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Volumn 74, Issue 5, 2003, Pages 782-793

An Antisense Construct Reduces N-Methyl-D-Aspartate Receptor 2A Expression and Receptor-Mediated Excitotoxicity as Determined by a Novel Flow Cytometric Approach

Author keywords

Antisense; Excitotoxicity; Flow cytometry; Green fluorescent protein; N methyl D aspartate receptor

Indexed keywords

HYBRID PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT; YELLOW FLUORESCENT PROTEIN;

EID: 0344430260     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10793     Document Type: Article
Times cited : (3)

References (62)
  • 1
    • 0034607753 scopus 로고    scopus 로고
    • N-methyl-D-aspartate receptor mediated toxicity in nonneuronal cell lines: Characterization using fluorescent measures of cell viability and reactive oxygen species production
    • Anegawa NJ, Guttmann RP, Grant ER, Anand R, Lindstrom J, Lynch DR. 2000. N-methyl-D-aspartate receptor mediated toxicity in nonneuronal cell lines: characterization using fluorescent measures of cell viability and reactive oxygen species production. Brain Res Mol Brain Res 77: 163-175.
    • (2000) Brain Res Mol Brain Res , vol.77 , pp. 163-175
    • Anegawa, N.J.1    Guttmann, R.P.2    Grant, E.R.3    Anand, R.4    Lindstrom, J.5    Lynch, D.R.6
  • 2
    • 0028934398 scopus 로고
    • Transfection of N-methyl-D-aspartate receptors in a nonneuronal cell line leads to cell death
    • Anegawa NJ, Lynch DR, Verdoorn TA, Pritchett DB. 1995. Transfection of N-methyl-D-aspartate receptors in a nonneuronal cell line leads to cell death. J Neurochem 64:2004-2012.
    • (1995) J Neurochem , vol.64 , pp. 2004-2012
    • Anegawa, N.J.1    Lynch, D.R.2    Verdoorn, T.A.3    Pritchett, D.B.4
  • 3
    • 0032724911 scopus 로고    scopus 로고
    • Novel mechanisms for antisense-mediated regulation of gene expression
    • Baker BF, Monia BP. 1999. Novel mechanisms for antisense-mediated regulation of gene expression. Biochim Biophys Acta 1489:3-18.
    • (1999) Biochim Biophys Acta , vol.1489 , pp. 3-18
    • Baker, B.F.1    Monia, B.P.2
  • 4
    • 0027476024 scopus 로고
    • A synaptic model of memory: Long-term potentiation in the hippocampus
    • Bliss TV, Collingridge GL. 1993. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
    • (1993) Nature , vol.361 , pp. 31-39
    • Bliss, T.V.1    Collingridge, G.L.2
  • 6
    • 0032055026 scopus 로고    scopus 로고
    • Glutamate receptors are expressed by bone cells and are involved in bone resorption
    • Chenu C, Serre CM, Raynal C, Burt-Pichat B, Delmas PD. 1998. Glutamate receptors are expressed by bone cells and are involved in bone resorption. Bone 22:295-299.
    • (1998) Bone , vol.22 , pp. 295-299
    • Chenu, C.1    Serre, C.M.2    Raynal, C.3    Burt-Pichat, B.4    Delmas, P.D.5
  • 7
    • 0028973158 scopus 로고
    • Cloning and characterization of chi-1: A developmentally regulated member of a novel class of the ionotropic glutamate receptor family
    • Ciabarra AM, Sullivan JM, Gahn LG, Pecht G, Heinemann S, Sevarino KA. 1995. Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. J Neurosci 15:6498-6508.
    • (1995) J Neurosci , vol.15 , pp. 6498-6508
    • Ciabarra, A.M.1    Sullivan, J.M.2    Gahn, L.G.3    Pecht, G.4    Heinemann, S.5    Sevarino, K.A.6
  • 8
    • 0032700656 scopus 로고    scopus 로고
    • Molecular mechanisms of action of antisense drugs
    • Crooke ST. 1999. Molecular mechanisms of action of antisense drugs. Biochim Biophys Acta 1489:31-44.
