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Volumn 161, Issue 10, 1998, Pages 5373-5381

Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers

Author keywords

[No Author keywords available]

Indexed keywords

HAPTEN; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 0032533470     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (143)

References (104)
  • 1
    • 0026670190 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers
    • Jacob, J., and G. Kelsoe. 1992. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 176:679.
    • (1992) J. Exp. Med. , vol.176 , pp. 679
    • Jacob, J.1    Kelsoe, G.2
  • 2
    • 0027269664 scopus 로고
    • Sites of B-cell activation in vivo
    • Kelsoe, G., and B. Zheng. 1993. Sites of B-cell activation in vivo. Curr. Opin. Immunol. 5:418.
    • (1993) Curr. Opin. Immunol. , vol.5 , pp. 418
    • Kelsoe, G.1    Zheng, B.2
  • 3
    • 0025951891 scopus 로고
    • Studies of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens
    • Liu, Y. J., J. Zhang, P. J. L. Lane, E. Y. T. Chan, and I. C. M. MacLennan. 1991. Studies of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21:2951.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 2951
    • Liu, Y.J.1    Zhang, J.2    Lane, P.J.L.3    Chan, E.Y.T.4    MacLennan, I.C.M.5
  • 4
    • 0020562931 scopus 로고
    • Relationship of germinal centers in the lymphoid tissue to immunological memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin
    • Coico, R. F., B. S. Bhogal, and G. J. Thorbecke. 1983. Relationship of germinal centers in the lymphoid tissue to immunological memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin. J. Immunol. 131:2254.
    • (1983) J. Immunol. , vol.131 , pp. 2254
    • Coico, R.F.1    Bhogal, B.S.2    Thorbecke, G.J.3
  • 5
    • 0026552673 scopus 로고
    • Among naive precursor cell populations only progenitors of memory B cells originate germinal centers
    • Linton, P. J., D. Lo, L. Lai, G. J. Thorbecke, and N. R. Klinman. 1992. Among naive precursor cell populations only progenitors of memory B cells originate germinal centers. Eur. J. Immunol. 22:1293.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1293
    • Linton, P.J.1    Lo, D.2    Lai, L.3    Thorbecke, G.J.4    Klinman, N.R.5
  • 8
    • 0024802909 scopus 로고
    • Primary antibody forming cells and secondary B cells are generated from separate precursor cell subpopulations
    • Linton, P.-J., D. J. Decker, and N. Klinman. 1989. Primary antibody forming cells and secondary B cells are generated from separate precursor cell subpopulations. Cell 59:1049.
    • (1989) Cell , vol.59 , pp. 1049
    • Linton, P.-J.1    Decker, D.J.2    Klinman, N.3
  • 10
    • 0015382576 scopus 로고
    • The mechanism of antigenic stimulation of primary and secondary clonal precursor cells
    • Klinman, N. R. 1972. The mechanism of antigenic stimulation of primary and secondary clonal precursor cells. J. Exp. Med. 136:241.
    • (1972) J. Exp. Med. , vol.136 , pp. 241
    • Klinman, N.R.1
  • 11
    • 0025856601 scopus 로고
    • Kinetic maturation of an immune response
    • Foote, J., and C. Milstein. 1991. Kinetic maturation of an immune response. Nature 352:530.
    • (1991) Nature , vol.352 , pp. 530
    • Foote, J.1    Milstein, C.2
  • 12
    • 0028988331 scopus 로고
    • T cell receptor antagonists and partial agonists
    • Jameson, S. C., and M. J. Bevan. 1995. T cell receptor antagonists and partial agonists. Immunity 2:1.
    • (1995) Immunity , vol.2 , pp. 1
    • Jameson, S.C.1    Bevan, M.J.2
  • 13
    • 0028902752 scopus 로고
    • Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
    • Madrenas, J., R. L. Wange, J. L. Wang, N. Isakov, L. E. Samelson, and R. N. Germain. 1995. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515.
    • (1995) Science , vol.267 , pp. 515
    • Madrenas, J.1    Wange, R.L.2    Wang, J.L.3    Isakov, N.4    Samelson, L.E.5    Germain, R.N.6
  • 15
    • 0011084483 scopus 로고
    • Variations in affinity of antibodies during the immune response
    • Eisen, H. N., and G. W. Siskind. 1964. Variations in affinity of antibodies during the immune response. Biochemistry 3:996.
    • (1964) Biochemistry , vol.3 , pp. 996
    • Eisen, H.N.1    Siskind, G.W.2
  • 16
    • 0022643955 scopus 로고
    • Several V genes participate in the early phenyloxazolone response in various combinations
    • Kaartinen, M., J. Pelkonen, and O. Makela. 1986. Several V genes participate in the early phenyloxazolone response in various combinations. Eur. J. Immunol. 16:98.
