Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation

Nature Structural Biology

Volumn 10, Issue 5, 2003, Pages 342-348

  Kim, Ho Min ^a   Yu, Kyung Sook ^b   Lee, Mi Eun ^a   Shin, Dong Ryeol ^a   Kim, Young Sang ^b   Paik, Sang Gi ^b   Yoo, Ook Joon ^a   Lee, Hayyoung ^b   Lee, Jie Oh ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CELL ACTIVATING FACTOR; BETA CELL ACTIVATING FACTOR RECEPTOR; CYSTEINE; PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL MATURATION; COMPLEX FORMATION; CRYSTAL STRUCTURE; HUMAN; MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN PURIFICATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; B-CELL ACTIVATING FACTOR; B-CELL ACTIVATION FACTOR RECEPTOR; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMUNOGLOBULIN G; MEMBRANE PROTEINS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTORS, TUMOR NECROSIS FACTOR; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0242684718     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb925     Document Type: Article

References (43)

1. Rolink, A.G. & Melchers, F. BAFFled B cells survive and thrive: roles of BAFF in B-cell development. Curr. Opin. Immunol. 14, 266-275 (2002).
2. Mackay, F. & Mackay, C.R. The role of BAFF in B-cell maturation, T-cell activation and autoimmunity. Trends Immunol. 23, 113-115 (2002).
3. Do, R.K. & Chen-Kiang, S. Mechanism of BLyS action in B cell immunity. Cytokine Growth Factor Rev. 13, 19-25 (2002).
4. Tribouley, C. et al. Characterization of a new member of the TNF family expressed on antigen-presenting cells. Biol. Chem. 380, 1443-1447 (1999).
5. Shu, H.B., Hu, W.H. & Johnson, H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leukoc. Biol. 65, 680-683 (1999).
6. 2-terminal kinase. J. Biol. Chem. 274, 15978-15981 (1999).
7. Hu, S., Tamada, K., Ni, J., Vincenz, C. & Chen, L. Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily. Genomics 62, 103-107 (1999).
8. Moore, P.A. et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 285, 260-263 (1999).
9. Schneider, P. et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J. Exp. Med. 189, 1747-1756 (1999).
10. Gross, J.A. et al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. Impaired B cell maturation in mice lacking BLyS. Immunity 15, 289-302 (2001).
11. Schiemann, B. et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293, 2111-2114 (2001).
12. Khare, S.D. et al. Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice. Proc. Natl. Acad. Sci. USA 97, 3370-3375 (2000).
13. Mackay, F. et al. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 190, 1697-1710 (1999).
14. Groom, J. et al. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogren's syndrome. J. Clin. Invest. 109, 59-68 (2002).
15. Gross, J.A. et al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 404, 995-999 (2000).
16. Zhang, J. et al. Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus. J. Immunol. 166, 6-10 (2001).
17. Cheema, G.S., Roschke, V., Hilbert, D.M. & Stohl, W. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum. 44, 1313-1319 (2001).
18. Yan, M. et al. Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat. Immunol. 1, 37-41 (2000).
19. Xia, X.Z. et al. TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation. J. Exp. Med. 192, 137-143 (2000).
20. Wang, H. et al. TACl-ligand interactions are required for T cell activation and collagen-induced arthritis in mice. Nat. Immunol. 2, 632-637 (2001).
21. Karpusas, M. et al. Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes. J. Mol. Biol. 315, 1145-1154 (2002).
22. Oren, D.A. et al. Structural basis of BLyS receptor recognition. Nat. Struct. Biol. 9, 288-292 (2002).
23. Liu, Y. et al. Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands. Cell 108, 383-394 (2002).
24. Yan, M. et al. Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr. Biol. 11, 1547-1552 (2001).
25. Thompson, J.S. et al. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293, 2108-2111 (2001).
26. Thompson, J.S. et al. BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population. J. Exp. Med. 192, 129-135 (2000).
27. Marsters, S.A. et al. Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr. Biol. 10, 785-788 (2000).
28. Seshasayee, D. et al. Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity 18, 279-288 (2003).
29. von Bulow, G.U., van Deursen, J.M. & Bram, R.J. Regulation of the T-independent humoral response by TACI. Immunity 14, 573-582 (2001).
30. Yan, M. et al. Activation and accumulation of B cells in TACI-deficient mice. Nat. Immunol. 2, 638-643 (2001).
31. Locksley, R.M., Killeen, N. & Lenardo, M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104, 487-501 (2001).
32. Bodmer, J.L., Schneider, P. & Tschopp, J. The molecular architecture of the TNF superfamily. Trends Biochem. Sci. 27, 19-26 (2002).
33. Naismith, J.H., Devine, T.Q., Kohno, T. & Sprang, S.R. Structures of the extracellular domain of the type I tumor necrosis factor receptor. Structure 4, 1251-1262 (1996).
34. Naismith, J.H. & Sprang, S.R. Modularity in the TNF-receptor family. Trends Biochem. Sci. 23, 74-79 (1998).
35. Mongkolsapaya, J. et al. Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation. Nat. Struct. Biol. 6, 1048-1053 (1999).
36. Hymowitz, S.G. et al. Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. Mol. Cell 4, 563-571 (1999).
37. Banner, D.W. et al. Crystal structure of the soluble human 5S kD TNF receptor-human TNF β-complex: implications for TNF receptor activation. Cell 73, 431-445 (1993).
38. Kayagaki, N. et al. BAFF/BLy5 receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-κB2. Immunity 17, 515-524 (2002).
39. Madry, C. et al. The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily. Int. Immunol. 10, 1693-1702 (1998).
40. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997).
41. Brunger, A.T. et al. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. A 54, 905-921 (1998).
42. Jones, T.A., Zou, J.Y., Cowan, S.W. & Kjeldgaard, M. Improved methods for binding protein models in electron density maps and the location of errors in these models. Acta. Crystallogr. A 47, 110-119 (1991).
43. Vriend, G. WHAT IF: a molecular modeling and drug design program. J. Mol. Graph. 8, 52-56 (1990).