    • (1999) Biochim Biophys Acta , vol.1489 , pp. 31-44
    • Crooke, S.T.1
  • 9
    • 0035369112 scopus 로고    scopus 로고
    • NMDA receptor subunits: Diversity, development and disease
    • Cull-Candy S, Brickley S, Farrant M. 2001. NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 11:327-335.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 327-335
    • Cull-Candy, S.1    Brickley, S.2    Farrant, M.3
  • 11
    • 0032967382 scopus 로고    scopus 로고
    • The role of excitotoxicity in neurodegenerative disease: Implications for therapy
    • Doble A. 1999. The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacol Ther 81:163-221.
    • (1999) Pharmacol Ther , vol.81 , pp. 163-221
    • Doble, A.1
  • 12
    • 0031664003 scopus 로고    scopus 로고
    • Pathophysiological mechanisms of central neuropathic pain after spinal cord injury
    • Eide PK. 1998. Pathophysiological mechanisms of central neuropathic pain after spinal cord injury. Spinal Cord 36:601-612.
    • (1998) Spinal Cord , vol.36 , pp. 601-612
    • Eide, P.K.1
  • 13
    • 0024365739 scopus 로고
    • The role of excitatory amino acids and NMDA receptors in traumatic brain injury
    • Faden AI, Demediuk P, Panter SS, Vink R. 1989. The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 244:798-800.
    • (1989) Science , vol.244 , pp. 798-800
    • Faden, A.I.1    Demediuk, P.2    Panter, S.S.3    Vink, R.4
  • 14
    • 0035918465 scopus 로고    scopus 로고
    • In vivo control of NMDA receptor transcript level in motoneurons by viral transduction of a short antisense gene
    • Finegold AA, Perez FM, Iadarola MJ. 2001. In vivo control of NMDA receptor transcript level in motoneurons by viral transduction of a short antisense gene. Brain Res Mol Brain Res 90:17-25.
    • (2001) Brain Res Mol Brain Res , vol.90 , pp. 17-25
    • Finegold, A.A.1    Perez, F.M.2    Iadarola, M.J.3
  • 15
    • 0344519489 scopus 로고    scopus 로고
    • Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice
    • Fukaya M, Kato A, Lovett C, Tonegawa S, Watanabe M. 2003. Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc Natl Acad Sci USA 100:4855-4860.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4855-4860
    • Fukaya, M.1    Kato, A.2    Lovett, C.3    Tonegawa, S.4    Watanabe, M.5
  • 16
    • 0035366509 scopus 로고    scopus 로고
    • The NR1 subunit of the N-methyl-D-aspartate receptor can be efficiently expressed alone in the cell surface of mammalian cells and is required for the transport of the NR2A subunit
    • Garcia-Gallo M, Renart J, Diaz-Guerra M. 2001. The NR1 subunit of the N-methyl-D-aspartate receptor can be efficiently expressed alone in the cell surface of mammalian cells and is required for the transport of the NR2A subunit. Biochem J 356:539-547.
    • (2001) Biochem J , vol.356 , pp. 539-547
    • Garcia-Gallo, M.1    Renart, J.2    Diaz-Guerra, M.3
  • 17
    • 0033013541 scopus 로고    scopus 로고
    • NMDA receptor subunit gene expression in the rat brain: A quantitative analysis of endogenous mRNA levels of NK1Com, NK2A, NK2B, NK2C, NK2D and NK3A
    • Goebel DJ, Poosch MS. 1999. NMDA receptor subunit gene expression in the rat brain: a quantitative analysis of endogenous mRNA levels of NK1Com, NK2A, NK2B, NK2C, NK2D and NK3A. Brain Res Mol Brain Res 69:164-170.
    • (1999) Brain Res Mol Brain Res , vol.69 , pp. 164-170
    • Goebel, D.J.1    Poosch, M.S.2
  • 19
    • 0034041222 scopus 로고    scopus 로고
    • The use of NMDA-receptor antagonists in the treatment of chronic pain
    • Hewitt DJ. 2000. The use of NMDA-receptor antagonists in the treatment of chronic pain. Clin J Pain 16(Suppl):73-79.