    • (1986) Eur. J. Immunol. , vol.16 , pp. 98
    • Kaartinen, M.1    Pelkonen, J.2    Makela, O.3
  • 17
    • 0015289461 scopus 로고
    • Studies on antibody affinity at the cellular level
    • Anderson, B. 1972. Studies on antibody affinity at the cellular level. J. Exp. Med. 135:312.
    • (1972) J. Exp. Med. , vol.135 , pp. 312
    • Anderson, B.1
  • 18
    • 0014561360 scopus 로고
    • Determination of avidity of anti-albumin antibodies in mice
    • Celada, F., D. Schmidt, and R. Strom. 1969. Determination of avidity of anti-albumin antibodies in mice. Immunology 17:189.
    • (1969) Immunology , vol.17 , pp. 189
    • Celada, F.1    Schmidt, D.2    Strom, R.3
  • 19
    • 0023829551 scopus 로고
    • Analysis of the B lymphocyte repertoire by polyclonal activation: Hindrance by clones yielding antibodies which bind promiscuously to plastic
    • Conger, J. D., B. L. Pike, and G. J. V. Nossal. 1988. Analysis of the B lymphocyte repertoire by polyclonal activation: hindrance by clones yielding antibodies which bind promiscuously to plastic. J. Immunol. Methods 106:181.
    • (1988) J. Immunol. Methods , vol.106 , pp. 181
    • Conger, J.D.1    Pike, B.L.2    Nossal, G.J.V.3
  • 20
    • 0018957509 scopus 로고
    • Fine specificity and idiotypes of early antibodies against (4-hydroxy-3-nitrophenyl)acetyl (NP)
    • Karjalainen, K., B. Bang, and O. Makela. 1980. Fine specificity and idiotypes of early antibodies against (4-hydroxy-3-nitrophenyl)acetyl (NP). J. Immunol. 125: 313.
    • (1980) J. Immunol. , vol.125 , pp. 313
    • Karjalainen, K.1    Bang, B.2    Makela, O.3
  • 21
    • 0025213248 scopus 로고
    • V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin
    • Clarke, S. H., L. M. Staudt, J. Kavaler, D. Schwartz, W. U. Gerhard, and M. G. Weigert. 1990. V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin. J. Immunol. 144: 2795.
    • (1990) J. Immunol. , vol.144 , pp. 2795
    • Clarke, S.H.1    Staudt, L.M.2    Kavaler, J.3    Schwartz, D.4    Gerhard, W.U.5    Weigert, M.G.6
  • 22
    • 0014642258 scopus 로고
    • Cell selection by antigen in the immune response
    • F. J. Dixon and H. G. Kunkel, eds. Academic Press, New York
    • Siskind, G. W., and B. Benacerraf. 1969. Cell selection by antigen in the immune response. In Advances in Immunology, Vol. 10. F. J. Dixon and H. G. Kunkel, eds. Academic Press, New York, pp. 1-50.
    • (1969) Advances in Immunology , vol.10 , pp. 1-50
    • Siskind, G.W.1    Benacerraf, B.2
  • 23
    • 0014291199 scopus 로고
    • Quantitative studies of the specificity of anti-pneumococcal polysaccharide antibodies, types 3 and 8: Binding of a labeled oligosaccharide derived from S8 by anti-S8 antibodies
    • Pappenheimer, A. M. J., W. P. Reed, and R. Brown. 1968. Quantitative studies of the specificity of anti-pneumococcal polysaccharide antibodies, types 3 and 8: binding of a labeled oligosaccharide derived from S8 by anti-S8 antibodies. J. Immunol. 100:1237.
    • (1968) J. Immunol. , vol.100 , pp. 1237
    • Pappenheimer, A.M.J.1    Reed, W.P.2    Brown, R.3
  • 24
    • 0016275147 scopus 로고
    • Inheritance of antibody specificity. I. Anti-(4-hydroxy-3-nitrophenyl)acetyl in mouse
    • Imanishi, T., and O. Makela. 1974. Inheritance of antibody specificity. I. Anti-(4-hydroxy-3-nitrophenyl)acetyl in mouse. J. Exp. Med. 140:1498.
    • (1974) J. Exp. Med. , vol.140 , pp. 1498
    • Imanishi, T.1    Makela, O.2
  • 25
    • 0014814268 scopus 로고
    • Studies on the regulation of avidity at the level of the single antibody-forming cell: The effect of antigen dose and time of immunization
    • Anderson, B. 1970. Studies on the regulation of avidity at the level of the single antibody-forming cell: the effect of antigen dose and time of immunization. J. Exp. Med. 132:77.
