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Roelse, J.2
Hämmerling, G.J.3
Neefjes, J.J.4
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45
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0028408339
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Human transporters associated with antigen processing possess a promiscuous peptide-binding site
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Androlewicz MJ, Cresswell P. Human transporters associated with antigen processing possess a promiscuous peptide-binding site. Immunity. 1:1994;7-14.
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Androlewicz, M.J.1
Cresswell, P.2
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46
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0028676237
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Substrate specificity of allelic variants of the TAP peptide transporter
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Heemels M-T, Ploegh HL. Substrate specificity of allelic variants of the TAP peptide transporter. Immunity. 1:1994;775-784.
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Heemels, M.-T.1
Ploegh, H.L.2
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47
-
-
0029809474
-
Translocation of long peptides by transporters associated with antigen processing (TAP)
-
of special interest. This study shows that peptides up to 40 amino acids can be substrates for TAP, but optimal transport is obtained with 8-12 mers.
-
Koopmann J-O, Post M, Neefjes JJ, Hämmerling GJ, Momburg F. Translocation of long peptides by transporters associated with antigen processing (TAP). of special interest Eur J Immunol. 26:1996;1720-1728 This study shows that peptides up to 40 amino acids can be substrates for TAP, but optimal transport is obtained with 8-12 mers.
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(1996)
Eur J Immunol
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, pp. 1720-1728
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Koopmann, J.-O.1
Post, M.2
Neefjes, J.J.3
Hämmerling, G.J.4
Momburg, F.5
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48
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-
0028082509
-
A subset of HLA-B27 molecules contains peptides much longer than nonamers
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Urban RG, Chicz RM, Lane WS, Strominger JL, Rehm A, Kenter MJH, UytdeHaag FGCM, Ploegh H, Uchanska-Ziegler B, Ziegler A. A subset of HLA-B27 molecules contains peptides much longer than nonamers. Proc Natl Acad Sci USA. 91:1994;1534-1538.
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Proc Natl Acad Sci USA
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Urban, R.G.1
Chicz, R.M.2
Lane, W.S.3
Strominger, J.L.4
Rehm, A.5
Kenter, M.J.H.6
Uytdehaag, F.7
Ploegh, H.8
Uchanska-Ziegler, B.9
Ziegler, A.10
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49
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0028117199
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Selectivity of MHC-encoded peptide transporters from human, mouse and rat
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Momburg F, Roelse J, Howard JC, Butcher GW, Hämmerling GJ, Neefjes JJ. Selectivity of MHC-encoded peptide transporters from human, mouse and rat. Nature. 367:1994;648-651.
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Nature
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Momburg, F.1
Roelse, J.2
Howard, J.C.3
Butcher, G.W.4
Hämmerling, G.J.5
Neefjes, J.J.6
-
50
-
-
0028965526
-
Analysis of the fine specificity of rat, mouse and human TAP peptide transporters
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Neefjes J, Gottfried E, Roelse J, Grommé M, Obst R, Hämmerling GJ, Momburg F. Analysis of the fine specificity of rat, mouse and human TAP peptide transporters. Eur J Immunol. 25:1995;1133-1136.
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Eur J Immunol
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, pp. 1133-1136
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Neefjes, J.1
Gottfried, E.2
Roelse, J.3
Grommé, M.4
Obst, R.5
Hämmerling, G.J.6
Momburg, F.7
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51
-
-
0028829908
-
Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences
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Neisig A, Roelse J, Sijts AJAM, Ossendorp F, Feltkamp MCW, Kast WM, Melief CJM, Neefjes JJ. Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences. J Immunol. 154:1995;1273-1279.
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J Immunol
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-
Neisig, A.1
Roelse, J.2
Sijts, A.3
Ossendorp, F.4
Feltkamp, M.C.W.5
Kast, W.M.6
Melief, C.J.M.7
Neefjes, J.J.8
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52
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0029065730
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Restriction of self-antigen presentation to cytolytic T lymphocytes by mouse peptide pumps
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Gournier H, Pascolo S, Siegrist C-A, Jehan J, Pérarnau B, Garcia Z, Rose T, Neefjes J, Lemonnier FA. Restriction of self-antigen presentation to cytolytic T lymphocytes by mouse peptide pumps. Eur J Immunol. 25:1995;2019-2026.
