Cyclic phosphinamides and phosphonamides, novel series of potent matrix metalloproteinase inhibitors with antitumour activity

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 24, 2003, Pages 5461-5484

  Sørensen, Morten Dahl ^a   Blæhr, Lars K A ^a   Christensen, Mette K ^a   Høyer, Thomas ^a   Latini, Scilla ^a   Hjarnaa, Pernille Julia V ^a   Björkling, Fredrik ^a  

^a LEO PHARMA A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC PHOSPHINAMIDE DERIVATIVE; CYCLIC PHOSPHONAMIDE DERIVATIVE; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE INHIBITOR; N HYDROXY 2 [4 (4 BROMOPHENOXY)PHENYL] 2 OXO 1,3,2 OXAZAPHOSPHOREPAN 3 ACETAMIDE; N HYDROXY 2 [4 (4 CHLOROPHENOXY)PHENYL] 2 OXO 1,3,2 OXAZAPHOSPHOREPAN 3 ACETAMIDE; N HYDROXY 2 [4 (4 CHLOROPHENOXY)PHENYL] 2 OXOAZAPHOSPHORIN 4 EN 1 ACETAMIDE; N HYDROXY 2 [4 (4 CHLOROPHENYLOXY)PHENYL] ALPHA (2 METHYLETHYL) 2 OXO 1,3,2 OXAZAPHOSPHORINAN 3 ACETAMIDE; PRINOMASTAT; STROMELYSIN; UNCLASSIFIED DRUG; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CHIRALITY; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; FEMALE; FIBROSARCOMA; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOLECULAR MODEL; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH; WEIGHT REDUCTION; X RAY ANALYSIS;

EID: 0344851558     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.09.015     Document Type: Article

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