    • (1970) J. Exp. Med. , vol.132 , pp. 77
    • Anderson, B.1
  • 26
    • 0023103262 scopus 로고
    • Germ-line affinity and germ-line variable-region genes in the B cell response
    • Chua, M.-M., S. H. Goodgal, and F. Karush. 1987. Germ-line affinity and germ-line variable-region genes in the B cell response. J. Immunol. 138:1281.
    • (1987) J. Immunol. , vol.138 , pp. 1281
    • Chua, M.-M.1    Goodgal, S.H.2    Karush, F.3
  • 27
    • 0016284015 scopus 로고
    • Similar idiotypes in antibody-forming cells and in cells synthesizing immunoglobulins without detectable antibody function
    • Cazenave, P. A., T. Ternynck, and S. Avrameas. 1974. Similar idiotypes in antibody-forming cells and in cells synthesizing immunoglobulins without detectable antibody function. Proc. Natl. Acad. Sci. USA 71:4500.
    • (1974) Proc. Natl. Acad. Sci. USA , vol.71 , pp. 4500
    • Cazenave, P.A.1    Ternynck, T.2    Avrameas, S.3
  • 28
    • 3643058390 scopus 로고
    • Restriction in IgM expression. II. Affinity analysis of monoclonal anti-lactose antibodies
    • Mandal, C., and F. Karush. 1981. Restriction in IgM expression. II. Affinity analysis of monoclonal anti-lactose antibodies. J. Immunol. 127:1241.
    • (1981) J. Immunol. , vol.127 , pp. 1241
    • Mandal, C.1    Karush, F.2
  • 29
    • 0016671543 scopus 로고
    • Synthesis of antibodies and immunoglobulins without detectable antibody function in cells responding to horseradish peroxidase
    • Miller, H. P., T. Ternynck, and S. Avrameas. 1974. Synthesis of antibodies and immunoglobulins without detectable antibody function in cells responding to horseradish peroxidase. J. Immunol. 114:626.
    • (1974) J. Immunol. , vol.114 , pp. 626
    • Miller, H.P.1    Ternynck, T.2    Avrameas, S.3
  • 30
    • 0014879122 scopus 로고
    • Concomitant synthesis, in separate cells, of non-reactive immunoglobulins and specific antibodies after immunization with tobacco mosaic virus
    • Urbain-Vansanten, G. 1970. Concomitant synthesis, in separate cells, of non-reactive immunoglobulins and specific antibodies after immunization with tobacco mosaic virus. Immunology 19:783.
    • (1970) Immunology , vol.19 , pp. 783
    • Urbain-Vansanten, G.1
  • 31
    • 0015080111 scopus 로고
    • Possible relationships between antibodies and non-specific immunoglobulins simultaneously induced after antigenic stimulation
    • Vos-Cloetens, C. D., V. Minsart-Baleriaux, and G. Urbain-Vansanten. 1971. Possible relationships between antibodies and non-specific immunoglobulins simultaneously induced after antigenic stimulation. Immunology 20:955.
    • (1971) Immunology , vol.20 , pp. 955
    • Vos-Cloetens, C.D.1    Minsart-Baleriaux, V.2    Urbain-Vansanten, G.3
  • 33
    • 0001152394 scopus 로고
    • Allergy and immunology
    • Talmage, D. 1957. Allergy and immunology. Annu. Rev. Med. 8:239.
    • (1957) Annu. Rev. Med. , vol.8 , pp. 239
    • Talmage, D.1
  • 35
    • 0022628080 scopus 로고
    • The affinity threshold for antigenic triggering differs for tolerance susceptible immature precursors vs. mature primary B cells
    • Riley, R. L., and N. R. Klinman. 1986. The affinity threshold for antigenic triggering differs for tolerance susceptible immature precursors vs. mature primary B cells. J. Immunol. 136:3147.
    • (1986) J. Immunol. , vol.136 , pp. 3147
    • Riley, R.L.1    Klinman, N.R.2
  • 36
    • 0030250062 scopus 로고    scopus 로고
    • The "clonal selection hypothesis" and current concepts of B cell tolerance
    • Klinman, N. R. 1996. The "clonal selection hypothesis" and current concepts of B cell tolerance. Immunity. 5:189.
    • (1996) Immunity , vol.5 , pp. 189
    • Klinman, N.R.1
  • 37
    • 0027380109 scopus 로고
    • Influence of membrane Ig receptor density and affinity on B cell signaling by antigen
    • George, J., S. J. Penner, J. Weber, J. Berry, and J. L. Claflin. 1993. Influence of membrane Ig receptor density and affinity on B cell signaling by antigen. J. Immunol. 151:5955.
