Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors

Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2003, Pages 1456-1464

  Kim, Deog Il ^a   Schweri, Margaret M ^b   Deutsch, Howard M ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; BENZYLAMINE; CITALOPRAM; COCAINE; CYCLOPENTANONE DERIVATIVE; DOPAMINE TRANSPORTER; DOPAMINE UPTAKE INHIBITOR; FORMALDEHYDE; HYDROXYL GROUP; ISOTROPANE (3 AZABICYCLO[3.22.1]OCTANE); N BENZYL 3 AZABICYCLO[3.2.1]OCTAN 8 ONE; PHENYL GROUP; SEROTONIN TRANSPORTER; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GRIGNARD REACTION; MANNICH REACTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; RAT; X RAY CRYSTALLOGRAPHY;

ANIMALS; BICYCLO COMPOUNDS; CARRIER PROTEINS; CEREBRAL CORTEX; COCAINE-RELATED DISORDERS; CORPUS STRIATUM; CRYSTALLOGRAPHY, X-RAY; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT MODULATORS; MEMBRANE TRANSPORT PROTEINS; MEMBRANES; NERVE TISSUE PROTEINS; OCTANES; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES;

EID: 0242669290     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020410t     Document Type: Article

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