Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components

Biochemical Journal

Volumn 347, Issue 1, 2000, Pages 89-96

  Schuringa, Jan Jacob ^a,b   Jonk, Luigi J C ^a   Dokter, Wim H A ^b   Vellenga, Edo ^b   Kruijer, Wiebe ^a  

^a University of Groningen Center of Biological Sciences Haren   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Cytokine signalling; Gp130; Serine phosphorylation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANISOMYCIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; SERINE; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ARTICLE; CELL STRAIN HEPG2; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSACTIVATION;

AMINO ACID SUBSTITUTION; CARCINOMA, HEPATOCELLULAR; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; ENZYME INHIBITORS; GENES, REPORTER; HUMANS; IMIDAZOLES; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-VAV; PYRIDINES; RAC GTP-BINDING PROTEINS; RECOMBINANT PROTEINS; SERINE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034176912     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3470089     Document Type: Article

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