The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells

Journal of Experimental Medicine

Volumn 183, Issue 3, 1996, Pages 801-810

  Griggs, Nathan D ^a   Agersborg, Sally S ^a   Noelle, Randolf J ^b   Ledbetter, Jeffrey A ^c   Linsley, Peter S ^c   Tung, Kenneth S K ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CLONAL ANERGY; HUMORAL IMMUNITY; IMMUNE RESPONSE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; ZONA PELLUCIDA;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY FORMATION; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION; AUTOANTIBODIES; CD40 LIGAND; CELLS, CULTURED; CLONAL ANERGY; CYTOKINES; FEMALE; IMMUNOCONJUGATES; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED A; MICE, INBRED C57BL; OOPHORITIS; OVARY; PEPTIDES; T-LYMPHOCYTES; ZONA PELLUCIDA;

EID: 0029862933     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.3.801     Document Type: Article

References (43)

1. Mueller, D., M. Jenkins, and R. Schwartz. 1989. Clonal expression versus functional clonal inactrvation. Annu. Rev. Immunol. 7:445-480.
2. Bretscher, P., and M. Cohn. 1970. A theory of self-nonself discrimination. Science (Wash. DC). 169:1042-1049.
3. Lafferty, K., S. Prowse, C. Simeonovic, and H. Warren. 1983. Immunobiology of tissue transplantation: a return to the passenger leukocyte concept. Annu. Rev. Immunol. 1:143-173.
4. Schwartz, R. 1990. A cell culture model for T lymphocyte clonal anergy. Science (Wash. DC). 248:1349-1356.
5. Schwartz, R. 1992. Costimulation of T lymphocytes: the role of CD28, CTLA4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell. 71:1065-1068.
6. June, C., J. Bluestone, L. Nadler, and C. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today. 15: 321-331.
7. Chen, C., and N. Nabavi. 1994. In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2. Immunity. 1:147-154.
8. Weaver, C., and E. Unanue. 1990. The costimulatory function of antigen-presenting cells. Immunol. Today. 11:49-55.
9. Jenkins, M., D. Pardoll, J. Mizuguchi, H. Quill, and R. Schwartz. 1987. T cell unresponsiveness in vivo and in vitro: fine specificity in induction and molecular characterization of the unresponsive state. Immunol. Rev. 95:113-135.
10. Shahinian, A., K. Pfeffer, K. Lee, T. Kundig, K. Kishihara, A. Wakemam, K. Kawai, P. Ohashi, C. Thompson, and T. Mak. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science (Wash. DC). 261:609-612.
11. Brunet, J., F. Denizot, M. Luciani, M. Roux-Dosseto, M. Suzan, M. Mattei, and P. Golstein. 1987. A new member of the immunoglobulin superfamily: CTLA-4. Nature (Lond.). 328:267-270.
12. Linsley, P., W. Brady, M. Urnes, L. Grosmaire, N. Damle, and J. Ledbetter. 1991. CTLA-4 is a second receptor for the B-cell activation antigen B7. J. Exp. Med. 174:561-564.
13. Walunus, T., D. Lenschow, C. Bakker, P. Linsley, G. Freeman, J. Green, C. Thompson, and J. Bluestone. 1994. CTLA-4 can function as a negative regulator of a T cell activation. Immunity. 1:405-413.
14. Lenschow, D., G. Su, L. Zuckerman, N. Nabavi, C. Jellis, G. Gray, J. Miller, and J. Bluestone. 1993. Expression and functional significance of an additional ligand for CTLA-4. Proc. Natl. Acad. Sci. USA. 90:11054-11058.
15. Lenschow, D., Y. Zeng, J. Thistlethwaite, A. Montag, W. Brady, M. Gibson, P. Linsley, and J. Bluestone. 1992. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4-Ig. Science (Wash. DC). 257:789-792.
16. Turka, L., P. Linsley, H. Lin, W. Brady, J. Leiden, R. Wei, M. Gibson, X. Zhen, S. Myrdal, D. Gordon, et al. 1992. T cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proc. Natl. Acad. Sci. USA. 89: 11102-11105.
17. Foy, T., J. Laman, J. Ledbetter, A. Aruffo, E. Claassen, and R. Noelle. 1994. gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. J. Exp. Med. 180:157-165.