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Eur J Immunol
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, pp. 2019-2026
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-
Gournier, H.1
Pascolo, S.2
Siegrist, C.-A.3
Jehan, J.4
Pérarnau, B.5
Garcia, Z.6
Rose, T.7
Neefjes, J.8
Lemonnier, F.A.9
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53
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0028501327
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A sequential model for peptide binding and transport by the transporters associated with antigen processing
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Van Endert PM, Tampé R, Meyer TH, Tisch R, Bach J-F, McDevitt HO. A sequential model for peptide binding and transport by the transporters associated with antigen processing. Immunity. 1:1994;491-500.
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Immunity
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, pp. 491-500
-
-
Van Endert, P.M.1
Tampé, R.2
Meyer, T.H.3
Tisch, R.4
Bach, J.-F.5
McDevitt, H.O.6
-
54
-
-
0028819781
-
The peptide-binding motif for the human transporter associated with antigen processing
-
of special interest. Based on an investigation of numerous peptides, this paper delineates residues that are important for binding to TAP.
-
Van Endert PM, Riganelli D, Greco G, Fleischhauer K, Sidney J, Sette A, Bach J-F. The peptide-binding motif for the human transporter associated with antigen processing. of special interest J Exp Med. 182:1995;1883-1895 Based on an investigation of numerous peptides, this paper delineates residues that are important for binding to TAP.
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(1995)
J Exp Med
, vol.182
, pp. 1883-1895
-
-
Van Endert, P.M.1
Riganelli, D.2
Greco, G.3
Fleischhauer, K.4
Sidney, J.5
Sette, A.6
Bach, J.-F.7
-
55
-
-
0029148985
-
Requirements for peptide binding to the human transporter associated with antigen processing revealed by peptide scans and complex peptide libraries
-
Uebel S, Meyer TH, Kraas W, Kienle S, Jung G, Wiesmüller K-H, Tampé R. Requirements for peptide binding to the human transporter associated with antigen processing revealed by peptide scans and complex peptide libraries. J Biol Chem. 270:1995;18512-18516.
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(1995)
J Biol Chem
, vol.270
, pp. 18512-18516
-
-
Uebel, S.1
Meyer, T.H.2
Kraas, W.3
Kienle, S.4
Jung, G.5
Wiesmüller, K.-H.6
Tampé, R.7
-
56
-
-
0029930418
-
The rat cim effect: TAP allele-dependent changes in a class I MHC anchor motif and evidence against carboxy-terminal trimming of peptides in the ER
-
of special interest. This paper, together with [57], demonstrates strong effects of selective peptide transport in class I loading in vivo.
-
Powis SJ, Young LL, Joly E, Barker PJ, Richardson L, Brandt RP, Melief CJ, Howard JC, Butcher GW. The rat cim effect: TAP allele-dependent changes in a class I MHC anchor motif and evidence against carboxy-terminal trimming of peptides in the ER. of special interest Immunity. 4:1996;159-165 This paper, together with [57], demonstrates strong effects of selective peptide transport in class I loading in vivo.
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(1996)
Immunity
, vol.4
, pp. 159-165
-
-
Powis, S.J.1
Young, L.L.2
Joly, E.3
Barker, P.J.4
Richardson, L.5
Brandt, R.P.6
Melief, C.J.7
Howard, J.C.8
Butcher, G.W.9
-
57
-
-
0030056877
-
Rat MHC-linked peptide transporter alleles strongly influence peptide binding by HLA-B27 but not B27-associated inflammatory disease
-
Simmons WA, Leong LYW, Satumtira N, Butcher GW, Howard JC, Richardson JA, Slaughter CA, Hammer RE, Taurog JD. Rat MHC-linked peptide transporter alleles strongly influence peptide binding by HLA-B27 but not B27-associated inflammatory disease. J Immunol. 156:1996;1661-1667.