    • (1993) J. Immunol. , vol.151 , pp. 5955
    • George, J.1    Penner, S.J.2    Weber, J.3    Berry, J.4    Claflin, J.L.5
  • 39
    • 0028785538 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance
    • Han, S., J. Dal Porto, B. Zheng, and G. Kelsoe. 1995. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance. J. Exp. Med. 182:1635.
    • (1995) J. Exp. Med. , vol.182 , pp. 1635
    • Han, S.1    Dal Porto, J.2    Zheng, B.3    Kelsoe, G.4
  • 40
    • 0027305024 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells
    • Jacob, J., J. Pryzlepa, C. Miller, and G. Kelsoe. 1993. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J. Exp. Med. 178:1293.
    • (1993) J. Exp. Med. , vol.178 , pp. 1293
    • Jacob, J.1    Pryzlepa, J.2    Miller, C.3    Kelsoe, G.4
  • 41
    • 0024044570 scopus 로고
    • Antibody engineering for the analysis of affinity maturation of an anti-hapten response
    • Allen, D., T. Simon, F. Sablitzky, K. Rajewsky, and A. Cumano. 1988. Antibody engineering for the analysis of affinity maturation of an anti-hapten response. EMBO J. 7:1995.
    • (1988) EMBO J. , vol.7 , pp. 1995
    • Allen, D.1    Simon, T.2    Sablitzky, F.3    Rajewsky, K.4    Cumano, A.5
  • 42
    • 0023101997 scopus 로고
    • Maturation of the immune response to (4-hydroxy-3-nitrophenyl)acetyl (NP) haptens in C57BL/6 mice
    • Azuma, T., N. Sakato, and H. Fujio. 1987. Maturation of the immune response to (4-hydroxy-3-nitrophenyl)acetyl (NP) haptens in C57BL/6 mice. Mol. Immunol. 24:287.
    • (1987) Mol. Immunol. , vol.24 , pp. 287
    • Azuma, T.1    Sakato, N.2    Fujio, H.3
  • 43
    • 0018578942 scopus 로고
    • Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies
    • Reth, M., T. Imanishi-Kari, and K. Rajewsky. 1979. Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies. Eur. J. Immunol. 9:1004.
    • (1979) Eur. J. Immunol. , vol.9 , pp. 1004
    • Reth, M.1    Imanishi-Kari, T.2    Rajewsky, K.3
  • 44
    • 0023652377 scopus 로고
    • Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses
    • Siekevitz, M., C. Kocks, K. Rajewsky, and R. Dildrop. 1987. Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses. Cell 48:757.
    • (1987) Cell , vol.48 , pp. 757
    • Siekevitz, M.1    Kocks, C.2    Rajewsky, K.3    Dildrop, R.4
  • 45
    • 0025601012 scopus 로고
    • The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response
    • Weiss, U., and K. Rajewsky. 1990. The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response. J. Exp. Med. 172:1681.
    • (1990) J. Exp. Med. , vol.172 , pp. 1681
    • Weiss, U.1    Rajewsky, K.2
  • 46
    • 0003575039 scopus 로고
    • Stepwise intraclonal maturation of antibody affinity through somatic hypermutation
    • Kocks, C., and K. Rajewsky. 1988. Stepwise intraclonal maturation of antibody affinity through somatic hypermutation. Proc. Natl. Acad. Sci. USA 85:8206.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 8206
    • Kocks, C.1    Rajewsky, K.2
  • 48
    • 0025726702 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations
    • Jacob, J., R. Kassir, and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173:1165.
    • (1991) J. Exp. Med. , vol.173 , pp. 1165
    • Jacob, J.1    Kassir, R.2    Kelsoe, G.3
  • 50
    • 0018179467 scopus 로고
    • Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in primary and hyperimmune responses
    • Reth, M., G. J. Hammerling, and K. Rajewsky. 1978. Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in primary and hyperimmune responses. Eur. J. Immunol. 130:393.
    • (1978) Eur. J. Immunol. , vol.130 , pp. 393
    • Reth, M.1    Hammerling, G.J.2    Rajewsky, K.3
  • 51
    • 0026060620 scopus 로고
    • Intraclonal generation of antibody mutants in germinal centres
    • Jacob, J., G. Kelsoe, K. Rajewsky, and U. Weiss. 1991. Intraclonal generation of antibody mutants in germinal centres. Nature 354:389.
    • (1991) Nature , vol.354 , pp. 389
    • Jacob, J.1    Kelsoe, G.2    Rajewsky, K.3    Weiss, U.4
  • 52
    • 0028983212 scopus 로고
    • H hypermutation is absent in the germinal centers of aged mice
    • H hypermutation is absent in the germinal centers of aged mice. J. Immunol. 155:3377.
