A point mutation in HLA-A*0201 results in failure to bind the TAP complex and to present virus-derived peptides to CTL

Immunity

Volumn 4, Issue 5, 1996, Pages 505-514

  Peace Brewer, Amy L ^a   Tussey, Lynda G ^a   Matsui, Masanori ^a   Li, Guoxuan ^b   Quinn, Daniel G ^a   Frelinger, Jeffrey A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA A ANTIGEN; LYSINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; THREONINE;

ANTIGEN PRESENTATION; ARTICLE; CELL LINE; CELL SURFACE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MAJOR HISTOCOMPATIBILITY COMPLEX; POINT MUTATION; PRIORITY JOURNAL;

EID: 0030152620     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80416-1     Document Type: Article

References (42)

1. Androlewicz, M., and Cresswell, P. (1994). Human transporters associated with antigen processing possess a promiscuous peptide-binding site. Immunity 1, 7-14.
2. Androlewicz, M., Anderson, K., and Cresswell, P. (1993). Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner. Proc. Natl. Acad. Sci. USA 90, 9130-9134.
3. Baas, E., van Santen, H., Kleijmeer, M., Geuze, H., Peters, P., and Ploegh, H. (1992). Peptide-induced stabilization and intracellular localization of empty HLA class I complexes. J. Exp. Med. 176, 147-156.
4. Barnstable, C., Bodmer, W., Brown, G., Galfre, G., Milstein, C., Williams, A., and Ziegler, A. (1978). Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis. Cell 14, 9-20.
5. Bijlmakers, M., and Ploegh, H. (1993). Putting together an MHC class I molecule. Curr. Opin. Immunol. 5, 21-26.
6. Bjorkman, P.J., Saper, M.A., Samraoui, B., Bennett, W.S., Strominger, J.L., and Wiley, D.C. (1987). Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329, 506-512.
7. Carreno, B.M., Solheim, J., Harris, M., Stroynowski, I., Connolly, J., and Hansen, T. (1995). TAP associates with a unique class I conformation, whereas calnexin associates with multiple class I forms in mouse and man. J. Immunol. 155, 4726-4733.
8. Cerundolo, V., Alexander, J., Anderson, K., Lamb, C., Cresswell, P., McMichael, A., Gotch, F., and Townsend, A. (1990). Presentation of viral antigen controlled by a gene in the major histocompatibility complex. Nature 345, 449-452.
9. DeMars, R., Rudersdorf, R., Chang, C., Petersen, J., Strandtmann, J., Korn, N., Sidwell, B., and Orr, H. (1985). Mutations that impair a posttranscriptional step in expression of HLA-A and -B antigens. Proc. Natl. Acad. Sci. USA 82, 8183-8187.
10. Deverson, E.V., Gow, I.R., Coadwell, W.J., Monaco, J.J., Butcher, G.W., and Howard, J.C. (1990). MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters. Nature 348, 738-741.
11. Falk, K., Rotzschke, O., Stevanovic, S., Jung, G., and Rammensee, H.G. (1991). Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351, 290-296.
12. Germain, R. (1994). MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76, 287-299.
13. Grandea, A., Androlewicz, M., Athwal, R., Geraghty, D., and Spies, T. (1995). Dependence of peptide binding by MHC class I molecules on their interaction with TAP. Science 270, 105-108.
14. Guagliardi, L., Koppelman, B., Blum, J., Marks, M., Cresswell, P., and Brodsky, F. (1990). Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment. Nature 343, 133-139.
15. Henderson, R.A., Michel, H., Sakaguchi, K., Shabanowitz, J., Appella, E., Hunt, D.F., and Engelhard, V.H. (1992). HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation. Science 255, 1264-1266.
16. Hill, A., Takiguchi, M., and McMichael, A. (1993). Different rates of HLA class I molecule assembly which are determined by amino acid sequence in the alpha 2 domain, Immunogenetics 37, 95-101.
17. Hosken, N.A., and Bevan, M.J. (1990). Defective presentation of endogenous antigen by a cell line expressing class I molecules. Science 248, 367-370.
18. Kelly, A., Powis, S., Kerr, L., Mockridge, I., Elliott, T., Bastin, J., Uchanska-Ziegler, B., Ziegler, A., Trowsdale, J., and Townsend, A. (1992). Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. Nature 355, 641-644.
19. Laemmli, U. (1970). Cleavage of structural proteins during assembly of bacteriophage T4. Nature 227, 680-685.
20. Lee, N., Malacko, A.R., Ishitani, A., Chen, M., Bajorath, J., Marquardt, H., and Geraghty, D. (1995). The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association. Immunity 3, 591-600.
