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Tumor immunology
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Schreiber H: Tumor immunology. In Fundamental Immunology, edn 5. Edited by Paul W. Philadelphia: Lippincott-Raven Publishers; 2003: 1557-1593.
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Fundamental Immunology, Edn 5
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Schreiber, H.1
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Positive and negative selection of T cells
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A comprehensive review of thymic selection
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Starr T.K., Jameson S.C., Hogquist K.A. Positive and negative selection of T cells. Annu. Rev. Immunol. 21:2003;139-176 A comprehensive review of thymic selection.
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Starr, T.K.1
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Development and maturation of secondary lymphoid tissues
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Tolerance and loss of tolerance to self tissues
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Edited by Janeway CATT, Walport M, Shlomchik M. New York: Garland Publishing
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Goodnow C: Tolerance and loss of tolerance to self tissues. In Immunobiology: The Immune System in Health and Disease, edn 5. Edited by Janeway CATT, Walport M, Shlomchik M. New York: Garland Publishing; 2001: 533-545.
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Immunobiology: The Immune System in Health and Disease, Edn 5
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Goodnow, C.1
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0033514923
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Immune surveillance against a solid tumor fails because of immunological ignorance
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Ochsenbein A.F., Klenerman P., Karrer U., Ludewig B., Pericin M., Hengartner H., Zinkernagel R.M. Immune surveillance against a solid tumor fails because of immunological ignorance. Proc. Natl. Acad. Sci. U S A. 96:1999;2233-2238.
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Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction
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Ochsenbein A.F., Sierro S., Odermatt B., Pericin M., Karrer U., Hermans J., Hemmi S., Hengartner H., Zinkernagel R.M. Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction. Nature. 411:2001;1058-1064.
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Ochsenbein, A.F.1
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0031821976
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Major histocompatibility complex class I restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction
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Kurts C., Miller J.F., Subramaniam R.M., Carbone F.R., Heath W.R. Major histocompatibility complex class I restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. J. Exp. Med. 188:1998;409-414.
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Kurts, C.1
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0036911269
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Increasing tumor antigen expression overcomes 'ignorance' to solid tumors via crosspresentation by bone marrow-derived stromal cells
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Using a tamoxifen-regulated Cre-loxP system, an inducible cancer cell line is generated to show that only solid tumors expressing higher levels of antigen induce an immune response. This article also suggests that the tumor stroma determines the level of antigen necessary to induce an immune response
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Spiotto M.T., Yu P., Rowley D.A., Nishimura M.I., Meredith S.C., Gajewski T.F., Fu Y.X., Schreiber H. Increasing tumor antigen expression overcomes 'ignorance' to solid tumors via crosspresentation by bone marrow-derived stromal cells. Immunity. 17:2002;737-747 Using a tamoxifen-regulated Cre-loxP system, an inducible cancer cell line is generated to show that only solid tumors expressing higher levels of antigen induce an immune response. This article also suggests that the tumor stroma determines the level of antigen necessary to induce an immune response.
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Immunity
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Spiotto, M.T.1
Yu, P.2
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Gajewski, T.F.6
Fu, Y.X.7
Schreiber, H.8
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0033607257
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+ T cell ignorance or tolerance to islet antigens depends on antigen dose
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+ T cell ignorance or tolerance to islet antigens depends on antigen dose. Proc. Natl. Acad. Sci. U S A. 96:1999;12703-12707.
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Kurts, C.1
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Carbone, F.R.7
Miller, J.F.8
Heath, W.R.9
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11
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0037443473
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Endogenous dendritic cells are required for amplification of T cell responses induced by dendritic cell vaccines in vivo
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This article shows that endogenous DCs are necessary for peptide-loaded DCs to induce an immune response, suggesting that effective immune responses require the re-presentation of antigen by a second APC in the DLN
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Kleindienst P., Brocker T. Endogenous dendritic cells are required for amplification of T cell responses induced by dendritic cell vaccines in vivo. J. Immunol. 170:2003;2817-2823 This article shows that endogenous DCs are necessary for peptide-loaded DCs to induce an immune response, suggesting that effective immune responses require the re-presentation of antigen by a second APC in the DLN.
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Kleindienst, P.1
Brocker, T.2
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Cross-presentation: A general mechanism for CTL immunity and tolerance
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Carbone F.R., Kurts C., Bennett S.R., Miller J.F., Heath W.R. Cross-presentation: a general mechanism for CTL immunity and tolerance. Immunol. Today. 19:1998;368-373.
