-
1
-
-
0023318765
-
Role of somatic mutation in the generation of lymphocyte diversity
-
Role of somatic mutation in the generation of lymphocyte diversity. Immunol Rev 1987;96:1-162.
-
(1987)
Immunol Rev
, vol.96
, pp. 1-162
-
-
-
2
-
-
0023090516
-
Somatic hypermutation of an immunoglobulin transgene in κ transgenic mice
-
O'Brein RL, Brinster RL, Storb U. Somatic hypermutation of an immunoglobulin transgene in κ transgenic mice. Nature 1987;326:405-409.
-
(1987)
Nature
, vol.326
, pp. 405-409
-
-
O'Brein, R.L.1
Brinster, R.L.2
Storb, U.3
-
3
-
-
0028270307
-
Elements regulating somatic hypermutation of an immunoglobulin kappa gene: Critical role for the intron enhancer/matrix attachment region
-
Betz AG, Milstein C, Gonzalez-Fernandez A, Pannell R, Larson T, Neuberger MS. Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell 1994;77:239-248.
-
(1994)
Cell
, vol.77
, pp. 239-248
-
-
Betz, A.G.1
Milstein, C.2
Gonzalez-Fernandez, A.3
Pannell, R.4
Larson, T.5
Neuberger, M.S.6
-
4
-
-
0029067875
-
Targeting of non-Ig sequences in place of the V segment by somatic hypermutation
-
Yelamos J, et al. Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature 1995;376:225-229.
-
(1995)
Nature
, vol.376
, pp. 225-229
-
-
Yelamos, J.1
-
5
-
-
0030063726
-
Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
-
Peters A, Storb U. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 1996;4:57-65.
-
(1996)
Immunity
, vol.4
, pp. 57-65
-
-
Peters, A.1
Storb, U.2
-
6
-
-
0028968928
-
A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene
-
Zhu M, Rabinowitz JL, Green NS, Kobrin BJ, Scharff MD. A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene. Proc Natl Acad Sci USA 1995;92:2810-2814.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 2810-2814
-
-
Zhu, M.1
Rabinowitz, J.L.2
Green, N.S.3
Kobrin, B.J.4
Scharff, M.D.5
-
7
-
-
15844408823
-
Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines
-
Zhu M, Green NS, Rabinowitz JL, Scharff MD. Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines. EMBO J 1996;15:2738-2747.
-
(1996)
EMBO J
, vol.15
, pp. 2738-2747
-
-
Zhu, M.1
Green, N.S.2
Rabinowitz, J.L.3
Scharff, M.D.4
-
8
-
-
0029965649
-
Enhancers of hypermutation
-
Bachl J, Wabl, M. Enhancers of hypermutation. Immunogenetics 1996;45:59-64.
-
(1996)
Immunogenetics
, vol.45
, pp. 59-64
-
-
Bachl, J.1
Wabl, M.2
-
9
-
-
0027468552
-
Somatic hypermutation of an immunoglobulin m heavy chain transgene
-
Sohn J, Gerstein RM, Hsieh C-L, Lemer M, Selsing E. Somatic hypermutation of an immunoglobulin m heavy chain transgene. J Exp Med 1993;177:493-504.
-
(1993)
J Exp Med
, vol.177
, pp. 493-504
-
-
Sohn, J.1
Gerstein, R.M.2
Hsieh, C.-L.3
Lemer, M.4
Selsing, E.5
-
10
-
-
0027963309
-
Dependence of enhancer mediated transcription of the immunoglobulin m gene on nuclear matrix attachment regions
-
Forrester WC, Genderen CV, Jenuwien T. Grosschedl R. Dependence of enhancer mediated transcription of the immunoglobulin m gene on nuclear matrix attachment regions. Science 1994;264:1221-1225.
-
(1994)
Science
, vol.264
, pp. 1221-1225
-
-
Forrester, W.C.1
Genderen, C.V.2
Jenuwien, T.3
Grosschedl, R.4
-
11
-
-
0023187644
-
Mitogen driven B cell proliferation and differentiation are not accompanied by hypermutation of immunoglobulin variable region genes
-
Manser T. Mitogen driven B cell proliferation and differentiation are not accompanied by hypermutation of immunoglobulin variable region genes. J Immunol 1987;139:234-238.
-
(1987)
J Immunol
, vol.139
, pp. 234-238
-
-
Manser, T.1
-
12
-
-
0026515682
-
B-cell proliferation initiated by Ia cross-linking and sustained by interleukins leads to class switching but not somatic mutation in vitro
-
Wysocki LJ, Creadon G, Lehmann KR, Cambier JC. B-cell proliferation initiated by Ia cross-linking and sustained by interleukins leads to class switching but not somatic mutation in vitro. Immunology 1992;75:116-121.
-
(1992)
Immunology
, vol.75
, pp. 116-121
-
-
Wysocki, L.J.1
Creadon, G.2
Lehmann, K.R.3
Cambier, J.C.4
-
13
-
-
0029055061
-
Generation of memory B cells and plasma cells in vitro
-
Arpin C, et al. Generation of memory B cells and plasma cells in vitro. Science 1995;268:720-722.