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(1996)
J Immunol
, vol.156
, pp. 1661-1667
-
-
Simmons, W.A.1
Leong, L.Y.W.2
Satumtira, N.3
Butcher, G.W.4
Howard, J.C.5
Richardson, J.A.6
Slaughter, C.A.7
Hammer, R.E.8
Taurog, J.D.9
-
58
-
-
0029127236
-
TAP polymorphism does not influence transport of peptide variants in mice and humans
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Obst R, Armandola EA, Nijenhuis M, Momburg F, Hämmerling GJ. TAP polymorphism does not influence transport of peptide variants in mice and humans. Eur J Immunol. 25:1995;2170-2176.
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(1995)
Eur J Immunol
, vol.25
, pp. 2170-2176
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Obst, R.1
Armandola, E.A.2
Nijenhuis, M.3
Momburg, F.4
Hämmerling, G.J.5
-
60
-
-
0029122282
-
Polymorphic peptide transporters in MHC class I monomorphic Syrian hamster
-
of special interest. This paper provides evidence that the class I monomorphic Syrian hamster expresses functionally polymorphic TAPs.
-
Lobigs M, Rothenfluh HS, Blanden RV, Müllbacher A. Polymorphic peptide transporters in MHC class I monomorphic Syrian hamster. of special interest Immunogenetics. 42:1995;398-407 This paper provides evidence that the class I monomorphic Syrian hamster expresses functionally polymorphic TAPs.
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(1995)
Immunogenetics
, vol.42
, pp. 398-407
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Lobigs, M.1
Rothenfluh, H.S.2
Blanden, R.V.3
Müllbacher, A.4
-
61
-
-
0026603535
-
Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule
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Powis SJ, Deverson EV, Coadwel WJ, Ciruela A, Huskisson NS, Smith H, Butcher GW, Howard JC. Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule. Nature. 357:1992;211-215.
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(1992)
Nature
, vol.357
, pp. 211-215
-
-
Powis, S.J.1
Deverson, E.V.2
Coadwel, W.J.3
Ciruela, A.4
Huskisson, N.S.5
Smith, H.6
Butcher, G.W.7
Howard, J.C.8
-
62
-
-
0030023563
-
Residues in TAP2 peptide transporters controlling substrate specificity
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of special interest. This study identifies polymorphic TAP2 residues that control permissive versus selective transport patterns in the rat.
-
Momburg F, Armandola EA, Post M, Hämmerling GJ. Residues in TAP2 peptide transporters controlling substrate specificity. of special interest J Immunol. 156:1996;1756-1763 This study identifies polymorphic TAP2 residues that control permissive versus selective transport patterns in the rat.
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(1996)
J Immunol
, vol.156
, pp. 1756-1763
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-
Momburg, F.1
Armandola, E.A.2
Post, M.3
Hämmerling, G.J.4
-
63
-
-
0029789436
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A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity
-
Armandola EA, Momburg F, Nijenhuis M, Bulbuc N, Früh K, Hämmerling GJ. A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity. Eur J Immunol. 26:1996;1748-1755.
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(1996)
Eur J Immunol
, vol.26
, pp. 1748-1755
-
-
Armandola, E.A.1
Momburg, F.2
Nijenhuis, M.3
Bulbuc, N.4
Früh, K.5
Hämmerling, G.J.6
-
65
-
-
0029960763
-
Identification of a contact region for peptide on the TAP1 chain of the transporter associated with antigen processing
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By photoaffinity labeling, TAP1 domains are mapped that are involved in peptide binding.
-
Nijenhuis M, Schmitt S, Armandola EA, Obst R, Brunner J, Hämmerling GJ. Identification of a contact region for peptide on the TAP1 chain of the transporter associated with antigen processing. J Immunol. 156:1996;2186-2195 By photoaffinity labeling, TAP1 domains are mapped that are involved in peptide binding.
