Comparative Studies of Somatic and Ongoing Mutations in Immunoglobulin Heavy-Chain Variable Region Genes in Diffuse Large B-Cell Lymphomas of the Stomach and the Small Intestine

Archives of Pathology and Laboratory Medicine

Volumn 127, Issue 11, 2003, Pages 1443-1450

  Go, Jai Hyang ^b   Kim, Dae Shick ^b   Kim, Tae Jin ^b   Ko, Young H ^b   Ra, Hyun Ki ^b   Rhee, Jong Chul ^b   Kim, Seon Woo ^b   Ree, Howe J ^a  

^a Seoul Medical Science Institute   (South Korea)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; IMMUNOGLOBULIN HEAVY CHAIN;

ADULT; AGED; ARTICLE; B CELL LYMPHOMA; CLINICAL ARTICLE; DNA SEQUENCE; GENE MUTATION; HUMAN; HUMAN TISSUE; ILEUM; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; INTESTINE LYMPHOMA; LARGE CELL LYMPHOMA; MALE; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; SOMATIC MUTATION; STOMACH LYMPHOMA; CELL CLONE; COMPARATIVE STUDY; COMPLEMENTARITY DETERMINING REGION; GENE REARRANGEMENT; GENETIC VARIABILITY; GENETICS; INTESTINE TUMOR; MIDDLE AGED; MUTAGENESIS; MUTATION; SMALL INTESTINE; SOMATIC HYPERMUTATION; STOMACH TUMOR;

ADULT; AGED; CLONE CELLS; COMPLEMENTARITY DETERMINING REGIONS; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; INTESTINAL NEOPLASMS; INTESTINE, SMALL; LYMPHOMA, B-CELL; LYMPHOMA, LARGE-CELL, DIFFUSE; MALE; MIDDLE AGED; MUTAGENESIS; MUTATION; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; STOMACH NEOPLASMS; VARIATION (GENETICS);