    • (1995) J. Immunol. , vol.155 , pp. 3377
    • Miller, C.1    Kelsoe, G.2
  • 54
    • 0020338539 scopus 로고
    • Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity
    • Bruggemann, M., A. Radbruch, and K. Rajewsky. 1982. Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity. EMBO J. 1:629.
    • (1982) EMBO J. , vol.1 , pp. 629
    • Bruggemann, M.1    Radbruch, A.2    Rajewsky, K.3
  • 55
    • 0022742672 scopus 로고
    • Idiotypic selection of an antibody mutant with changed hapten binding specificity, resulting from a point mutation in position 50 of the heavy chain
    • Bruggemann, M., H.-J. Muller, C. Burger, and K. Rajewsky. 1986. Idiotypic selection of an antibody mutant with changed hapten binding specificity, resulting from a point mutation in position 50 of the heavy chain. EMBO J. 5:1561.
    • (1986) EMBO J. , vol.5 , pp. 1561
    • Bruggemann, M.1    Muller, H.-J.2    Burger, C.3    Rajewsky, K.4
  • 56
    • 0021888368 scopus 로고
    • Structure of primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice
    • Cumano, A., and K. Rajewsky. 1985. Structure of primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice. Eur. J. Immunol. 15:512.
    • (1985) Eur. J. Immunol. , vol.15 , pp. 512
    • Cumano, A.1    Rajewsky, K.2
  • 57
    • 0025980973 scopus 로고
    • Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice
    • Erikson, J., M. Z. Radic, S. A. Camper, R. R. Hardy, and M. G. Weigert. 1991. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 349:331.
    • (1991) Nature , vol.349 , pp. 331
    • Erikson, J.1    Radic, M.Z.2    Camper, S.A.3    Hardy, R.R.4    Weigert, M.G.5
  • 58
    • 0005374813 scopus 로고
    • Quenching of antibody fluorescence by haptens: A method for determining antibody-ligand affinity
    • C. A. Williams and M. W. Chase, eds. Academic Press, Inc., New York and London
    • Eisen, H. N., and J. E. McGuigan. 1971. Quenching of antibody fluorescence by haptens: a method for determining antibody-ligand affinity. In Methods in Immunology and Immunochemistry. Vol. 3. C. A. Williams and M. W. Chase, eds. Academic Press, Inc., New York and London, pp. 395-411.
    • (1971) Methods in Immunology and Immunochemistry , vol.3 , pp. 395-411
    • Eisen, H.N.1    McGuigan, J.E.2
  • 59
    • 0022558297 scopus 로고
    • Replacing the complementarity-determining regions in a human antibody with those from a mouse
    • Jones, P. T., P. H. Dear, J. Foote, M. S. Neuberger, and G. Winter. 1986. Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature 321:522.
    • (1986) Nature , vol.321 , pp. 522
    • Jones, P.T.1    Dear, P.H.2    Foote, J.3    Neuberger, M.S.4    Winter, G.5
  • 60
    • 0021825461 scopus 로고
    • Preparation and characterization of murine monoclonal antibodies that express both cold agglutinin and cryoglobulin activities
    • Patel, R. D., and J. C. Brown. 1985. Preparation and characterization of murine monoclonal antibodies that express both cold agglutinin and cryoglobulin activities. J. Immunol. 134:4041.
    • (1985) J. Immunol. , vol.134 , pp. 4041
    • Patel, R.D.1    Brown, J.C.2
  • 61
    • 3643058389 scopus 로고
    • B. Mishell, and S. Shiigi, eds. W. H. Freeman and Co., San Francisco, CA
    • Mishell, B. 1980. Selected Methods in Cellular Immunology. B. Mishell, and S. Shiigi, eds. W. H. Freeman and Co., San Francisco, CA, pp. 135-145.
    • (1980) Selected Methods in Cellular Immunology , pp. 135-145
    • Mishell, B.1
  • 62
    • 0022802257 scopus 로고
    • Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP
    • Cumano, A., and K. Rajewsky. 1986. Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP. EMBO J. 5:2459.
    • (1986) EMBO J. , vol.5 , pp. 2459
    • Cumano, A.1    Rajewsky, K.2
  • 65
    • 0028071173 scopus 로고
    • Analysis of individual immunoglobulin λ light chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center B cell somatic mutation
    • Ford, J. E., M. G. McHeyzer-Williams, and M. R. Lieber. 1994. Analysis of individual immunoglobulin λ light chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center B cell somatic mutation. Eur. J. Immunol. 24:1816.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1816
    • Ford, J.E.1    McHeyzer-Williams, M.G.2    Lieber, M.R.3
  • 66
    • 0027960893 scopus 로고
    • Locus-specific somatic hypermutation in germinal centre T cells
    • Zheng, B., W. Xue, and G. Kelsoe. 1994. Locus-specific somatic hypermutation in germinal centre T cells. Nature 372:556.