18. Xu, J., T. Foy, J. Laman, E. Elliott, J. Dunn, T. Waldschmidt, J. Elsemore, R. Noelle, and R. Flavell 1994. Mice deficient for the CD40 ligand. Immunity. 1:423-431.
19. Renshaw, B., W. Fanslow, R. Armitage, K. Campbell, D. Liggitt, B. Wright, B. Davison, and C. Maliszewski. 1994. Humoral immune responses in CD40 ligand-deficient mice. J. Exp. Med. 180:1889-1990.
20. Di Santo, J., G. de Saint Basile, A. Durandy, and A. Fischer. 1994. Hyper-IgM syndrome. Res. Immunol. 145:199-249.
21. Durie, F., A. Aruffo, J. Ledbetter, K. Crassi, W. Green, L. Fast, and R. Noelle. 1994. Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease. J. Clin. Invest. 94:1333-1338.
22. Durie, F., R. Fava, T. Foy, A. Aruffo, J. Ledbetter, and R. Noelle. 1993. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science (Wash. DC). 261:1328-1330.
23. Mohan, C., Y. Shi, J. Laman, and S. Datta. 1994. Interaction between CD40 and its ligand gp39 in the development of murine lupus nephrite. J. Immunol. 154:1470-1480.
24. Milich, D., P. Linsley, J. Hughes, and J. Jones. 1994. Soluble CTLA-4 can suppress autoantibody production and elicit long term unresponsiveness in a novel transgenic model. J. Immunol. 153:429-435.
25. 2 production as a sensitive and rapid assay for the quantitation oi murine IFN-γ. J. Immunol. Methods. 139:107-114.
26. Lou, Y., and K. Tung. 1993. T cell peptide of a self-protein elicits autoantibody to the protein antigen. J. Immunol. 151: 5790-5799.
27. Rhim, S., S. Millar, F. Robey, A. Lou, Y. Lou, T. Yule, P. Allen, J. Dean, and K. Tung. 1992. Autoimmune disease of the ovary induced by a ZP3 peptide from mouse zona pellucida. J. Clin. Invest. 89:28-35.
28. Lou, A., K. Garza, D. Hunt, and K. Tung. 1993. Antigen mimicry in autoimmune disease sharing of amino acid residues critical for pathogenic T cell activation. J. Clin. Invest. 92:2117-2123.
29. Lou, Y.H., J. Ang, H. Thai, F. McElveen, and K.S.K. Tung. 1995. Zona pellucida-3 peptide vaccine induces antibody and reversible infertility without ovarian pathology. J. Immunol. 155:2715-2719.
30. Foy, T., D. Shepherd, F. Durie, A. Aruffo, J. Ledbetter, and R. Noelle. 1993. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the human immune response by an antibody to the ligand for CD40, gp39. J. Exp. Med. 178:1567-1575.
31. Finck, B., P. Linsley, and D. Wofsy. 1994. Treatment of murine lupus with CTLA4-Ig. Science (Wash. DC). 265:1225-1227.
32. + T lymphocytes. J. Immunol. 151:2368-2379.
33. Damle, N., K. Klussman, G. Leytze, H. Ochs, A. Aruffo, P. Linsley, and J. Ledbetter. 1993. Costimulation via vascular adhesion molecule-1 induces in T cells increased responsiveness to the CD28 counter-receptor B7. Cell. Immunol. 148: 144-156.
34. Verweij, C., M. Geerts, and L. Aarden. 1991. Activation of interleukin-2 gene transcription via T cell surface molecule CD28 is mediated through an NF-κB-like response element. J. Biol. Chem. 266:14179-14182.
35. Fraser, J., B. Irving, G. Crabtree, and A. Weiss. 1991. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science (Wash. DC). 251:313-316.
36. - T cells and defective antibody production in vivo. J. Exp. Med. 179:809-817.
37. + T cells in vivo is dependent on CD28 costimulation and inhibition by CTLA4. J. Immunol. 155:1032-1036.
38. Durie, F., T. Foy, S. Masters, J. Laman, and R. Noelle. 1994. The role of CD40 in the regulation of humoral and cell-mediated immunity. Immunol. Today. 15:406-411.
39. + T cells. Annu. Rev. Immunol. 12:635-673.
40. + T lymphocytes. J. Immunol. 152:1523-1531.
41. Notarangelo, L., M. Duse, and A. Ugazio. 1992. Immunodeficiency with hyper-IgM. Immunodefic. Rev. 3:101-121.
42. Alderson, M., R. Armitage, T. Tough, L. Strockbine, W. Fanslow, and M. Spriggs. 1993. CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J. Exp. Med. 178:669-674.
43. Ohashi, P. 1994. Ignorance is bliss. Immunologist. 2:87-92.