Chronic restraint stress massively alters the expression of genes important for lipid metabolism and detoxification in liver

Toxicology Letters

Volumn 146, Issue 1, 2003, Pages 49-63

  Ha, Hye Yeong ^a   Kim, Kyoung Shim ^a   Yeom, Young Il ^b   Lee, Ja Kyeong ^c   Han, Pyung Lim ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Inha University School of Medicine   (South Korea)

Author keywords

Cytochrome p450; Detoxification; Farnesyl transferase; Fatty acid synthase; Lipid metabolism; Liver; Microarray; PPAR; Restraint stress

Indexed keywords

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; DNA DETERMINATION; DNA MICROARRAY; GENE EXPRESSION; GENE IDENTIFICATION; GENOME; IMMOBILIZATION STRESS; LIPID METABOLISM; LIVER; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UNINDEXED SEQUENCE;

EID: 0242654825     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2003.09.006     Document Type: Article

References (42)

1. Ader R., Cohen N. Psychoneuroimmunology: conditioning and stress. Ann. Rev. Psychol. 44:1993;53-85.
2. Armstrong R.N. Structure, catalytic mechanism, and evolution of the glutathione transferase. Chem. Res. Toxicol. 10:1997;2-18.
3. Bartosiewicz M.J., Jenkins D., Penn S., Emery J., Buckpitt A. Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants. J. Pharmacol. Exp. Ther. 297:2001;895-905.
4. Berger, A., Mutch, D., German, J.B., Roberts, M.A., 2002. Unraveling lipid metabolism with microarrays: effects of arachidonate and docosahexaenoate acid on murine hepatic and hippocampal gene expression. Genome Biol. 3, 0004.1-0004.53 (Preprint).
5. Bocher V., Millatt L.J., Fruchart J.C., Staels B. Liver X receptors: new players in atherogenesis? Curr. Opin. Lipidol. 14:2003;137-143.
6. Bowen W.D., Hellewell S.B., McGarry K.A. Evidence for a multisite mode of the rat brain σ receptor. Eur. J. Pharmacol. 163:1989;309-318.
7. Cox A.D., Der C.J. Farnesyltransferase inhibitors: promises and realities. Curr. Opin. Pharmacol. 2:2002;388-393.
8. Desvergne B., Ijipenberg A., Devchand P.R., Wahli W. The peroxisomal proliferator-activated receptors at the cross-road of diet and hormonal signaling. J. Steroid Biochem. Mol. Biol. 65:1998;65-74.
9. Enriquez A., Leclercq I., Farrell G.C., Robertson G. Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats. Biochem. Biophys. Res. Commun. 255:1999;300-306.
10. Ghoshal K., Wang Y., Sheridan J.F., Jacob S.T. Metallothionein induction in response to restraint stress. Transcriptional control, adaptation to stress, and role of glucocorticoid. J. Biol. Chem. 273:1998;27904-27910.
11. Heng T.M., Kuo C.W.S., Jones P., Savory R., Schulz R.M., Tomlinson S.R., Gray T.J.B., Bell D.R. A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b but not of CYP4F, gene in mouse and humans. Biochem. J. 325:1997;741-749.
12. Hirvonen A., Pelin K., Tammilehto L., Karjalainen A., Mattson K., Linnainmaa K. Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma. Cancer Res. 55:1995;2981-2983.
13. Jacob S.T., Ghoshal K., Sheridan J.F. Induction of metallothionein by stress and its molecular mechanisms. Gene. Exp. 7:1999;301-310.
14. Jiang H., Klein R.M., Du M., Niederacher D., Gulker H. Possible role of estrogen receptor and apolipoprotein B-100 polymorphisms in coronary heart disease. Cardiology. 98:2002;100-101.
15. Kaikaus R.M., Chan W.K., Lysenko N., Ray R., de Montellano O., Baas N.M. Induction of peroxisome fatty acid-oxidation and liver fatty acid-binding protein by peroxisome proliferators. J. Biol. Chem. 268:1993;9593-9603.
16. Krueger K.E., Papadopoulos V. Mitochondrial benzodiazepine receptors and the regulation of steroid biosynthesis. Annu. Rev. Pharmacol. Toxicol. 32:1992;211-237.
17. Kuhajda F.P. Fatty-acid synthase and human cancer: new perspectives on its roles in tumor biology. Nutrition. 16:2000;202-208.
18. Labit-Le Bouteiller C., James M.F., David M., Silve S., Lanau C., Dhers C., Picard C., Rahier A., Taton M., Loison G., Caput D., Ferrara P., Lupker J. Antiproliferative effects of SR31747A in animal cell lines are mediated by inhibition of cholesterol biosynthesis at the sterol isomease step. Eur. J. Biochem. 256:1998;342-349.