-
(1995)
Science
, vol.268
, pp. 720-722
-
-
Arpin, C.1
-
14
-
-
0343417077
-
Induction of somatic mutation in a human B cell line in vitro
-
Denepoux S, et al. Induction of somatic mutation in a human B cell line in vitro. Immunity 1997;6:35-16.
-
(1997)
Immunity
, vol.6
, pp. 35-116
-
-
Denepoux, S.1
-
15
-
-
0027410278
-
Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: Implications for the location of cis-acting elements required for somatic mutation
-
Giusti AM, Manser T. Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation. J Exp Med 1993;177:797-809.
-
(1993)
J Exp Med
, vol.177
, pp. 797-809
-
-
Giusti, A.M.1
Manser, T.2
-
16
-
-
0026470102
-
Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice
-
Giusti AM, Coffee R, Manser T. Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice. Proc Natl Acad Sci USA 1992;89:10321-10325.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 10321-10325
-
-
Giusti, A.M.1
Coffee, R.2
Manser, T.3
-
17
-
-
0028006250
-
Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion
-
Giusti AM, Manser T. Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion. J Exp Med 1994;179:235-248.
-
(1994)
J Exp Med
, vol.179
, pp. 235-248
-
-
Giusti, A.M.1
Manser, T.2
-
18
-
-
0025000908
-
Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes
-
Gerstein, RM, et al. Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes. Cell 1990;63:537-547.
-
(1990)
Cell
, vol.63
, pp. 537-547
-
-
Gerstein, R.M.1
-
19
-
-
0030863389
-
Evaluation of the role of the 3′ alpha heavy chain enhancer (3′αE(hs1,2)) in Vh gene somatic hypermutation
-
Tumas-Brundage KM, Vora KA, Manser T. Evaluation of the role of the 3′ alpha heavy chain enhancer (3′αE(hs1,2)) in Vh gene somatic hypermutation. Mol Immunol 1997;34:367-378.
-
(1997)
Mol Immunol
, vol.34
, pp. 367-378
-
-
Tumas-Brundage, K.M.1
Vora, K.A.2
Manser, T.3
-
20
-
-
0028988293
-
Identification of 3′ alpha-hs-4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation
-
Michaelson JS, Giannini SL, Birshtein BK. Identification of 3′ alpha-hs-4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation. Nucleic Acids Res. 1995;23:975-981.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 975-981
-
-
Michaelson, J.S.1
Giannini, S.L.2
Birshtein, B.K.3
-
21
-
-
0028203509
-
Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM
-
Taylor LD, et al. Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM. Int Immunol 1994;6:579-591.
-
(1994)
Int Immunol
, vol.6
, pp. 579-591
-
-
Taylor, L.D.1
-
22
-
-
0030221606
-
Strategies for the expressing human antibody repertoires in transgenic mice
-
Bruggemann M, Neuberger M. Strategies for the expressing human antibody repertoires in transgenic mice. Immunol Today 1996;17:391-397.
-
(1996)
Immunol Today
, vol.17
, pp. 391-397
-
-
Bruggemann, M.1
Neuberger, M.2
-
23
-
-
0025630537
-
Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene
-
Lebecque SG, Gearhart PJ. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene. J Exp Med 1990;172:1717-1727.
-
(1990)
J Exp Med
, vol.172
, pp. 1717-1727
-
-
Lebecque, S.G.1
Gearhart, P.J.2
-
24
-
-
0025774040
-
Somatic mutation in constant regions of mouse λ1 light chains
-
Motoyama N, Okada H, Azuma T. Somatic mutation in constant regions of mouse λ1 light chains. Proc Natl Acad Sci USA 1991;88:7933-7937.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 7933-7937
-
-
Motoyama, N.1
Okada, H.2
Azuma, T.3
-
25
-
-
0027194781
-
Somatic hypermutation in 5′ flanking regions of heavy chain antibody variable regions
-
Rothenfluh HS, Taylor L, Bothwell ALM, Both GW, Steele EJ. Somatic hypermutation in 5′ flanking regions of heavy chain antibody variable regions. Eur J Immunol 1993;23:2152-2159.
-
(1993)
Eur J Immunol
, vol.23
, pp. 2152-2159
-
-
Rothenfluh, H.S.1
Taylor, L.2
Bothwell, A.L.M.3
Both, G.W.4
Steele, E.J.5
-
26
-
-
0028125606
-
Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes
-
Rogerson BJ. Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes. Mol Immunol 1994;31:83-98.
-
(1994)
Mol Immunol
, vol.31
, pp. 83-98
-
-
Rogerson, B.J.1
-
27
-
-
0028243803
-
The 5′ boundary of somatic hypermutation in a V kappa gene is in the leader intron
-
Rada C, Gonzalez-Fernandez A, Jarvis JM, Milstein C. The 5′ boundary of somatic hypermutation in a V kappa gene is in the leader intron. Eur J Immunol 1994;24:1453-1457.
