Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E

Journal of Clinical Investigation

Volumn 102, Issue 2, 1998, Pages 386-394

  Osuga, Jun Ichi ^a   Yonemoto, Mari ^b   Yamada, Nobuhiro ^a   Shimano, Hitoshi ^a   Yagyu, Hiroaki ^a   Ohashi, Ken ^a   Harada, Kenji ^a   Kamei, Toshio ^b   Yazaki, Yoshio ^a   Ishibashi, Shun ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Apo E; Atherosclerosis; Hypercholesterolemia; Knockout mouse; Low density lipoprotein receptor

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL EXPERIMENT; AORTA SINUS; ARTICLE; ATHEROGENIC DIET; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; HYPERCHOLESTEROLEMIA; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0032527612     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1124     Document Type: Article

References (31)

1. Mahley, R.W. 1988. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 240:622-630.
2. Brown, M.S., and J.L. Goldstein. 1986. A receptor pathway for cholesterol homeostasis. Science. 232:34-37.
3. Yamada, N., D.M. Shames, J.B. Stoudmire, and R.J. Havel. 1987. Metabolism of lipoproteins containing apolipoprotein B-100 in blood plasma of rabbits: heterogeneity related to the presence of apolipoprotein E. Proc. Natl. Acad. Sci. USA. 83:3479-3483.
4. Ji, Z.-S., S. Fazio, Y.-L. Lee, and R.W. Mahley. 1994. Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycan. J. Biol. Chem. 269:2764-2772.
5. Kita, T., M.S. Brown, D.W. Bilheimer, and J.L. Goldstein. 1982. Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits. Proc. Natl. Acad. Sci. USA. 79:5693-5697.
6. Ishibashi, S., J. Herz, N. Maeda, J.L. Goldstein, and M.S. Brown. 1994. The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proc. Natl. Acad. Sci. USA. 91:4431-4435.
7. Herz, J., U. Hamann, S. Rogne, O. Myklebost, H. Gausepohl, and K.K. Stanley. 1988. Surface location and high affinity for calcium of a 500 kDa liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO (Eur. Mol. Biol. Organ.) J. 7:4119-4127.
8. Willnow, T.E., Z. Sheng, S. Ishibashi, and J. Herz. 1994. Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Science. 264:1471-1474.
9. Rohlmann, A., M. Gotthardt, R.E. Hammer, and J. Herz. 1998. Inducible inactivation of hepatic LRP by Cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J. Clin. Invest. 101:689-695.
10. Yamada, N., H. Shimano, H. Mokuno, S. Ishibashi, T. Gotohda, K. Kawakami, Y. Watanabe, Y. Akanuma, T. Murase, and F. Takaku. 1989. Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits. Proc. Natl. Acad. Sci. USA. 86:665-669.
11. Mahley, R.W., K.H. Weisgraber, M.M. Hussain, B. Greenman, M. Fisher, T. Vogel, and M. Gorecki. 1989. Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits. J. Clin. Invest. 83: 2125-2130.
12. Yamada, N., I. Inoue, M. Kawamura, K. Harada, Y. Watanabe, H. Shimano, T. Gotoda, M. Shimada, K. Kohzaki, T. Tsukada, M. Shiomi, Y. Watanabe, and Y. Yazaki. 1992. Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits. J. Clin. Invest. 89: 706-711.
13. Shimano, H., N. Yamada, M. Katsuki, M. Shimada, T. Gotoda, K. Harada, T. Murase, F. Fukazawa, F. Takaku, and Y. Yazaki. 1992. Overexpression of apolipoprotein E in transgenic mice: a marked reduction in plasma lipoproteins except high density lipoprotein, and resistance against diet-induced hypercholesterolemia. Proc. Natl. Acad. Sci. USA. 89:1750-1754.
