Oligonucleotide scanning of native mRNAs in extracts predicts intracellular ribozyme efficiency: Ribozyme-mediated reduction of the murine DNA methyltransferase

Molecular Therapy

Volumn 2, Issue 1, 2000, Pages 26-38

  Scherr, Michaela ^a,b   Reed, Michael ^a   Huang, Chiung Fang ^a   Riggs, Arthur D ^a   Rossi, John J ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Antisense; Cleavage site mapping; DNA methyltransferase 1; Epigenetic silencing; Gene therapy; Pol III promoter; Ribozyme

Indexed keywords

MURINAE;

DNA (CYTOSINE 5) METHYLTRANSFERASE; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; OLIGONUCLEOTIDE; PHOTOPROTEIN; RIBONUCLEASE; RIBOZYME;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL STRAIN 3T3; CONFORMATION; CPG ISLAND; GENE SILENCING; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; GENETICS; HUMAN; METABOLISM; METHYLATION; MOUSE; NORTHERN BLOTTING; ONCOGENE; PLASMID; PROMOTER REGION; REPORTER GENE; RETROVIRUS; SOUTHERN BLOTTING;

3T3 CELLS; ANIMALS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CPG ISLANDS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; GENE SILENCING; GENES, INTRACISTERNAL A-PARTICLE; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; METHYLATION; MICE; MODELS, GENETIC; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; PLASMIDS; PROMOTER REGIONS (GENETICS); RETROVIRIDAE; RIBONUCLEASES; RNA, CATALYTIC; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSDUCTION, GENETIC;

EID: 0034223563     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2000.0091     Document Type: Article

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