-
(1994)
Eur J Immunol
, vol.24
, pp. 1453-1457
-
-
Rada, C.1
Gonzalez-Fernandez, A.2
Jarvis, J.M.3
Milstein, C.4
-
28
-
-
0025911081
-
κ and its 5′ flanking sequences determines the location of somatic mutations in the Jκ locus
-
κ and its 5′ flanking sequences determines the location of somatic mutations in the Jκ locus. J Immunol 1991;146:3652-3655.
-
(1991)
J Immunol
, vol.146
, pp. 3652-3655
-
-
Weber, J.S.1
Berry, J.2
Manser, T.3
Claflin, J.L.4
-
29
-
-
0028061856
-
Mutations in Ig V(D)J genes are distributed asymmetrically and independendy of the position of V(D)J
-
Weber JS, Berry J, Manser T, Claflin JL. Mutations in Ig V(D)J genes are distributed asymmetrically and independendy of the position of V(D)J. J Immunol 1994;153:3594-3602.
-
(1994)
J Immunol
, vol.153
, pp. 3594-3602
-
-
Weber, J.S.1
Berry, J.2
Manser, T.3
Claflin, J.L.4
-
30
-
-
0031041632
-
The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
-
Tumas-Brundage K, Manser T. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J Exp Med 1997;185:239-250.
-
(1997)
J Exp Med
, vol.185
, pp. 239-250
-
-
Tumas-Brundage, K.1
Manser, T.2
-
31
-
-
0029871507
-
Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D)
-
Wagner SD, Elvin JG, Norris P, McGregor JM, Neuberger MS. Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D). Int Immunol 1996;8:701-705.
-
(1996)
Int Immunol
, vol.8
, pp. 701-705
-
-
Wagner, S.D.1
Elvin, J.G.2
Norris, P.3
McGregor, J.M.4
Neuberger, M.S.5
-
32
-
-
0030761761
-
B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes
-
Kim N, Kage K, Matsuda F, Lefranc MP, Storb U. B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes. J Exp Med 1997;186:413-419.
-
(1997)
J Exp Med
, vol.186
, pp. 413-419
-
-
Kim, N.1
Kage, K.2
Matsuda, F.3
Lefranc, M.P.4
Storb, U.5
-
33
-
-
0023161405
-
Evolution of antibody variable region structure during the immune response
-
Manser T, Wysocki LJ, Margolies MN, Gefter ML. Evolution of antibody variable region structure during the immune response. Immunol Rev 1987;96:141-162.
-
(1987)
Immunol Rev
, vol.96
, pp. 141-162
-
-
Manser, T.1
Wysocki, L.J.2
Margolies, M.N.3
Gefter, M.L.4
-
34
-
-
0023510298
-
Evolutionary and somatic selection of the antibody repertoire in the mouse
-
Rajewsky K, Forster I, Cumano A. Evolutionary and somatic selection of the antibody repertoire in the mouse. Science 1987;238:1088-1094.
-
(1987)
Science
, vol.238
, pp. 1088-1094
-
-
Rajewsky, K.1
Forster, I.2
Cumano, A.3
-
35
-
-
0023161406
-
Mutation drift and repertiore shift in the maturation of the immune response
-
Berek C, Milstein C. Mutation drift and repertiore shift in the maturation of the immune response. Immunol Rev 1987;96:23-41.
-
(1987)
Immunol Rev
, vol.96
, pp. 23-41
-
-
Berek, C.1
Milstein, C.2
-
36
-
-
0025358376
-
Structural correlates of high antibody affinity: Three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsomate antibody 200-fold
-
Sharon J. Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsomate antibody 200-fold. Proc Natl Acad Sci USA 1990;87:4814-4819.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 4814-4819
-
-
Sharon, J.1
-
37
-
-
0028909056
-
Altering the antibody repertoire via transgene homologous recombination: Evidence for global and done autonomous regulation of antigen driven B cell differentiation
-
Vora KA, Manser T. Altering the antibody repertoire via transgene homologous recombination: evidence for global and done autonomous regulation of antigen driven B cell differentiation. J Exp Med 1995;181:271-281.
-
(1995)
J Exp Med
, vol.181
, pp. 271-281
-
-
Vora, K.A.1
Manser, T.2
-
39
-
-
0025726702
-
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations
-
Jacob J, Kassir R, Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J Exp Med 1991;173:1165-1175.
-
(1991)
J Exp Med
, vol.173
, pp. 1165-1175
-
-
Jacob, J.1
Kassir, R.2
Kelsoe, G.3
-
41
-
-
0027260343
-
The maturation of the immune response
-
Berek C, Ziegner T. The maturation of the immune response. Immunol Today 1993;14:400-404.
-
(1993)
Immunol Today
, vol.14
, pp. 400-404
-
-
Berek, C.1
Ziegner, T.2
-
42
-
-
0028182886
-
Differentiation of the secondary B-lymphocyte repertoire. The germinal center reaction
-
Nossal GJV. Differentiation of the secondary B-lymphocyte repertoire. The germinal center reaction. Immunol Rev 1994;137:172-182.