21. Ljunggren, H.G., Stam, N.J., Ohlen, C., Neefjes, J.J., Hoglund, P., Heemels, M.T., Bastin, J., Schumacher, T.N., Townsend, A., Karre, K., and Ploegh, H. (1990). Empty MHC class I molecules come out in the cold. Nature 346, 476-480.
22. McMichael, A., Gotch, F., Santos-Aguado, J., and Strominger, J. (1988). Effect of mutations and variations of HLA-A2 on recognition of a virus peptide epitope by cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 85, 9194-9198.
23. Monaco, J.J., Cho, S., and Attaya, M. (1990). Transport protein genes in the murine MHC: possible implications for antigen processing. Science 250, 1723-1726.
24. Moots, R., Matsui, M., Pazmany, L., McMichael, A., and Frelinger, J. (1991). A cluster of mutations in HLA-A2 alpha 2 helix abolishes peptide recognition by T cells, Immunogenetics 34, 141-148.
25. Neefjes, J., Doxiadis, I., Stam, N., Beckers, C., and Ploegh, H. (1986). An analysis of class I antigens of man and other species by one-dimensional IEF and immunoblotting. Immunogenetics 23, 164-171.
26. Neefjes, J., Hammerling, G., and Momburg, F. (1993). Folding and assembly of major histocompatibility complex class I heterodimers in the endoplasmic reticulum of intact cells precedes the binding of peptide. J. Exp. Med. 178, 1971-1980.
27. Ortmann, B., Androlewicz, M., and Cresswell, P. (1994). MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding. Nature 368, 864-867.
28. Parham, P., and Brodsky, F. (1981). Partial purification and some properties of BB7.2: a cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28. Human Immunol. 3, 277-299.
29. Pogue, R., Eron, J., Frelinger, J., and Matsui, M. (1995). Amino-terminal alteration of the HLA-A*0201-restricted human immunodeficiency virus pol peptide increases complex stability and in vitro immunogenicity. Proc. Natl. Acad. Sci. USA 92, 8166-8170.
30. Salter, R., and Cresswell, P. (1986). Impaired assembly and transport of HLA-A and -B antigens in a mutant TXB cell hybrid. EMBO J. 5, 943-949.
31. Schumacher, T., Heemels, M., Neefjes, J., Kast, W., Melief, C., and Ploegh, H. (1990). Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro. Cell 62, 563-567.
32. Shepherd, J., Schumacher, T., Ashton-Rickardt, P., Imaeda, S., Ploegh, H., Janeway, C., Jr., and Tonegawa, S. (1993). TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell 74, 577-584.
33. Spies, T., Bresnahan, M., Bahram, S., Arnold, D., Blanck, G., Mellins, E., Pious, D., and DeMars, R. (1990). A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway. Nature 348, 744-747.
34. Spies, T., Cerundolo, V., Colonna, M., Cresswell, P., Townsend, A., and DeMars, R. (1992). Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer. Nature 355, 644-646.
35. Storkus, W., Howell, D., Salter, R., Dawson, J., and Cresswell, P. (1987). NK susceptibility varies inversely with target cell class I HLA antigen expression. J. Immunol. 138, 1657-1659.
36. Suh, W., Cohen-Doyle, M., Fruh, K., Wang, K., Peterson, P., and Williams, D. (1994). Interaction of MHC class I molecules with the transporter associated with antigen processing. Science 264, 1322-1326.
37. Townsend, A., Ohlen, C., Bastin, J., Ljunggren, H., Foster, L., and Karre, K. (1989). Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 340, 443-448.
38. Townsend, A.R., Gotch, F.M., and Davey, J. (1985). Cytotoxic T cells recognize fragments of the influenza nucleoprotein. Cell 42, 457-467.
39. Trowsdale, J., Hanson, I., Mockridge, I., Beck, S., Townsend, A., and Kelly, A. (1990). Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. Nature 348, 741-744.
40. Tussey, L., Rowland-Jones, S., Zheng, T., Androlewicz, M., Cresswell, P., Frelinger, J., and McMichael, A. (1995). Different MHC class I alleles compete for presentation of overlapping viral epitopes. Immunity 3, 65-77.
41. Wei, M., and Cresswell, P. (1992). HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature 356, 443-446.
42. Zweerink, H.J., Gammon, M.C., Utz, U., Sauma, S.Y., Harrer, T., Hawkins, J.C., Johnson, R.P., Sirotina, A., Hermes, J.D., Walker, B.D., and Biddison, W.E. (1993). Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells. J. Immunol. 150, 1763-1771.