EID: 0242367230     PISSN: 00039985     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer. 1972;29:252-260.
2. Isaacson PG, Norton AJ. Malignant lymphoma of the upper aerodigestive tract. In: Isaacson PG, Norton AJ, eds. Extranodal Lymphomas. London, England: Churchill Livingstone; 1994:193-215.
3. Domizio P, Owen RA, Shepherd NA, et al. Primary lymphoma of the small intestine: a clinicopathological study of 119 cases. Am J Surg Pathol. 1993;17:429-432.
4. van Krieken JHJM, Otter R, Hermans J, et al. Malignant lymphoma of the gastrointestinal tract and mesentery: a clinicopathologic study of the significance of histologic classification. Am J Pathol. 1989;135:287-289.
5. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasm: a proposal from the International Lymphoma Study Group. Blood. 1994;84:1361-1392.
6. Chan JKC, Ng CS, Isaacson PG. Relationship between high-grade lymphoma and low-grade B-cell mucosa-associated lymphoid tissue lymphoma (MALToma) of the stomach. Am J Pathol. 1990;136:1153-1164.
7. Cogliatti SB, Schmid U, Schumacher U, et al. Primary B-cell gastric lymphoma: a clinicopathological study of 145 patients. Gastroenterology. 1991;101:1159-1170.
8. Müller-Hermelink HK, Zettl A, Pfeifer W, Ott G. Pathology of lymphoma progression. Histopathology. 2001;38:285-306.
9. De Wolf-Peeters C, Achten R. The histogenesis of large-cell gastric lymphomas. Histopathology. 1999;34:71-75.
10. Bereck C. The development of B cells and the B-cell repertoire in the microenvironment of the germinal center. Immunol Rev. 1992;126:5-19.
11. Klein U, Goossens T, Fischer M, et al. Somatic hypermutation in normal and transformed human B cells. Immunol Rev. 1998;162:261-280.
12. Qin Y, Greiner A, Trunk MJ, et al. Somatic hypermutation in low-grade mucosa-associated lymphoid tissue-type B-cell lymphoma. Blood. 1995;86:3528-3534.
13. Qin Y, Greiner A, Hallas C. Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis. Lab Invest. 1997;76:477-485.
14. Du M, Diss TC, Xu C, et al. Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion. Leukemia. 1996;10:1190-1197.
15. Du MQ, Xu CF, Diss TC, et al. Intestinal dissemination of gastric mucosa-associated lymphoid tissue lymphoma. Blood. 1996;88:4445-4451.
16. Driessen A, Tierens A, Ectors N, et al. Primary diffuse large B cell lymphoma of the stomach: analysis of somatic mutations in the rearranged immunoglobulin heavy chain variable genes indicates antigen selection. Leukemia. 1993;13:1085-1092.
17. H genes of high-grade mucosa-associated lymphoid tissue lymphomas show a high load of somatic mutations and evidence of antigen-dependent affinity maturation. Lab Invest. 1998;78:277-287.
18. Jacob J, Kelsoe G, Rajewsky K, et al. Intraclonal generation of antibody mutants in germinal centers. Nature. 1991;354:389-392.
19. Bahler DW, Levy R. Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc Natl Acad Sci U S A. 1992;89:6770-6774.
20. Zelenetz AD, Chen TT, Levy R. Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection. J Exp Med. 1992;176:1137-1148.
21. Bahler DW, Miklos JA, Swerdlow SH. Ongoing Ig gene hypermutation in salivary gland mucosa-associated lymphoid tissue-type lymphomas. Blood. 1997;89:3335-3344.
22. Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Hematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001.
23. H genes with no or very little somatic mutations like the physiologic cells of the follicle mantle. Blood 1994;84:403-407.
24. H genes with a moderate number of antigen-selected somatic mutations. Am J Pathol. 1995;147:1398-1407.
25. Mosteller F, Rourke REK. Study Statistics. Reading, Mass: Addison-Wesley; 1973:54-84.
26. H genes are inherently susceptible to amino acid replacement. Immunol Today. 1994;15:367-373.
27. Jukes TH, King JL. Evolutionary nucleotide replacements in DNA. Nature. 1979;281:605-606.
28. Ottensmeier CH, Thompsett AR, Zhu D, et al. Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression. Blood. 1998;91:4292-4299.
29. H genes expressed in prolymphocytic leukemia. Blood. 1996;88:3953-3961.
30. Shlomchik MJ, Marshak-Rothstein A, Wolfowicz CB, et al. The role of clonal selection and somatic mutation in autoimmunity. Nature. 1987;328:805-811.
31. Amit AG, Mariuzza RA, Phillips SEV, et al. Three-dimensional structure of an antigen-antibody complex at 6 A resolution. Nature. 1985;313:156-158.
32. Hussell T, Isaacson PG, Crabtree JE, et al. Immunoglobulin specificity of low grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type. Am J Pathol. 1993;142:285-292.
33. Greiner A, Marx A, Heesemann J, et al. Idiotype identity in a MALT-type lymphoma and B cells in Helicobacter pylori-associated chronic gastritis. Lab Invest. 1994;70:572-578.
34. Zelenetz AD, Chen TT, Levy R. Histologic transformation of follicular lymphoma to diffuse lymphoma represents tumor progression by a single malignant B cell. J Exp Med. 1991;173:197-207.
35. Zhu D, Hawkins RE, Hamblin TJ, et al. Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes. Br J Haematol. 1994;86:505-512.
36. Lossos IS, Okada CY, Tibshirani R, et al. Molecular analysis of immunoglobulin genes in diffuse large B-cell lymphomas. Blood. 2000;95:1797-1803.
37. Küppers R, Rajewsky K, Hansmann ML. Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression. Eur J Immunol. 1997;27:1398-1405.
38. + diffuse large B-cell lymphomas express VH genes with somatic mutation. Blood. 1998;91:1145-1151.
39. Stiernholm N, Kuzniar B, Berinstein NL. Absence of immunoglobulin variable region hypermutation in a large cell lymphoma after in vivo and in vitro propagation. Blood. 1992;80:738-743.
40. Lossos IS, Alizadeh AA, Eisen MB, et al. Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas. Proc Natl Acad Sci U S A. 2000;97:10209-10213.
41. LeBrun DP, Kamel OW, Cleary ML, et al. Follicular lymphomas of the gastrointestinal tract: pathologic features in 31 cases and bcl-2 oncogenic protein expression. Am J Pathol. 1992;140:1327-1335.
42. Dunn-Walters DK, Isaacson PG, Spencer J. Sequence analysis of human IgVH genes indicates that ileal lamina propria plasma cells are derived from Peyer's patches. Eur J Immunol. 1997;27:463-467.
43. Dunn-Walters DK, Boursier L, Spencer J. Hypermutation, diversity and dissemination of human lamina propria plasma cells. Eur J Immunol. 1997;27:2959-2964.
44. Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403:503-511.