-
(1994)
Immunol Rev
, vol.137
, pp. 172-182
-
-
Nossal, G.J.V.1
-
43
-
-
0031225905
-
Amplified follicular immune complex deposition in mice lacking the Fc receptor γ-chain does not alter maturation of the B cell response
-
Vora KA, Ravetch JV, Manser T. Amplified follicular immune complex deposition in mice lacking the Fc receptor γ-chain does not alter maturation of the B cell response. J Immunol 1997;159:2116-2124.
-
(1997)
J Immunol
, vol.159
, pp. 2116-2124
-
-
Vora, K.A.1
Ravetch, J.V.2
Manser, T.3
-
44
-
-
0019231835
-
The follicular dendritic cell: Long term antigen retention during immunity
-
Mandel TE, Phipps RP, Abbot A, Tew JG. The follicular dendritic cell: long term antigen retention during immunity. Immunol Rev 1980;53:29-59.
-
(1980)
Immunol Rev
, vol.53
, pp. 29-59
-
-
Mandel, T.E.1
Phipps, R.P.2
Abbot, A.3
Tew, J.G.4
-
45
-
-
0023761867
-
B-cell memory is short-lived in the absence of antigen
-
Gray D, Skarvall H. B-cell memory is short-lived in the absence of antigen. Nature 1988;336:70-73.
-
(1988)
Nature
, vol.336
, pp. 70-73
-
-
Gray, D.1
Skarvall, H.2
-
46
-
-
0023622462
-
Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with dramatically reduced affinity for p-azophenylarsonate: By-products of an antigen driven immune response?
-
Manser T, Parhami-Seren B, Margolies MN, Gefter ML. Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with dramatically reduced affinity for p-azophenylarsonate: by-products of an antigen driven immune response? J Exp Med 1987;166:1456-1463.
-
(1987)
J Exp Med
, vol.166
, pp. 1456-1463
-
-
Manser, T.1
Parhami-Seren, B.2
Margolies, M.N.3
Gefter, M.L.4
-
47
-
-
0027305024
-
In situ studies of the primary immune respone to (4-hydroxy-3-nitrophenyl) acetyl. III. The kinetics of V-region mutation and selection in germinal center B-cells
-
Jacob J, Przylepa J, Miller C, Kelsoe G. In situ studies of the primary immune respone to (4-hydroxy-3-nitrophenyl) acetyl. III. The kinetics of V-region mutation and selection in germinal center B-cells. J Exp Med 1993;178:1293-1307.
-
(1993)
J Exp Med
, vol.178
, pp. 1293-1307
-
-
Jacob, J.1
Przylepa, J.2
Miller, C.3
Kelsoe, G.4
-
48
-
-
0025955528
-
Mutation and selection during the secondary response to 2-phenyloxazolone
-
Rada C, Gupta SK, Gherardi E, Milstein C. Mutation and selection during the secondary response to 2-phenyloxazolone. Proc Natl Acad Sci USA 1991;88:5508-5513.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 5508-5513
-
-
Rada, C.1
Gupta, S.K.2
Gherardi, E.3
Milstein, C.4
-
49
-
-
0027454579
-
Recruiting memory B cells with changed antigenic specificity
-
Ellenberger J, Creadon G, Zhang X, Wysocki LJ. Recruiting memory B cells with changed antigenic specificity. J Immunol 1993;151:5272-5285.
-
(1993)
J Immunol
, vol.151
, pp. 5272-5285
-
-
Ellenberger, J.1
Creadon, G.2
Zhang, X.3
Wysocki, L.J.4
-
51
-
-
0026782875
-
Generation and analysis of random point mutations in an antibody CDR2 sequence: Many mutated antibodies lose their ability to bind antigen
-
Chen C, Roberts VA, Rittenberg MB. Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen. J Exp Med 1992;176:855-866.
-
(1992)
J Exp Med
, vol.176
, pp. 855-866
-
-
Chen, C.1
Roberts, V.A.2
Rittenberg, M.B.3
-
52
-
-
0001578946
-
The influence of somatic mutation on clonal expansion
-
Shlomchik MJ, Litwin S, Weigert M. The influence of somatic mutation on clonal expansion. Prog Immunol 1989;7:415-435.
-
(1989)
Prog Immunol
, vol.7
, pp. 415-435
-
-
Shlomchik, M.J.1
Litwin, S.2
Weigert, M.3
-
53
-
-
0023244110
-
Somatic evolution of diversity among anti-phosphocholine antibodies induced with Proteus morganii
-
Claflin JL, Berry J, Flaherty D, Dunnick W. Somatic evolution of diversity among anti-phosphocholine antibodies induced with Proteus morganii. J Immunol 1987;138:3060-3068.