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(1996)
J Immunol
, vol.156
, pp. 2186-2195
-
-
Nijenhuis, M.1
Schmitt, S.2
Armandola, E.A.3
Obst, R.4
Brunner, J.5
Hämmerling, G.J.6
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66
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0030589291
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Multiple regions of the transporter associated with antigen processing (TAP) contribute to its binding site
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Nijenhuis M, Hämmerling GJ. Multiple regions of the transporter associated with antigen processing (TAP) contribute to its binding site. J Immunol. 157:1997;5467-5477.
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(1997)
J Immunol
, vol.157
, pp. 5467-5477
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-
Nijenhuis, M.1
Hämmerling, G.J.2
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67
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0028798015
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Getting the inside out: The transporter associated with antigen processing (TAP) and the presentation of viral antigen
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Hill A, Ploegh H. Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigen. Proc Natl Acad Sci USA. 92:1995;341-343.
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(1995)
Proc Natl Acad Sci USA
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, pp. 341-343
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Hill, A.1
Ploegh, H.2
-
68
-
-
0029034237
-
Herpes simplex virus turns off the TAP to evade host immunity
-
of special interest. Together with [69], this paper shows the inhibition of peptide transport by the cytosolic Herpes simplex virus protein ICP47.
-
Hill A, Jugovic P, York I, Russ G, Bennink J, Yewdell J, Ploegh H, Johnson D. Herpes simplex virus turns off the TAP to evade host immunity. of special interest Nature. 375:1995;411-415 Together with [69], this paper shows the inhibition of peptide transport by the cytosolic Herpes simplex virus protein ICP47.
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(1995)
Nature
, vol.375
, pp. 411-415
-
-
Hill, A.1
Jugovic, P.2
York, I.3
Russ, G.4
Bennink, J.5
Yewdell, J.6
Ploegh, H.7
Johnson, D.8
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69
-
-
0029069681
-
A viral inhibitor of peptide transporters for antigen presentation
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of special interest. See annotation [68].
-
Früh K, Ahn K, Djaballah H, Sempé P, Van Endert PM, Tampé R, Peterson PA, Yang Y. A viral inhibitor of peptide transporters for antigen presentation. of special interest Nature. 375:1995;415-418 See annotation [68].
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(1995)
Nature
, vol.375
, pp. 415-418
-
-
Früh, K.1
Ahn, K.2
Djaballah, H.3
Sempé, P.4
Van Endert, P.M.5
Tampé, R.6
Peterson, P.A.7
Yang, Y.8
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70
-
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0030016036
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Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus protein ICP47
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Ahn K, Meyer TH, Uebel S, Sempé P, Djaballah H, Yang Y, Peterson PA, Früh K, Tampé R. Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus protein ICP47. EMBO J. 15:1996;3247-3255.
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(1996)
EMBO J
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, pp. 3247-3255
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-
Ahn, K.1
Meyer, T.H.2
Uebel, S.3
Sempé, P.4
Djaballah, H.5
Yang, Y.6
Peterson, P.A.7
Früh, K.8
Tampé, R.9
-
71
-
-
0030035445
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Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP
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Tomazin R, Hill AB, Jugovic P, York I, van Endert P, Ploegh HL, Andrews DW, Johnson DC. Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP. EMBO J. 15:1996;3256-3266.
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(1996)
EMBO J
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, pp. 3256-3266
-
-
Tomazin, R.1
Hill, A.B.2
Jugovic, P.3
York, I.4
Van Endert, P.5
Ploegh, H.L.6
Andrews, D.W.7
Johnson, D.C.8
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72
-
-
0029791030
-
Human cytomegalovirus inhibits peptide translocation into the endoplasmic reticulum for MHC class I assembly
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of special interest. This paper shows that an early gene product of human cytomegalovirus blocks peptide transport.
