Critical role of p42/44(MAPK) activation in anisomycin and hepatocyte growth factor-induced LDL receptor expression: Activation of Raf-1/MEK- 1/p42/44(MAPK) cascade alone is sufficient to induce LDL receptor expression

Journal of Lipid Research

Volumn 40, Issue 10, 1999, Pages 1911-1919

  Dhawan, Punita ^b   Bell, April ^b   Kumar, Amit ^a,b   Golden, Carmen ^b   Mehta, Kamal D ^b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Anisomycin; Hepatocyte growth factor; LDL receptor induction; Mitogen activated protein kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANISOMYCIN; FULVESTRANT; LOW DENSITY LIPOPROTEIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; SCATTER FACTOR;

ARTICLE; CELL STRAIN HEPG2; DRUG EFFECT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANISOMYCIN; CARCINOMA, HEPATOCELLULAR; CYCLOHEXIMIDE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HEPATOCYTE GROWTH FACTOR; HUMANS; LIVER NEOPLASMS; MAP KINASE KINASE KINASE 1; MAP KINASE KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-RAF; PUROMYCIN; RECEPTORS, LDL; TUMOR CELLS, CULTURED;

EID: 0032857028     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell. 80: 179-185.
2. Seger, R., and E. G. Krebs. 1995. The MAPK signaling cascade. FASEB J. 9: 726-735.
3. Treisman, R. 1996. Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell Biol. 8: 205-215.
4. Robinson, M. J., and M. H. Cobb. 1997. Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 9: 180-186.
5. Cano, E., and L. C. Mahadevan. 1995. Parallel signal processing among mammalian MAPKs. Trends Biochem. Sci. 20: 117-122.
6. Swantek, J. L., M. H. Cobb, and T. D. Geppert. 1997. Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-α) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK. Mol. Cell. Biol. 17: 6274-6282.
7. Weinbrenner, C., G. S. Liu, M. V. Cohen, and J. M. Downey. 1997. Phosphorylation of tyrosine 182 of p38 mitogen-activated protein kinase correlates with the protection of preconditioning in the rabbit heart. J. Mol. & Cell. Cardiol. 29: 2383-2391.
8. Kuroki, D. W., A. Minden, I. Sanchez, and E. V. Wattenberg. 1997. Regulation of a c-jun amino-terminal kinase/stress-activated protein kinase cascade by a sodium-dependent signal transduction pathway. J. Biol. Chem. 272: 23905-23911.
9. Morley, S. J., and L. McKendrick. 1997. Involvement of stress-activated protein kinase and p38/RKmitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells. J. Biol. Chem. 272: 17887-17893.
10. Moxham, C. M., A. Tabrizchi, R. J. Davis, and C. C. Malbon. 1996. Jun N-terminal kinase mediates activation of skeletal muscle glycogen synthase by insulin in vivo. J. Biol. Chem. 271: 30765-30773.
11. Park, J., I. Kim, Y. Oh, K. Lee, P. L. Han, and E. J. Choi. 1997. Activation of c-jun N-terminal kinase antagonizes an anti-apoptotic action of Bcl-2. J. Biol. Chem. 272: 16725-16728.
12. Bogoyevitch, M. A., A. J. Ketterman, and P. H. Sugden. 1995. Cellular stresses differentially activate c:Jun N-terminal protein kinases and extracellular signal-regulated protein kinases in cultured ventricular myocytes. J. Biol. Chem. 270: 29710-29717.
13. Shu, J., M. Hitomi, and D. Stacey. 1996. Activation of JNK/SAPK pathway is not directly inhibitory for cell cycle progression in NIH3T3 cells. Oncogene. 13: 2421-2430.
14. Nahas, N., T. F. Molski, G. A. Fernandez, and R. I. Shaafi. 1996. Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists. Biochem. J. 318: 247-253.
15. Waskiewicz, A. J., and J. A. Cooper. 1995. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeasts. Curr. Opin. Cell Biol. 7: 798-805.
16. Bravo, R. 1990. Growth factor-responsive genes in fibroblasts. Cell Growth Differ. 1: 305-309.
17. Hazzalin, C. A., R. L. Panse, E. Cano, and L. C. Mahadevan. 1998. Anisomycin selectively desensitizes signaling components involved in stress kinase activation and fos and jun induction. Mol. Cell. Biol. 18: 1844-1854.
18. Makar, R. S., P. E. Lipsky, and J. A. Cuthbert. 1994. Non-sterol regulation of low density lipoprotein receptor gene expression in T cells. J. Lipid Res. 35: 1888-1895.