-
(1987)
J Immunol
, vol.138
, pp. 3060-3068
-
-
Claflin, J.L.1
Berry, J.2
Flaherty, D.3
Dunnick, W.4
-
55
-
-
0023652377
-
Analysis of somatic mutation and class switching in naive and memory B cell generating adoptive primary and secondary responses
-
Siekevitz M, Kocks C, Rajewsky K, Dildrop R. Analysis of somatic mutation and class switching in naive and memory B cell generating adoptive primary and secondary responses. Cell 1987;48:757-785.
-
(1987)
Cell
, vol.48
, pp. 757-785
-
-
Siekevitz, M.1
Kocks, C.2
Rajewsky, K.3
Dildrop, R.4
-
56
-
-
0024470168
-
Molecular analysis of original antigenic sin. I. Somatic mutation, clonal selection and isotype switching during a memory B cell response
-
Fish S, Zenowich E, Fleming M, Manser T. Molecular analysis of original antigenic sin. I. Somatic mutation, clonal selection and isotype switching during a memory B cell response. J Exp Med 1989;170:1191-1210.
-
(1989)
J Exp Med
, vol.170
, pp. 1191-1210
-
-
Fish, S.1
Zenowich, E.2
Fleming, M.3
Manser, T.4
-
57
-
-
0026060620
-
Intraclonal generation of antibody mutants in germinal centres
-
Jacob J, Kelsoe G, Rajewsky K, Weiss U. Intraclonal generation of antibody mutants in germinal centres. Nature 1991;354:389-393.
-
(1991)
Nature
, vol.354
, pp. 389-393
-
-
Jacob, J.1
Kelsoe, G.2
Rajewsky, K.3
Weiss, U.4
-
58
-
-
0026331458
-
Maturation of the immune response in germinal centers
-
Berek C, Berger A, Apel M. Maturation of the immune response in germinal centers. Cell 1991;67:1121-1129.
-
(1991)
Cell
, vol.67
, pp. 1121-1129
-
-
Berek, C.1
Berger, A.2
Apel, M.3
-
59
-
-
43949172221
-
Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation
-
Kepler TB, Perelson AS. Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation. Immunol Today 1993;14:412-415.
-
(1993)
Immunol Today
, vol.14
, pp. 412-415
-
-
Kepler, T.B.1
Perelson, A.S.2
-
60
-
-
0024496737
-
Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten
-
Sharon J, Gefter ML, Wysocki LJ, Margolies MN. Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten. J Immunol 1989;142:596-601.
-
(1989)
J Immunol
, vol.142
, pp. 596-601
-
-
Sharon, J.1
Gefter, M.L.2
Wysocki, L.J.3
Margolies, M.N.4
-
61
-
-
0025981495
-
Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response
-
Fish S, Fleming M, Sharon J, Manser T. Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response. J Exp Med 1991;173:665-671.
-
(1991)
J Exp Med
, vol.173
, pp. 665-671
-
-
Fish, S.1
Fleming, M.2
Sharon, J.3
Manser, T.4
-
62
-
-
0028930257
-
Antigen-binding B Cells and polyreactive antibodies
-
Chen ZJ, Wheeler J, Notkins AL. Antigen-binding B Cells and polyreactive antibodies. Eur J Immunol 1995;25:579-586.
-
(1995)
Eur J Immunol
, vol.25
, pp. 579-586
-
-
Chen, Z.J.1
Wheeler, J.2
Notkins, A.L.3
-
63
-
-
0027272719
-
The natural autoantibody system: Between hypotheses and facts
-
Avrameas S, Ternynck T. The natural autoantibody system: between hypotheses and facts. Mol Immunol 1993;30:1133-1142.
-
(1993)
Mol Immunol
, vol.30
, pp. 1133-1142
-
-
Avrameas, S.1
Ternynck, T.2
-
64
-
-
0003430697
-
Autoantibodies and the physiological role of immunoglobulins
-
Grabar P. Autoantibodies and the physiological role of immunoglobulins. Immunol Today 1983;4:337-340.
-
(1983)
Immunol Today
, vol.4
, pp. 337-340
-
-
Grabar, P.1
-
65
-
-
0024378538
-
A substantial proportion of the adult BALB/c available B cell repertoire consists of multireactive B cells
-
Rousseau PG, Mallett CP, Smith-Gill SJ. A substantial proportion of the adult BALB/c available B cell repertoire consists of multireactive B cells. Mol Immunol 1989;26:993-1006.
-
(1989)
Mol Immunol
, vol.26
, pp. 993-1006
-
-
Rousseau, P.G.1
Mallett, C.P.2
Smith-Gill, S.J.3
-
66
-
-
0022555558
-
H gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus
-
H gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus. J Exp Med 1986;164:614-626.
-
(1986)
J Exp Med
, vol.164
, pp. 614-626
-
-
Naparstek, Y.1
-
67
-
-
0024458158
-
Evolution of antibody structure during the immune response: The differentiative potential of a single B-lymphocyte
-
Manser T. Evolution of antibody structure during the immune response: the differentiative potential of a single B-lymphocyte. J Exp Med 1989;170:1211-1230.
-
(1989)
J Exp Med
, vol.170
, pp. 1211-1230
-
-
Manser, T.1
-
68
-
-
0023821899
-
The immune response to the hapten NP in C57B1/6 mice: Insights into the structure of the B-cell repertoire
-
Blier PR, Bothwell ALM. The immune response to the hapten NP in C57B1/6 mice: insights into the structure of the B-cell repertoire. Immunol Rev 1988;105:27-43.
-
(1988)
Immunol Rev
, vol.105
, pp. 27-43
-
-
Blier, P.R.1
Bothwell, A.L.M.2
-
69
-
-
0021855144
-
Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin
-
Clarke SH, Huppi K, Ruezinsky D, Staudt L, Gerhard W, Weigert M. Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin. J Exp Med 1985;161:687-700.
-
(1985)
J Exp Med
, vol.161
, pp. 687-700
-
-
Clarke, S.H.1
Huppi, K.2
Ruezinsky, D.3
Staudt, L.4
Gerhard, W.5
Weigert, M.6
-
70
-
-
0019488559
-
Idiotypic repertoire of anti-hen eggwhite lysozyme antibodies probed with hybridomas. Selection after immunization of an Idx marker common to antibodies of distinct epitope specificity
-
Metzger DW, Miller A, Sercarz EE. Idiotypic repertoire of anti-hen eggwhite lysozyme antibodies probed with hybridomas. Selection after immunization of an Idx marker common to antibodies of distinct epitope specificity. J Exp Med 1981;154:701-721.
-
(1981)
J Exp Med
, vol.154
, pp. 701-721
-
-
Metzger, D.W.1
Miller, A.2
Sercarz, E.E.3
-
71
-
-
0023181057
-
Molecular analysis of heavy and light chains used by primary and secondary anti-(T,G)-A - L antibodies produced by normal and xid mice
-
Busto P, Gerstein R, Dupre L, Giorgetti CA, Selsing E, Press JL. Molecular analysis of heavy and light chains used by primary and secondary anti-(T,G)-A - L antibodies produced by normal and xid mice. J Immunol 1987;139:608-618.
-
(1987)
J Immunol
, vol.139
, pp. 608-618
-
-
Busto, P.1
Gerstein, R.2
Dupre, L.3
Giorgetti, C.A.4
Selsing, E.5
Press, J.L.6
-
72
-
-
0025988387
-
A B cell population that dominates the primary response to influenza virus hemagglutinin does not participate in the memory response
-
Kavaler J, Caton AJ, Staudt LM, Gerhard W. A B cell population that dominates the primary response to influenza virus hemagglutinin does not participate in the memory response. Eur J Immunol 1991;21:2687-2695.
-
(1991)
Eur J Immunol
, vol.21
, pp. 2687-2695
-
-
Kavaler, J.1
Caton, A.J.2
Staudt, L.M.3
Gerhard, W.4
-
73
-
-
0026052840
-
Tolerance susceptibility of newly generated memory B cells
-
Linton P-J, Rudie A, Klinman NR. Tolerance susceptibility of newly generated memory B cells. J Immunol 1991;146:4099-4104.
-
(1991)
J Immunol
, vol.146
, pp. 4099-4104
-
-
Linton, P.-J.1
Rudie, A.2
Klinman, N.R.3
-
75
-
-
0029148418
-
Random mutagenesis of two CDR amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen
-
Casson L, Manser T. Random mutagenesis of two CDR amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen. J Exp Med 1995;182:743-750.
-
(1995)
J Exp Med
, vol.182
, pp. 743-750
-
-
Casson, L.1
Manser, T.2
-
76
-
-
0026750095
-
The role of somatic mutation in the pathogenic anti-DNA response
-
Diamond B, Katz JB, Paul E, Aranow C, Lustgarten D, Scharff MD. The role of somatic mutation in the pathogenic anti-DNA response. Annu Rev Immunol 1992;10:731-760.
-
(1992)
Annu Rev Immunol
, vol.10
, pp. 731-760
-
-
Diamond, B.1
Katz, J.B.2
Paul, E.3
Aranow, C.4
Lustgarten, D.5
Scharff, M.D.6
-
77
-
-
0028292951
-
Genetic and structural evidence for antigen selection of anti-DNA antibodies
-
Radic MZ, Weigert M. Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu Rev Immunol 1994;12:487-512.
-
(1994)
Annu Rev Immunol
, vol.12
, pp. 487-512
-
-
Radic, M.Z.1
Weigert, M.2
-
78
-
-
0026612988
-
Selection of immunoglobulin variable regions in autoimmunity to DNA
-
Marion TN, Tillman DM, Jou NT, Hill RJ. Selection of immunoglobulin variable regions in autoimmunity to DNA. Immunol Rev 1992;128:123-143.
-
(1992)
Immunol Rev
, vol.128
, pp. 123-143
-
-
Marion, T.N.1
Tillman, D.M.2
Jou, N.T.3
Hill, R.J.4
-
79
-
-
0000399627
-
Structure-function correlates of autoantibodies to nucleic acids: Lessons from immunochemical, genetic and structural studies
-
Eilat D, Anderson WF. Structure-function correlates of autoantibodies to nucleic acids: lessons from immunochemical, genetic and structural studies. Mol Immunol 1994;27:203-233.