19. Leclerq I.A., Farrell G.C., Field J., Bell D.R., Gonzalez F.J., Robertson G.R. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J. Clin. Invest. 105:2000;1067-1075.
20. McEwen B.S. Stress, adaptation. Ann. N. Y. Acad. Sci. 840:1998;33-44.
21. McEwen B.S., Stellar E. Stress and the individual. Mechanisms leading to disease. Arch. Intern. Med. 153:1993;2093-2101.
22. Mihalik S.J., Morrell J.C., Kim D. Identification of PAHX a Refsum disease gene. Nat. Genet. 17:1997;185-189.
23. Millatt L.J., Bocher V., Fruchart J.C., Staels B. Liver X receptors and the control of cholesterol homeostasis: potential therapeutic targets for the treatment of atherosclerosis. Biochim. Biophys. Acta. 1631:2003;107-118.
24. Moores S.L., Schaber M.D., Mosser S.D., Rands E., O'Hara M.B., Garsky V.M., Marshall M.S., Pompliano D.L., Gibbs J.B. Sequence dependence of protein isoprenylation. J. Biol. Chem. 266:2000;14603-14610.
25. Moran J.L., Siegel D., Ross D. A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. Proc. Natl. Acad. Sci. U.S.A. 96:1999;8150-8155.
26. Nicolas G., Viatte L., Bennoun M., Beaumont C., Kahn A., Vaulont S. Hepcidin: a new iron regulatory peptide. Blood Cells Mol. Dis. 29:2002;327-335.
27. Nukina H., Sudo N., Aiba Y., Oyama N., Koga Y., Kubo C. Restraint stress elevates the plasma interleukin-6 levels in germ-free mice. J. Neuroimmunol. 115:2001;46-52.
28. North A.C.T. Structural homology in ligand-specific transport protein. Biochem. Soc. Sym. 57:1989;35-48.
29. Ovnic M., Tepperman K., Medda S., Elliott R.W., Stephenson D.A., Grant S.G., Ganschow R.E. Characterization of a murine cDNA encoding a member of the carboxylesterase multigene family. Genomics. 9:1991;344-354.
30. Puskas L.G., Kitajka K., Nyakas C., Barcelo-Coblijn G., Farkas T. Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus. Proc. Natl. Acad. Sci. U.S.A. 100:2003;1580-1585.
31. Schmitt J., Pohl J., Stunnenberg H.G. Cloning and expression of a mouse cDNA encoding p59, an immunophilin that associates with the glucocorticoid receptor. Gene. 132:1993;267-271.
32. Stulnig T.M., Steffensen K.R., Gao H., Reimers M., Dahlman-Wright K., Schuster G.U., Gustafsson J.A. Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue. Mol. Pharmacol. 62:2002;1299-1305.
33. Sueyoshi T., Negishi M. Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu. Rev. Pharmacol. Toxicol. 41:2001;123-143.
34. Szolkiewicz M., Nieweglowski T., Korczynska J., Sucajtys E., Stelmanska E., Goyke E., Swierczynski J., Rutkowski B. Upregulation of fatty acid synthase gene expression in experimental chronic renal failure. Metabolism. 51:2002;1605-1610.
35. Tamanoi F., Gau C.L., Jiang C., Edamatsu H., Kato-Stankiewicz J. Protein farnesylation in mammalian cells: effects of farnesyltransferase inhibitors on cancer cells. Cell Mol. Life Sci. 58:2001;1636-1659.
36. Takahashi M., Tsuboyama-Kasaoka N., Nakatani T., Ishii M., Aburatani H., Ezaki O. Fish oil feeding alters liver gene expressions to defend against PPARα activation and ROS production. Am. J. Physiol. Gastrointest. Liver Physiol. 282:2002;G338-G348.
37. Ueda A., Hamadeh H.K., Webb H.K., Yamamoto Y., Sueyoshi T., Afshari G.A., Lehmann J.M., Negishi M. Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol. Pharmacol. 61:2002;1-6.
38. Walker J.M., Brown W.D., Walker F.O., Matsumoto R.E., De Costa B., Rice K.R. Sigma receptors: biology and function. Pharmacol. Rev. 42:1990;355-402.
39. Wallenius V., Wallenius K., Ahren B., Rudling M., Carlsten H., Dickson S.L., Ohlsson C., Jansson J.O. Interleukin-6-deficient mice develop mature-onset obesity. Nat. Med. 8:2002;75-79.
40. Waxman D.J. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch. Biochem. Biophys. 369:1999;11-23.
41. Wong J.S., Gill S.S. Gene expression changes induced in mouse liver by di(2-ethylhexyl) phthalate. Toxicol. Appl. Pharmacol. 185:2002;180-196.
42. Wu W., Yamaura T., Murakami K., Murata J., Matsumoto K., Watanabe H., Saiki I. Social isolation stress enhanced liver metastasis of murine colon 26-15 carcinoma cells by suppressing immune responses in mice. Life Sci. 66:2000;1827-1838.