Mechanism of BLyS action in B cell immunity

Cytokine and Growth Factor Reviews

Volumn 13, Issue 1, 2002, Pages 19-25

  Do, Richard Kinh Gian ^a   Chen Kiang, Selina ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Apoptosis; Autoimmunity; Humoral immune response; NF kappaB; TNF

Indexed keywords

B LYMPHOCYTE STIMULATOR; BLYS RECEPTOR; LIGAND; MEMBRANE PROTEIN; TALL 1 PROTEIN; TALL-1 PROTEIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR DERIVATIVE; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; ANTIBODY RESPONSE; APOPTOSIS; AUTOIMMUNITY; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; BIOLOGICAL MODEL; CELL MATURATION; CONTROLLED STUDY; GENETICS; HUMAN; HUMORAL IMMUNITY; IMMUNOLOGY; LIGAND BINDING; METABOLISM; MOUSE; NONHUMAN; PATHOGENESIS; PHYSIOLOGY; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SHORT SURVEY; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSGENIC MOUSE; REVIEW;

ANIMAL; B-LYMPHOCYTES; HUMAN; LIGANDS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; PROTEIN BINDING; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR NECROSIS FACTOR;

EID: 0036006815     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6101(01)00025-9     Document Type: Short Survey

References (52)

1. BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator
2. BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population
3. Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity
4. Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI
5. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
6. TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation
7. BAFF-R, a novel TNF receptor that specifically interacts with BAFF
8. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
9. Synthesis and release of B-lymphocyte stimulator from myeloid cells
10. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens
11. Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response
12. APRIL a new ligand of the tumor necrosis factor family stimulates tumor cell growth
13. APRIL and TALL-1 and receptors BCMA and TACI: System for regulating humoral immunity
14. NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily
15. The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily
16. A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth
17. TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice
18. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
19. Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice
20. Relevance of systemic lupus erythematosus nephritis animal models to human disease
21. Cutting edge: A role for B lymphocyte stimulator in systemic lupus erythematosus
22. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases
23. B-Cell Maturation Protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses
24. Regulation of the T-independent humoral response by taci
25. Activation and accumulation of B cells in TACI-deficient mice
26. Taci-ig neutralizes molecules critical for B cell development and autoimmune disease, impaired B cell maturation in mice lacking BLyS
27. An essential role for BAFF in the normal development of B Cells through a BCMA-independent pathway
28. Apoptosis genes and autoimmunity
29. BAFF mediates survival of peripheral immature B lymphocytes
30. BLyS binds to B cells with high affinity and induces activation of the transcription factors NF-kappaB and ELF-1
31. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis
32. NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis
33. NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes
34. Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis
35. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control
36. NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
37. NF-kappaB signals induce the expression of c-FLIP
38. Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells
39. B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells
40. B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching
41. RelB nuclear translocation regulates B cell MHC molecule, CD40 expression, and antigen-presenting cell function
42. Nuclear factor kappa B is required for the development of marginal zone B lymphocytes
43. Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice
44. Enforced Bcl-2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
45. Bcl-2 maintains B cell memory
46. Germinal center cells express Bcl-2 protein after activation by signals which prevent their entry into apoptosis
47. Bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells
48. TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappaB, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase
49. B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1A
50. Identification and characterization of a novel cytokine, THANK a TNF homologue that activates apoptosis nuclear factor-kappaB and c-Jun NH2-terminal kinase
51. The role of TALL-1 and APRIL in immune regulation
52. Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS