A mathematical model on germinal center kinetics and termination

Journal of Immunology

Volumn 163, Issue 5, 1999, Pages 2463-2469

  Keşmir, Can ^a   De Boer, Rob J ^b  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN;

ARTICLE; B LYMPHOCYTE; CELL DIVISION; CELL INTERACTION; CELL SELECTION; DENDRITIC CELL; DYNAMICS; GERMINAL CENTER; HELPER CELL; KINETICS; MATHEMATICAL MODEL; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIGEN-ANTIBODY COMPLEX; B-LYMPHOCYTES; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; DENDRITIC CELLS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; GERMINAL CENTER; IMMUNIZATION; KINETICS; MATHEMATICAL COMPUTING; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTES; TIME FACTORS;

EID: 0344131926     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Berek, C., A. Berger, and M. Apel. 1991. Maturation of the immune response in germinal centers. Cell 67:1121.
2. MacLennan, I. C. 1994. Germinal centers. Annu. Rev. Immunol. 12:117.
3. Jacob, J., G. Kelsoe, K. Rajewsky, and U. Weiss. 1991. Intraclonal generation of antibody mutants in germinal centres. Nature 354:389.
4. Leanderson, T., E. Kallberg, and D. Gray. 1992. Expansion, selection and mutation of antigen-specific B cells in germinal centers. Immunol. Rev. 126:47.
5. Koopman, G., R. M. Keehnen, E. Lindhout, D. F. Zhou, C. De Groot, and S. T. Pals. 1997. Germinal center B cells rescued from apoptosis by CD40 ligation or attachment to follicular dendritic cells, but not by engagement of surface immunoglobulin or adhesion receptors, become resistant to CD95-induced apoptosis. Eur. J. Immunol. 27:1.
6. MacLennan, I. C., A. Gulbranson-Judge, K. M. Toellner, M. Casamayor-Palleja, E. Chan, D. M. Sze, S. A. Luther, and H. A. Orbea. 1997. The changing preference of T and B cells for partners as T-dependent antibody responses develop. Immunol. Rev. 156:53.
7. Lindhout, E., G. Koopman, S. T. Pals, and C. De Groot. 1997. Triple check for antigen specificity of B cells during germinal centre reactions. Immunol. Today 18:573.
8. Zheng, B., S. Han, and G. Kelsoe. 1996. T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1. J. Exp. Med. 184:1083.
9. Zheng, B., S. Han, Q. Zhu, R. Goldsby, and G. Kelsoe. 1996. Alternative pathways for the selection of antigen-specific peripheral T cells. Nature 384:263.
10. Garside, P., E. Ingulli, R. R. Merica, J. G. Johnson, R. J. Noelle, and M. K. Jenkins. 1998. Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281:96.
11. + T cells and defective antibody production in vivo. J. Exp. Med. 179:809.
12. Linsley, P. S., P. M. Wallace, J. Johnson, M. G. Gibson, J. L. Greene, J. A. Ledbetter, C. Singh, and M. A. Tepper. 1992. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 257:792.
13. Han, S., K. Hathcock, B. Zheng, T. B. Kepler, R. Hodes, and G. Kelsoe. 1995. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 155:556.
14. Gray, D., P. Dullforce, and S. Jainandunsing. 1994. Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction. J. Exp. Med. 180:141.
15. MacLennan, I. C. M., M. Casamayor-Palleja, K. M. Toellner, A. Gulbranson-Judge, and J. Gordon. 1997. Memory B-cell clones and the diversity of their members. Semin. Immunol. 9:229.
16. Yellin, M. J., J. Sinning, L. R. Covey, W. Sherman, J. J. Lee, E. Glickman-Nir, K. C. Sippel, J. Rogers, A. M. Cleary, M. Parker, et al. 1994. T lymphocyte T cell-B cell-activating molecule/CD40-L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7/BB-1) and enhance their costimulatory activity. J. Immunol. 153:666.
17. Manser, T., K. M. Tumas-Brundage, L. P. Casson, A. M. Giusti, S. Hande, E. Notidis, and K. A. Vora. 1998. The roles of antibody variable region hypermutation and selection in the development of the memory B-cell compartment. Immunol. Rev. 162:183.
18. XOx1 gene. Eur. J. Immunol. 25:2349.
19. Oprea, M., and A. S. Perelson. 1997. Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts. J. Immunol. 158:5155.
20. Weinand, R. G. 1990. Somatic mutation, affinity maturation and the antibody repertoire: a computer model. J. Theor. Biol. 143:343.
21. Weinand, R. G., and M. Conrad. 1988. Maturation of the immune response: a computational model. J. Theor. Biol. 133:409.
22. Kepler, T. B., and A. S. Perelson. 1993. Somatic hypermutation in B cells: an optimal control treatment. J. Theor. Biol. 164:37.
23. Celada, F., and P. E. Seiden. 1996. Affinity maturation and hypermutation in a simulation of the humoral immune response. Eur. J. Immunol. 26:1350.
24. Tarlinton, D. 1998. Germinal centers: form and function. Curr. Opin. Immunol. 10:245.
25. Liu, Y. J., J. Zhang, P. J. Lane, E. Y. Chan, and I. C. MacLennan. 1991. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol 21:2951.
26. Jacob, J., R. Kassir, and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173:1165.
27. Kroese, F. G., A. S. Wubbena, H. G. Seijen, and P. Nieuwenhuis. 1987. Germinal centers develop oligoclonally. Eur. J. Immunol. 17:1069.
28. + memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex. J. Exp. Med. 181:1293.
29. Kepler, T. B., and A. S. Perelson. 1993. Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation. Immunol. Today 14:412.
30. Casamayor-Palleja, M., A. Gulbranson-Judge, and I. C. MacLennan. 1997. T cells in the selection of germinal center B cells. Chem. Immunol 67:27.
31. Ridderstad, A., and D. M. Tarlinton. 1998. Kinetics of establishing the memory B cell population as revealed by CD38 expression. J. Immunol. 160:4688.
32. Smith, K. G., A. Light, G. J. Nossal, and D. M. Tarlinton. 1997. The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response. EMBO. J. 16:2996.
33. Kelsoe, G. 1996. The germinal center: a crucible for lymphocyte selection. Semin. Immunol 8:179.
34. Camacho, S. A., M. H. Kosco-Vilbois, and C. Berek. 1998. The dynamic structure of the germinal center. Immunol. Today 19:511.
35. Grouard, G., O. De Bouteiller, J. Banchereau, and Y. J. Liu. 1995. Human follicular dendritic cells enhance cytokine-dependent growth and differentiation of CD40-activated B cells. J. Immunol. 155:3345.
36. Vora, K. A., J. V. Ravetch, and T. Manser. 1997. Amplified follicular immune complex deposition in mice lacking the Fc receptor gamma-chain does not alter maturation of the B cell response. J. Immunol. 159:2116.
37. Bachmann, M. F., B. Odermatt, H. Hengartner, and R. M. Zinkernagel. 1996. Induction of long-lived germinal centers associated with persisting antigen after viral infection. J. Exp. Med. 183:2259.
38. Dal Porto, J. M., A. M. Haberman, M. J. Shlomchik, and G. Kelsoe. 1998. Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers. J. Immunol. 161:5373.
39. Vora, K. A., and T. Manser. 1995. Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation. J. Exp. Med. 181:271.
40. + T cells are an important site of HIV replication in vivo. AIDS 11:849.
41. Cohen, J. J., R. C. Duke, V. A. Fadok, and K. S. Sellins. 1992. Apoptosis and programmed cell death in immunity. Annu. Rev. Immunol. 10:267.
42. Liu, Y. J., C. Barthelemy, O. de Bouteiller, and J. Banchereau. 1994. The differences in survival and phenotype between centroblasts and centrocytes. Adv. Exp. Med. Biol. 355:213.