    • (2000) Clin J Pain , vol.16 , Issue.SUPPL. , pp. 73-79
    • Hewitt, D.J.1
  • 20
    • 0034022527 scopus 로고    scopus 로고
    • A multi-mutant herpes simplex virus vector has minimal cytotoxic effects on the distribution of filamentous actin, alpha-actinin 2 and a glutamate receptor in differentiated PC12 cells
    • Holmes KD, Cassam AK, Chan B, Peters AA, Weaver LC, Dekaban GA. 2000. A multi-mutant herpes simplex virus vector has minimal cytotoxic effects on the distribution of filamentous actin, alpha-actinin 2 and a glutamate receptor in differentiated PC12 cells. J Neurovirol 6:33-45.
    • (2000) J Neurovirol , vol.6 , pp. 33-45
    • Holmes, K.D.1    Cassam, A.K.2    Chan, B.3    Peters, A.A.4    Weaver, L.C.5    Dekaban, G.A.6
  • 21
    • 0037059768 scopus 로고    scopus 로고
    • The N-methyl-D-aspartate receptor splice variant NR1-4 C-terminal domain. Deletion analysis and role in subcellular distribution
    • Holmes KD, Mattar PA, Marsh DR, Weaver LC, Dekaban GA. 2002a. The N-methyl-D-aspartate receptor splice variant NR1-4 C-terminal domain. Deletion analysis and role in subcellular distribution, J Biol Chem 277:1457-1468.
    • (2002) J Biol Chem , vol.277 , pp. 1457-1468
    • Holmes, K.D.1    Mattar, P.A.2    Marsh, D.R.3    Weaver, L.C.4    Dekaban, G.A.5
  • 22
    • 0036316743 scopus 로고    scopus 로고
    • The C-terminal C1 cassette of the N-methyl-D-aspartate receptor 1 subunit contains a bi-partite nuclear localization sequence
    • Holmes KD, Mattar P, Marsh DR, Jordan V, Weaver LC, Dekaban GA. 2002b. The C-terminal C1 cassette of the N-methyl-D-aspartate receptor 1 subunit contains a bi-partite nuclear localization sequence. J Neurochem 81:1152-1165.
    • (2002) J Neurochem , vol.81 , pp. 1152-1165
    • Holmes, K.D.1    Mattar, P.2    Marsh, D.R.3    Jordan, V.4    Weaver, L.C.5    Dekaban, G.A.6
  • 23
    • 0032923309 scopus 로고    scopus 로고
    • Turnover analysis of glutamate receptors identifies a rapidly degraded pool of the N-methyl-D-aspartate receptor subunit, NR1, in cultured cerebellar granule cells
    • Huh KH, Wenthold RJ. 1999. Turnover analysis of glutamate receptors identifies a rapidly degraded pool of the N-methyl-D-aspartate receptor subunit, NR1, in cultured cerebellar granule cells. J Biol Chem 274:151-157.
    • (1999) J Biol Chem , vol.274 , pp. 151-157
    • Huh, K.H.1    Wenthold, R.J.2
  • 27
    • 0034859802 scopus 로고    scopus 로고
    • The NMDA receptor complex: A promising target for novel antiepileptic strategies
    • Kohl BK, Dannhardt G. 2001. The NMDA receptor complex: a promising target for novel antiepileptic strategies. Curr Med Chem 8:1275-1289.
    • (2001) Curr Med Chem , vol.8 , pp. 1275-1289
    • Kohl, B.K.1    Dannhardt, G.2
  • 28
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 29
    • 0032543711 scopus 로고    scopus 로고
    • Analysis of a multi-mutant herpes simplex virus type 1 for gene transfer into sympathetic preganglionic neurons and a comparison to adenovirus vectors
    • LeVatte MA, Cassam AK, Dekaban GA, Weaver LC. 1998. Analysis of a multi-mutant herpes simplex virus type 1 for gene transfer into sympathetic preganglionic neurons and a comparison to adenovirus vectors. Neuroscience 86:1321-1336.
    • (1998) Neuroscience , vol.86 , pp. 1321-1336
    • LeVatte, M.A.1    Cassam, A.K.2    Dekaban, G.A.3    Weaver, L.C.4
  • 30
    • 0030806185 scopus 로고    scopus 로고
    • Gene transfer into sympathetic preganglionic neurons in vivo using a non-replicating thymidine kinase-deficient herpes simplex virus type 1
    • LeVatte MA, Dekaban GA, Weaver LC. 1997. Gene transfer into sympathetic preganglionic neurons in vivo using a non-replicating thymidine kinase-deficient herpes simplex virus type 1. Neuroscience 80:893-906.
