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Volumn 90, Issue 4, 2003, Pages 837-855

Strong Induction of p73 Protein In Vivo Coincides With the Onset of Apoptosis in Rat Liver After Treatment With the Hepatocarcinogen N-Nitrosomorpholine (NNM)

Author keywords

Activation of NF B; Caspase activation; Cytochrome C release; p53 response; PARP 1 cleavage; TUNEL assay

Indexed keywords

APOPTOSIS INDUCING FACTOR; GENE PRODUCT; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITROSOMORPHOLINE; PROTEIN MDM2; PROTEIN P53; PROTEIN P73;

EID: 0242695558     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10678     Document Type: Article
Times cited : (7)

References (57)
  • 1
    • 0033600240 scopus 로고    scopus 로고
    • Interaction of c-Abl and p73 and their collaboration to induce apoptosis
    • Agami R, Blandino G, Oren M, Shaul Y. 1999. Interaction of c-Abl and p73 and their collaboration to induce apoptosis. Nature 399:809-813.
    • (1999) Nature , vol.399 , pp. 809-813
    • Agami, R.1    Blandino, G.2    Oren, M.3    Shaul, Y.4
  • 2
    • 0030969225 scopus 로고    scopus 로고
    • p53 deficiency in liver reduces local control of survival and proliferation, but does not affect apoptosis after DNA damage
    • Bellamy CO, Clarke AR, Wyllie AH, Harrison DJ. 1997. p53 deficiency in liver reduces local control of survival and proliferation, but does not affect apoptosis after DNA damage. FASEB J 11:591-599.
    • (1997) FASEB J , vol.11 , pp. 591-599
    • Bellamy, C.O.1    Clarke, A.R.2    Wyllie, A.H.3    Harrison, D.J.4
  • 3
    • 0023191188 scopus 로고
    • Dose-response curves for DNA fragmentation induced in rats by sixteen N-nitroso compounds as measured by viscometric and alkaline elution analyses
    • Brambilla G, Carlo P, Finollo R, Sciaba L. 1987. Dose-response curves for DNA fragmentation induced in rats by sixteen N-nitroso compounds as measured by viscometric and alkaline elution analyses. Cancer Res 47:3485-3491.
    • (1987) Cancer Res , vol.47 , pp. 3485-3491
    • Brambilla, G.1    Carlo, P.2    Finollo, R.3    Sciaba, L.4
  • 4
    • 0023579723 scopus 로고
    • Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: Association with DNA replication sites
    • Bravo R, Macdonald-Bravo H. 1987. Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: Association with DNA replication sites. J Cell Biol 105:1549-1554.
    • (1987) J Cell Biol , vol.105 , pp. 1549-1554
    • Bravo, R.1    Macdonald-Bravo, H.2
  • 5
    • 0023091627 scopus 로고
    • Cyclin/PCNA is the auxiliary protein of DNA polymerase
    • Bravo R, Frank R, Blundell PA, Macdonald-Bravo H. 1987. Cyclin/PCNA is the auxiliary protein of DNA polymerase. Nature 326:515-517.
    • (1987) Nature , vol.326 , pp. 515-517
    • Bravo, R.1    Frank, R.2    Blundell, P.A.3    Macdonald-Bravo, H.4
  • 6
    • 0034617449 scopus 로고    scopus 로고
    • Apoptosis-inducing factor (AIF): A ubiquitous mitochondrial oxidoreductase involved in apoptosis
    • Daugas E, Nochy D, Ravagnan L, Loeffler M, Susin SA, Zamzami N, Kroemer G. 2000. Apoptosis-inducing factor (AIF): A ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett 476:118-123.
    • (2000) FEBS Lett , vol.476 , pp. 118-123
    • Daugas, E.1    Nochy, D.2    Ravagnan, L.3    Loeffler, M.4    Susin, S.A.5    Zamzami, N.6    Kroemer, G.7
  • 10
    • 0023277394 scopus 로고
    • Morphometric study of alterations of extrafocal hepatocytes of rat liver treated with N-nitrosomorpholine
    • Enzmann H, Bannasch P. 1987. Morphometric study of alterations of extrafocal hepatocytes of rat liver treated with N-nitrosomorpholine. Virchows Arch B Cell Pathol Incl Mol Pathol 53:218-226.
    • (1987) Virchows Arch B Cell Pathol Incl Mol Pathol , vol.53 , pp. 218-226
    • Enzmann, H.1    Bannasch, P.2