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14
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0037416178
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+ T cells
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This article demonstrates that antigen-specific T cells can lyse endothelial cells in islet-organ cultures and adhere to endothelial cell monolayers, suggesting that cross-presentation of antigen by endothelial cells is a major pathway for antigen presentation at the tissue site
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+ T cells. J. Exp. Med. 197:2003;643-656 This article demonstrates that antigen-specific T cells can lyse endothelial cells in islet-organ cultures and adhere to endothelial cell monolayers, suggesting that cross-presentation of antigen by endothelial cells is a major pathway for antigen presentation at the tissue site.
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Savinov, A.Y.1
Wong, F.S.2
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0035287995
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Lack of ignorance to tumor antigens: Evaluation using nominal antigen transfection and T-cell receptor transgenic lymphocytes in Lyons-Parish analysis - Implications for tumor tolerance
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Robinson B.W., Scott B.M., Lake R.A., Stumbles P.A., Nelson D.J., Fisher S., Marzo A.L. Lack of ignorance to tumor antigens: evaluation using nominal antigen transfection and T-cell receptor transgenic lymphocytes in Lyons-Parish analysis - implications for tumor tolerance. Clin. Cancer Res. 7:2001;S811-S817.
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Robinson, B.W.1
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Fisher, S.6
Marzo, A.L.7
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16
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0037128173
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Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance
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This article demonstrates that tumor growth can enhance cross-presentation and enhance the activation of high-avidity T cells. Although it is difficult to dissect how tumor growth affects cross-presentation and T cell activation, it is interesting to speculate how these processes may be linked
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Nguyen L.T., Elford A.R., Murakami K., Garza K.M., Schoenberger S.P., Odermatt B., Speiser D.E., Ohashi P.S. Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance. J. Exp. Med. 195:2002;423-435 This article demonstrates that tumor growth can enhance cross-presentation and enhance the activation of high-avidity T cells. Although it is difficult to dissect how tumor growth affects cross-presentation and T cell activation, it is interesting to speculate how these processes may be linked.
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Nguyen, L.T.1
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Odermatt, B.6
Speiser, D.E.7
Ohashi, P.S.8
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17
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0036141519
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Presented antigen from damaged pancreatic β cells activates autoreactive T cells in virus-mediated autoimmune diabetes
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This study demonstrates that islet destruction is required to release sequestered antigen and induce diabetes, indicating that viral destruction of somatic cells can release antigens and induce immune responses to antigens that are normally ignored
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Horwitz M.S., Ilic A., Fine C., Rodriguez E., Sarvetnick N. Presented antigen from damaged pancreatic β cells activates autoreactive T cells in virus-mediated autoimmune diabetes. J. Clin. Invest. 109:2002;79-87 This study demonstrates that islet destruction is required to release sequestered antigen and induce diabetes, indicating that viral destruction of somatic cells can release antigens and induce immune responses to antigens that are normally ignored.
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Horwitz, M.S.1
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18
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0038326676
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+ T cells
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Demonstrating that increased cell death in tumors can enhance cross-presentation, this report shows that low dose chemotherapy may be immunostimulatory
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+ T cells. J. Immunol. 170:2003;4905-4913 Demonstrating that increased cell death in tumors can enhance cross-presentation, this report shows that low dose chemotherapy may be immunostimulatory.
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Nowak, A.K.1
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Collins, E.J.6
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Robinson, B.W.8
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19
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18144437002
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Heteroclitic immunization induces tumor immunity
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Dyall R., Bowne W.B., Weber L.W., LeMaoult J., Szabo P., Moroi Y., Piskun G., Lewis J.J., Houghton A.N., Nikolic-Zugic J. Heteroclitic immunization induces tumor immunity. J. Exp. Med. 188:1998;1553-1561.
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Dyall, R.1
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Lewis, J.J.8
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Nikolic-Zugic, J.10
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20
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0031852722
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Gp100/pmel 17 is a murine tumor rejection antigen: Induction of 'self'-reactive, tumoricidal T cells using high-affinity, altered peptide ligand
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Overwijk W.W., Tsung A., Irvine K.R., Parkhurst M.R., Goletz T.J., Tsung K., Carroll M.W., Liu C., Moss B., Rosenberg S.A., Restifo N.P. gp100/pmel 17 is a murine tumor rejection antigen: induction of 'self'-reactive, tumoricidal T cells using high-affinity, altered peptide ligand. J. Exp. Med. 188:1998;277-286.
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Overwijk, W.W.1
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+ T cell ignorance and induction of anti-tumor immunity by peptide-pulsed APC
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+ T cell ignorance and induction of anti-tumor immunity by peptide-pulsed APC. J. Immunol. 165:2000;6731-6737.
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Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells
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Dhodapkar M.V., Steinman R.M., Sapp M., Desai H., Fossella C., Krasovsky J., Donahoe S.M., Dunbar P.R., Cerundolo V., Nixon D.F., Bhardwaj N. Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells. J. Clin. Invest. 104:1999;173-180.
