The C-terminal C1 cassette of the N-methyl-D-aspartate receptor 1 subunit contains a bi-partite nuclear localization sequence

Journal of Neurochemistry

Volumn 81, Issue 6, 2002, Pages 1152-1165

  Holmes, K D ^a,b   Mattar, P ^a,b   Marsh, D R ^a   Jordan, V ^a,b   Weaver, L C ^b   Dekaban, G A ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

NMDA receptor; Nuclear localization; Splice variant

Indexed keywords

HELIX LOOP HELIX PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ALGORITHM; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EXPRESSION VECTOR; GENE CASSETTE; GENE CONTROL; GENE SEQUENCE; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN SECRETION; PROTEIN TRANSPORT; RAT; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CELL EXTRACTS; CELL LINE; CELL NUCLEUS; CLONE CELLS; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; PC12 CELLS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT PROTEINS;

ANIMALIA; VECTORS;

EID: 0036316743     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00865.x     Document Type: Article

References (77)

1. A strategy for the analysis of gene expression during neural development
2. Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin
3. Novel functions of the cytoplasmic domain of neuregulin
4. Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
5. A generalized profile syntax for biomolecular sequence motifs and its function in automatic sequence interpretation
6. Biochemical evidence for the existence of a pool of unassembled C2 exon-containing NR1 subunits of the mammalian forebrain NMDA receptor
7. How the protease thrombin talks to cells
8. A functional nuclear localization sequence in the c-terminal domain of shp-1
9. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
10. Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons
11. Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit
12. Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: Implications for notch function
13. Incorporation of non-local interactions in protein secondary structure prediction from the amino acid sequence
14. The C2A domain of double C2 protein gamma contains a functional nuclear localization signal
15. PDZ domains in synapse assembly and signalling
16. Neuregulins and neuregulin receptors in neural development
17. Potentiation of NMDA receptor function by the serine protease thrombin
18. Thrombin
19. Recombinant human NMDA homomeric NR1 receptors expressed in mammalian cells form a high-affinity glycine antagonist binding site
20. Improved performance in protein secondary structure prediction by inhomogeneous score combination
21. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice
22. Identification of a bipartite nuclear localization sequence necessary for nuclear import of 5-lipoxygenase
23. The PROSITE database, its status in 1999
24. A multi-mutant herpes simplex virus vector has minimal cytotoxic effects on the distribution of filamentous actin, alpha-actinin 2 and a glutamate receptor in differentiated PC12 cells
25. Anchoring of glutamate receptors at the synapse
26. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element
27. Turnover analysis of glutamate receptors identifies a rapidly degraded pool of N-methyl-D-aspartate receptor subunit, NR1, in cultured cerebellar granule cells
28. Molecular characterization of the family of N-methyl-D-aspartate receptor subunits
29. Signal transduction molecules at the glutamatergic post-synaptic membrane
30. Transcription control and differentiation: The HLH family, c-myc and C/EBP
31. Molecular diversity of the NMDA receptor channel
32. Analysis of a multi-mutant herpes simplex virus type 1 for gene transfer into sympathetic pre-ganglionic neurons and a comparison to adenovirus vectors
33. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei
34. Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn
35. Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation
36. Role of spinal NMDA and AMPA receptors in episodic hypertension in conscious spinal rats
37. Long-term potentiation: A decade of progress?
38. Herpes simplex viral and amplicon vector-mediated gene transfer into glia and neurons in organotypic spinal cord and dorsal root ganglion cultures
39. Distribution of an NMDA receptor-GFP fusion protein in sensory neurons is altered by a C-terminal construct
40. The jellyfish green fluorescent protein a new tool for studying ion channel expression and function
41. Nucleocytoplasmic transport: The soluble phase
42. Identification of amino acid sequence in the hinge region of human vitamin D receptor that transfers a cytosolic protein to the nucleus
43. Nuclear localization and dominant-negative suppression by a mutant skca3 n-terminal channel fragment identified in a patient with schizophrenia
44. The excitatory amino acid receptors: Their classes, pharmacology, and distinct properties in the function of the central nervous system
45. Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
46. Molecular cloning and characterization of the rat NMDA receptor
47. NeuN, a neuronal specific nuclear protein in vertebrates
48. A knowledge base for predicting protein localization sites in eukaryotic cells
49. The proteolytic activity of tissue plasminogen activator enhances NMDA-induced excitotoxicity
50. Molecular mechanisms of glutamate receptor clustering at excitatory synapses
51. Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors
52. Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor
53. Intracellular localization of human cytidine deaminase. Identification of a functional nuclear localization signal
54. Mapping of nuclear localization signals by simultaneous fusion to green fluorescent protein and to β-galactosidase
55. PDZ-domain suppression of an ER retention signal in NMDAR1 splice variants
56. Nuclear access and action of notch in vivo
57. Structural analysis based on state-space modeling
58. Predicting protein structure with probabilistic models
59. Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing
60. Identification of a long variant of mRNA encoding the NR3 subunit of the NMDA receptor: Its regional distribution and developmental expression in the rat brain
61. Quantitative analysis of gene expression in organotypic slice-explant cultures by particle-mediated gene transfer
62. Synaptic plasticity: Building memories to last
63. Characterization of protein kinase A and protein kinase phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies
64. Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain
65. The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray
66. Cellular and subcellular distribution of NMDAR1 splice variant mRNA in the rat lumbar spinal cord
67. The role of thrombin-like (serine) proteases in the development, plasticity and pathology of the nervous system
68. Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains
69. Protein classification by stochastic modeling and optimal filtering of amino-acid sequences
70. NeuN: A useful neuronal marker for diagnostic histopathology
71. PC12-E2 cells: A stable variant with altered responses to growth factor stimulation
72. Competitive binding of alpha-actinin and calmodulin to the NMDA receptor
73. Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in γ-secretase processing of the APP and Notch1 transmembrane domains
74. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites
75. Sequence of a HeLa cDNA provides the DNA binding domain and corboxy terminus of HE47: A human helix-loop-helix protein related to the enhancer binding factor E47
76. Nuclear translocation of the N-terminal prodomain of interleukin-16