  • 11
    • 0033571275 scopus 로고    scopus 로고
    • Comparative analysis of p73 and p53 regulation and effector functions
    • Fang L, Lee SW, Aaronson SA. 1999. Comparative analysis of p73 and p53 regulation and effector functions. J Cell Biol 147:823-830.
    • (1999) J Cell Biol , vol.147 , pp. 823-830
    • Fang, L.1    Lee, S.W.2    Aaronson, S.A.3
  • 12
    • 0033910863 scopus 로고    scopus 로고
    • Apoptosis-related activities measured with isolated mitochondria and digitonin-permeabilized cells
    • Fiskum G, Kowaltowksi AJ, Andreyev AY, Kushnareva YE, Starkov AA. 2000. Apoptosis-related activities measured with isolated mitochondria and digitonin-permeabilized cells. Methods Enzymol 322:222-234.
    • (2000) Methods Enzymol , vol.322 , pp. 222-234
    • Fiskum, G.1    Kowaltowksi, A.J.2    Andreyev, A.Y.3    Kushnareva, Y.E.4    Starkov, A.A.5
  • 17
    • 0027407260 scopus 로고
    • Wild-type p53 adopts a"mutant"-like conformation when bound to DNA
    • Halazonetis TD, Davis LJ, Kandil AN. 1993. Wild-type p53 adopts a"mutant"-like conformation when bound to DNA. EMBO J 12:1021-1028.
    • (1993) EMBO J , vol.12 , pp. 1021-1028
    • Halazonetis, T.D.1    Davis, L.J.2    Kandil, A.N.3
  • 18
    • 0029845760 scopus 로고    scopus 로고
    • Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies
    • Harris CC. 1996. Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies. J Natl Cancer Inst 88:1442-1445.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1442-1445
    • Harris, C.C.1
  • 20
    • 0033379005 scopus 로고    scopus 로고
    • p53 family genes: Structural comparison, expression and mutation
    • Ikawa S, Nakagawara A, Ikawa Y. 1999. p53 family genes: Structural comparison, expression and mutation. Cell Death Differ 6:1154-1161.
    • (1999) Cell Death Differ , vol.6 , pp. 1154-1161
    • Ikawa, S.1    Nakagawara, A.2    Ikawa, Y.3
  • 23
    • 0031564954 scopus 로고    scopus 로고
    • p73 is a human p53-related protein that can induce apoptosis
    • Jost CA, Marin MC, Kaelin WG, Jr. 1997. p73 is a human p53-related protein that can induce apoptosis. Nature 389:191-194.
    • (1997) Nature , vol.389 , pp. 191-194
    • Jost, C.A.1    Marin, M.C.2    Kaelin W.G., Jr.3
  • 25
    • 0344766067 scopus 로고    scopus 로고
    • The emerging p53 gene family
    • Kaelin WG, Jr. 1999. The emerging p53 gene family. J Natl Cancer Inst 91:594-598.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 594-598
    • Kaelin W.G., Jr.1
  • 28
    • 0031045565 scopus 로고    scopus 로고
    • PCNA: Structure, functions and interactions
    • Kelman Z. 1997. PCNA: Structure, functions and interactions. Oncogene 14:629-640.
    • (1997) Oncogene , vol.14 , pp. 629-640
    • Kelman, Z.1
  • 29
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzled and paradigm
    • Ko LJ, Prives C. 1996. p53: Puzzled and paradigm. Genes Dev 10:1054-1072.
    • (1996) Genes Dev , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 30
    • 0034710534 scopus 로고    scopus 로고
    • Characterization of dictinct consecutive phases in non-genotoxic p53-induced apoptosis of Ewing tumor cells and the rate-limiting role of caspase 8
    • Kovar H, Jug G, Printz D, Schmid G, Wesierska-Gadek J. 2000. Characterization of dictinct consecutive phases in non-genotoxic p53-induced apoptosis of Ewing tumor cells and the rate-limiting role of caspase 8. Oncogene 19:4096-4107.
    • (2000) Oncogene , vol.19 , pp. 4096-4107
    • Kovar, H.1    Jug, G.2    Printz, D.3    Schmid, G.4    Wesierska-Gadek, J.5
  • 31
    • 0033595124 scopus 로고    scopus 로고
    • Promoter specificity and stability control of the p53-related protein p73
    • Lee C-W, La Thangue NB. 1999. Promoter specificity and stability control of the p53-related protein p73. Oncogene 18:4171-4181.
