The role of BAFF in B-cell maturation, T-cell activation and autoimmunity

Trends in Immunology

Volumn 23, Issue 3, 2002, Pages 113-115

  Mackay, Fabienne ^a   Mackay, Charles R ^a  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR; B CELL ACTIVATING FACTOR RECEPTOR; B CELL MATURATION ANTIGEN RECEPTOR; B LYMPHOCYTE RECEPTOR; GAMMA INTERFERON; RECEPTOR; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CELL DEATH; CELL MATURATION; CELL SURVIVAL; HUMAN; INFLAMMATION; KNOCKOUT MOUSE; MOLECULE; MYASTHENIA GRAVIS; NONHUMAN; PHENOTYPE; PROTEIN BINDING; PROTEIN BLOOD LEVEL; RHEUMATOID ARTHRITIS; SHORT SURVEY; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

EID: 0036498694     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(01)02159-7     Document Type: Review

References (19)

1. B-cell development in the spleen takes place in discrete steps and is determined by the quality of B-cell-receptor-derived signals
2. Immunobiology of the immature B cell: Plasticity in the B-cell-antigen-receptor-induced response fine tunes negative selection
3. BAFF mediates survival of peripheral immature B lymphocytes
4. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
5. TACI-Ig neutralizes molecules critical for B-cell development and autoimmune disease. Impaired B-cell maturation in mice lacking BLyS
6. Identification of a novel receptor for B-lymphocyte stimulator that is mutated in a mouse strain with severe B-cell deficiency
7. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF
8. B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses
9. Activation and accumulation of B cells in TACI-deficient mice
10. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
11. Severe B-cell hyperplasia and autoimmune disease in TALL-1 transgenic mice
12. Association of BAFF/BLyS overexpression and altered B-cell differentiation with Sjögren's syndrome
13. A role for B-lymphocyte stimulator in systemic lupus erythematosus
14. Elevated serum B-lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases
15. Sjögren's syndrome
16. TACI-ligand interactions are required for T-cell activation and collagen-induced arthritis in mice
17. T-cell costimulation by the TNF ligand BAFF
18. Attenuation of apoptosis underlies B-lymphocyte stimulator enhancement of humoral immune response
19. Synthesis and release of B-lymphocyte stimulator from myeloid cells