    • (1997) Neuroscience , vol.80 , pp. 893-906
    • LeVatte, M.A.1    Dekaban, G.A.2    Weaver, L.C.3
  • 31
    • 0033365738 scopus 로고    scopus 로고
    • Casein kinase-II regulates NMDA channel function in hippocampal neurons
    • Lieberman DN, Mody I. 1999. Casein kinase-II regulates NMDA channel function in hippocampal neurons. Nat Neurosci 2:125-132.
    • (1999) Nat Neurosci , vol.2 , pp. 125-132
    • Lieberman, D.N.1    Mody, I.2
  • 34
    • 0036120942 scopus 로고    scopus 로고
    • Functional expression of distinct NMDA channel subunits tagged with green fluorescent protein in hippocampal neurons in culture
    • Luo JH, Fu ZY, Losi G, Kim BG, Prybylowski K, Vissel B, Vicini S. 2002. Functional expression of distinct NMDA channel subunits tagged with green fluorescent protein in hippocampal neurons in culture. Neuropharmacology 42:306-318.
    • (2002) Neuropharmacology , vol.42 , pp. 306-318
    • Luo, J.H.1    Fu, Z.Y.2    Losi, G.3    Kim, B.G.4    Prybylowski, K.5    Vissel, B.6    Vicini, S.7
  • 35
    • 33751285255 scopus 로고    scopus 로고
    • Role of spinal NMDA and AMPA receptors in episodic hypertension in conscious spinal rats
    • Maiorov DN, Krenz NR, Krassioukov AV, Weaver LC. 1997. Role of spinal NMDA and AMPA receptors in episodic hypertension in conscious spinal rats. Am J Physiol 273:1266-1274.
    • (1997) Am J Physiol , vol.273 , pp. 1266-1274
    • Maiorov, D.N.1    Krenz, N.R.2    Krassioukov, A.V.3    Weaver, L.C.4
  • 36
    • 0033578855 scopus 로고    scopus 로고
    • Long-term potentiation - A decade of progress?
    • Malenka RC, Nicoll RA. 1999. Long-term potentiation - a decade of progress? Science 285:1870-1874.
    • (1999) Science , vol.285 , pp. 1870-1874
    • Malenka, R.C.1    Nicoll, R.A.2
  • 37
    • 0028809337 scopus 로고
    • The jellyfish green fluorescent protein: A new tool for studying ion channel expression and function
    • Marshall J, Molloy R, Moss GW, Howe JR, Hughes TE. 1995. The jellyfish green fluorescent protein: a new tool for studying ion channel expression and function. Neuron 14:211-215.
    • (1995) Neuron , vol.14 , pp. 211-215
    • Marshall, J.1    Molloy, R.2    Moss, G.W.3    Howe, J.R.4    Hughes, T.E.5
  • 38
    • 0030610604 scopus 로고    scopus 로고
    • Absence of prostaglandin E2-induced hyperalgesia in NMDA receptor epsilon subunit knockout mice
    • Minami T, Sugatani J, Sakimura K, Abe M, Mishina M, Ito S. 1997. Absence of prostaglandin E2-induced hyperalgesia in NMDA receptor epsilon subunit knockout mice. Br J Pharmacol 120:1522-1526.
    • (1997) Br J Pharmacol , vol.120 , pp. 1522-1526
    • Minami, T.1    Sugatani, J.2    Sakimura, K.3    Abe, M.4    Mishina, M.5    Ito, S.6
  • 39
    • 0028343648 scopus 로고
    • Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
    • Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH. 1994. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12:529-540.
    • (1994) Neuron , vol.12 , pp. 529-540
    • Monyer, H.1    Burnashev, N.2    Laurie, D.J.3    Sakmann, B.4    Seeburg, P.H.5
  • 40
    • 0032400783 scopus 로고    scopus 로고
    • Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor
    • Morikawa E, Mori H, Kiyama Y, Mishina M, Asano T, Kirino T. 1998. Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor. J Neurosci 18:9727-9732.