    • (1999) Oncogene , vol.18 , pp. 4171-4181
    • Lee, C.-W.1    La Thangue, N.B.2
  • 33
    • 0017820717 scopus 로고
    • Metabolism of N-nitrosomorpholine by the rat in vivo and by rat liver microsomes and its oxidation by the Fenton system
    • Manson D, Cox PJ, Jarman M. 1978. Metabolism of N-nitrosomorpholine by the rat in vivo and by rat liver microsomes and its oxidation by the Fenton system. Chem Biol Interact 20:341-354.
    • (1978) Chem Biol Interact , vol.20 , pp. 341-354
    • Manson, D.1    Cox, P.J.2    Jarman, M.3
  • 34
    • 0026649648 scopus 로고
    • The MDM-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. 1992. The MDM-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 35
    • 0020365210 scopus 로고
    • The dose dependence and sequential appearance of putative preneoplastic populations induced in the rat liver by stop experiments with N-nitrosomorpholine
    • Moore MA, Mayer D, Bannasch P. 1982. The dose dependence and sequential appearance of putative preneoplastic populations induced in the rat liver by stop experiments with N-nitrosomorpholine. Carcinogenesis 3:1429-31436.
    • (1982) Carcinogenesis , vol.3 , pp. 1429-31436
    • Moore, M.A.1    Mayer, D.2    Bannasch, P.3
  • 36
    • 0030034524 scopus 로고    scopus 로고
    • Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53
    • Morris GF, Bischoff JR, Mathews MB. 1996. Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53. Proc Natl Acad Sci USA 93:895-899.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 895-899
    • Morris, G.F.1    Bischoff, J.R.2    Mathews, M.B.3
  • 37
    • 0034738967 scopus 로고    scopus 로고
    • A ribonucleotide reductase gene is a transcriptional target of p53 and p73
    • Nakano K, Balint E, Ashkroft M, Vousden KH. 2000. A ribonucleotide reductase gene is a transcriptional target of p53 and p73. Oncogene 19:4283-4289.
    • (2000) Oncogene , vol.19 , pp. 4283-4289
    • Nakano, K.1    Balint, E.2    Ashkroft, M.3    Vousden, K.H.4
  • 39
    • 0034610752 scopus 로고    scopus 로고
    • Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus
    • Rubbi CP, Milner J. 2000. Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus. Oncogene 19:85-96.
    • (2000) Oncogene , vol.19 , pp. 85-96
    • Rubbi, C.P.1    Milner, J.2
  • 41
    • 0344284564 scopus 로고    scopus 로고
    • Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin
    • Shimodaira H, Yoshioka-Yamashita A, Kolodner RD, Wang JY. 2003. Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Proc Natl Acad Sci USA 100:2420-2425.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2420-2425
    • Shimodaira, H.1    Yoshioka-Yamashita, A.2    Kolodner, R.D.3    Wang, J.Y.4
  • 42
    • 0026546407 scopus 로고
    • Proliferating cell nuclear antigen is required for DNA excision repair
    • Shivji MKK, Kenny MK, Wood RD. 1992. Proliferating cell nuclear antigen is required for DNA excision repair. Cell 69:367-374.
    • (1992) Cell , vol.69 , pp. 367-374
    • Shivji, M.K.K.1    Kenny, M.K.2    Wood, R.D.3
  • 44
    • 0016766048 scopus 로고
    • Acute biochemical and morphological effects of N-nitrosomorpholine in comparison to dimethyl- and diethyl-nitrosamine
    • Stewart BW, Hicks RM, Magee PN. 1975. Acute biochemical and morphological effects of N-nitrosomorpholine in comparison to dimethyl- and diethyl-nitrosamine. Chem Biol Interact 11:413-429.
    • (1975) Chem Biol Interact , vol.11 , pp. 413-429
    • Stewart, B.W.1    Hicks, R.M.2    Magee, P.N.3
  • 45
    • 0037341354 scopus 로고    scopus 로고
    • Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors
    • Sutton VR, Wowk ME, Cancilla M, Trapani JA. 2003. Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors. Immunity 18:319-329.