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Hengel H, Flohr T, Hämmerling GJ, Koszinowski UH, Momburg F. Human cytomegalovirus inhibits peptide translocation into the endoplasmic reticulum for MHC class I assembly. of special interest J Gen Virol. 77:1996;2287-2296 This paper shows that an early gene product of human cytomegalovirus blocks peptide transport.
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(1996)
J Gen Virol
, vol.77
, pp. 2287-2296
-
-
Hengel, H.1
Flohr, T.2
Hämmerling, G.J.3
Koszinowski, U.H.4
Momburg, F.5
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74
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0028170597
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An unstable β2-microglobulin: Major histocompatibility complex class I heavy chain intermediate dissociates from calnexin and then is stabilized by binding peptide
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Sugita M, Brenner MB. An unstable β2-microglobulin: major histocompatibility complex class I heavy chain intermediate dissociates from calnexin and then is stabilized by binding peptide. J Exp Med. 180:1994;2163-2171.
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J Exp Med
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, pp. 2163-2171
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Sugita, M.1
Brenner, M.B.2
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75
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0029925940
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The molecular chaperone calnexin facilitates folding and assembly of class I histocompatibility molecules
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Vassilakos A, Cohen-Doyle M, Peterson PA, Jackson MR, Williams DB. The molecular chaperone calnexin facilitates folding and assembly of class I histocompatibility molecules. EMBO J. 15:1996;1495-1506.
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(1996)
EMBO J
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, pp. 1495-1506
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Vassilakos, A.1
Cohen-Doyle, M.2
Peterson, P.A.3
Jackson, M.R.4
Williams, D.B.5
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76
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0028917887
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Species-specific differences in chaperone interaction of human and mouse histocompatibility complex class I molecules
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Nöβner E, Parham P. Species-specific differences in chaperone interaction of human and mouse histocompatibility complex class I molecules. J Exp Med. 181:1995;327-337.
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J Exp Med
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Nößner, E.1
Parham, P.2
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78
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0029009565
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MHC class I expression and transport in a calnexin-deficient cell line
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Scott JE, Dawson JR. MHC class I expression and transport in a calnexin-deficient cell line. J Immunol. 155:1995;143-148.
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J Immunol
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, pp. 143-148
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Scott, J.E.1
Dawson, J.R.2
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79
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0028810104
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Unique expression of the major histocompatibility complex class I proteins in the absence of glucose trimming and calnexin association
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Balow JP, Weissman JD, Kearse KP. Unique expression of the major histocompatibility complex class I proteins in the absence of glucose trimming and calnexin association. J Biol Chem. 270:1995;29025-29029.
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J Biol Chem
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Balow, J.P.1
Weissman, J.D.2
Kearse, K.P.3
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80
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0030217926
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Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP
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of outstanding interest. The first description of calreticulin and tapasin as being components of the transient class I-TAP complex. 721.220 cells are shown to lack tapasin (see [85]).
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Sadasivan B, Lehner PJ, Ortmann B, Spies T, Cresswell P. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. of outstanding interest Immunity. 5:1996;103-114 The first description of calreticulin and tapasin as being components of the transient class I-TAP complex. 721.220 cells are shown to lack tapasin (see [85]).
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(1996)
Immunity
, vol.5
, pp. 103-114
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Sadasivan, B.1
Lehner, P.J.2
Ortmann, B.3
Spies, T.4
Cresswell, P.5
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82
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0028282108
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2-microglobulin complexes associate with TAP transporters before peptide binding
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2-microglobulin complexes associate with TAP transporters before peptide binding. Nature. 368:1994;864-867.
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(1994)
Nature
, vol.368
, pp. 864-867
-
-
Ortmann, B.1
Androlewicz, M.J.2
Cresswell, P.3
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83
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0028239443
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Interaction of MHC class I molecules with the transporter associated with antigen processing
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Suh W-K, Cohen-Doyle MF, Früh K, Wang K, Peterson PA, Williams DB. Interaction of MHC class I molecules with the transporter associated with antigen processing. Science. 264:1994;1322-1326.