    • (1998) J Neurosci , vol.18 , pp. 9727-9732
    • Morikawa, E.1    Mori, H.2    Kiyama, Y.3    Mishina, M.4    Asano, T.5    Kirino, T.6
  • 41
    • 0035650937 scopus 로고    scopus 로고
    • Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner
    • Nishi M, Hinds H, Lu HP, Kawata M, Hayashi Y. 2001. Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner. J Neurosci 21:185.
    • (2001) J Neurosci , vol.21 , pp. 185
    • Nishi, M.1    Hinds, H.2    Lu, H.P.3    Kawata, M.4    Hayashi, Y.5
  • 42
    • 0035876476 scopus 로고    scopus 로고
    • Glutamate release and neuronal damage in ischemia
    • Nishizawa Y. 2001. Glutamate release and neuronal damage in ischemia. Life Sci 69:369-381.
    • (2001) Life Sci , vol.69 , pp. 369-381
    • Nishizawa, Y.1
  • 43
    • 0031912995 scopus 로고    scopus 로고
    • Glutamate receptors in the mammalian central nervous system
    • Ozawa S, Kamiya H, Tsuzuki K. 1998. Glutamate receptors in the mammalian central nervous system. Prog Neurobiol 54:581-618.
    • (1998) Prog Neurobiol , vol.54 , pp. 581-618
    • Ozawa, S.1    Kamiya, H.2    Tsuzuki, K.3
  • 44
    • 0035840856 scopus 로고    scopus 로고
    • NMDA receptors as targets for drug action in neuropathic pain
    • Parsons G. 2001. NMDA receptors as targets for drug action in neuropathic pain. Eur J Pharm 429:71-78.
    • (2001) Eur J Pharm , vol.429 , pp. 71-78
    • Parsons, G.1
  • 45
    • 0032534034 scopus 로고    scopus 로고
    • Construction of a directed hammerhead ribozyme library: Towards the identification of optimal target sites for antisense-mediated gene inhibition
    • Pierce ML, Ruffner DE. 1998. Construction of a directed hammerhead ribozyme library: towards the identification of optimal target sites for antisense-mediated gene inhibition. Nucleic Acids Res 26:5093-5101.
    • (1998) Nucleic Acids Res , vol.26 , pp. 5093-5101
    • Pierce, M.L.1    Ruffner, D.E.2
  • 48
    • 0034223563 scopus 로고    scopus 로고
    • Oligonucleotide scanning of native mRNAs in extracts predicts intracellular ribozyme efficiency: Ribozyme-mediated reduction of the murine DNA methyl-transferase
    • Scherr M, Reed M, Huang CF, Riggs AD, Rossi JJ. 2000. Oligonucleotide scanning of native mRNAs in extracts predicts intracellular ribozyme efficiency: ribozyme-mediated reduction of the murine DNA methyl-transferase. Mol Ther 2:26-38.
    • (2000) Mol Ther , vol.2 , pp. 26-38
    • Scherr, M.1    Reed, M.2    Huang, C.F.3    Riggs, A.D.4    Rossi, J.J.5
  • 49
    • 0037174634 scopus 로고    scopus 로고
    • Postsynaptic signaling and plasticity mechanisms
    • Sheng M, Kim MJ. 2002. Postsynaptic signaling and plasticity mechanisms. Science 298:776-780.
    • (2002) Science , vol.298 , pp. 776-780
    • Sheng, M.1    Kim, M.J.2
  • 50
    • 0037213559 scopus 로고    scopus 로고
    • Mammalian RNAi for the masses
    • Shi Y. 2003. Mammalian RNAi for the masses. Trends Genet 19:9-12.
    • (2003) Trends Genet , vol.19 , pp. 9-12
    • Shi, Y.1
  • 51
    • 0035873670 scopus 로고    scopus 로고
    • Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo
    • Sohail M, Hochegger H, Klotzbucher A, Guellec RL, Hunt T, Southern EM. 2001. Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo. Nucleic Acids Res 29:2041-2051.
    • (2001) Nucleic Acids Res , vol.29 , pp. 2041-2051
    • Sohail, M.1    Hochegger, H.2    Klotzbucher, A.3    Guellec, R.L.4    Hunt, T.5    Southern, E.M.6
  • 52
    • 0033009994 scopus 로고    scopus 로고
    • Mice with genetically modified NMDA and AMPA receptors
    • Sprengel R, Single FN. 1999. Mice with genetically modified NMDA and AMPA receptors. Ann N Y Acad Sci 868:494-501.