14. Shimano, H., N. Yamada, M. Katsuki, K. Yamamoto, T. Gotoda, K. Harada, M. Shimada, and Y. Yazaki. 1992. Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B. J. Clin. Invest. 90:2084-2091.
15. Ishibashi, S., M.S. Brown, J.L. Goldstein, R.D. Gerard, R.E. Hammer, and J. Herz. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92:883-893.
16. Shimada, M., S. Ishibashi, T. Inaba, H. Yagyu, K. Harada, J. Osuga, K. Ohashi, Y. Yazaki, and N. Yamada. 1996. Suppression of diet-induced atherosclerosis in low density lipoprtein receptor knockout mice overexpressing lipoprotein lipase. Proc. Natl. Acad. Sci. USA. 93:7242-7246.
17. Kotite, L., N. Bergeron, and R.J. Havel. 1995. Quantitation of apolipoprotein B-100, B-48, and E in human triglyceride-rich lipoproteins. J. Lipid Res. 36:890-900.
18. Noma, A., T. Yokosuka, and K. Kitamura. 1983. Plasma lipids and apolipoproteins as determinators for presence and severity of angioraphycally defined coronary artery disease. Atherosclerosis. 49:1-7.
19. Kataoka, S., M. Paidi, and B.V. Howard. 1994. Simplified isoelectric focusing/immunoblotting determination of apolipoprotein E phenotype. Clin. Chem. 40:11-13.
20. Havel, R.J., H.A. Eder, and J.H. Bragdon. 1955. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34:1345-1353.
21. Bergeron, N., L. Kotite, and R.J. Havel. 1996. Simultaneous quantitation of apolipoproteins B-100, B-48, and E separated by SDS-PAGE. Methods Enzymol. 262:82-94.
22. Goldstein, J.L., S.K. Basu, and M.S. Brown. 1983. Receptor-mediated endocytosis of LDL in cultured cells. Methods Enzymol. 98:241-260.
23. 131I-labeled plasma proteins. Phys. Med. Biol. 2:36-53.
24. Paigen, B., A. Morrow, P.A. Holmes, D. Mitchell, and R.A Williams. 1987. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 68:231-240.
25. Ishibashi, S., N. Yamada, H. Shimano, N. Mori, K. Mokuno, T. Gptoda, M. Mawamaki, T. Murase, and F. Takaku. 1990. Apolipoprotein E and lipoprotein lipase secreted from human monocyte-derived macrophages modulate very low density lipoprotein uptake. J. Biol. Chem. 265:3040-3047.
26. Shimano, H., Y. Namba, J. Ohsuga, M. Kawamura, K. Yamamoto, M. Shimada, T. Gotoda, K. Harada, Y. Yazaki, and N. Yamada. 1994. Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice. J. Clin. Invest. 93:2215-2223.
27. Ishibashi, S., S. Perrey, Z. Chen, J. Osuga, M. Shimada, K. Ohashi, K. Harada, Y. Yazaki, and N. Yamada. 1996. Role of the low density lipoprotein receptor pathway in the metabolism of chylomicron remnants: a quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E or both. J. Biol. Chem. 271:22422-22427.
28. Kobayashi, K., K. Oka, T. Forte, B. Ishida, B. Teng, K. Ishimura-Oka, M. Nakamuta, and L. Chan. 1996. Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor. J. Biol. Chem. 271:6852-6856.
29. Kozarsky, K.F., K. Jooss, M. Donahee, J.F. Strauss, III, and J.M. Wilson. 1996. Effective treatment of familial hypercholesterolemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Nat. Genet. 13:54-62.
30. Teng, B., B. Ishida, T.M. Forte, S. Blumenthal, L.-Z. Song, A.M. Gotto, Jr., and L. Chan. 1997. Fffective lowering of plasma, LDL, and esterified cho0 lesterol in LDL receptor-knockout mice by adenovirous-mediated gene delivery of apo B mRNA editing enzyme (Apobec1). Arterioscler. Thromb. Vasc. Biol. 17:889-897.
31. Spady, D.K., J.A. Cuthbert, M.N. Willard, and R.S. Meidell. 1998. Overexpression of cholesterol 7α-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene: LDL transport and plasma LDL concentrations are reduced. J. Biol. Chem. 273:126-132.