Two Listeria monocytogenes CTL epitopes are processed from the same antigen with different efficiencies

Journal of Immunology

Volumn 156, Issue 2, 1996, Pages 685-692

  Sijts, Alice J A M ^a   Neisig, Anne ^b   Neefjes, Jacques ^b   Pamer, Eric G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; CARRIER PROTEIN; EPITOPE; HYDROLASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN KINASE P60; ABC TRANSPORTER; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BACTERIUM ANTIBODY; H 2K(K) ANTIGEN; H-2K(K) ANTIGEN; H2 ANTIGEN; N ACETYLMURAMOYLALANINE AMIDASE; PEPTIDE FRAGMENT; TAP1 PROTEIN, HUMAN; TAP1 PROTEIN, MOUSE;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; LISTERIA MONOCYTOGENES; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CLONE; COMPARATIVE STUDY; CROSS BREEDING; ENZYMOLOGY; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; BASE SEQUENCE; CLONE CELLS; CROSSES, GENETIC; EPITOPES; FEMALE; H-2 ANTIGENS; LISTERIA MONOCYTOGENES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; N-ACETYLMURAMOYL-L-ALANINE AMIDASE; PEPTIDE FRAGMENTS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0030583875     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Gellin, B. G., and C. V. Broome 1989. Listeriosis. JAMA 261:1313
2. Bielecki, J., P Youngman, P. Connelly, and D. A. Portnoy. 1990. Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells. Nature 345:175.
3. Tilney, L. G., and D. A Portnoy. 1989. Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes J Cell Biol. 109:1597.
4. Germain, R. N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76.287.
5. Villanueva, M. S., A. J. A M. Sijts, and E. G. Pamer. 1995. Listeriolysin is processed efficiently into an MHC class I-associated epitope in Listeria monocytogenes-infected cells. J. Immunol. 155:5227.
6. Wuenscher, M. D., S. Kohler, A. Bubert U. Gerike, and W. Goebel 1993. The iap gene of Listeria monocytogenes is essential for cell viability, and its gene product, p60, has bacteriolytic activity. J. Bacteriol. 175:3491.
7. Pamer, E G. 1994. Direct sequence identification and kinetic analysis of an MHC class I restricted Listeria monocytogenes CTL epitope. J. Immunol. 152:686
8. Villanueva, M. S , P Fischer, K. Feen, and E. G Pamer. 1994. Efficiency of MHC class 1 antigen processing, a quantitative analysis. Immunity 1:479.
9. Rock, K., C Gramm, L. Rothstein, K. Clark, R Stein, L. Dick, D. Hwang, and A. Goldberg. 1994. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761.
10. Driscoll, J., M. Brown, D. Finley, and J. Monaco. 1993. MHC linked LMP gene products specifically alter peptidase activities of the proteasome Nature 365:262.
11. Gaczynska, M., K. Rock, and A. Goldberg. 1993. γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes Nature 365:264
12. Fehling, H., W. Swat, C. Laplace, R. Kuhn, K. Rajewsky, U. Muller, and H. von Boehmer. 1994. MHC class I expression in mice lacking the proteasome subunit LMP-7 Science 265.1234.
13. Van Kaer, L, P Ashton-Rickardt, M. Eichelberger, M. Gaczynska, K Nagashima, K. Rock, A. Goldberg, P. Doherty, and S. Tonegawa. 1994. Altered peptidase and viral- specific response in LMP2 mutant mice. Immunity 1 533.
14. Niedermann, G., S. Butz, H G. Ihlenfeld, R. Grimm, M. Lucchiari, H. Hoschutzky, G. Jung, B. Maier, and K Eichmann 1995. Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules. Immunity 2.289.
15. Androlewicz, M , and P. Cresswell. 1994 Human transporters associated with antigen processing possess a promiscuous peptide-binding site. Immunity 1:7
16. Momburg, F., J Roelse, G. Hammerling, and J. Neefjes. 1994 Peptide size selection by the major histocompatibility complex-encoded peptide transporter. J. Exp. Med. 179.1613.
17. Schumacher, T., D. Kantesaria, M.-T. Heemels, P Ashton- Rickardt, J Shepherd, K. Fruh, Y. Yang, P. Peterson, S Tonegawa, and H. Ploegh. 1994. Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator. J. Exp. Med 179:533
18. Powis, S., E. Deverson, W Coadwell, A Ciruela, N. Huskisson, H. Smith, G. Butcher, and J. Howard. 1992. Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule Nature 357 211.
19. Momburg, F , J. Roelse, J. Howard, G. Butcher, G Hammerling, and J. Neefjes. 1994 Selectivity of MHC-encoded peptide transporters from human, mouse and rat. Nature 367.648.
20. Pamer, E. G., J. T. Harty, and M. J Bevan 1991 Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes. Nature 353:852
21. d class I molecule. Eur. J. Immunol. 23:2005.
22. b-restricted ovalbumin peptide and an assessment of the predictive power of MHC-binding motifs. Eur. J. Immunol. 22:2663.
23. Chen, W., S. Khilko, J. Fecondo, D. H. Margulies, and J. McCluskey. 1994. Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues. J. Exp. Med 180:1471.
24. Ljunggren, H.-G., and K. Karre. 1985. Host resistance directed selectively against H-2-deficient lymphoma variants: analysis of the mechanism. J. Exp. Med 162: 1745.
25. Neisig, A., J. Roelse, A. J. A. M. Sijts, F. Ossendorp, M. C. W. Feltkamp, W. M. Kast, C. J. M. Melief, and J. J. Neefjes. 1995. Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences. J. Immunol. 154:1273.
26. Neefjes, J. J., F. Momburg, and G. J. Hammerling. 1993. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science 261:769.
27. Hunt, D F , R. A. Henderson, J. Shabanowitz, K. Sakaguchi, H. Michel, N. Sevilir, A. L. Cox, E. Apella, and V. H. Engelhard. 1992. Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 255:1261.
28. Wei, M. L., and P. Cresswell. 1992. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature 356:443.
29. Harty, J. T., and E. G. Pamer. 1995. CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection. J. Immunol. 154: 4642.
30. d-s: sequence motif, quantitative binding, and molecular modeling of the complex. J. Exp. Med 176:1681.
31. d exploits a four residue peptide binding motif. J Exp. Med. 178:1877.
32. H epitope by influenza virus-specific class I major histocompatibility complex-restricted cytolytic T lymphocytes. J Exp. Med. 179:195.
33. Del Val, M., H.-J. Schlicht, T. Ruppert, M. J. Reddehase, and U. H. Koszinowski. 1991. Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein. Cell 66: 1145.