypothesis: proteasomal dysfunction: a primary event in neurogeneration that leads to nitrative and oxidative stress and subsequent cell death. Ann. N. Y. Acad. Sci. 962, 182-194.
35. Reinheckel, T., Sitte, N., Ullrich, O., Knuckelkorn, U., and Davies, K. J. (1998) Comparative resistance of the 20S and 26S proteasome to oxidative stress. Biochem. J. 335, 637-642.
36. Strack, P. R., Waxman, L., and Fagan, J. M. (1996) Activation of the multicatalytic endopeptidase by oxidants. Effects on the enzyme structure. Biochemistry. 35, 7142-7149.
37. Bender, A. T., Demady, D. R., and Osawa, Y. (2000) Ubiquitination of neuronal nitric-oxide synthase in vitro and in vivo. J. Biol. Chem. 275, 17407-17411.
38. Noguchi, S., Jianmongkol, S., Bender, A. T., Kamada, Y., Demady, D. R., and Osawa, Y. J. (2000) Guanabenz-mediated inactivation and enhanced proteolytic degradation of neuronal nitric-oxide synthase. J. Biol. Chem. 275, 2376-2380.