    • (1999) Ann N Y Acad Sci , vol.868 , pp. 494-501
    • Sprengel, R.1    Single, F.N.2
  • 53
    • 0031740135 scopus 로고    scopus 로고
    • Rapid evaluation in Escherichia coli of antisense RNAs and ribozymes
    • Tatout C, Gauthier E, Pinon H. 1998. Rapid evaluation in Escherichia coli of antisense RNAs and ribozymes. Lett Appl Microbiol 27:297-301.
    • (1998) Lett Appl Microbiol , vol.27 , pp. 297-301
    • Tatout, C.1    Gauthier, E.2    Pinon, H.3
  • 54
    • 0036469040 scopus 로고    scopus 로고
    • Turnover analysis of N-methyl-D-aspartate receptor subunit NR1 protein in PC12 cells
    • Vazhappilly R, Sucher NJ. 2002. Turnover analysis of N-methyl-D-aspartate receptor subunit NR1 protein in PC12 cells. Neurosci Lett 318:153-157.
    • (2002) Neurosci Lett , vol.318 , pp. 153-157
    • Vazhappilly, R.1    Sucher, N.J.2
  • 55
    • 0034889654 scopus 로고    scopus 로고
    • Modulation of NMDA-mediated excitotoxicity by protein kinase C
    • Wagey R, Hu J, Pelech SL, Raymond LA, Krieger C. 2001. Modulation of NMDA-mediated excitotoxicity by protein kinase C. J Neurochem 78: 715-726.
    • (2001) J Neurochem , vol.78 , pp. 715-726
    • Wagey, R.1    Hu, J.2    Pelech, S.L.3    Raymond, L.A.4    Krieger, C.5
  • 58
    • 0029872060 scopus 로고    scopus 로고
    • The 5′-untranslated region of the N-methyl-D-aspartate receptor NR2A subunit controls efficiency of translation
    • Wood MW, VanDongen HM, VanDongen AM. 1996. The 5′-untranslated region of the N-methyl-D-aspartate receptor NR2A subunit controls efficiency of translation. J Biol Chem 271:8115-8120.
    • (1996) J Biol Chem , vol.271 , pp. 8115-8120
    • Wood, M.W.1    VanDongen, H.M.2    VanDongen, A.M.3
  • 59
    • 0343963180 scopus 로고    scopus 로고
    • Mapping of accessible sites for oligonucleotide hybridization on hepatitis delta virus ribozymes
    • Wrzesinski J, Legiewicz M, Ciesiolka J. 2000. Mapping of accessible sites for oligonucleotide hybridization on hepatitis delta virus ribozymes. Nucleic Acids Res 28:1785-1793.
    • (2000) Nucleic Acids Res , vol.28 , pp. 1785-1793
    • Wrzesinski, J.1    Legiewicz, M.2    Ciesiolka, J.3
  • 60
    • 0026515135 scopus 로고
    • Ribozymes which cleave arenavirus RNAs: Identification of susceptible target sites and inhibition by target site secondary structure
    • Xing Z, Whitton JL. 1992. Ribozymes which cleave arenavirus RNAs: identification of susceptible target sites and inhibition by target site secondary structure. J Virol 66:1361-1369.
    • (1992) J Virol , vol.66 , pp. 1361-1369
    • Xing, Z.1    Whitton, J.L.2
  • 61
    • 0032483347 scopus 로고    scopus 로고
    • Cleavage of highly structured viral RNA molecules by combinatorial libraries of hairpin ribozymes. The most effective ribozymes are not predicted by substrate selection rules
    • Yu Q, Pecchia DB, Kingsley SL, Heckman JE, Burke JM. 1998. Cleavage of highly structured viral RNA molecules by combinatorial libraries of hairpin ribozymes. The most effective ribozymes are not predicted by substrate selection rules. J Biol Chem 273:23524-23533.
    • (1998) J Biol Chem , vol.273 , pp. 23524-23533
    • Yu, Q.1    Pecchia, D.B.2    Kingsley, S.L.3    Heckman, J.E.4    Burke, J.M.5


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