19. Mazzone, T. K., K. Basheeruddin, and H. Duncan. 1989. Inhibitors of translation induce low density lipoprotein receptor gene expression in human skin fibroblasts. J. Biol. Chem. 264: 15529-15539.
20. Greenberg, M. E., A. L. Hermanowski, and E. B. Ziff. 1986. Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription. Mol. Cell. Biol. 6: 1050-1057.
21. Subramaniam, M., L. J. Schmidt, C. E. Crutchfield, and M. J. Getz. 1989. Negative regulation of serum-responsive enhancer elements. Nature. 340: 64-66.
22. Kumar, A., T. C. Chambers, B. A. Cloud-Heflin, and K. D. Mehta. 1997. Phorbol ester-induced low density lipoprotein receptor gene expression in HepG2 cells involves protein kinase C-mediated p42/44MAP kinase activation. J. Lipid Res. 38: 4220-4228.
23. MAPK in interleukin-1β and tumor necrosis factor-α-induced low density lipoprotein expression in HepG2 cells. J. Biol. Chem. 273: 15742-15748.
24. Singh, R. P., P. Dhawan, C. Golden, G. S. Kapoor, and K. D. Mehta. 1999. One-way cross-talk between p38MAPK and p42/44MAPK: Inhibition of p38MAPK a-isoform induces LDL receptor expression through activation of the p42/44MAPK cascade. J. Biol. Chem. 274: 19593-19600.
25. Mehta, K. D., R. Chang, J. Underwood, J. Wise, and A. Kumar. 1996. Identification of a novel cis-acting element participating in maximal induction of the human low density lipoprotein receptor gene transcription in response to low cellular cholesterol levels. J. Biol. Chem. 271: 33616-33622.
26. Bosch, E., H. Cherwinski, D. Peterson, and M. McMahon. 1997. Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1. Oncogene. 15: 1021-1033.
27. Woods, D., D. Parry, H. Cherwinski, E. Bosch, E. Lees, and M. McMartin. 1997. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cipl. Mol. Cell. Biol. 17: 5598-5611.
28. Pang, L., T. Sawada, S. J. Decker, and A. R. Saltiel. 1995. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J. Biol. Chem. 270: 13585-13588.
29. Lee, J. C., J. T. Laydon, P. C. McDonnell, T. F. Gallagher, S. Kumar, D. Green, D. McNulty, M. J. Blumenthal, J. R. Heys, S. W. Landvatter, J. E. Strickler, M. M. McLaughlin, I. R. Siemens, S. M. Fisher, G. P. Livi, J. R. White, J. L. Adams, and P. R. Young. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 372: 739-746.
30. Cuenda, A., J. Rouse, Y. N. Doza, R. Meier, P. Cohen, T. F. Gallagher, P. R. Young, and J. C. Lee. 1995. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364: 229-233.
31. James, G. L., J. L. Goldstein, M. S. Brown, T. E. Rawson, T. C. Somers, R. S. McDowell, C. W. Crowley, B. K. Lucas, A. D. Levinson, and J. J. Marsters. 1993. Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation inanimal cells. Science. 260: 1937-1942.
32. Adachi, T., S. Nakashima, S. Saji, T. Nakamura, and Y. Nozawa. 1996. Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: involvement of protein tyrosine kinase and protein kinase C. Hepatology. 23: 1244-1253.
33. Dhawan, P., M. McMartin, and K. D. Mehta. 1999. LDL receptor expression is regulated positively by the p42/44MAPK pathway in hepatic cells. Experimental Biology '99, Washington DC, April 17-21, 1999.
34. Barratt, M. J., C. A. Hazzalin, N. Zhelev, and L. C. Mahadevan. 1994. A mitogen-and anisomycin-stimulated kinase phosphorylates HMG-14 in its basic amino-terminal domain in vivo and on isolated mononucleosomes. EMBO J. 13: 4524-4535.
35. Erhardt, P., J. Troppmair, U. R. Rapp, and G. M. Cooper. 1995. Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells. Mol. Cell. Biol. 15: 5524-5530.
36. Kawasaki, H., T. Moriguchi, S. Matsuda, H. Zen Li, S. Makamura, S. Simohama, J. Kimura, Y. Gotoh, and E. Nishida. 1996. Rasdependent and Ras-independent activation pathways for the stress-activated-protein kinase cascade. Eur. J. Biochem. 241: 315-321.
37. Auer, K. L., J. Contessa, S. Brenz-Verca, L. Pirola, S. Rusconi, G. Cooper, A. Abo, M. P. Wymann, R. J. Davis, M. Birrer, and P. Dent. 1998. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Mol. Biol. Cell. 9: 561-573.