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(1994)
Science
, vol.264
, pp. 1322-1326
-
-
Suh, W.-K.1
Cohen-Doyle, M.F.2
Früh, K.3
Wang, K.4
Peterson, P.A.5
Williams, D.B.6
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84
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0031091739
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2-miroglobulin, class I heavy chain conformation, and tapasin in the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing
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in press
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2-miroglobulin, class I heavy chain conformation, and tapasin in the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing. J Immunol. 1997;. in press.
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(1997)
J Immunol
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-
Solheim, J.C.1
Harris, M.R.2
Kindle, C.S.3
Hansen, T.H.4
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85
-
-
0028817950
-
Dependence of peptide binding by MHC class I molecules on their interaction with ATP
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of outstanding interest. Due to a gene defect on chromosome 6, class I molecules in 721.220 mutant cells fail to interact with TAP. See also annotation [80].
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Grandea AG III, Androlewicz MJ, Athwal RS, Geraghty DE, Spies T. Dependence of peptide binding by MHC class I molecules on their interaction with ATP. of outstanding interest Science. 270:1995;105-108 Due to a gene defect on chromosome 6, class I molecules in 721.220 mutant cells fail to interact with TAP. See also annotation [80].
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(1995)
Science
, vol.270
, pp. 105-108
-
-
Grandea A.G. III1
Androlewicz, M.J.2
Athwal, R.S.3
Geraghty, D.E.4
Spies, T.5
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86
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0027988164
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Novel allele-specific, post-translational reduction in HLA class I surface expression in a human B cell line
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Greenwood R, Shimizu Y, Sekhon GS, DeMars R. Novel allele-specific, post-translational reduction in HLA class I surface expression in a human B cell line. J Immunol. 153:1994;5525-5536.
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J Immunol
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Greenwood, R.1
Shimizu, Y.2
Sekhon, G.S.3
DeMars, R.4
-
87
-
-
0029974597
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Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing
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of special interest. This study demonstrates a low degree of TAP association for some HLA-B alleles.
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Neisig A, Wubbolts R, Zang X, Melief C, Neefjes J. Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing. of special interest J Immunol. 156:1996;3196-3206 This study demonstrates a low degree of TAP association for some HLA-B alleles.
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(1996)
J Immunol
, vol.156
, pp. 3196-3206
-
-
Neisig, A.1
Wubbolts, R.2
Zang, X.3
Melief, C.4
Neefjes, J.5
-
89
-
-
0030198868
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Point mutations in the α2 domain of HLA-A2.1 define a functionally relevant interaction with TAP
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of special interest. See annotation [88].
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Lewis JW, Neisig A, Neefjes J, Elliott T. Point mutations in the α2 domain of HLA-A2.1 define a functionally relevant interaction with TAP. of special interest Curr Biol. 6:1996;873-883 See annotation [88].
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Curr Biol
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-
Lewis, J.W.1
Neisig, A.2
Neefjes, J.3
Elliott, T.4
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90
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0029042511
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Crystal structure of the 20S proteasome form the archaeon T. acidophilum at 3.4 Å resolution
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of outstanding interest. The structure of an archaebacterial proteasome is revealed by X-ray crystallography. By labelling with a peptide aldehyde inhibitor, active sites on β subunits were identified that point towards the central cavity of the proteasome.
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Löwe J, Stock D, Jap B, Zwickl P, Baumeister W, Huber R. Crystal structure of the 20S proteasome form the archaeon T. acidophilum at 3.4 Å resolution. of outstanding interest Science. 268:1995;533-539 The structure of an archaebacterial proteasome is revealed by X-ray crystallography. By labelling with a peptide aldehyde inhibitor, active sites on β subunits were identified that point towards the central cavity of the proteasome.
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(1995)
Science
, vol.268
, pp. 533-539
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Löwe, J.1
Stock, D.2
Jap, B.3
Zwickl, P.4
Baumeister, W.5
Huber, R.6
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