-
(1994)
Mol Immunol
, vol.27
, pp. 203-233
-
-
Eilat, D.1
Anderson, W.F.2
-
80
-
-
0028278774
-
Molecular analysis of anti-DNA antibodies
-
Stollar BD. Molecular analysis of anti-DNA antibodies. FASEB J 1994;8:337-342.
-
(1994)
FASEB J
, vol.8
, pp. 337-342
-
-
Stollar, B.D.1
-
81
-
-
0024521441
-
bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
-
McDonnell TJ, et al. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 1989;57:79-88.
-
(1989)
Cell
, vol.57
, pp. 79-88
-
-
McDonnell, T.J.1
-
82
-
-
0025751550
-
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
-
Sentman CL, Shutter JR, Hockenberry D, Kanagawa O, Korsmeyer SJ. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 1991;67:879-888.
-
(1991)
Cell
, vol.67
, pp. 879-888
-
-
Sentman, C.L.1
Shutter, J.R.2
Hockenberry, D.3
Kanagawa, O.4
Korsmeyer, S.J.5
-
83
-
-
0027260581
-
The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow
-
Nisitani S, Tsubata T, Murakami M, Okamoto M, Honjo T. The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. J Exp Med 1993;178:1247-1254.
-
(1993)
J Exp Med
, vol.178
, pp. 1247-1254
-
-
Nisitani, S.1
Tsubata, T.2
Murakami, M.3
Okamoto, M.4
Honjo, T.5
-
85
-
-
0028789148
-
Anatomy of autoantibody production: Dominant localization of antibody producing cells to T cell zones in Fas-deficient mice
-
Jacobson BA, Panka DJ, Nguyen K-A, Erikson J, Abbas AK, Marshak-Rothstein A. Anatomy of autoantibody production: dominant localization of antibody producing cells to T cell zones in Fas-deficient mice. Immunity 1995;3:509-519.
-
(1995)
Immunity
, vol.3
, pp. 509-519
-
-
Jacobson, B.A.1
Panka, D.J.2
Nguyen, K.-A.3
Erikson, J.4
Abbas, A.K.5
Marshak-Rothstein, A.6
-
86
-
-
0030070295
-
Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatiod arthritis
-
Schroder AE, Greiner A, Seyfert C, Berek C. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatiod arthritis. Proc Natl Acad Sci USA 1996;93:221-225.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 221-225
-
-
Schroder, A.E.1
Greiner, A.2
Seyfert, C.3
Berek, C.4
-
87
-
-
0027999391
-
The mechanism of autoantibody production in an autoimmune MRL/lpr mouse
-
Shan H, Shlomchik MJ, Marshak-Rothstein A, Pisetsky DS, Litwin S, Weigert MG. The mechanism of autoantibody production in an autoimmune MRL/lpr mouse. J Immunol 1994;153:5104-5120.
-
(1994)
J Immunol
, vol.153
, pp. 5104-5120
-
-
Shan, H.1
Shlomchik, M.J.2
Marshak-Rothstein, A.3
Pisetsky, D.S.4
Litwin, S.5
Weigert, M.G.6
-
88
-
-
0030039654
-
Both Sm and DNA are selecting antigens in the anti-Sm B cell response in autoimmune MRL/lpr mice
-
Retter MW, Cohen PL, Eisenberg RA, Clarke SH. Both Sm and DNA are selecting antigens in the anti-Sm B cell response in autoimmune MRL/lpr mice. J Immunol 1996;156:1296-1306.
-
(1996)
J Immunol
, vol.156
, pp. 1296-1306
-
-
Retter, M.W.1
Cohen, P.L.2
Eisenberg, R.A.3
Clarke, S.H.4
-
89
-
-
0028785538
-
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance
-
Han S, Zheng B, Dal Porto J, Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance. J Exp Med 1995;182:1635-1644.
-
(1995)
J Exp Med
, vol.182
, pp. 1635-1644
-
-
Han, S.1
Zheng, B.2
Dal Porto, J.3
Kelsoe, G.4
-
90
-
-
0029059370
-
Soluble antigen can cause enhanced apoptosis of germinal-center B cells
-
Pulendran B, Kannourakis G, Nouri S, Smith KGC, Nossal GJV. Soluble antigen can cause enhanced apoptosis of germinal-center B cells. Nature 1995;375:331-334.
-
(1995)
Nature
, vol.375
, pp. 331-334
-
-
Pulendran, B.1
Kannourakis, G.2
Nouri, S.3
Smith, K.G.C.4
Nossal, G.J.V.5
-
91
-
-
0029014435
-
Antigen-induced B-cell death and elimination during germinal-centre immune responses
-
Shokat K, Goodnow CC. Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature 1995;375:334-338.
-
(1995)
Nature
, vol.375
, pp. 334-338
-
-
Shokat, K.1
Goodnow, C.C.2
-
92
-
-
0029076561
-
CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells
-
Rathmell JC, et al. CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. Nature 1995;376:181-184.