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Immunologic properties of purified epidermal Langerhans cells. Distinct requirements for stimulation of unprimed and sensitized T lymphocytes
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Inaba K., Schuler G., Witmer M.D., Valinksy J., Atassi B., Steinman R.M. Immunologic properties of purified epidermal Langerhans cells. Distinct requirements for stimulation of unprimed and sensitized T lymphocytes. J. Exp. Med. 164:1986;605-613.
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Generation of tumor immunity by bone-marrow-derived dendritic cells correlates with dendritic cell maturation stage
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Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
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28
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0037013829
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+ T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function
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+ T cells. The mice possess activated and cytolytic T cells but these T cells cannot proliferate in response to antigen
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+ T cells. The mice possess activated and cytolytic T cells but these T cells cannot proliferate in response to antigen.
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Ohlen, C.1
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0038325761
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+ T cell tolerance
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This study developed a DC model capable of presenting an antigen either on a mature DC or on an immature DC. Depending on the maturational state of the DC, the same antigen resulted in tolerance or immunity
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+ T cell tolerance. Immunity. 18:2003;713-720 This study developed a DC model capable of presenting an antigen either on a mature DC or on an immature DC. Depending on the maturational state of the DC, the same antigen resulted in tolerance or immunity.
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Immunity
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Probst, H.C.1
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Toll-like receptors control activation of adaptive immune responses
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Schnare M., Barton G.M., Holt A.C., Takeda K., Akira S., Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat. Immunol. 2:2001;947-950.
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TNF-α-dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection
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Trevejo J.M., Marino M.W., Philpott N., Josien R., Richards E.C., Elkon K.B., Falck-Pedersen E. TNF-α-dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection. Proc. Natl. Acad. Sci. U S A. 98:2001;12162-12167.
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Trevejo, J.M.1
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Cutting edge: Cutting edge commentary: A Copernican revolution? Doubts about the danger theory
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Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15
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+ T cells expanded in vitro with IL-15 and CD80 survived longer in vivo. IL-15 administration in vivo is also required to sustain anti-tumor activity in vivo
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+ T cells expanded in vitro with IL-15 and CD80 survived longer in vivo. IL-15 administration in vivo is also required to sustain anti-tumor activity in vivo.
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Brentjens, R.J.1
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34
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0034658049
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Sustaining the graft-versus-tumor effect through post-transplant immunization with granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing tumor vaccines
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Borrello I., Sotomayor E.M., Rattis F.M., Cooke S.K., Gu L., Levitsky H.I. Sustaining the graft-versus-tumor effect through post-transplant immunization with granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing tumor vaccines. Blood. 95:2000;3011-3019.
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Borrello, I.1
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36
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0037174674
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Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
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These studies demonstrate that in murine models and cancer patients lymphodepletion can enhance tumor immunity. This enhancement occurs during the induction phase, preferentially expanding reactive T cells and maintaining this T cell response during the effector phase
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Dudley M.E., Wunderlich J.R., Robbins P.F., Yang J.C., Hwu P., Schwartzentruber D.J., Topalian S.L., Sherry R., Restifo N.P., Hubicki A.M., et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science. 298:2002;850-854 These studies demonstrate that in murine models and cancer patients lymphodepletion can enhance tumor immunity. This enhancement occurs during the induction phase, preferentially expanding reactive T cells and maintaining this T cell response during the effector phase.
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Science
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Dudley, M.E.1
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37
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0036195860
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Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
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Using tumors that are refractory to 4-1BB tumor immunotherapy, this report demonstrates that these tumors are ignored by the immune system. Upon immunization, 4-1BB immunotherapy became effective against these tumors
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Wilcox R.A., Flies D.B., Zhu G., Johnson A.J., Tamada K., Chapoval A.I., Strome S.E., Pease L.R., Chen L. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J. Clin. Invest. 109:2002;651-659 Using tumors that are refractory to 4-1BB tumor immunotherapy, this report demonstrates that these tumors are ignored by the immune system. Upon immunization, 4-1BB immunotherapy became effective against these tumors.
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J. Clin. Invest.
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Wilcox, R.A.1
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38
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17944364189
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Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: Comparison of prophylaxis and therapy
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van Elsas A., Sutmuller R.P., Hurwitz A.A., Ziskin J., Villasenor J., Medema J.P., Overwijk W.W., Restifo N.P., Melief C.J., Offringa R., et al. Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J. Exp. Med. 194:2001;481-489.
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Biologic activity of cytotoxic T lymphocyte associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
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+ T cells. Furthermore, CTLA-4 blockade induced tumor reactive T cells in murine models and in cancer patients
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+ T cells. Furthermore, CTLA-4 blockade induced tumor reactive T cells in murine models and in cancer patients.
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