    • (1994) Nature , vol.372 , pp. 556
    • Zheng, B.1    Xue, W.2    Kelsoe, G.3
  • 67
    • 0028909056 scopus 로고
    • Altering the antibody repertoire via transgene homologous recombination: Evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation
    • Vora, K. A., and T. Manser. 1995. Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation. J. Exp. Med. 181:271.
    • (1995) J. Exp. Med. , vol.181 , pp. 271
    • Vora, K.A.1    Manser, T.2
  • 68
    • 0023930399 scopus 로고
    • Affinity of anti-peptide antibodies measured by resonance energy transfer
    • Karush, F., and X. X. Tang. 1988. Affinity of anti-peptide antibodies measured by resonance energy transfer. J. Immunol. Methods 106:63.
    • (1988) J. Immunol. Methods , vol.106 , pp. 63
    • Karush, F.1    Tang, X.X.2
  • 69
    • 0016326987 scopus 로고
    • Model for the binding of multivalent antigen to cells
    • Bell, G. I. 1974. Model for the binding of multivalent antigen to cells. Nature 248:430.
    • (1974) Nature , vol.248 , pp. 430
    • Bell, G.I.1
  • 70
    • 0026724485 scopus 로고
    • Membrane IgM-mediated signaling of human B cells: Effect of increased ligand binding site valency on the affinity and concentration requirements for inducing diverse stages of activation
    • Mongini, P. K., C. A. Blessinger, P. F. Highet, and J. K. Inman. 1992. Membrane IgM-mediated signaling of human B cells: effect of increased ligand binding site valency on the affinity and concentration requirements for inducing diverse stages of activation. J. Immunol. 148:3892.
    • (1992) J. Immunol. , vol.148 , pp. 3892
    • Mongini, P.K.1    Blessinger, C.A.2    Highet, P.F.3    Inman, J.K.4
  • 71
    • 0026633673 scopus 로고
    • Artifacts and limitations of enzyme immunoassays
    • Pesce, A. J., and J. G. Michael. 1992. Artifacts and limitations of enzyme immunoassays. J. Immunol. Methods 150:111.
    • (1992) J. Immunol. Methods , vol.150 , pp. 111
    • Pesce, A.J.1    Michael, J.G.2
  • 72
    • 0020622755 scopus 로고
    • Affinity requirements for antibody assays mapped by monoclonal antibodies
    • Peterfy, F., P. Kusela, and O. Makela. 1983. Affinity requirements for antibody assays mapped by monoclonal antibodies. J. Immunol. 130:1809.
    • (1983) J. Immunol. , vol.130 , pp. 1809
    • Peterfy, F.1    Kusela, P.2    Makela, O.3
  • 73
    • 0021914125 scopus 로고
    • The importance of antibody affinity in the performance of immunoassays for antibody
    • Steward, M. W., and A. M. Lew. 1985. The importance of antibody affinity in the performance of immunoassays for antibody. J. Immunol. Methods 78:173.
    • (1985) J. Immunol. Methods , vol.78 , pp. 173
    • Steward, M.W.1    Lew, A.M.2
  • 74
    • 0026331458 scopus 로고
    • Maturation of the immune response in germinal centers
    • Berek, C., A. Berger, and M. Apel. 1991. Maturation of the immune response in germinal centers. Cell 67:1121.
    • (1991) Cell , vol.67 , pp. 1121
    • Berek, C.1    Berger, A.2    Apel, M.3
  • 75
    • 0027260343 scopus 로고
    • The maturation of the immune response
    • Berek, C., and M. Ziegner. 1993. The maturation of the immune response. Immunol. Today 14:400.
    • (1993) Immunol. Today , vol.14 , pp. 400
    • Berek, C.1    Ziegner, M.2
  • 76
    • 0028875542 scopus 로고
    • Evaluation of loss and change of specificity resulting from random mutagenesis of an antibody VH region
    • Casson, L. P., and T. Manser. 1995. Evaluation of loss and change of specificity resulting from random mutagenesis of an antibody VH region. J. Immunol. 155:5647.
    • (1995) J. Immunol. , vol.155 , pp. 5647
    • Casson, L.P.1    Manser, T.2
  • 77
    • 0029148418 scopus 로고
    • Random mutagenesis of two complementary determining region amino acids
    • Casson, L. P., and T. Manser. 1995. Random mutagenesis of two complementary determining region amino acids. J. Exp. Med. 182:743.