-
(1995)
Nature
, vol.376
, pp. 181-184
-
-
Rathmell, J.C.1
-
93
-
-
0028920079
-
Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells
-
Rothstein T, et al. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature 1995;374:163-165.
-
(1995)
Nature
, vol.374
, pp. 163-165
-
-
Rothstein, T.1
-
95
-
-
0027994675
-
Biology of germinal centers in lymphoid tissue
-
Thorbecke GJ, Amin AR, Tsiagbe VK. Biology of germinal centers in lymphoid tissue. FASEB J 1994;8:832-840.
-
(1994)
FASEB J
, vol.8
, pp. 832-840
-
-
Thorbecke, G.J.1
Amin, A.R.2
Tsiagbe, V.K.3
-
96
-
-
0029917123
-
Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, p53 and Bax but not the survival gene bcl-2
-
Martinez-Valdez H, Guret C, de Bouteiller O, Fugier I, Banchereau J, Liu YJ. Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, p53 and Bax but not the survival gene bcl-2. J Exp Med 1996;183:971-977.
-
(1996)
J Exp Med
, vol.183
, pp. 971-977
-
-
Martinez-Valdez, H.1
Guret, C.2
De Bouteiller, O.3
Fugier, I.4
Banchereau, J.5
Liu, Y.J.6
-
97
-
-
0029933460
-
Pathogenic autoantibodies are routinely generated during the response to foreign antigen: A paradigm for autoimmune disease
-
Ray SK, Putterman C, Diamond B. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. Proc Natl Acad Sci USA. 1996;93:2019-2024.
-
(1996)
Proc Natl Acad Sci USA.
, vol.93
, pp. 2019-2024
-
-
Ray, S.K.1
Putterman, C.2
Diamond, B.3
-
98
-
-
0028577302
-
Control of autoantibody affinity by selection against amino acid replacements in the complemetarity determining regions
-
Borrentzen M, Randen I, Zdarsky E, Forre O, Natvig JB, Thompson KM. Control of autoantibody affinity by selection against amino acid replacements in the complemetarity determining regions. Proc Natl Acad Sci USA 1994;91:12917-12921.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 12917-12921
-
-
Borrentzen, M.1
Randen, I.2
Zdarsky, E.3
Forre, O.4
Natvig, J.B.5
Thompson, K.M.6
-
99
-
-
0029558132
-
The BALB/c mouse B-cell response to pigeon cytochrome C initiates as a heteroclitic response specific for the self antigen mouse cytochrome c
-
Minnerath JM, Wakem LP, Comfort LL, Sherman F, Jemmerson R. The BALB/c mouse B-cell response to pigeon cytochrome C initiates as a heteroclitic response specific for the self antigen mouse cytochrome c. Proc Natl Acad Sci USA 1995;92:12379-12383.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 12379-12383
-
-
Minnerath, J.M.1
Wakem, L.P.2
Comfort, L.L.3
Sherman, F.4
Jemmerson, R.5
-
100
-
-
0026442095
-
Patterns of antibody specificity during the BALB/c immune response to hen eggwhite lysozyme
-
Newman MA, Mainhart CR, Mallett CP, Lavoie TB, Smith-Gill SJ. Patterns of antibody specificity during the BALB/c immune response to hen eggwhite lysozyme. J Immunol 1992;149:3260-3272
-
(1992)
J Immunol
, vol.149
, pp. 3260-3272
-
-
Newman, M.A.1
Mainhart, C.R.2
Mallett, C.P.3
Lavoie, T.B.4
Smith-Gill, S.J.5
-
101
-
-
0028921553
-
Binding analysis of antibodies produced by precursors and branchpoint intermediates of an anti-influenza hemagglutinin B cell clone. Parallel replacement mutations do not confer increased avidity for hemagglutinin
-
Rickert RC, Wloch MK, Hahn RL, Clarke SH. Binding analysis of antibodies produced by precursors and branchpoint intermediates of an anti-influenza hemagglutinin B cell clone. Parallel replacement mutations do not confer increased avidity for hemagglutinin. J Immunol 1995;154:2209-2216.
-
(1995)
J Immunol
, vol.154
, pp. 2209-2216
-
-
Rickert, R.C.1
Wloch, M.K.2
Hahn, R.L.3
Clarke, S.H.4
-
102
-
-
0029653339
-
Early high-affinity neutralizating anti-viral IgG responses without further overall improvements of affinity
-
Roost HP, et al. Early high-affinity neutralizating anti-viral IgG responses without further overall improvements of affinity. Proc Natl Acad Sci USA 1995;92:1257-1261.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 1257-1261
-
-
Roost, H.P.1
-
103
-
-
0014872131
-
Selection under a somatic model
-
Cohn M. Selection under a somatic model. Cell Immunol 1970;1:461-467.
-
(1970)
Cell Immunol
, vol.1
, pp. 461-467
-
-
Cohn, M.1
|