    • (2003) Immunity , vol.18 , pp. 319-329
    • Sutton, V.R.1    Wowk, M.E.2    Cancilla, M.3    Trapani, J.A.4
  • 46
    • 0035240260 scopus 로고    scopus 로고
    • Apoptosis: Implications of basic research for clinical oncology
    • Tamm I, Schriever F, Doerken B. 2001. Apoptosis: Implications of basic research for clinical oncology. Lancet Oncol 2:33-42.
    • (2001) Lancet Oncol , vol.2 , pp. 33-42
    • Tamm, I.1    Schriever, F.2    Doerken, B.3
  • 48
    • 0016367848 scopus 로고
    • Isolation of nuclei from rat liver and other tissues
    • Tata JR. 1974. Isolation of nuclei from rat liver and other tissues. Methods Enzymol 31:253-262.
    • (1974) Methods Enzymol , vol.31 , pp. 253-262
    • Tata, J.R.1
  • 49
  • 50
    • 0036561484 scopus 로고    scopus 로고
    • p53 leans on its siblings
    • Urist M, Prives C. 2002. p53 leans on its siblings. Cancer Cell 1:311-313.
    • (2002) Cancer Cell , vol.1 , pp. 311-313
    • Urist, M.1    Prives, C.2
  • 51
    • 0034650611 scopus 로고    scopus 로고
    • p73 competes with p53 and attenuates its response in a human ovarian cancer cell line
    • Vikhanskaya F, D'Incalci M, Broggini M. 2000. p73 competes with p53 and attenuates its response in a human ovarian cancer cell line. Nucleic Acids Res 28:513-519.
    • (2000) Nucleic Acids Res , vol.28 , pp. 513-519
    • Vikhanskaya, F.1    D'Incalci, M.2    Broggini, M.3
  • 52
    • 0028303881 scopus 로고
    • Dose and time dependence of the cellular phenotype in rat hepatic preneoplasia and neoplasia induced by continuous oral exposure to N-nitrosomorpholine
    • Weber E, Bannasch P. 1994. Dose and time dependence of the cellular phenotype in rat hepatic preneoplasia and neoplasia induced by continuous oral exposure to N-nitrosomorpholine. Carcinogenesis 15:1235-1242.
    • (1994) Carcinogenesis , vol.15 , pp. 1235-1242
    • Weber, E.1    Bannasch, P.2
  • 53
    • 0031915958 scopus 로고    scopus 로고
    • Members of the glutathione S-transferase gene family are antigens in autoimmune hepatitis
    • Wesierska-Gadek J, Grimm R, Hitchman E, Penner E. 1998. Members of the glutathione S-transferase gene family are antigens in autoimmune hepatitis. Gastroenterology 114:329-335.
    • (1998) Gastroenterology , vol.114 , pp. 329-335
    • Wesierska-Gadek, J.1    Grimm, R.2    Hitchman, E.3    Penner, E.4
  • 54
    • 2542509324 scopus 로고    scopus 로고
    • Cleavage of poly(ADP-ribose) transferase during p53-independent apoptosis in rat liver after treatment with N-nitrosomorpholine and cyproterone acetat
    • Wesierska-Gadek J, Bugajska-Schretter A, Löw-Baselli A, Grasl-Kraupp B. 1999. Cleavage of poly(ADP-ribose) transferase during p53-independent apoptosis in rat liver after treatment with N-nitrosomorpholine and cyproterone acetat. Mol Carcinog 24:263-275.
    • (1999) Mol Carcinog , vol.24 , pp. 263-275
    • Wesierska-Gadek, J.1    Bugajska-Schretter, A.2    Löw-Baselli, A.3    Grasl-Kraupp, B.4
  • 55
    • 0028915836 scopus 로고
    • Accumulation of p53 protein in chemically induced oval cells during early stages of rodent hepatocarcinogenesis
    • Wirnitzer U, Enzmann H, Rosenbruch M, Bomhard EM. 1995. Accumulation of p53 protein in chemically induced oval cells during early stages of rodent hepatocarcinogenesis. Carcinogenesis 16:697-701.
    • (1995) Carcinogenesis , vol.16 , pp. 697-701
    • Wirnitzer, U.1    Enzmann, H.2    Rosenbruch, M.3    Bomhard, E.M.4
  • 56
    • 0028030791 scopus 로고
    • U.V. induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle
    • Yamaizumi M, Sugano T. 1994. U.V. induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle. Oncogene 9:2775-2784.
    • (1994) Oncogene , vol.9 , pp. 2775-2784
    • Yamaizumi, M.1    Sugano, T.2


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