    • (1995) J. Exp. Med. , vol.182 , pp. 743
    • Casson, L.P.1    Manser, T.2
  • 78
    • 0026782875 scopus 로고
    • Generation and analysis of random point mutations in an antibody CDR2 sequence: Many mutated antibodies lose their ability to bind antigen
    • Chen, C., V. A. Roberts, and M. B. Rittenberg. 1992. Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen. J. Exp. Med. 176:855.
    • (1992) J. Exp. Med. , vol.176 , pp. 855
    • Chen, C.1    Roberts, V.A.2    Rittenberg, M.B.3
  • 79
    • 0029047689 scopus 로고
    • Enhancement and destruction of antibody function by somatic mutation: Unequal occurrence is controlled by V gene combinatorial associations
    • Chen, C., V. A. Roberts, S. Stevens, M. Brown, M. P. Stenzel-Poore, and M. B. Rittenberg. 1995. Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations. EMBO J. 14:2784.
    • (1995) EMBO J. , vol.14 , pp. 2784
    • Chen, C.1    Roberts, V.A.2    Stevens, S.3    Brown, M.4    Stenzel-Poore, M.P.5    Rittenberg, M.B.6
  • 81
    • 0029653368 scopus 로고
    • Kinetic and affinity limits on antibodies produced during immune responses
    • Foote, J., and H. N. Eisen. 1995. Kinetic and affinity limits on antibodies produced during immune responses. Proc. Natl. Acad. Sci. USA 92:1254.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1254
    • Foote, J.1    Eisen, H.N.2
  • 82
    • 0020341181 scopus 로고
    • Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes
    • Dildrop, R., M. Bruggemann, A. Radbruch, K. Rajewsky, and K. Beyruether. 1982. Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes. EMBO J. 1:635.
    • (1982) EMBO J. , vol.1 , pp. 635
    • Dildrop, R.1    Bruggemann, M.2    Radbruch, A.3    Rajewsky, K.4    Beyruether, K.5
  • 83
    • 0028943268 scopus 로고
    • Choices following antigen entry: Antibody formation or immunological tolerance
    • Nossal, G. J. V. 1995. Choices following antigen entry: antibody formation or immunological tolerance. Annu. Rev. Immunol. 13:1.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 1
    • Nossal, G.J.V.1
  • 84
    • 0029916530 scopus 로고    scopus 로고
    • Antibody response to a T-dependent antigen requires B cell expression of complement receptors
    • Croix, D. A., J. M. Ahearn, A. M. Rosengard, S. Han, G. Kelsoe, M. Ma, and M. C. Carroll. 1996. Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J. Exp. Med. 183:1857.
    • (1996) J. Exp. Med. , vol.183 , pp. 1857
    • Croix, D.A.1    Ahearn, J.M.2    Rosengard, A.M.3    Han, S.4    Kelsoe, G.5    Ma, M.6    Carroll, M.C.7
  • 86
    • 0021752918 scopus 로고
    • Blood clearance by anti-phosphocholine antibodies as a mechanism of protection in experimental pneumococcal bacteremia
    • McDaniel, L. S., W. H. Benjamin, Jr., C. Forman, and D. E. Briles. 1984. Blood clearance by anti-phosphocholine antibodies as a mechanism of protection in experimental pneumococcal bacteremia. J. Immunol. 133:3308.
    • (1984) J. Immunol. , vol.133 , pp. 3308
    • McDaniel, L.S.1    Benjamin Jr., W.H.2    Forman, C.3    Briles, D.E.4
  • 87
    • 0031910110 scopus 로고    scopus 로고
    • Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice
    • Seiler, P., U. Kalinke, T. Rulicke, E. M. Bucher, C. Bose, R. M. Zinkernagel, and H. Hengartner. 1998. Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice. J. Virol. 72:2253.
    • (1998) J. Virol. , vol.72 , pp. 2253
    • Seiler, P.1    Kalinke, U.2    Rulicke, T.3    Bucher, E.M.4    Bose, C.5    Zinkernagel, R.M.6    Hengartner, H.7
  • 88
    • 0029028986 scopus 로고
    • Initiation of the phosphocholine-specific response to Proteus morganii: B cell transfectants expressing unmutated VH/VL can respond to stimulation by P. morganii antigen
    • Penner, S. J., J. George, and L. Claflin. 1995. Initiation of the phosphocholine-specific response to Proteus morganii: B cell transfectants expressing unmutated VH/VL can respond to stimulation by P. morganii antigen. J. Immunol. 155: 2387.
    • (1995) J. Immunol. , vol.155 , pp. 2387
    • Penner, S.J.1    George, J.2    Claflin, L.3
  • 90
    • 0026845876 scopus 로고
    • Maturation and dispersal of B cell clones during T cell-dependent antibody response
    • MacLennan, I. C. M., Y. T. Liu, and G. D. Johnson. 1992. Maturation and dispersal of B cell clones during T cell-dependent antibody response. Immunol. Res. 126:143.
