Inducible nitric oxide synthase-derived nitric oxide in gene regulation, cell death and cell survival

International Immunopharmacology

Volumn 1, Issue 8, 2001, Pages 1407-1420

  Kröncke, Klaus Dietrich ^a   Fehsel, Karin ^a   Suschek, Christoph ^a   Kolb Bachofen, Victoria ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Apoptosis; Diabetes; Glutathione; Nitric oxide; Transcription; UV irradiation

Indexed keywords

APOPTOSIS INDUCING FACTOR; BUTHIONINE SULFOXIMINE; CARMUSTINE; CYTOKINE; DNA; GLUTATHIONE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN; PROTEIN BAX; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

APOPTOSIS; BINDING SITE; CELL DEATH; CELL LEVEL; CELL MEMBRANE; CELL PROTECTION; CELL SURVIVAL; DIABETES MELLITUS; DNA BINDING; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION; HUMAN; INFLAMMATION; LIPID PEROXIDATION; NITROSATION; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RADIATION RESPONSE; REVIEW; TRANSCRIPTION REGULATION; ULTRAVIOLET A RADIATION;

ANIMALS; CELL DEATH; CELL SURVIVAL; GENE EXPRESSION REGULATION; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II;

EID: 0034935623     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(01)00087-X     Document Type: Review

References (46)

1. Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation
2. Glutathione
3. Regulation of cellular thiol redox status by nitric oxide
4. Zinc finger transcription factors as molecular targets for nitric oxide-mediated immunosuppression: Inhibition of IL-2 gene expression in murine lymphocytes
5. Influence of nitric oxide on the intracellular reduced glutathione pool: Different cellular capacities and strengths to encounter NO-mediated stress
6. Inhibition of NF-κB DNA binding by nitric oxide
7. Effects of hydrogen peroxide, nitric oxide and antioxidants on NF-κB
8. Inhibition of AP-1 DNA binding by nitric oxide involving conserved cysteine residues in Jun and Fos
9. Nitric oxide (NO) disrupts DNA binding of the transcription factor c-Myb in vitro
10. A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1
11. Inactivation of zinc finger transcription factors provides a mechanism for a gene-regulatory role of nitric oxide
12. A Sp1 binding site of the tumor necrosis factor α promoter functions as a nitric oxide response element
13. Nitric oxide: A pathogenic factor in autoimmunity
14. Pancreatic islet cells are highly susceptible towards the cytotoxic effects of chemically generated nitric oxide
15. Apoptosis and the pathogenesis of IDDM: A question of life and death
16. Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats
17. Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4
18. Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: Identification of iNOS-expressing cells and relationships to cytokines expressed in the islets
19. Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice
20. An immunhistochemical study of macrophage influx and the co-localization of inducible nitric oxide synthase in the pancreas of non-obese diabetic (NOD) mice during disease acceleration with cyclophosphamide
21. Endothelial cells as cytotoxic effector cells: Cytokine-activated islet endothelial cells lyse syngeneic islet cells via nitric oxide
22. Nitric oxide-induced expression of C-reactive protein in islet cells as a very early marker for islet stress in the rat pancreas
23. Islet cell DNA is a target of inflammatory attack by nitric oxide
24. Mice lacking the poly(ADP-ribose)polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin
25. Poly(ADP-ribose)polymerase is a mediator of necrotic cell death by ATP depletion
26. Potent beta-cell protection in vitro by an isoquinolinone-derived PARP inhibitor
27. Interleukin-1 beta-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells
28. Apoptotic cell death triggered by nitric oxide in panceatic β-cells
29. Superoxide, nitric oxide, peroxynitrite and cytokine combinations all cause functional impairment and morphological changes in rat islets of Langerhans and insulin secreting cell lines, but dictate cell death by different mechanisms
30. In situ nick translation detects focal apoptosis in thymuses of glucocorticoid- and lipopolysaccharid-treated mice
31. Nitric oxide induces thymocyte apoptosis via a caspase-1-dependent mechanism
32. Nitric oxide induces apoptosis in mouse thymocytes
33. Expression of an inducible type of nitric oxide (NO) synthase in the thymus and involvement of NO in deletion of TCR-stimulated double-positive thymocytes
34. Thymic dendritic cells express inducible nitric oxide synthase and generate nitric oxide in response to self- and alloantigens
35. Nitric oxide-induced apoptosis in human leukemic requires mitochondrial lipid degradation and cytochrome c release
36. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
37. Neuronal cell death: A demise with different shapes
38. Aberant timing in epidermal expression of inducible nitric oxide synthase after UV irradiation in cutaneous lupus erythematosus
39. Nitric oxide fully protects against UVA-induced apoptosis in tight correlation with Bcl-2 up-regulation
40. Even after UVA-exposure will nitric oxide protect cells from reactive oxygen intermediate-mediated apoptosis and necrosis
41. Implications of inducible nitric oxide synthase expression and enzyme activity
42. Biphasic effect of exogenous nitric oxide on proliferation and differentiation in skin derived keratinocytes but not fibroblasts
43. Nitric oxide mediates intracytoplasmic and intranuclear zinc release
44. Nitric oxide and its implications in skin homeostasis and disease - A review
45. Nitric oxide in autoimmune disease: Cytotoxic or regulatory mediator?
46. Zinc finger proteins as molecular targets for nitric-oxide-mediated gene regulation