Pleiotropic role for GRKs and β-arrestins in receptor regulation

News in Physiological Sciences

Volumn 12, Issue 4, 1997, Pages 145-151

  Ferguson, Stephen S G ^b   Zhang, Jie ^b   Barak, Larry S ^b   Caron, Marc G ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001003295     PISSN: 08861714     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiologyonline.1997.12.4.145     Document Type: Article

References (15)

1. Arriza, J. L., T. M. Dawson, R. B. Simerly, L. J. Martin, M. G. Caron, S. H. Snyder, and R. J. Lefkowitz. The G-protein-coupled receptor kinases βARK1 and βARK2 are widely distributed at synapses in rat brain. J. Neurosci. 12: 4045-4055, 1992.
2. Attramadal, H., J. L. Arriza, C. Aoki, T. M. Dawson, J. Codina, M. M. Kwatra, S. H. Snyder, M. G. Caron, and R. J. Lefkowitz. β-Arrestin2, a novel member of the arrestin/β-arrestin gene family. J. Biol. Chem. 267: 17882-17890, 1992.
3. 2-adrenergic receptor. Biochemistry 34: 15407-15414, 1995.
4. 2-adrenergic receptor sequestration. J. Biol. Chem. 269: 2790-2795, 1994.
5. Chen, W.-J., J. L. Goldstein, and M. S. Brown. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J. Biol. Chem. 265: 3116-3123, 1990.
6. Ferguson, S. S. G., L. S. Barak, J. Zhang, and M. G. Caron. G protein-coupled receptor regulation: role of G protein-coupled receptor kinases and arrestins. Can. J. Physiol. Pharmacol. 74: 1095-1110, 1996.
7. Ferguson, S. S. G., W. E. Downey III, A.-M. Colapietro, L. S. Barak, L. Ménard, and M. G. Caron. Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science 271: 363-366, 1996.
8. 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by βARK1. J. Biol. Chem. 270: 24782-24789, 1995.
9. 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J. Biol. Chem. 264: 12657-12665, 1989.
10. 2-adrenergic receptor and rhodopsin systems. J. Biol. Chem. 267: 8558-8564, 1992.
11. 2-adrenergic receptor desensitization. Delineation with specific inhibitors. J. Biol. Chem. 265: 3202-3209, 1990.
12. 2-adrenergic receptor facilitate sequestration. Biochemistry 35: 4155-4160, 1996.
13. Premont, R. T., J. Inglese, and R. J. Lefkowitz. Protein kinases that phosphorylate activated G protein-coupled receptors. FASEB J. 9: 175-182, 1995.
14. Ungerer, M., G. Parruti, M. Böhm, M. Puzicha, A. De Blasi, E. Erdmann, and M. J. Lohse. Expression of β-arrestins and β-adrenergic receptor kinases in the failing human heart. Circ. Res. 74: 206-213, 1994.
15. Zhang, J., S. S. G. Ferguson, L. S. Barak, L. Ménard, and M. G. Caron. Dynamin and β-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization. J. Biol. Chem. 271: 18302-18305, 1996.