    • (1992) Immunol. Res. , vol.126 , pp. 143
    • MacLennan, I.C.M.1    Liu, Y.T.2    Johnson, G.D.3
  • 91
    • 0023510298 scopus 로고
    • Evolution and somatic selection of the antibody repertoire in the mouse
    • Rajewsky, K., I. Forster, and A. Cumano. 1987. Evolution and somatic selection of the antibody repertoire in the mouse. Science 238:749.
    • (1987) Science , vol.238 , pp. 749
    • Rajewsky, K.1    Forster, I.2    Cumano, A.3
  • 92
    • 0032536872 scopus 로고    scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection
    • Takahashi, Y., P. R. Dutta, D. M. Cerasoli, and G. Kelsoe. 1998. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J. Exp. Med. 187:885.
    • (1998) J. Exp. Med. , vol.187 , pp. 885
    • Takahashi, Y.1    Dutta, P.R.2    Cerasoli, D.M.3    Kelsoe, G.4
  • 93
    • 0013953355 scopus 로고
    • Learning and memory in the immune response
    • Eisen, H. N. 1966. Learning and memory in the immune response. Cancer Res. 26:2005.
    • (1966) Cancer Res. , vol.26 , pp. 2005
    • Eisen, H.N.1
  • 94
    • 0021711720 scopus 로고
    • Somatic mutations and maturation of the immune response to z-phenyl oxazolone
    • Griffiths, G. M., C. Berek, M. Kaartinen, and C. Milstein. 1984. Somatic mutations and maturation of the immune response to z-phenyl oxazolone. Nature 312:271.
    • (1984) Nature , vol.312 , pp. 271
    • Griffiths, G.M.1    Berek, C.2    Kaartinen, M.3    Milstein, C.4
  • 95
    • 0025783070 scopus 로고
    • Molecular characterization of single memory B cells
    • McHeyzer-Williams, M. G., G. J. V. Nossal, and P. A. Lalor. 1991. Molecular characterization of single memory B cells. Nature 350:502.
    • (1991) Nature , vol.350 , pp. 502
    • McHeyzer-Williams, M.G.1    Nossal, G.J.V.2    Lalor, P.A.3
  • 96
    • 0028128577 scopus 로고
    • Development of antibody diversity in single germinal centers: Selective expansion of high-affinity variants
    • Ziegner, M., G. Steinhauser, and C. Berek. 1994. Development of antibody diversity in single germinal centers: selective expansion of high-affinity variants. Eur. J. Immunol. 24:239.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 239
    • Ziegner, M.1    Steinhauser, G.2    Berek, C.3
  • 98
    • 0026427043 scopus 로고
    • Growing human B lymphocytes in the CD40 system
    • Banchereau, J., and F. Rousset. 1991. Growing human B lymphocytes in the CD40 system. Nature 353:678.
    • (1991) Nature , vol.353 , pp. 678
    • Banchereau, J.1    Rousset, F.2
  • 99
    • 0344039778 scopus 로고
    • Three restriction points in the cell cycle of activated murine B lymphocytes
    • Melchers, F., and W. Lernhardt. 1985. Three restriction points in the cell cycle of activated murine B lymphocytes. Proc. Natl. Acad. Sci. USA 82:7681.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 7681
    • Melchers, F.1    Lernhardt, W.2
  • 101
    • 0019231835 scopus 로고
    • The follicular dendritic cell: Long term antigen retention during immunity
    • Mandel, T. E., R. P. Phipps, A. Abbot, and J. G. Tew. 1980. The follicular dendritic cell: long term antigen retention during immunity. Immunol. Rev. 53: 29.
    • (1980) Immunol. Rev. , vol.53 , pp. 29
    • Mandel, T.E.1    Phipps, R.P.2    Abbot, A.3    Tew, J.G.4
  • 103
    • 0023604840 scopus 로고
    • A limited number of B cell lineages generate the heterogeneity of a secondary immune response
    • Blier, P. R., and A. L. M. Bothwell. 1987. A limited number of B cell lineages generate the heterogeneity of a secondary immune response. EMBO J. 139: 3996.
    • (1987) EMBO J. , vol.139 , pp. 3996
    • Blier, P.R.1    Bothwell, A.L.M.2
  • 104
    • 0023761867 scopus 로고
    • B cell memory is short-lived in the absence of antigen
    • Gray, D., and H. Skarvall. 1988. B cell memory is short-lived in the absence of antigen. Nature 336:70.
    • (1988) Nature , vol.336 , pp. 70
    • Gray, D.1    Skarvall, H.2


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